CA2221323A1 - Administration par voie orale de produits de recombinaison geniques - Google Patents

Administration par voie orale de produits de recombinaison geniques Download PDF

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Publication number
CA2221323A1
CA2221323A1 CA002221323A CA2221323A CA2221323A1 CA 2221323 A1 CA2221323 A1 CA 2221323A1 CA 002221323 A CA002221323 A CA 002221323A CA 2221323 A CA2221323 A CA 2221323A CA 2221323 A1 CA2221323 A1 CA 2221323A1
Authority
CA
Canada
Prior art keywords
gene construct
delivery
gene
formulation
therapeutic protein
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002221323A
Other languages
English (en)
Inventor
Gamil G. De Chadarevian
Joseph A. Fix
Peter E. Daddona
Howard B. Rosen
Phyllis I. Gardner
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Alza Corp
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2221323A1 publication Critical patent/CA2221323A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
    • A61K9/0004—Osmotic delivery systems; Sustained release driven by osmosis, thermal energy or gas
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4808—Preparations in capsules, e.g. of gelatin, of chocolate characterised by the form of the capsule or the structure of the filling; Capsules containing small tablets; Capsules with outer layer for immediate drug release
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)

Abstract

L'invention porte sur un procédé d'administration d'un produit de recombinaison génique destiné à une région ciblée des voies digestives. Ledit produit de recombinaison se présente sous la forme d'une dose de charge en bolus qui produit l'expression d'une quantité à effet thérapeutique d'une protéine traitante dans le site cible. L'invention porte également sur le dispositif permettant d'acheminer ledit produit de recombinaison génique jusqu'à un site cible.
CA002221323A 1995-06-07 1996-06-07 Administration par voie orale de produits de recombinaison geniques Abandoned CA2221323A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US47596195A 1995-06-07 1995-06-07
US08/475,961 1995-06-07

Publications (1)

Publication Number Publication Date
CA2221323A1 true CA2221323A1 (fr) 1996-12-19

Family

ID=23889916

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002221323A Abandoned CA2221323A1 (fr) 1995-06-07 1996-06-07 Administration par voie orale de produits de recombinaison geniques

Country Status (6)

Country Link
EP (1) EP0831771A2 (fr)
JP (1) JPH11507340A (fr)
KR (1) KR19990022184A (fr)
AU (1) AU6097896A (fr)
CA (1) CA2221323A1 (fr)
WO (1) WO1996040081A2 (fr)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5976571A (en) * 1991-01-31 1999-11-02 Port Systems, L.L.C. Method for making a multi-stage drug delivery system
IL122349A0 (en) * 1995-06-07 1998-04-05 Univ Yale Adeno-associated viral vectors
US6225290B1 (en) 1996-09-19 2001-05-01 The Regents Of The University Of California Systemic gene therapy by intestinal cell transformation
CA2294988C (fr) 1997-07-01 2015-11-24 Isis Pharmaceuticals Inc. Compositions et procedes d'apport d'oligonucleotides par le tube digestif
AU1556399A (en) 1997-12-12 1999-07-05 Synoptik A/S Container for timed release of substances
EP1140213A1 (fr) * 1998-12-14 2001-10-10 Synoptik Holding A/S Systeme de nettoyage de verres de contact
WO2002089855A1 (fr) * 2001-04-27 2002-11-14 Auckland Uniservices Limited Transduction perorale d'hepatocytes dans le traitement d'une maladie

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2115742A1 (fr) * 1991-08-20 1993-03-04 Ronald G. Crystal Transfert de genes aux cellules du tractus gastro-intestinal medie par adenovirus
WO1993019660A1 (fr) * 1992-04-03 1993-10-14 Baylor College Of Medicine Therapie genique utilisant l'intestin

Also Published As

Publication number Publication date
KR19990022184A (ko) 1999-03-25
JPH11507340A (ja) 1999-06-29
AU6097896A (en) 1996-12-30
WO1996040081A3 (fr) 1997-02-20
WO1996040081A2 (fr) 1996-12-19
EP0831771A2 (fr) 1998-04-01

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Legal Events

Date Code Title Description
FZDE Discontinued