CA2201779C - Fabrication de levobupivacaine et de ses analogues a partir de l-lysine - Google Patents

Fabrication de levobupivacaine et de ses analogues a partir de l-lysine Download PDF

Info

Publication number
CA2201779C
CA2201779C CA 2201779 CA2201779A CA2201779C CA 2201779 C CA2201779 C CA 2201779C CA 2201779 CA2201779 CA 2201779 CA 2201779 A CA2201779 A CA 2201779A CA 2201779 C CA2201779 C CA 2201779C
Authority
CA
Canada
Prior art keywords
lysine
carboxanilide
compound
levobupivacaine
manufacture
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA 2201779
Other languages
English (en)
Other versions
CA2201779A1 (fr
Inventor
Gordon Eric Hutton
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Darwin Discovery Ltd
Original Assignee
Darwin Discovery Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB9420243A external-priority patent/GB9420243D0/en
Priority claimed from GBGB9504928.4A external-priority patent/GB9504928D0/en
Application filed by Darwin Discovery Ltd filed Critical Darwin Discovery Ltd
Priority claimed from PCT/GB1995/002385 external-priority patent/WO1996011181A1/fr
Publication of CA2201779A1 publication Critical patent/CA2201779A1/fr
Application granted granted Critical
Publication of CA2201779C publication Critical patent/CA2201779C/fr
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Landscapes

  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

On prépare un nouveau composé représenté par la formule (X) à partir de L-lysine et on le convertit en Levobupivacaïne par cyclisation.
CA 2201779 1994-10-07 1995-10-09 Fabrication de levobupivacaine et de ses analogues a partir de l-lysine Expired - Fee Related CA2201779C (fr)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GB9420243A GB9420243D0 (en) 1994-10-07 1994-10-07 Complex and its use
GB9504928.4 1995-03-10
GB9420243.9 1995-03-10
GBGB9504928.4A GB9504928D0 (en) 1995-03-10 1995-03-10 Diazotisation and cyclisation
PCT/GB1995/002385 WO1996011181A1 (fr) 1994-10-07 1995-10-09 Fabrication de levobupivacaine et de ses analogues a partir de l-lysine

Publications (2)

Publication Number Publication Date
CA2201779A1 CA2201779A1 (fr) 1996-04-18
CA2201779C true CA2201779C (fr) 2007-01-16

Family

ID=29407338

Family Applications (1)

Application Number Title Priority Date Filing Date
CA 2201779 Expired - Fee Related CA2201779C (fr) 1994-10-07 1995-10-09 Fabrication de levobupivacaine et de ses analogues a partir de l-lysine

Country Status (1)

Country Link
CA (1) CA2201779C (fr)

Also Published As

Publication number Publication date
CA2201779A1 (fr) 1996-04-18

Similar Documents

Publication Publication Date Title
US7531673B2 (en) Preparation of amino acid amides
AU695479B2 (en) Racemisation and asymmetric transformation processes used in the manufacture of levobupivacaine and analogues thereof
WO1991001957A1 (fr) Resolution de melanges racemiques
HU204508B (en) Process for producing (s)-alpha-ethyl-2-oxo-1-pyrrolidin-acetamide
EP0206993A1 (fr) Esters d'acides sulfoniques
ZA200601262B (en) Cycloakylaminoacid compounds, processes for making and uses thereof
CA2201779C (fr) Fabrication de levobupivacaine et de ses analogues a partir de l-lysine
AU761721B2 (en) Method for producing enantiomer-free N-methyl-N- ((1S)-1-phenyl- 2-((3S)- 3-hydroxypyrrolidine- 1-yl)ethyl)- 2,2-diphenyl acetamide
AU695348B2 (en) The manufacture of levobupivacaine and analogues thereof from L-lysine
JP3125101B2 (ja) 光学異性ヒダントインの分割方法
JPH02172956A (ja) エリスロ―３―（３，４―ジヒドロキシフェニル）セリン誘導体の新規製造法
JPH06340595A (ja) 光学的に純粋なアミノアルコールの製造方法
US6610855B2 (en) Synthesis of 3-amino-3-aryl propanoates
US5166361A (en) Methods for preparing captopril and its analogues
US5623087A (en) Method for preparation of optically active diarylalanines
US5280122A (en) Resolution of 2-benzyl-4-piperidone-succinic acid
EP0481118A1 (fr) Procédé de préparation de 3'-(1H-tétrazol-5-yl)oxanilate de butyle
JP4532801B2 (ja) （−）−（１ｓ，４ｒ）ｎ保護４−アミノ−２−シクロペンテン−１−カルボン酸エステルの調製法
CN111247127B (zh) 用于合成药物的中间体化合物的生产方法
KR100850558B1 (ko) 아토르바스타틴의 효율적인 제조방법
US6313315B1 (en) Methods for producing N-protected-azetidine-2-carboxylic acids
US3105852A (en) Process for the preparation of l-(+)-glutamine
JPH04500673A (ja) カプトプリルおよびその類縁体の製法
KR100445781B1 (ko) (ｓ)-1-아세틸-2-피롤리딘카복스아미드의 제조방법
US5969179A (en) Method for preparing enantiomeric forms of amino alkylaminophenyl propanoic acid

Legal Events

Date Code Title Description
EEER Examination request
MKLA Lapsed

Effective date: 20151009