CA2225808C - Silver-based pharmaceutical compositions - Google Patents
Silver-based pharmaceutical compositions Download PDFInfo
- Publication number
- CA2225808C CA2225808C CA002225808A CA2225808A CA2225808C CA 2225808 C CA2225808 C CA 2225808C CA 002225808 A CA002225808 A CA 002225808A CA 2225808 A CA2225808 A CA 2225808A CA 2225808 C CA2225808 C CA 2225808C
- Authority
- CA
- Canada
- Prior art keywords
- silver
- composition
- pharmaceutical mixture
- antimicrobial
- pharmaceutical
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 229910052709 silver Inorganic materials 0.000 title claims abstract description 200
- 239000004332 silver Substances 0.000 title claims abstract description 200
- BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 title claims abstract description 171
- 239000008194 pharmaceutical composition Substances 0.000 title abstract description 211
- 239000000203 mixture Substances 0.000 claims abstract description 460
- 230000000845 anti-microbial effect Effects 0.000 claims abstract description 128
- 150000001450 anions Chemical class 0.000 claims abstract description 83
- 229920000570 polyether Polymers 0.000 claims abstract description 75
- 238000000034 method Methods 0.000 claims abstract description 59
- 125000002015 acyclic group Chemical group 0.000 claims abstract description 32
- 230000000087 stabilizing effect Effects 0.000 claims abstract description 19
- 239000003795 chemical substances by application Substances 0.000 claims description 129
- 229920001223 polyethylene glycol Polymers 0.000 claims description 95
- 239000004599 antimicrobial Substances 0.000 claims description 65
- 239000002202 Polyethylene glycol Substances 0.000 claims description 53
- FOIXSVOLVBLSDH-UHFFFAOYSA-N Silver ion Chemical compound [Ag+] FOIXSVOLVBLSDH-UHFFFAOYSA-N 0.000 claims description 51
- JYGXADMDTFJGBT-VWUMJDOOSA-N hydrocortisone Chemical compound O=C1CC[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 JYGXADMDTFJGBT-VWUMJDOOSA-N 0.000 claims description 38
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 claims description 24
- 229960003640 mafenide Drugs 0.000 claims description 21
- TYMRLRRVMHJFTF-UHFFFAOYSA-N Mafenide Chemical compound NCC1=CC=C(S(N)(=O)=O)C=C1 TYMRLRRVMHJFTF-UHFFFAOYSA-N 0.000 claims description 20
- 229960000890 hydrocortisone Drugs 0.000 claims description 19
- MINDHVHHQZYEEK-UHFFFAOYSA-N (E)-(2S,3R,4R,5S)-5-[(2S,3S,4S,5S)-2,3-epoxy-5-hydroxy-4-methylhexyl]tetrahydro-3,4-dihydroxy-(beta)-methyl-2H-pyran-2-crotonic acid ester with 9-hydroxynonanoic acid Natural products CC(O)C(C)C1OC1CC1C(O)C(O)C(CC(C)=CC(=O)OCCCCCCCCC(O)=O)OC1 MINDHVHHQZYEEK-UHFFFAOYSA-N 0.000 claims description 18
- SYCBXBCPLUFJID-UHFFFAOYSA-N Pramoxine hydrochloride Chemical compound Cl.C1=CC(OCCCC)=CC=C1OCCCN1CCOCC1 SYCBXBCPLUFJID-UHFFFAOYSA-N 0.000 claims description 18
- DDHVILIIHBIMQU-YJGQQKNPSA-L mupirocin calcium hydrate Chemical compound O.O.[Ca+2].C[C@H](O)[C@H](C)[C@@H]1O[C@H]1C[C@@H]1[C@@H](O)[C@@H](O)[C@H](C\C(C)=C\C(=O)OCCCCCCCCC([O-])=O)OC1.C[C@H](O)[C@H](C)[C@@H]1O[C@H]1C[C@@H]1[C@@H](O)[C@@H](O)[C@H](C\C(C)=C\C(=O)OCCCCCCCCC([O-])=O)OC1 DDHVILIIHBIMQU-YJGQQKNPSA-L 0.000 claims description 18
- 229940019974 pramoxine hydrochloride Drugs 0.000 claims description 18
- GHXZTYHSJHQHIJ-UHFFFAOYSA-N Chlorhexidine Chemical compound C=1C=C(Cl)C=CC=1NC(N)=NC(N)=NCCCCCCN=C(N)N=C(N)NC1=CC=C(Cl)C=C1 GHXZTYHSJHQHIJ-UHFFFAOYSA-N 0.000 claims description 17
- 229960003260 chlorhexidine Drugs 0.000 claims description 17
- XMBWDFGMSWQBCA-UHFFFAOYSA-N hydrogen iodide Chemical compound I XMBWDFGMSWQBCA-UHFFFAOYSA-N 0.000 claims description 16
- 229960003128 mupirocin Drugs 0.000 claims description 16
