CA2215152A1 - Ancres de proteines seriques et cellulaires destinees a l'imagerie diagnostique - Google Patents

Ancres de proteines seriques et cellulaires destinees a l'imagerie diagnostique Download PDF

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Publication number
CA2215152A1
CA2215152A1 CA002215152A CA2215152A CA2215152A1 CA 2215152 A1 CA2215152 A1 CA 2215152A1 CA 002215152 A CA002215152 A CA 002215152A CA 2215152 A CA2215152 A CA 2215152A CA 2215152 A1 CA2215152 A1 CA 2215152A1
Authority
CA
Canada
Prior art keywords
vascular
functional group
reactive functional
vascular system
binding member
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002215152A
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English (en)
Inventor
Alexander Krantz
Alan M. Ezrin
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ConjuChem Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2215152A1 publication Critical patent/CA2215152A1/fr
Abandoned legal-status Critical Current

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2123/00—Preparations for testing in vivo

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nanotechnology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Optics & Photonics (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

Cette invention concerne des procédés de diagnostic non invasifs qui utilisent des molécules d'ancrage bifonctionnelles. Ces molécules d'ancrage bifonctionnelles ont un groupe fonctionnel susceptible d'être activé qui, lorsqu'il est activé, peut former une liaison covalente avec une fonctionnalité réactive sur une protéine cible présente dans le système vasculaire mammalien, "ancrant" ainsi la molécule à cette protéine cible. Ces ancres bifonctionnelles sont également conjuguées, soit directement soit indirectement, à un agent diagnostique intéressant qui fournit la possibilité d'imager, aux fins de diagnostic et de manière non invasive, l'espace vasculaire mammalien. Les cibles vasculaires comprennent des protéines cellulaires et non cellulaires présentes dans le système vasculaire mammalien. Ces procédés trouvent leur utilisation dans de nombreuses applications découlant de la possibilité d'imager aux fins de diagnostic l'espace vasculaire mammalien pendant une période prolongée ou, de préférence, d'imager aux fins de diagnostic, uniquement un type de cellule spécifique ou une subdivision de l'espace vasculaire mammalien.
CA002215152A 1996-01-12 1997-01-07 Ancres de proteines seriques et cellulaires destinees a l'imagerie diagnostique Abandoned CA2215152A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US58891296A 1996-01-12 1996-01-12
US08/588,912 1996-01-12

Publications (1)

Publication Number Publication Date
CA2215152A1 true CA2215152A1 (fr) 1997-07-17

Family

ID=24355824

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002215152A Abandoned CA2215152A1 (fr) 1996-01-12 1997-01-07 Ancres de proteines seriques et cellulaires destinees a l'imagerie diagnostique

Country Status (5)

Country Link
EP (1) EP0814850A1 (fr)
JP (1) JP2000504316A (fr)
AU (1) AU713616B2 (fr)
CA (1) CA2215152A1 (fr)
WO (1) WO1997025074A2 (fr)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2305597C (fr) 1997-11-07 2008-07-29 Conjuchem Inc. Marqueurs d'affinite pour la serum-albumine humaine
EP1079859B1 (fr) 1998-05-22 2010-07-14 The Board Of Trustees Of The Leland Stanford Junior University Molecules bifonctionnelles et therapies basees sur celles-ci
US7601691B2 (en) 1999-05-17 2009-10-13 Conjuchem Biotechnologies Inc. Anti-obesity agents
BR0010750A (pt) 1999-05-17 2002-02-26 Conjuchem Inc Peptìdeos insulinotrópicos de longa duração
US6887842B1 (en) 1999-11-19 2005-05-03 The Board Of Trustees Of The Leland Stanford Junior University Modulating a pharmacokinetic property of a drug by administering a bifunctional molecule containing the drug
US7498025B1 (en) 1999-11-19 2009-03-03 The Board Of Trustees Of The Leland Stanford Junior University Targeted bifunctional molecules and therapies based thereon
US7220552B1 (en) 1999-11-19 2007-05-22 The Board Of Trustees Of The Leland Stanford Junior University Bifunctional molecules and their use in the disruption of protein-protein interactions
DE60226702D1 (de) 2001-02-16 2008-07-03 Conjuchem Biotechnologies Inc Lang wirkendes glucagon-ähnliches peptid-2 für die behandlung von gastrointestinalen krankheiten und störungen
DE602004027000D1 (de) 2003-01-17 2010-06-17 Advanced Proteome Therapeutics Verfahren zur Identifizierung aktivierter Polymer-Komplexe zur sekundären Stellen-spezifischen Modifikation von Protein Ziel-Gruppen.

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2390408A1 (fr) * 1977-05-11 1978-12-08 Philips France Procede de marquage par un isotope radioactif d'un sel hydrosoluble d'oxine, ou de ses derives halogenes ou sulfones, produits ainsi marques, procede de marquage des elements figures du sang, et medicaments ainsi obtenus
FR2486657A1 (fr) * 1980-07-09 1982-01-15 Pasteur Institut Procede de detection et de dosage d'une substance biologique par erythroadsorption
FR2644059B1 (fr) * 1989-03-08 1994-03-04 Fabre Medicament Pierre Compositions aerosols destinees a l'imagerie, au diagnostic et a la therapie ciblee de foyers inflammatoires et tumoraux
FR2660864A1 (fr) * 1990-04-13 1991-10-18 Guerbet Sa Composition de contraste, procede de preparation de cette composition et application a l'imagerie.
FR2698272B1 (fr) * 1992-11-20 1994-12-30 Cis Bio Int Procédé de marquage cellulaire au moyen de complexes nitruro-bis (dithiocarbamato)Tc-99m et trousse pour la mise en Óoeuvre de ce procédé.

Also Published As

Publication number Publication date
AU1527797A (en) 1997-08-01
WO1997025074A2 (fr) 1997-07-17
EP0814850A1 (fr) 1998-01-07
WO1997025074A3 (fr) 1997-11-13
AU713616B2 (en) 1999-12-09
JP2000504316A (ja) 2000-04-11

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Legal Events

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EEER Examination request
FZDE Dead