CA2221570A1 - Neutralisation d'epitopes conformationnels du virus de l'anemie infectieuse du poulet - Google Patents

Neutralisation d'epitopes conformationnels du virus de l'anemie infectieuse du poulet Download PDF

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Publication number
CA2221570A1
CA2221570A1 CA002221570A CA2221570A CA2221570A1 CA 2221570 A1 CA2221570 A1 CA 2221570A1 CA 002221570 A CA002221570 A CA 002221570A CA 2221570 A CA2221570 A CA 2221570A CA 2221570 A1 CA2221570 A1 CA 2221570A1
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Canada
Prior art keywords
cav
virus
neutralizing
recombinant
epitope
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002221570A
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English (en)
Inventor
Matheus Hubertus Maria Noteborn
Guus Koch
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Leadd BV
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Individual
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Filing date
Publication date
Priority claimed from US08/480,020 external-priority patent/US5932476A/en
Application filed by Individual filed Critical Individual
Publication of CA2221570A1 publication Critical patent/CA2221570A1/fr
Abandoned legal-status Critical Current

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/08Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/081Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from DNA viruses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011Details
    • C12N2710/14011Baculoviridae
    • C12N2710/14111Nucleopolyhedrovirus, e.g. autographa californica nucleopolyhedrovirus
    • C12N2710/14141Use of virus, viral particle or viral elements as a vector
    • C12N2710/14143Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011Details
    • C12N2710/16011Herpesviridae
    • C12N2710/16311Mardivirus, e.g. Gallid herpesvirus 2, Marek-like viruses, turkey HV
    • C12N2710/16341Use of virus, viral particle or viral elements as a vector
    • C12N2710/16343Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2750/00MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
    • C12N2750/00011Details
    • C12N2750/10011Circoviridae
    • C12N2750/10022New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2750/00MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
    • C12N2750/00011Details
    • C12N2750/10011Circoviridae
    • C12N2750/10034Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2750/00MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
    • C12N2750/00011Details
    • C12N2750/10011Circoviridae
    • C12N2750/10061Methods of inactivation or attenuation
    • C12N2750/10062Methods of inactivation or attenuation by genetic engineering

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Virology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Immunology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)

Abstract

L'invention concerne la production de l'épitope conformationnel qui neutralise le virus de l'anémie infectieuse du poulet et des compositions prophylactiques ou thérapeutiques de l'anémie infectieuse du poulet, notamment des vaccins moins pathogènes que le virus lui-même de l'anémie infectieuse du poulet. Toutes ces compositions synthétisent l'épitope conformationnel neutralisant nécessaire pour déclencher une réponse immunitaire de protection contre l'anémie infectieuse du poulet. L'invention concerne des molécules d'ADN recombinant dérivées du génome du virus de l'anémie infectieuse du poulet et des fragments d'ADN recombinant du génome du virus de l'anémie infectieuse du poulet intégrés dans le génome d'autres vecteurs de virus. En particulier, ces compositions comprennent une sous-unité de vaccination, un vaccin à virus vivants recombinants et un vaccin atténué contre l'anémie infectieuse du poulet. L'invention concerne en outre la production d'anticorps neutralisants du virus de l'anémie infectieuse du poulet et des kits de diagnostic qui permettent de détecter l'anémie infectieuse du poulet.
CA002221570A 1995-06-07 1996-06-07 Neutralisation d'epitopes conformationnels du virus de l'anemie infectieuse du poulet Abandoned CA2221570A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/480,020 US5932476A (en) 1990-09-12 1995-06-07 Cloning of chicken anemia virus DNA
US08/480,020 1995-06-07

Publications (1)

Publication Number Publication Date
CA2221570A1 true CA2221570A1 (fr) 1996-12-19

Family

ID=23906352

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002221570A Abandoned CA2221570A1 (fr) 1995-06-07 1996-06-07 Neutralisation d'epitopes conformationnels du virus de l'anemie infectieuse du poulet

Country Status (7)

Country Link
EP (1) EP0832242A1 (fr)
JP (1) JPH11510367A (fr)
CN (1) CN1194001A (fr)
AU (1) AU720640B2 (fr)
CA (1) CA2221570A1 (fr)
NZ (1) NZ309172A (fr)
WO (1) WO1996040931A1 (fr)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7192594B2 (en) 1997-10-03 2007-03-20 Merial Limited Postweaning multisystemic wasting syndrome and porcine circovirus from pigs
FR2772047B1 (fr) 1997-12-05 2004-04-09 Ct Nat D Etudes Veterinaires E Sequence genomique et polypeptides de circovirus associe a la maladie de l'amaigrissement du porcelet (map), applications au diagnostic et a la prevention et/ou au traitement de l'infection
PT2363488E (pt) 1997-12-11 2015-01-13 Univ Belfast Síndrome multi-sistémica do definhamento pós-desmame de porcos
JP2001275664A (ja) * 2000-02-29 2001-10-09 Akzo Nobel Nv 低い病原性のニワトリ貧血ウイルス
AUPR567401A0 (en) 2001-06-14 2001-07-12 University Of Melbourne, The Circovirus vaccines
EP1610757A4 (fr) * 2003-04-10 2007-05-30 Transform Pharmaceuticals Inc Profilage de variants conformationnels, compositions anticorps et procedes d'utilisation associes
JP6821429B2 (ja) 2013-09-25 2021-01-27 ゾエティス・サービシーズ・エルエルシー Pcv2b分岐ワクチン組成物及び使用方法
CN113897356B (zh) * 2021-10-20 2024-04-30 佛山科学技术学院 一种检测鸡传染性贫血病毒荧光定量pcr试剂盒及引物
CN118028252A (zh) * 2024-04-15 2024-05-14 中国农业科学院哈尔滨兽医研究所(中国动物卫生与流行病学中心哈尔滨分中心) 表达ciav vp1和vp2基因的重组鸡马立克病病毒疫苗株及其应用

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0473210B1 (fr) * 1990-07-30 1994-04-13 Akzo Nobel N.V. Virus recombinant de la maladie de Marek
NL9002008A (nl) * 1990-09-12 1992-04-01 Stichting Centr Diergeneeskund Recombinant dna en rna en daarvan afgeleide produkten.
NL9301272A (nl) * 1993-07-20 1995-02-16 Aesculaap Bv Chicken Anemia Virus mutanten en vaccins en toepassingen gebaseerd op de virale eiwitten VP1, VP2 en VP3 of daarvoor coderende sequenties van dat virus.
ZA918426B (en) * 1990-10-31 1992-12-30 Akzo Nv Chicken anemia virus vaccine and diagnostic

Also Published As

Publication number Publication date
WO1996040931A1 (fr) 1996-12-19
NZ309172A (en) 1999-11-29
JPH11510367A (ja) 1999-09-14
CN1194001A (zh) 1998-09-23
AU5913796A (en) 1996-12-30
AU720640B2 (en) 2000-06-08
EP0832242A1 (fr) 1998-04-01

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FZDE Discontinued