- 229930187697 mupirocin Natural products 0.000 claims description 16
- 150000003431 steroids Chemical group 0.000 claims description 15
- 230000003444 anaesthetic effect Effects 0.000 claims description 14
- CPELXLSAUQHCOX-UHFFFAOYSA-M Bromide Chemical compound [Br-] CPELXLSAUQHCOX-UHFFFAOYSA-M 0.000 claims description 13
- NNJVILVZKWQKPM-UHFFFAOYSA-N Lidocaine Chemical compound CCN(CC)CC(=O)NC1=C(C)C=CC=C1C NNJVILVZKWQKPM-UHFFFAOYSA-N 0.000 claims description 13
- 229960004194 lidocaine Drugs 0.000 claims description 13
- IAIWVQXQOWNYOU-FPYGCLRLSA-N nitrofural Chemical compound NC(=O)N\N=C\C1=CC=C([N+]([O-])=O)O1 IAIWVQXQOWNYOU-FPYGCLRLSA-N 0.000 claims description 13
- 229960001907 nitrofurazone Drugs 0.000 claims description 13
- BLFLLBZGZJTVJG-UHFFFAOYSA-N benzocaine Chemical compound CCOC(=O)C1=CC=C(N)C=C1 BLFLLBZGZJTVJG-UHFFFAOYSA-N 0.000 claims description 12
- VAOCPAMSLUNLGC-UHFFFAOYSA-N metronidazole Chemical compound CC1=NC=C([N+]([O-])=O)N1CCO VAOCPAMSLUNLGC-UHFFFAOYSA-N 0.000 claims description 12
- 229960000282 metronidazole Drugs 0.000 claims description 12
- VHVPQPYKVGDNFY-DFMJLFEVSA-N 2-[(2r)-butan-2-yl]-4-[4-[4-[4-[[(2r,4s)-2-(2,4-dichlorophenyl)-2-(1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazin-1-yl]phenyl]-1,2,4-triazol-3-one Chemical compound O=C1N([C@H](C)CC)N=CN1C1=CC=C(N2CCN(CC2)C=2C=CC(OC[C@@H]3O[C@](CN4N=CN=C4)(OC3)C=3C(=CC(Cl)=CC=3)Cl)=CC=2)C=C1 VHVPQPYKVGDNFY-DFMJLFEVSA-N 0.000 claims description 7
- 239000004099 Chlortetracycline Substances 0.000 claims description 7
- MUQNGPZZQDCDFT-JNQJZLCISA-N Halcinonide Chemical compound C1CC2=CC(=O)CC[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@H]3OC(C)(C)O[C@@]3(C(=O)CCl)[C@@]1(C)C[C@@H]2O MUQNGPZZQDCDFT-JNQJZLCISA-N 0.000 claims description 7
- XWALNWXLMVGSFR-HLXURNFRSA-N Methandrostenolone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@](C)(O)[C@@]1(C)CC2 XWALNWXLMVGSFR-HLXURNFRSA-N 0.000 claims description 7
- 239000004100 Oxytetracycline Substances 0.000 claims description 7
- 229930182555 Penicillin Natural products 0.000 claims description 7
- JGSARLDLIJGVTE-MBNYWOFBSA-N Penicillin G Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)CC1=CC=CC=C1 JGSARLDLIJGVTE-MBNYWOFBSA-N 0.000 claims description 7
- 239000004098 Tetracycline Substances 0.000 claims description 7
- 229960004150 aciclovir Drugs 0.000 claims description 7
- MKUXAQIIEYXACX-UHFFFAOYSA-N aciclovir Chemical compound N1C(N)=NC(=O)C2=C1N(COCCO)C=N2 MKUXAQIIEYXACX-UHFFFAOYSA-N 0.000 claims description 7
- 229960000870 betamethasone benzoate Drugs 0.000 claims description 7
- SOQJPQZCPBDOMF-YCUXZELOSA-N betamethasone benzoate Chemical compound O([C@]1([C@@]2(C)C[C@H](O)[C@]3(F)[C@@]4(C)C=CC(=O)C=C4CC[C@H]3[C@@H]2C[C@@H]1C)C(=O)CO)C(=O)C1=CC=CC=C1 SOQJPQZCPBDOMF-YCUXZELOSA-N 0.000 claims description 7
- 229960004311 betamethasone valerate Drugs 0.000 claims description 7
- SNHRLVCMMWUAJD-SUYDQAKGSA-N betamethasone valerate Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@H](C)[C@@](C(=O)CO)(OC(=O)CCCC)[C@@]1(C)C[C@@H]2O SNHRLVCMMWUAJD-SUYDQAKGSA-N 0.000 claims description 7
- WIIZWVCIJKGZOK-RKDXNWHRSA-N chloramphenicol Chemical compound ClC(Cl)C(=O)N[C@H](CO)[C@H](O)C1=CC=C([N+]([O-])=O)C=C1 WIIZWVCIJKGZOK-RKDXNWHRSA-N 0.000 claims description 7
- 229960005091 chloramphenicol Drugs 0.000 claims description 7
- CYDMQBQPVICBEU-UHFFFAOYSA-N chlorotetracycline Natural products C1=CC(Cl)=C2C(O)(C)C3CC4C(N(C)C)C(O)=C(C(N)=O)C(=O)C4(O)C(O)=C3C(=O)C2=C1O CYDMQBQPVICBEU-UHFFFAOYSA-N 0.000 claims description 7
- 229960004475 chlortetracycline Drugs 0.000 claims description 7
