CA2191733A1 - Procedes d'inhibition des reponses des lymphocytes t specifiques a un antigene - Google Patents
Procedes d'inhibition des reponses des lymphocytes t specifiques a un antigeneInfo
- Publication number
- CA2191733A1 CA2191733A1 CA002191733A CA2191733A CA2191733A1 CA 2191733 A1 CA2191733 A1 CA 2191733A1 CA 002191733 A CA002191733 A CA 002191733A CA 2191733 A CA2191733 A CA 2191733A CA 2191733 A1 CA2191733 A1 CA 2191733A1
- Authority
- CA
- Canada
- Prior art keywords
- antibody
- cell
- cells
- agent
- recipient
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/70521—CD28, CD152
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/244—Interleukins [IL]
- C07K16/247—IL-4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2827—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2839—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily
- C07K16/2845—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily against integrin beta2-subunit-containing molecules, e.g. CD11, CD18
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Transplantation (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Cell Biology (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
Procédés d'inhibition des réponses des lymphocytes T spécifiques à un antigène qui consistent à utiliser un agent qui inhibe un signal de co-stimulation dans les lymphocytes T. Afin d'inhiber les réponses des lymphocytes T spécifiques à un antigène, on utilise de préférence un premier agent qui inhibe un signal de co-stimulation dans le lymphocyte T (par exemple une protéine de fusion CTLA41g) ainsi qu~un deuxième agent qui inhibe une autre fonction du lymphocyte T, telle que l'adhésion du lymphocyte T à une cellule qui présente un antigène dirigié contre les lymphocytes T. Par exemple, pour inhiber l'adhésion d'un lymphocyte T à une cellule présentant un antigène, on peut utiliser un anticorps anti-LFA-1 associé à une protéine de fusion CTLA41g. De plus, on peut également utiliser un autre agent qui inhibe un signal de co-stimulation dans les lymphocytes T, tel qu'un anticorps anti-B7-1 ou un anticorps anti-B7-2, conjointement avec un deuxième agent qui inhibe un signal de prolifération dans le lymphocyte T, par exemple un anticorps du récepteur anti-IL-2. Ces procédés sont particulièrement utiles pour inhiber la réaction du greffon contre l'hôte et le rejet de tissus ou d'organes transplantés.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US25526794A | 1994-06-07 | 1994-06-07 | |
US08/255,267 | 1994-06-07 | ||
US47269795A | 1995-06-06 | 1995-06-06 | |
US08/472,697 | 1995-06-06 |
Publications (1)
Publication Number | Publication Date |
---|---|
CA2191733A1 true CA2191733A1 (fr) | 1995-12-21 |
Family
ID=26944578
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002191733A Abandoned CA2191733A1 (fr) | 1994-06-07 | 1995-06-07 | Procedes d'inhibition des reponses des lymphocytes t specifiques a un antigene |
Country Status (5)
Country | Link |
---|---|
EP (1) | EP0784482A2 (fr) |
JP (1) | JPH10501815A (fr) |
AU (1) | AU2701895A (fr) |
CA (1) | CA2191733A1 (fr) |
WO (1) | WO1995034320A2 (fr) |
Families Citing this family (46)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1996014865A1 (fr) * | 1994-11-10 | 1996-05-23 | Repligen Corporation | Procedes d'inhibition de la reaction du greffon contre l'hote lors d'une greffe de moelle osseuse |
US7067318B2 (en) | 1995-06-07 | 2006-06-27 | The Regents Of The University Of Michigan | Methods for transfecting T cells |
US6692964B1 (en) | 1995-05-04 | 2004-02-17 | The United States Of America As Represented By The Secretary Of The Navy | Methods for transfecting T cells |
