CA2218664C - Nouveaux derives de 4-hydroxyphenylamine n-acyles ayant des proprietes analgesiques et compositions pharmaceutiques contenant ces composes - Google Patents
Nouveaux derives de 4-hydroxyphenylamine n-acyles ayant des proprietes analgesiques et compositions pharmaceutiques contenant ces composes Download PDFInfo
- Publication number
- CA2218664C CA2218664C CA002218664A CA2218664A CA2218664C CA 2218664 C CA2218664 C CA 2218664C CA 002218664 A CA002218664 A CA 002218664A CA 2218664 A CA2218664 A CA 2218664A CA 2218664 C CA2218664 C CA 2218664C
- Authority
- CA
- Canada
- Prior art keywords
- compound
- benzisothiazol
- dihydro
- oxo
- 1dioxide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D275/00—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings
- C07D275/04—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings condensed with carbocyclic rings or ring systems
- C07D275/06—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings condensed with carbocyclic rings or ring systems with hetero atoms directly attached to the ring sulfur atom
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
La présente invention concerne une série de nouveaux dérivés de 4-hydroxyphénylamine N-acylés, lesquels sont liés par l'intermédiaire d'un pont alkylène à l'atome d'azote d'un groupe 1,2-benzisothiazol-3(2H)-one 1,1-dioxyde, et correspondent à la formule (I) où n est un nombre choisi entre 1 et 5. Cette invention concerne également des processus de préparation de ces dérivés ainsi que des compositions pharmaceutiques contenant ces derniers. Ces composés possèdent une activité analgésique importante, aucune activité antipyrétique, et n'ont que des effets hépatotoxiques limités.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/426,234 | 1995-04-21 | ||
| US08/426,234 US5554636A (en) | 1995-04-21 | 1995-04-21 | N-acylated 4-hydroxphenylamine derivatives with analgesic properties and pharmaceutical compositions containing them |
| PCT/US1996/005456 WO1996032940A1 (fr) | 1995-04-21 | 1996-04-18 | Nouveaux derives de 4-hydroxyphenylamine n-acyles ayant des proprietes analgesiques et compositions pharmaceutiques contenant ces composes |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2218664A1 CA2218664A1 (fr) | 1996-10-24 |
| CA2218664C true CA2218664C (fr) | 2007-08-21 |
Family
ID=38434573
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002218664A Expired - Fee Related CA2218664C (fr) | 1995-04-21 | 1996-04-18 | Nouveaux derives de 4-hydroxyphenylamine n-acyles ayant des proprietes analgesiques et compositions pharmaceutiques contenant ces composes |
Country Status (1)
| Country | Link |
|---|---|
| CA (1) | CA2218664C (fr) |
-
1996
- 1996-04-18 CA CA002218664A patent/CA2218664C/fr not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| CA2218664A1 (fr) | 1996-10-24 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| MKLA | Lapsed |
Effective date: 20130418 |
|
| MKLA | Lapsed |
Effective date: 20130418 |