- CYDMQBQPVICBEU-XRNKAMNCSA-N chlortetracycline Chemical compound C1=CC(Cl)=C2[C@](O)(C)[C@H]3C[C@H]4[C@H](N(C)C)C(O)=C(C(N)=O)C(=O)[C@@]4(O)C(O)=C3C(=O)C2=C1O CYDMQBQPVICBEU-XRNKAMNCSA-N 0.000 claims description 7
- 235000019365 chlortetracycline Nutrition 0.000 claims description 7
- 229960001747 cinchocaine Drugs 0.000 claims description 7
- PUFQVTATUTYEAL-UHFFFAOYSA-N cinchocaine Chemical compound C1=CC=CC2=NC(OCCCC)=CC(C(=O)NCCN(CC)CC)=C21 PUFQVTATUTYEAL-UHFFFAOYSA-N 0.000 claims description 7
- 229960003662 desonide Drugs 0.000 claims description 7
- WBGKWQHBNHJJPZ-LECWWXJVSA-N desonide Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@@H]2[C@@H]1[C@@H]1C[C@H]3OC(C)(C)O[C@@]3(C(=O)CO)[C@@]1(C)C[C@@H]2O WBGKWQHBNHJJPZ-LECWWXJVSA-N 0.000 claims description 7
- FEBLZLNTKCEFIT-VSXGLTOVSA-N fluocinolone acetonide Chemical compound C1([C@@H](F)C2)=CC(=O)C=C[C@]1(C)[C@]1(F)[C@@H]2[C@@H]2C[C@H]3OC(C)(C)O[C@@]3(C(=O)CO)[C@@]2(C)C[C@@H]1O FEBLZLNTKCEFIT-VSXGLTOVSA-N 0.000 claims description 7
- 229960002383 halcinonide Drugs 0.000 claims description 7
- 229960004130 itraconazole Drugs 0.000 claims description 7
- 229960003377 metandienone Drugs 0.000 claims description 7
- 229960000625 oxytetracycline Drugs 0.000 claims description 7
- IWVCMVBTMGNXQD-PXOLEDIWSA-N oxytetracycline Chemical compound C1=CC=C2[C@](O)(C)[C@H]3[C@H](O)[C@H]4[C@H](N(C)C)C(O)=C(C(N)=O)C(=O)[C@@]4(O)C(O)=C3C(=O)C2=C1O IWVCMVBTMGNXQD-PXOLEDIWSA-N 0.000 claims description 7
- 235000019366 oxytetracycline Nutrition 0.000 claims description 7
- 229940049954 penicillin Drugs 0.000 claims description 7
- IWVCMVBTMGNXQD-UHFFFAOYSA-N terramycin dehydrate Natural products C1=CC=C2C(O)(C)C3C(O)C4C(N(C)C)C(O)=C(C(N)=O)C(=O)C4(O)C(O)=C3C(=O)C2=C1O IWVCMVBTMGNXQD-UHFFFAOYSA-N 0.000 claims description 7
- 229960002180 tetracycline Drugs 0.000 claims description 7
- 235000019364 tetracycline Nutrition 0.000 claims description 7
- 229930101283 tetracycline Natural products 0.000 claims description 7
- 150000003522 tetracyclines Chemical class 0.000 claims description 7
- 229960005274 benzocaine Drugs 0.000 claims description 6
- 238000012377 drug delivery Methods 0.000 claims description 6
- 229960001347 fluocinolone acetonide Drugs 0.000 claims description 6
- 239000007943 implant Substances 0.000 claims description 6
- 229920001451 polypropylene glycol Polymers 0.000 claims description 6
- 238000001228 spectrum Methods 0.000 claims description 6
- 208000015181 infectious disease Diseases 0.000 abstract description 46
- 230000002265 prevention Effects 0.000 abstract description 13
- 201000010099 disease Diseases 0.000 abstract description 12
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract description 12
- 150000001768 cations Chemical class 0.000 abstract description 8
- SQGYOTSLMSWVJD-UHFFFAOYSA-N silver(1+) nitrate Chemical compound [Ag+].[O-]N(=O)=O SQGYOTSLMSWVJD-UHFFFAOYSA-N 0.000 description 121
- 239000000243 solution Substances 0.000 description 77
- 238000012360 testing method Methods 0.000 description 69
- 229910001961 silver nitrate Inorganic materials 0.000 description 61
- -1 silver ions Chemical class 0.000 description 57
- 238000002156 mixing Methods 0.000 description 48
- 239000000463 material Substances 0.000 description 40
- 239000004721 Polyphenylene oxide Substances 0.000 description 39
- 208000027418 Wounds and injury Diseases 0.000 description 39
- 206010052428 Wound Diseases 0.000 description 38
- 239000000853 adhesive Substances 0.000 description 38
- 230000001070 adhesive effect Effects 0.000 description 38
- 239000006260 foam Substances 0.000 description 38
- 239000000416 hydrocolloid Substances 0.000 description 35
- 239000003814 drug Substances 0.000 description 33
