CA2191583C - Methods and compositions for modulating morphogenic protein expression - Google Patents
Methods and compositions for modulating morphogenic protein expression Download PDFInfo
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- CA2191583C CA2191583C CA002191583A CA2191583A CA2191583C CA 2191583 C CA2191583 C CA 2191583C CA 002191583 A CA002191583 A CA 002191583A CA 2191583 A CA2191583 A CA 2191583A CA 2191583 C CA2191583 C CA 2191583C
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- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/51—Bone morphogenetic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6897—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids involving reporter genes operably linked to promoters
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/008—Vector systems having a special element relevant for transcription cell type or tissue specific enhancer/promoter combination
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/42—Vector systems having a special element relevant for transcription being an intron or intervening sequence for splicing and/or stability of RNA
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- Biomedical Technology (AREA)
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- Orthopedic Medicine & Surgery (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
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- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US25525094A | 1994-06-07 | 1994-06-07 | |
| US255,250 | 1994-06-07 | ||
| PCT/US1995/007349 WO1995033831A1 (en) | 1994-06-07 | 1995-06-07 | Methods and compositions for modulating morphogenic protein expression |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2191583A1 CA2191583A1 (en) | 1995-12-14 |
| CA2191583C true CA2191583C (en) | 2007-03-27 |
Family
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Family Applications (1)
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|---|---|---|---|
| CA002191583A Expired - Fee Related CA2191583C (en) | 1994-06-07 | 1995-06-07 | Methods and compositions for modulating morphogenic protein expression |
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| EP (1) | EP0804573A1 (enExample) |
| JP (2) | JPH10505223A (enExample) |
| AU (1) | AU703445B2 (enExample) |
| CA (1) | CA2191583C (enExample) |
| WO (1) | WO1995033831A1 (enExample) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6103491A (en) * | 1995-07-26 | 2000-08-15 | Creative Biomolecules, Inc. | Methods and compositions for identifying morphogen analogs |
| US7306903B1 (en) | 1995-07-26 | 2007-12-11 | Curis, Inc. | Methods and compositions for identifying morphogen analogs |
| US6090544A (en) * | 1995-07-26 | 2000-07-18 | Creative Biomolecules, Inc. | Methods and compositions for identifying morphogen analogs |
| US5834188A (en) * | 1995-07-26 | 1998-11-10 | Creative Biomolecule, Inc. | Methods and compositions for identifying morphogen analogs |
| US5932716A (en) * | 1995-07-26 | 1999-08-03 | Creative Biomolecules, Inc. | Morphogen-responsive regulatory elements |
| EP0862651A2 (en) * | 1995-10-16 | 1998-09-09 | Chiron Corporation | Method of screening for factors that modulate gene expression |
| BR9713130A (pt) * | 1996-11-22 | 2000-02-08 | Akzo Nobel Nv | Região promotora de bmp-4 e seus fragmentos, vetor compreendendo uma região promotora de bmp-4 ou seus fragmentos, célula hospedeira, processo para a identificação de agentes terapêuticos para a prevenção e/ou tratamento da osteoporose, e, uso de ici 164384. |
| US6828095B1 (en) | 1997-05-29 | 2004-12-07 | Curis, Inc. | Modulators of morphogen expression and methods of identifying the same |
| JPH11313675A (ja) | 1998-04-30 | 1999-11-16 | Hoechst Marion Roussel Kk | ヒトｂｍｐ−７プロモーターおよびこれを用いた骨関連物質の探索法 |
| GB9828709D0 (en) * | 1998-12-24 | 1999-02-17 | Novartis Ag | Assay |
| US7598079B2 (en) | 1998-12-24 | 2009-10-06 | Novation Pharmaceuticals, Inc. | Assay for identifying compounds which affect stability of mRNA |
| US8426194B2 (en) | 2003-01-21 | 2013-04-23 | Ptc Therapeutics, Inc. | Methods and agents for screening for compounds capable of modulating VEGF expression |
| US9068234B2 (en) | 2003-01-21 | 2015-06-30 | Ptc Therapeutics, Inc. | Methods and agents for screening for compounds capable of modulating gene expression |
| CA2514184C (en) | 2003-01-21 | 2016-04-12 | Ptc Therapeutics, Inc. | Methods for identifying compounds that modulate untranslated region-dependent gene expression and methods of using same |
| US8283115B1 (en) | 2007-06-20 | 2012-10-09 | Ptc Therapeutics, Inc. | Methods of screening for compounds for treating muscular dystrophy using UTRN mRNA translation regulation |
| US8283116B1 (en) | 2007-06-22 | 2012-10-09 | Ptc Therapeutics, Inc. | Methods of screening for compounds for treating spinal muscular atrophy using SMN mRNA translation regulation |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5266683A (en) * | 1988-04-08 | 1993-11-30 | Stryker Corporation | Osteogenic proteins |
| CA2110410C (en) * | 1991-06-05 | 1997-04-15 | The Procter & Gamble Company | Therapeutic compositions for osteoinduction |
| ATE197611T1 (de) * | 1991-08-30 | 2000-12-15 | Creative Biomolecules Inc | Screeningverfahren von morphogenischen proteinen |
| GB9206874D0 (en) * | 1992-03-30 | 1992-05-13 | Connaught Lab | Generation of improved inducible mammalian expression vectors |
| US5512483A (en) * | 1993-05-21 | 1996-04-30 | Mcgill University | Expression vectors responsive to steroid hormones |
| US5585237A (en) * | 1993-10-25 | 1996-12-17 | Creative Biomolecules, Inc. | Methods and compositions for high protein production from recombinant DNA |
| WO1995014104A1 (en) * | 1993-11-16 | 1995-05-26 | Children's Medical Center Corporation | Method of identifying a substance capable of inducing bone formation |
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1995
- 1995-06-07 EP EP95923784A patent/EP0804573A1/en not_active Withdrawn
- 1995-06-07 AU AU28223/95A patent/AU703445B2/en not_active Ceased
- 1995-06-07 JP JP8501323A patent/JPH10505223A/ja active Pending
- 1995-06-07 CA CA002191583A patent/CA2191583C/en not_active Expired - Fee Related
- 1995-06-07 WO PCT/US1995/007349 patent/WO1995033831A1/en not_active Ceased
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2005
- 2005-08-22 JP JP2005240508A patent/JP2006025796A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| WO1995033831A1 (en) | 1995-12-14 |
| AU2822395A (en) | 1996-01-04 |
| AU703445B2 (en) | 1999-03-25 |
| JPH10505223A (ja) | 1998-05-26 |
| JP2006025796A (ja) | 2006-02-02 |
| CA2191583A1 (en) | 1995-12-14 |
| EP0804573A1 (en) | 1997-11-05 |
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