ATE292689T1 (de) * | 1995-05-04 | 2005-04-15 | Us Navy | Verbesserte verfahren zur transfektion der t- zellen |
US5811097A (en) * | 1995-07-25 | 1998-09-22 | The Regents Of The University Of California | Blockade of T lymphocyte down-regulation associated with CTLA-4 signaling |
US5855887A (en) * | 1995-07-25 | 1999-01-05 | The Regents Of The University Of California | Blockade of lymphocyte down-regulation associated with CTLA-4 signaling |
US6051227A (en) | 1995-07-25 | 2000-04-18 | The Regents Of The University Of California, Office Of Technology Transfer | Blockade of T lymphocyte down-regulation associated with CTLA-4 signaling |
ATE244300T1 (de) * | 1996-01-17 | 2003-07-15 | Imp College Innovations Ltd | Immunotherapie mit verwendung von zytotoxischen t lymphozyten (ctl) |
PT892643E (pt) * | 1996-03-20 | 2002-09-30 | Univ Emory | Metodos para inibir uma resposta imunitaria bloqueando os circuitos de gp39/cd40 e ctla4/cd28/b7 e composicoes utilizaveis para o efeito |
US6060054A (en) * | 1996-04-10 | 2000-05-09 | National Jewish Medical And Research Center | Product for T lymphocyte immunosuppression |
ES2133085B1 (es) * | 1996-12-30 | 2000-04-01 | Hospital Universitario Virgen | Metodo de analisis del rechazo agudo en trasplante ortotopico de higado mediante la determinacion de la intensidad de expresion de las moleculas coestimuladoras (cd28, ctla-4, cd80 y cd86) en la superficie de linfocitos de sangre periferica por citometria de flujo. |
US7235653B2 (en) | 1996-12-31 | 2007-06-26 | Isis Pharmaceuticals, Inc. | Oligonucleotide compositions and methods for the modulation of the expression of B7 protein |
US6077833A (en) * | 1996-12-31 | 2000-06-20 | Isis Pharmaceuticals, Inc. | Oligonucleotide compositions and methods for the modulation of the expression of B7 protein |
US6319906B1 (en) | 1996-12-31 | 2001-11-20 | Isis Pharmaceuticals | Oligonucleotide compositions and methods for the modulation of the expression of B7 protein |
WO1998056417A1 (fr) * | 1997-06-11 | 1998-12-17 | The United States Of America, Represented By The Secretary Of The U.S. Department Of The Navy | Composition et procede pour prevenir des rejets de greffe ou d'autres reponses immunitaires non adaptives des lymphocytes t |
AU746825B2 (en) * | 1998-02-04 | 2002-05-02 | Brigham And Women's Hospital | Costimulatory blockade and mixed chimerism in allotransplantation |
US6841347B1 (en) | 1998-02-05 | 2005-01-11 | The General Hospital Corporation | In vivo construction of DNA libraries |
CN101239185A (zh) | 1998-03-17 | 2008-08-13 | 中外制药株式会社 | 一种包含il-6拮抗剂活性成分的炎性肠道疾病的预防或治疗剂 |
GB9809280D0 (en) * | 1998-04-30 | 1998-07-01 | Rpms Technology Ltd | Immunosupression |
AU5906099A (en) * | 1998-09-04 | 2000-03-27 | Baylor College Of Medicine | T cell peptides as therapeutics for immune-related disease |
EP1144010B1 (fr) * | 1999-01-08 | 2007-04-18 | Wisconsin Alumni Research Foundation | Prévention du rejet chronique de greffe par une combinaison d'immunotoxines et de bloqueurs de la costimulation |
CN1360596A (zh) | 1999-02-12 | 2002-07-24 | 遗传研究所有限公司 | 与b7分子发生反应的人源化免疫球蛋白及应用该免疫球蛋白的治疗方法 |
US6972125B2 (en) | 1999-02-12 | 2005-12-06 | Genetics Institute, Llc | Humanized immunoglobulin reactive with B7-2 and methods of treatment therewith |
US6541608B1 (en) | 1999-02-23 | 2003-04-01 | Baylor College Of Medicine | T cell receptor Vβ-Dβ-Jβ sequence and methods for its detection |
PL364917A1 (en) | 1999-02-23 | 2004-12-27 | Baylor College Of Medicine | T cell receptor vbeta-dbeta-jbeta sequence and methods for its detection |
DK1176981T3 (da) | 1999-05-07 | 2006-04-10 | Genentech Inc | Behandling af autoimmune sygdomme med antagonister som binder til B celleoverflademarkörer |