- 229920000642 polymer Polymers 0.000 description 32
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 30
- 229940079593 drug Drugs 0.000 description 30
- 239000011159 matrix material Substances 0.000 description 30
- 230000000699 topical effect Effects 0.000 description 30
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 30
- 239000002250 absorbent Substances 0.000 description 22
- 230000002745 absorbent Effects 0.000 description 22
- 239000006071 cream Substances 0.000 description 22
- 230000008859 change Effects 0.000 description 21
- 229920002635 polyurethane Polymers 0.000 description 21
- 239000004814 polyurethane Substances 0.000 description 21
- 238000002360 preparation method Methods 0.000 description 21
- 230000015572 biosynthetic process Effects 0.000 description 20
- 239000002244 precipitate Substances 0.000 description 20
- 238000010186 staining Methods 0.000 description 18
- SEEPANYCNGTZFQ-UHFFFAOYSA-N sulfadiazine Chemical compound C1=CC(N)=CC=C1S(=O)(=O)NC1=NC=CC=N1 SEEPANYCNGTZFQ-UHFFFAOYSA-N 0.000 description 18
- 229910052751 metal Inorganic materials 0.000 description 16
- 239000002184 metal Substances 0.000 description 16
- 229960003600 silver sulfadiazine Drugs 0.000 description 16
- 210000001519 tissue Anatomy 0.000 description 15
- 239000002313 adhesive film Substances 0.000 description 14
- 230000001464 adherent effect Effects 0.000 description 13
- YZIYKJHYYHPJIB-UUPCJSQJSA-N chlorhexidine gluconate Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O.C1=CC(Cl)=CC=C1NC(=N)NC(=N)NCCCCCCNC(=N)NC(=N)NC1=CC=C(Cl)C=C1 YZIYKJHYYHPJIB-UUPCJSQJSA-N 0.000 description 13
- 229960003333 chlorhexidine gluconate Drugs 0.000 description 13
- 238000002845 discoloration Methods 0.000 description 13
- YGSDEFSMJLZEOE-UHFFFAOYSA-N salicylic acid Chemical compound OC(=O)C1=CC=CC=C1O YGSDEFSMJLZEOE-UHFFFAOYSA-N 0.000 description 13
- 239000002904 solvent Substances 0.000 description 13
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 12
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 description 12
- 150000003839 salts Chemical class 0.000 description 11
- GGCZERPQGJTIQP-UHFFFAOYSA-N sodium;9,10-dioxoanthracene-2-sulfonic acid Chemical compound [Na+].C1=CC=C2C(=O)C3=CC(S(=O)(=O)O)=CC=C3C(=O)C2=C1 GGCZERPQGJTIQP-UHFFFAOYSA-N 0.000 description 10
- ALYNCZNDIQEVRV-UHFFFAOYSA-N 4-aminobenzoic acid Chemical compound NC1=CC=C(C(O)=O)C=C1 ALYNCZNDIQEVRV-UHFFFAOYSA-N 0.000 description 9
- FHVDTGUDJYJELY-UHFFFAOYSA-N 6-{[2-carboxy-4,5-dihydroxy-6-(phosphanyloxy)oxan-3-yl]oxy}-4,5-dihydroxy-3-phosphanyloxane-2-carboxylic acid Chemical compound O1C(C(O)=O)C(P)C(O)C(O)C1OC1C(C(O)=O)OC(OP)C(O)C1O FHVDTGUDJYJELY-UHFFFAOYSA-N 0.000 description 9
- 229940072056 alginate Drugs 0.000 description 9
- 235000010443 alginic acid Nutrition 0.000 description 9
- 229920000615 alginic acid Polymers 0.000 description 9
- 125000000524 functional group Chemical group 0.000 description 9
- 206010061218 Inflammation Diseases 0.000 description 8
- 208000002193 Pain Diseases 0.000 description 8
- 125000001033 ether group Chemical group 0.000 description 8
- 230000004054 inflammatory process Effects 0.000 description 8
- 238000004519 manufacturing process Methods 0.000 description 8
- 230000036407 pain Effects 0.000 description 8
- 238000003756 stirring Methods 0.000 description 8
- 239000000126 substance Substances 0.000 description 8
- 206010059866 Drug resistance Diseases 0.000 description 7
- 229920003171 Poly (ethylene oxide) Polymers 0.000 description 7
- 230000005764 inhibitory process Effects 0.000 description 7
- 238000010561 standard procedure Methods 0.000 description 7
