CA2199731A1 - Traitement de solutions de globules rouges par des agents antiviraux - Google Patents

Traitement de solutions de globules rouges par des agents antiviraux

Info

Publication number
CA2199731A1
CA2199731A1 CA 2199731 CA2199731A CA2199731A1 CA 2199731 A1 CA2199731 A1 CA 2199731A1 CA 2199731 CA2199731 CA 2199731 CA 2199731 A CA2199731 A CA 2199731A CA 2199731 A1 CA2199731 A1 CA 2199731A1
Authority
CA
Canada
Prior art keywords
compound
bis
chloroethyl
mixture
pathogens
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA 2199731
Other languages
English (en)
Inventor
Susan Wollowitz
Aileen Nerio
David Cook
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cerus Corp
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/486,821 external-priority patent/US6171777B1/en
Application filed by Individual filed Critical Individual
Publication of CA2199731A1 publication Critical patent/CA2199731A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/0005—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts
    • A61L2/0082—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts using chemical substances
    • A61L2/0088—Liquid substances
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2795/00—Bacteriophages
    • C12N2795/00011—Details
    • C12N2795/18011—Details ssRNA Bacteriophages positive-sense
    • C12N2795/18111—Leviviridae
    • C12N2795/18161—Methods of inactivation or attenuation
    • C12N2795/18163—Methods of inactivation or attenuation by chemical treatment

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Virology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

L'invention porte sur des procédés et des compositions d'élimination des éléments pathogènes d'un produit et notamment sur des procédés de décontamination de fluides corporels humains avant leur traitement en laboratoire, et des procédés de décontamination de produits sanguins avant leur emploi in vivo. Les techniques utilisées permettent de traiter d'importantes quantités de produits sanguins sans altérer les fonctions des constituants du sang. L'invention porte également sur de nouveaux composés de photodécontamination de produits biologiques compatibles avec les essais cliniques en ce qu'ils n'interfèrent pas avec les analytes du sérum.
CA 2199731 1995-06-07 1996-06-07 Traitement de solutions de globules rouges par des agents antiviraux Abandoned CA2199731A1 (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US08/476,842 1995-06-07
US08/486,821 1995-06-07
US08/486,821 US6171777B1 (en) 1994-11-14 1995-06-07 Treating blood or blood product with a compound having a mustard and a nucleic acid binding moiety
US08/476,842 US6143490A (en) 1994-11-14 1995-06-07 Treating blood or blood product with a compound having a mustard and a nucleic acid binding moiety

Publications (1)

Publication Number Publication Date
CA2199731A1 true CA2199731A1 (fr) 1996-12-19

Family

ID=27045311

Family Applications (1)

Application Number Title Priority Date Filing Date
CA 2199731 Abandoned CA2199731A1 (fr) 1995-06-07 1996-06-07 Traitement de solutions de globules rouges par des agents antiviraux

Country Status (4)