US7605238B2 (en) | 1999-08-24 | 2009-10-20 | Medarex, Inc. | Human CTLA-4 antibodies and their uses |
WO2001068134A2 (fr) * | 2000-03-14 | 2001-09-20 | Genetics Institute, Inc. | Therapies permettant d'ameliorer la survie d'un greffon |
US7094874B2 (en) | 2000-05-26 | 2006-08-22 | Bristol-Myers Squibb Co. | Soluble CTLA4 mutant molecules |
WO2001095928A2 (fr) | 2000-06-09 | 2001-12-20 | Bristol-Myers Squibb Company | Procedes de regulation de reponse immunitaire a mediation cellulaire au moyen du blocage des signaux lymphocytaires et du blocage de l'adhesion induite par l'antigene lfa-1 |
US20040022787A1 (en) | 2000-07-03 | 2004-02-05 | Robert Cohen | Methods for treating an autoimmune disease using a soluble CTLA4 molecule and a DMARD or NSAID |
KR100864120B1 (ko) | 2000-07-03 | 2008-10-16 | 브리스톨-마이어스스퀴브컴파니 | 가용성 ctla4 분자를 사용한 류마티스성 질환의 치료법 |
EP1334731B1 (fr) | 2000-10-25 | 2008-02-27 | Chugai Seiyaku Kabushiki Kaisha | Agents preventifs ou therapeutiques contre le psoriasis renfermant l'antagoniste de l'il-6 comme substance active |
DK1397153T3 (da) | 2001-05-23 | 2008-05-26 | Bristol Myers Squibb Co | Fremgangsmåde til beskyttelse af allogent ö-celle-transplantat ved anvendelse af oplöselige CTLA4-mutantmolekyler |
US7897582B2 (en) | 2003-05-23 | 2011-03-01 | Isis Pharmaceuticals, Inc. | Oligonucleotide compositions and methods for the modulation of the expression of B7 protein |
US7960355B2 (en) | 2003-05-23 | 2011-06-14 | Isis Pharmaceuticals, Inc. | Compositions and methods for the modulation of the expression of B7 protein |
KR20050082389A (ko) * | 2004-02-18 | 2005-08-23 | 메덱스젠 주식회사 | 직렬 연쇄체를 갖는 면역접합체를 포함하는 장기이식합병증 치료용 약제학적 조성물 |
CA2868733C (fr) * | 2004-03-22 | 2019-12-17 | Mesoblast International Sarl | Cellules souches mesenchymateuses destinees au traitement de l'inflammation |
EP1954311A4 (fr) | 2005-12-07 | 2009-12-23 | Medarex Inc | Régimes d'escalade de dose d'anticorps ctla-4 |
AR058568A1 (es) | 2005-12-20 | 2008-02-13 | Bristol Myers Squibb Co | Metodos para producir una composicion con moleculas ctla4-ig a partir de un medio de cultivo |
KR101398713B1 (ko) | 2005-12-20 | 2014-06-12 | 브리스톨-마이어스 스큅 컴퍼니 | 조성물 및 조성물의 제조 방법 |
US20090169522A1 (en) | 2006-01-13 | 2009-07-02 | Alla Danilkovitch | Mesenchymal stem cells expressing tnf-a receptor |
EP2624845A4 (fr) | 2010-10-08 | 2015-09-09 | Mesoblast Internat S Rl | Préparations de msc renforcées |
EP3898688A1 (fr) * | 2018-12-18 | 2021-10-27 | Catapult Therapeutics B.V. | Utilisation de mabs anti-ccr7 pour la prévention ou le traitement d'une maladie du greffon contre l'hôte (gvhd) |
WO2020172391A1 (fr) * | 2019-02-22 | 2020-08-27 | The Children's Medical Center | Méthodes et compositions se rapportant au traitement de la gvhd |
IL294921A (en) | 2020-01-24 | 2022-09-01 | Pfizer | Antibodies against E-selectin, preparations and methods of use |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH09500788A (ja) * | 1993-07-26 | 1997-01-28 | ダナ・ファーバー・キャンサー・インスティテュート・インコーポレイテッド | B7−2:ctla4/cd28カウンターレセプター |
-
1995
- 1995-06-07 CA CA002191733A patent/CA2191733A1/fr not_active Abandoned
- 1995-06-07 AU AU27018/95A patent/AU2701895A/en not_active Abandoned
- 1995-06-07 JP JP8502351A patent/JPH10501815A/ja not_active Ceased
- 1995-06-07 EP EP95922279A patent/EP0784482A2/fr not_active Withdrawn
- 1995-06-07 WO PCT/US1995/007351 patent/WO1995034320A2/fr not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
EP0784482A2 (fr) | 1997-07-23 |
WO1995034320A3 (fr) | 1996-01-18 |
JPH10501815A (ja) | 1998-02-17 |
AU2701895A (en) | 1996-01-05 |
WO1995034320A2 (fr) | 1995-12-21 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
EEER | Examination request | ||
FZDE | Dead |