- 229920001730 Moisture cure polyurethane Polymers 0.000 description 6
- 229920005830 Polyurethane Foam Polymers 0.000 description 6
- 150000001875 compounds Chemical class 0.000 description 6
- FJKROLUGYXJWQN-UHFFFAOYSA-N papa-hydroxy-benzoic acid Natural products OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 description 6
- 239000011496 polyurethane foam Substances 0.000 description 6
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- 229960004889 salicylic acid Drugs 0.000 description 6
- 239000011780 sodium chloride Substances 0.000 description 6
- 208000003322 Coinfection Diseases 0.000 description 5
- 206010020751 Hypersensitivity Diseases 0.000 description 5
- 230000001419 dependent effect Effects 0.000 description 5
- 238000010348 incorporation Methods 0.000 description 5
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- 239000000047 product Substances 0.000 description 5
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- CQLFBEKRDQMJLZ-UHFFFAOYSA-M silver acetate Chemical compound [Ag+].CC([O-])=O CQLFBEKRDQMJLZ-UHFFFAOYSA-M 0.000 description 5
- 229940071536 silver acetate Drugs 0.000 description 5
- 229940054334 silver cation Drugs 0.000 description 5
- 239000007787 solid Substances 0.000 description 5
- KUXUALPOSMRJSW-IFWQJVLJSA-N 2-[6-[[amino-[[amino-(4-chloroanilino)methylidene]amino]methylidene]amino]hexyl]-1-[amino-(4-chloroanilino)methylidene]guanidine;(2r,3s,4r,5r)-2,3,4,5,6-pentahydroxyhexanoic acid Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O.C1=CC(Cl)=CC=C1NC(=N)NC(=N)NCCCCCCNC(=N)NC(=N)NC1=CC=C(Cl)C=C1 KUXUALPOSMRJSW-IFWQJVLJSA-N 0.000 description 4
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 4
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- 239000002253 acid Substances 0.000 description 4
- 238000013459 approach Methods 0.000 description 4
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- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 3
- UILOTUUZKGTYFQ-UHFFFAOYSA-N Mafenide acetate Chemical compound CC(O)=O.NCC1=CC=C(S(N)(=O)=O)C=C1 UILOTUUZKGTYFQ-UHFFFAOYSA-N 0.000 description 3
- 241000124008 Mammalia Species 0.000 description 3
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- PXAJQJMDEXJWFB-UHFFFAOYSA-N acetone oxime Chemical compound CC(C)=NO PXAJQJMDEXJWFB-UHFFFAOYSA-N 0.000 description 3
- 230000003042 antagnostic effect Effects 0.000 description 3
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- 229960002721 mafenide acetate Drugs 0.000 description 3
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- 150000002739 metals Chemical class 0.000 description 3
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- 229920000915 polyvinyl chloride Polymers 0.000 description 3
- 239000004800 polyvinyl chloride Substances 0.000 description 3
- NLKNQRATVPKPDG-UHFFFAOYSA-M potassium iodide Chemical compound [K+].[I-] NLKNQRATVPKPDG-UHFFFAOYSA-M 0.000 description 3
- 229960001896 pramocaine Drugs 0.000 description 3
- DQKXQSGTHWVTAD-UHFFFAOYSA-N pramocaine Chemical compound C1=CC(OCCCC)=CC=C1OCCCN1CCOCC1 DQKXQSGTHWVTAD-UHFFFAOYSA-N 0.000 description 3
- 150000003378 silver Chemical class 0.000 description 3
- 238000005507 spraying Methods 0.000 description 3
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- 229910052717 sulfur Inorganic materials 0.000 description 3
- 238000003786 synthesis reaction Methods 0.000 description 3
- 230000001225 therapeutic effect Effects 0.000 description 3
- 230000029663 wound healing Effects 0.000 description 3
- SMZOUWXMTYCWNB-UHFFFAOYSA-N 2-(2-methoxy-5-methylphenyl)ethanamine Chemical compound COC1=CC=C(C)C=C1CCN SMZOUWXMTYCWNB-UHFFFAOYSA-N 0.000 description 2
