CA2221323A1 - Oral delivery of gene constructs - Google Patents

Oral delivery of gene constructs Download PDF

Info

Publication number
CA2221323A1
CA2221323A1 CA002221323A CA2221323A CA2221323A1 CA 2221323 A1 CA2221323 A1 CA 2221323A1 CA 002221323 A CA002221323 A CA 002221323A CA 2221323 A CA2221323 A CA 2221323A CA 2221323 A1 CA2221323 A1 CA 2221323A1
Authority
CA
Canada
Prior art keywords
gene construct
delivery
gene
formulation
therapeutic protein
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002221323A
Other languages
English (en)
French (fr)
Inventor
Gamil G. De Chadarevian
Joseph A. Fix
Peter E. Daddona
Howard B. Rosen
Phyllis I. Gardner
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Alza Corp
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2221323A1 publication Critical patent/CA2221323A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
    • A61K9/0004—Osmotic delivery systems; Sustained release driven by osmosis, thermal energy or gas
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4808—Preparations in capsules, e.g. of gelatin, of chocolate characterised by the form of the capsule or the structure of the filling; Capsules containing small tablets; Capsules with outer layer for immediate drug release
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
CA002221323A 1995-06-07 1996-06-07 Oral delivery of gene constructs Abandoned CA2221323A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US47596195A 1995-06-07 1995-06-07
US08/475,961 1995-06-07

Publications (1)

Publication Number Publication Date
CA2221323A1 true CA2221323A1 (en) 1996-12-19

Family

ID=23889916

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002221323A Abandoned CA2221323A1 (en) 1995-06-07 1996-06-07 Oral delivery of gene constructs

Country Status (6)

Country Link
EP (1) EP0831771A2 (ko)
JP (1) JPH11507340A (ko)
KR (1) KR19990022184A (ko)
AU (1) AU6097896A (ko)
CA (1) CA2221323A1 (ko)
WO (1) WO1996040081A2 (ko)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5976571A (en) * 1991-01-31 1999-11-02 Port Systems, L.L.C. Method for making a multi-stage drug delivery system
CA2222574A1 (en) * 1995-06-07 1996-12-19 Yale University Oral delivery of adeno-associated viral vectors
US6225290B1 (en) 1996-09-19 2001-05-01 The Regents Of The University Of California Systemic gene therapy by intestinal cell transformation
ATE321882T1 (de) 1997-07-01 2006-04-15 Isis Pharmaceuticals Inc Zusammensetzungen und verfahren zur verabreichung von oligonukleotiden über die speiseröhre
WO1999030746A1 (en) * 1997-12-12 1999-06-24 Synoptik A/S Container for timed release of substances
EP1140213A1 (en) * 1998-12-14 2001-10-10 Synoptik Holding A/S A system for cleaning contact lenses
WO2002089855A1 (en) * 2001-04-27 2002-11-14 Auckland Uniservices Limited Peroral transduction of hepatocytes in the treatment of disease

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU663725B2 (en) * 1991-08-20 1995-10-19 United States Of America, Represented By The Secretary, Department Of Health And Human Services, The Adenovirus mediated transfer of genes to the gastrointestinal tract
AU3972893A (en) * 1992-04-03 1993-11-08 Baylor College Of Medicine Gene therapy using the intestine

Also Published As

Publication number Publication date
KR19990022184A (ko) 1999-03-25
WO1996040081A2 (en) 1996-12-19
AU6097896A (en) 1996-12-30
WO1996040081A3 (en) 1997-02-20
EP0831771A2 (en) 1998-04-01
JPH11507340A (ja) 1999-06-29

Similar Documents

Publication Publication Date Title
US5443459A (en) Osmotic device for delayed delivery of agent
JP3307929B2 (ja) 薬剤の遅延投与のための浸透圧デバイス
US5391381A (en) Dispenser capable of delivering plurality of drug units
AU766293B2 (en) An oral formulation for gastrointestinal drug delivery
DK175860B1 (da) Afgiftssystem omfattende et middel til styring af væskeindtrængen i systemet
EP1620060B1 (en) Methods and devices for the sustained release of multiple drugs
AU682703B2 (en) Dosage form for administering drug in liquid formulation
TW420616B (en) Controlled-release dosage forms of azithromycin
JP2010502759A (ja) タンパク質物質の経口または直腸投与のための医薬組成物
WO2004026453A2 (en) Microcapsules and methods of use
JP2001508815A (ja) カチオン性ポリマー／脂質核酸送達ビヒクル
EP1090645A2 (en) Oral delivery of chemically modified proteins
JPH07504401A (ja) 薬物投与の遅延活性化による浸透デバイス
CA2221323A1 (en) Oral delivery of gene constructs
HU226669B1 (en) Dosage form comprising liquid formulation
CN102335431B (zh) 一种给药组合物及其制备和使用方法
AU1820999A (en) Grafted copolymers as gene carriers
EP0844004B1 (en) Collagen containing gene preparations
KR19990021985A (ko) 높은 약물 부하량을 갖는 삼투 장치 및 약물 전달의 지연활성화
KR100428273B1 (ko) 약물전달의지연된활성화및완전한약물방출기능을갖는삼투장치
WO2000016784A1 (fr) Systeme d'administration orale de medicament permettant d'ameliorer la biodisponibilite de la glycyrrhetine activee
CN1187118A (zh) 经口递送基因构建物
Mackay Delivery of therapeutic peptides and proteins
Truong-Le Synthesis, gene transfer properties, and delivery of genetic vaccines using the DNA-gelatin nanospheres
NZ268251A (en) Sustained release dosage form for delivering a drug in non-aqueous liquid form through an exit hole via a "push" composition

Legal Events

Date Code Title Description
FZDE Dead