Country Link
EP (1) EP0773716A4 (fr)
AU (1) AU722811B2 (fr)
CA (1) CA2199731A1 (fr)
WO (1) WO1996039818A1 (fr)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5691132A (en) 1994-11-14 1997-11-25 Cerus Corporation Method for inactivating pathogens in red cell compositions using quinacrine mustard
US6177441B1 (en) 1995-06-05 2001-01-23 Cerus Corporation Treating red blood cell solutions with anti-viral agents
US6136586A (en) * 1995-08-29 2000-10-24 Vi Technologies, Inc. Methods for the selective modification of viral nucleic acids
US6114108A (en) * 1995-08-29 2000-09-05 V.I. Technologies, Inc. Methods and compositions for the selective modification of viral nucleic acids
AU6021698A (en) * 1997-01-06 1998-08-03 Cerus Corporation Methods and devices for the reduction of small organic compounds from bloo d products
AU773836B2 (en) * 1997-01-06 2004-06-10 Cerus Corporation Methods and devices for the reduction of small organic compounds from blood products
EP1364944A1 (fr) * 1997-01-06 2003-11-26 Cerus Corporation Composés frangibles pour inactivation pathogène
AU744089C (en) * 1997-01-06 2003-07-31 Cerus Corporation Frangible compounds for pathogen inactivation
US20010018179A1 (en) 1998-01-06 2001-08-30 Derek J. Hei Batch devices for the reduction of compounds from biological compositions containing cells and methods of use
US6514987B1 (en) 1997-01-06 2003-02-04 Cerus Corporation Frangible compounds for pathogen inactivation
US6093725A (en) * 1997-01-06 2000-07-25 Cerus Corporation Frangible compounds for pathogen inactivation
US20010009756A1 (en) 1998-01-06 2001-07-26 Derek Hei Flow devices for the reduction of compounds from biological compositions and methods of use
US5891705A (en) * 1997-04-08 1999-04-06 Pentose Pharmaceuticals, Inc. Method for inactivating a virus
US6352695B1 (en) 1997-10-03 2002-03-05 V.I. Technologies, Inc. Methods and compositions for the selective modification of nucleic acids
US6093564A (en) * 1997-10-03 2000-07-25 V.I. Technologies, Inc. Methods and compositions for the selective modification of nucleic acids
JP4643004B2 (ja) * 1998-01-06 2011-03-02 シーラス コーポレイション 生体材料中の病原体不活性化剤をクエンチするための方法
CA2318508C (fr) * 1998-01-06 2004-04-20 Cerus Corporation Dispositifs de traitement discontinu permettant de reduire la concentration de composes dans des compositions biologiques contenant des cellules, et procedes associes
US7611831B2 (en) 1998-01-06 2009-11-03 Cerus Corporation Adsorbing pathogen-inactivating compounds with porous particles immobilized in a matrix
US6369048B1 (en) 1998-01-12 2002-04-09 V.I. Technologies, Inc. Methods and compositions for inactivating viruses
US6281225B1 (en) 1998-06-11 2001-08-28 Cerus Corporation Inhibiting proliferation of arterial smooth muscle cells
US6617100B2 (en) 1998-09-25 2003-09-09 V.I. Technologies, Inc. Solid phase quenching systems
US6403359B1 (en) 1998-09-25 2002-06-11 V. I. TECHNOLOGIES, Inc. Solid phase quenching systems
US6150109A (en) 1999-01-25 2000-11-21 V. I. TECHNOLOGIES, Inc. Lipophilic quenching of viral inactivating agents
DE10051628B4 (de) * 2000-10-18 2007-06-06 Fresenius Hemocare Beteiligungs Gmbh Einzelsträngiges Oligonukleotid und dessen Verwendung
US20020131958A1 (en) * 2001-01-22 2002-09-19 John Chapman Method for purifying a biological composition
US7695725B2 (en) 2003-02-06 2010-04-13 Aduro Biotech Modified free-living microbes, vaccine compositions and methods of use thereof
AU2004246999B2 (en) 2003-02-06 2010-06-10 Aduro Biotech, Inc., Listeria attenuated for entry into non-phagocytic cells, vaccines comprising the listeria, and methods of use thereof
US7833775B2 (en) 2003-02-06 2010-11-16 Aduro Biotech Modified free-living microbes, vaccine compositions and methods of use thereof
US20070099950A1 (en) * 2003-11-21 2007-05-03 Jongwon Lim Pyridin-4-ylamine compounds useful in the treatment of neuropathic pain
CN101094692A (zh) 2004-10-29 2007-12-26 塞鲁斯公司 用于红细胞灭活过程的改进的猝灭方法
JP5916383B2 (ja) 2008-04-09 2016-05-11 シーラス コーポレイション 赤血球病原体の不活化のための改善されたクエンチング方法
CN101857598B (zh) * 2010-06-25 2012-11-28 西安交通大学 一种具有降高血压活性的呋喃香豆素类化合物及其制备方法
US9221760B2 (en) 2011-05-09 2015-12-29 Van Andel Research Institute Autophagy inhibitors
CA2990864A1 (fr) 2015-06-26 2016-12-29 Cerus Corporation Compositions de cryoprecipites et leurs procedes de preparation
US10799533B2 (en) 2015-10-23 2020-10-13 Cerus Corporation Plasma compositions and methods of use thereof
US11235090B2 (en) 2017-03-03 2022-02-01 Cerus Corporation Kits and methods for preparing pathogen-inactivated platelet compositions
WO2019133929A1 (fr) 2017-12-29 2019-07-04 Cerus Corporation Systèmes et procédés pour traiter de fluides biologiques
US11883544B2 (en) 2019-06-28 2024-01-30 Cerus Corporation System and methods for implementing a biological fluid treatment device

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4182750A (en) * 1977-04-21 1980-01-08 Sullivan Thomas E Bloodcompatible functional polymers
US4613322A (en) * 1982-12-08 1986-09-23 Edelson Richard Leslie Method and system for externally treating the blood
ZA912842B (en) * 1990-04-16 1992-03-25 Cryopharm Corp Method of inactivation of viral and bacterial blood contaminants
US5399719A (en) * 1993-06-28 1995-03-21 Steritech, Inc. Compounds for the photodecontamination of pathogens in blood
US5593823A (en) * 1993-06-28 1997-01-14 Cerus Corporation Method for inactivating pathogens in blood using photoactivation of 4'-primary amino-substituted psoralens
ES2337852T3 (es) * 1995-06-07 2010-04-29 Cerus Corporation Metodos y dispositivos para la eliminacion de psoralenos de productos sanguineos.

Also Published As

Publication number Publication date
EP0773716A1 (fr) 1997-05-21
EP0773716A4 (fr) 1999-08-04
AU6104996A (en) 1996-12-30
AU722811B2 (en) 2000-08-10
WO1996039818A1 (fr) 1996-12-19

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US6177441B1 (en) Treating red blood cell solutions with anti-viral agents
US6544727B1 (en) Methods and devices for the removal of psoralens from blood products
EP0840781B1 (fr) Procedes et dispositif pour l'extraction des psoralenes des produits sanguins
US20020192632A1 (en) Method and devices for the removal of psoralens from blood products
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US6294361B1 (en) Processes for photoreactive inactivation of a virus in blood cell or coagulation factor containing compositions and use thereof for preparing compositions useful for transfusion
US6214534B1 (en) Biological compositions containing quenchers of type I and type II photodynamic reactions
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EP1021414B1 (fr) Composes frangibles pour inactivation pathogene
AU696246B2 (en) Process for the sterilization of biological compositions and the product produced thereby
US6514987B1 (en) Frangible compounds for pathogen inactivation
JP2004514680A (ja) 生物的汚染物質を不活性化するための光増感物質を含む保存溶液
US20020115585A1 (en) Method and devices for the removal of psoralens from blood products
EP1365750A2 (fr) Procedes d'inactivation de pathogenes dans des matieres biologiques
US20010046662A1 (en) Method of inactivating pathogens in a red blood cell-containing composition
AU7153800A (en) Treating red blood cell solutions with anti-viral agents
AU757224B2 (en) Method and devices for the removal of psoralens from blood products
JP2012067126A (ja) 血液製剤からソラレンを除去するための方法およびデバイス

Legal Events

Date Code Title Description
EEER Examination request
FZDE Dead