- NIXOWILDQLNWCW-UHFFFAOYSA-N 2-Propenoic acid Natural products OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 2
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Classifications
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- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
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- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
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- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
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- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
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- A61L2300/45—Mixtures of two or more drugs, e.g. synergistic mixtures
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Materials Engineering (AREA)
- Inorganic Chemistry (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Vascular Medicine (AREA)
- Hematology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Surgery (AREA)
- Dermatology (AREA)
- Agronomy & Crop Science (AREA)
- Plant Pathology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Transplantation (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pest Control & Pesticides (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Dentistry (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US73995P | 1995-06-30 | 1995-06-30 | |
| US60/000,739 | 1995-06-30 | ||
| PCT/US1996/010979 WO1997002038A1 (en) | 1995-06-30 | 1996-06-27 | Silver-based pharmaceutical compositions |
| USUNKNOWN | 1997-02-07 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2225808A1 CA2225808A1 (en) | 1997-01-23 |
| CA2225808C true CA2225808C (en) | 2002-12-17 |
Family
ID=21692815
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002225808A Expired - Fee Related CA2225808C (en) | 1995-06-30 | 1996-06-27 | Silver-based pharmaceutical compositions |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US5744151A (Direct) |
| EP (1) | EP0896541A1 (Direct) |
| AU (1) | AU6398796A (Direct) |
| CA (1) | CA2225808C (Direct) |
| WO (1) | WO1997002038A1 (Direct) |
Families Citing this family (134)
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| US7214847B1 (en) * | 1997-09-22 | 2007-05-08 | Argentum Medical, L.L.C. | Multilayer conductive appliance having wound healing and analgesic properties |
| US6087549A (en) * | 1997-09-22 | 2000-07-11 | Argentum International | Multilayer laminate wound dressing |
| US8455710B2 (en) | 1997-09-22 | 2013-06-04 | Argentum Medical, Llc | Conductive wound dressings and methods of use |
| US6861570B1 (en) | 1997-09-22 | 2005-03-01 | A. Bart Flick | Multilayer conductive appliance having wound healing and analgesic properties |
| US5814094A (en) | 1996-03-28 | 1998-09-29 | Becker; Robert O. | Iontopheretic system for stimulation of tissue healing and regeneration |
| US8801681B2 (en) | 1995-09-05 | 2014-08-12 | Argentum Medical, Llc | Medical device |
| JP2822317B2 (ja) * | 1996-04-15 | 1998-11-11 | 日鉄鉱業株式会社 | 抗菌性チタニア及びその製造方法 |
| US6093414A (en) * | 1997-08-11 | 2000-07-25 | Christopher C. Capelli | Silver-based antimicrobial compositions |
| US5931855A (en) | 1997-05-21 | 1999-08-03 | Frank Hoffman | Surgical methods using one-way suture |
| JP3051709B2 (ja) * | 1997-09-30 | 2000-06-12 | 憲司 中村 | 抗菌性セルロ−ス繊維及びその製造方法 |
| US6605751B1 (en) * | 1997-11-14 | 2003-08-12 | Acrymed | Silver-containing compositions, devices and methods for making |
| US6596401B1 (en) | 1998-11-10 | 2003-07-22 | C. R. Bard Inc. | Silane copolymer compositions containing active agents |
| US6242009B1 (en) | 1999-04-20 | 2001-06-05 | Kareem I. Batarseh | Microbicidal formulations and methods to control microorganisms |
| US6433003B1 (en) | 1999-04-23 | 2002-08-13 | Arthur M. Bobrove | Method for treating hyperhidrosis in mammals |
| US6485735B1 (en) | 1999-08-31 | 2002-11-26 | Phelps Dodge High Performance Conductors Of Sc & Ga, Inc. | Multilayer thermoset polymer matrix and structures made therefrom |
| EP1216065B1 (en) * | 1999-10-01 | 2008-10-29 | Acrymed | Silver-containing compositions, devices and methods for making |
| GB9924694D0 (en) * | 1999-10-20 | 1999-12-22 | Giltech Ltd | Anti-microbial device |
| US20040037871A1 (en) * | 1999-10-20 | 2004-02-26 | Healy David Michael | Suture material |
| JP2001151681A (ja) | 1999-11-24 | 2001-06-05 | Lintec Corp | 消化器系疾患の予防および／または治療剤 |
| US7179849B2 (en) * | 1999-12-15 | 2007-02-20 | C. R. Bard, Inc. | Antimicrobial compositions containing colloids of oligodynamic metals |
| US6716895B1 (en) | 1999-12-15 | 2004-04-06 | C.R. Bard, Inc. | Polymer compositions containing colloids of silver salts |
| US6579539B2 (en) | 1999-12-22 | 2003-06-17 | C. R. Bard, Inc. | Dual mode antimicrobial compositions |
| ATE327779T1 (de) | 1999-12-30 | 2006-06-15 | Acrymed | Methode und zusammensetzungen für verbesserte abgabevorrichtungen |
| US7137968B1 (en) * | 2000-03-13 | 2006-11-21 | Nucryst Pharmaceuticals Corp. | Transcutaneous medical device dressings and method of use |
| US6719987B2 (en) | 2000-04-17 | 2004-04-13 | Nucryst Pharmaceuticals Corp. | Antimicrobial bioabsorbable materials |
| US7427416B2 (en) * | 2000-07-27 | 2008-09-23 | Nucryst Pharmaceuticals Corp. | Methods of treating conditions using metal-containing materials |
| US7008647B2 (en) * | 2001-04-23 | 2006-03-07 | Nucryst Pharmaceuticals Corp. | Treatment of acne |
| US20030206966A1 (en) * | 2000-07-27 | 2003-11-06 | Burrell Robert E. | Methods of inducing apoptosis and modulating metalloproteinases |
| AU2001278322B2 (en) | 2000-07-27 | 2005-12-22 | Smith & Nephew (Overseas) Limited | Treatment of hyperproliferative skin disorders and diseases |
| US7001617B2 (en) | 2001-04-23 | 2006-02-21 | Nueryst Pharmaceuticals Corp. | Method of induction of apoptosis and inhibition of matrix metalloproteinases using antimicrobial metals |
| US20040191329A1 (en) * | 2000-07-27 | 2004-09-30 | Burrell Robert E. | Compositions and methods of metal-containing materials |
| US6989157B2 (en) * | 2000-07-27 | 2006-01-24 | Nucryst Pharmaceuticals Corp. | Dry powders of metal-containing compounds |
| US7255881B2 (en) * | 2000-07-27 | 2007-08-14 | Nucryst Pharmaceuticals Corp. | Metal-containing materials |
| US20030185901A1 (en) | 2000-07-27 | 2003-10-02 | Burrell Robert E. | Methods of treating conditions with a metal-containing material |
| US20030180379A1 (en) * | 2000-07-27 | 2003-09-25 | Burrell Robert E. | Solutions and aerosols of metal-containing compounds |
| EP1309279A4 (en) * | 2000-08-17 | 2008-04-09 | Tyco Healthcare | US SUTURES AND COATINGS FROM RESORBABLE THERAPEUTIC GLASS |
| US6932861B2 (en) | 2000-11-28 | 2005-08-23 | Fmc Corporation | Edible PGA coating composition |
| AU2002219937B9 (en) * | 2000-11-29 | 2006-03-16 | Convatec Technologies Inc. | Light stabilized antimicrobial materials |
| US6630172B2 (en) | 2001-01-22 | 2003-10-07 | Kareem I. Batarseh | Microbicidal composition containing potassium sodium tartrate |
| DE60210441T2 (de) * | 2001-04-23 | 2006-11-16 | Nucryst Pharmaceuticals Corp., Fort Saskatchewan | Arzneimittel oder pflaster enthaltend ein metall wie silber, gold, platin oder palladium als antimikrobiellen wirkstoff und dessen verwendung in der behandlung von hautentzündungen |
| US20020187175A1 (en) * | 2001-05-08 | 2002-12-12 | Petrea Randy D. | Antimicrobial polyurethane films |
| BRPI0209022B8 (pt) * | 2001-06-29 | 2021-06-22 | Dow Global Technologies Inc | polímero insolúvel em água, absorvente de água, na forma de partículas, seu processo de preparação e sua estrutura absorvente |
| US7056331B2 (en) | 2001-06-29 | 2006-06-06 | Quill Medical, Inc. | Suture method |
| AU2002357050A1 (en) * | 2001-12-03 | 2003-06-17 | C.R. Bard, Inc. | Microbe-resistant medical device, microbe-resistant polymeric coating and methods for producing same |
| ES2251623T3 (es) * | 2001-12-21 | 2006-05-01 | Coloplast A/S | Dispositivo de cuidado de heridas. |
| US7201925B2 (en) * | 2002-04-23 | 2007-04-10 | Nueryst Pharmaceuticals Corp. | Treatment of ungual and subungual diseases |
| US7160272B1 (en) | 2002-05-31 | 2007-01-09 | Elcam Plastic | Y-site medical valve |
| IL150907A (en) * | 2002-07-25 | 2007-07-04 | Stephan Cherkez | Process for the preparation of stable amorphous calcium pseudomonate |
| CN1678277B (zh) * | 2002-07-29 | 2010-05-05 | 艾克里麦德公司 | 治疗皮肤病的方法和组合物 |
| US6773450B2 (en) | 2002-08-09 | 2004-08-10 | Quill Medical, Inc. | Suture anchor and method |
| US8461410B2 (en) * | 2002-09-11 | 2013-06-11 | Ethicon, Inc. | Wound dressing materials comprising complexes of anionic polysaccharides with silver |
| GB0222259D0 (en) * | 2002-09-25 | 2002-10-30 | First Water Ltd | Antimicrobial compositions |
| US20040110738A1 (en) * | 2002-10-22 | 2004-06-10 | Gillis Scott H. | Prophylactic treatment methods |
| US7285576B2 (en) * | 2003-03-12 | 2007-10-23 | 3M Innovative Properties Co. | Absorbent polymer compositions, medical articles, and methods |
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| WO2004112805A1 (en) * | 2003-06-20 | 2004-12-29 | Johnson & Johnson Medical Limited | Antimicrobial silver comprising silver |
| GB2402880B (en) * | 2003-06-20 | 2008-01-23 | Johnson & Johnson Medical Ltd | Antimicrobial compositions comprising silver |
| US20050037057A1 (en) * | 2003-08-14 | 2005-02-17 | Schuette Robert L. | Silver-containing antimicrobial fabric |
| US7842306B2 (en) * | 2003-08-14 | 2010-11-30 | Milliken & Company | Wound care device having fluid transfer properties |
| US7118761B2 (en) | 2003-08-14 | 2006-10-10 | Canada T Andrew | Method for producing a silver-containing wound care device |
| US8563447B2 (en) * | 2003-08-14 | 2013-10-22 | Milliken & Company | Silver-containing wound care device |
| US20050147657A1 (en) * | 2003-08-14 | 2005-07-07 | Milliken & Company | White silver-containing wound care device |
| US20050035327A1 (en) * | 2003-08-14 | 2005-02-17 | Canada T. Andrew | Topical silver-based antimicrobial composition for wound care devices |
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| GB9210947D0 (en) * | 1992-05-22 | 1992-07-08 | Boots Co Plc | Oral hygiene composition |
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| GB9318170D0 (en) * | 1993-09-02 | 1993-10-20 | Kodak Ltd | Antimicrobial polymers and compositions containing them |
-
1996
- 1996-06-27 AU AU63987/96A patent/AU6398796A/en not_active Abandoned
- 1996-06-27 CA CA002225808A patent/CA2225808C/en not_active Expired - Fee Related
- 1996-06-27 WO PCT/US1996/010979 patent/WO1997002038A1/en not_active Ceased
- 1996-06-27 EP EP96923488A patent/EP0896541A1/en not_active Withdrawn
- 1996-06-27 US US08/671,897 patent/US5744151A/en not_active Expired - Lifetime
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| CA2225808A1 (en) | 1997-01-23 |
| AU6398796A (en) | 1997-02-05 |
| US5744151A (en) | 1998-04-28 |
| EP0896541A1 (en) | 1999-02-17 |
| WO1997002038A1 (en) | 1997-01-23 |
| EP0896541A4 (Direct) | 1999-03-24 |
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