CA2187373C - Procede et appareil permettant de localiser avec precision des points sur l'oeil - Google Patents
Procede et appareil permettant de localiser avec precision des points sur l'oeilInfo
- Publication number
- CA2187373C CA2187373C CA002187373A CA2187373A CA2187373C CA 2187373 C CA2187373 C CA 2187373C CA 002187373 A CA002187373 A CA 002187373A CA 2187373 A CA2187373 A CA 2187373A CA 2187373 C CA2187373 C CA 2187373C
- Authority
- CA
- Canada
- Prior art keywords
- eye
- laser beam
- registration
- coordinates
- pulsed laser
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 238000000034 method Methods 0.000 title claims abstract description 32
- 238000002679 ablation Methods 0.000 claims description 26
- 238000010304 firing Methods 0.000 claims description 7
- 238000001914 filtration Methods 0.000 claims description 4
- 230000004044 response Effects 0.000 claims description 3
- 238000006073 displacement reaction Methods 0.000 claims 1
- 238000000608 laser ablation Methods 0.000 abstract description 2
- 238000001356 surgical procedure Methods 0.000 description 12
- 230000003287 optical effect Effects 0.000 description 10
- 238000011282 treatment Methods 0.000 description 10
- 238000005286 illumination Methods 0.000 description 4
- 239000007799 cork Substances 0.000 description 3
- 210000004087 cornea Anatomy 0.000 description 3
- 238000010586 diagram Methods 0.000 description 3
- 239000000853 adhesive Substances 0.000 description 2
- 230000001070 adhesive effect Effects 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- CPBQJMYROZQQJC-UHFFFAOYSA-N helium neon Chemical compound [He].[Ne] CPBQJMYROZQQJC-UHFFFAOYSA-N 0.000 description 2
- 238000000265 homogenisation Methods 0.000 description 2
- 238000003384 imaging method Methods 0.000 description 2
- 230000004043 responsiveness Effects 0.000 description 2
- 230000002745 absorbent Effects 0.000 description 1
- 239000002250 absorbent Substances 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 201000009310 astigmatism Diseases 0.000 description 1
- 230000005540 biological transmission Effects 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 230000004424 eye movement Effects 0.000 description 1
- 210000000744 eyelid Anatomy 0.000 description 1
- 239000007789 gas Substances 0.000 description 1
- 229910052736 halogen Inorganic materials 0.000 description 1
- 150000002367 halogens Chemical class 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 230000036039 immunity Effects 0.000 description 1
- 238000002430 laser surgery Methods 0.000 description 1
- 239000003562 lightweight material Substances 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 229910001092 metal group alloy Inorganic materials 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 230000009972 noncorrosive effect Effects 0.000 description 1
- 230000037361 pathway Effects 0.000 description 1
- 210000001747 pupil Anatomy 0.000 description 1
- 238000010926 purge Methods 0.000 description 1
- 230000004461 rapid eye movement Effects 0.000 description 1
- 230000004599 slow eye movement Effects 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 230000000007 visual effect Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/18—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves
- A61B18/20—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F9/00—Methods or devices for treatment of the eyes; Devices for putting in contact-lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
- A61F9/007—Methods or devices for eye surgery
- A61F9/008—Methods or devices for eye surgery using laser
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F9/00—Methods or devices for treatment of the eyes; Devices for putting in contact-lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
- A61F9/007—Methods or devices for eye surgery
- A61F9/008—Methods or devices for eye surgery using laser
- A61F9/00802—Methods or devices for eye surgery using laser for photoablation
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B23—MACHINE TOOLS; METAL-WORKING NOT OTHERWISE PROVIDED FOR
- B23K—SOLDERING OR UNSOLDERING; WELDING; CLADDING OR PLATING BY SOLDERING OR WELDING; CUTTING BY APPLYING HEAT LOCALLY, e.g. FLAME CUTTING; WORKING BY LASER BEAM
- B23K26/00—Working by laser beam, e.g. welding, cutting or boring
- B23K26/02—Positioning or observing the workpiece, e.g. with respect to the point of impact; Aligning, aiming or focusing the laser beam
- B23K26/04—Automatically aligning, aiming or focusing the laser beam, e.g. using the back-scattered light
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B23—MACHINE TOOLS; METAL-WORKING NOT OTHERWISE PROVIDED FOR
- B23K—SOLDERING OR UNSOLDERING; WELDING; CLADDING OR PLATING BY SOLDERING OR WELDING; CUTTING BY APPLYING HEAT LOCALLY, e.g. FLAME CUTTING; WORKING BY LASER BEAM
- B23K26/00—Working by laser beam, e.g. welding, cutting or boring
- B23K26/02—Positioning or observing the workpiece, e.g. with respect to the point of impact; Aligning, aiming or focusing the laser beam
- B23K26/04—Automatically aligning, aiming or focusing the laser beam, e.g. using the back-scattered light
- B23K26/042—Automatically aligning the laser beam
- B23K26/043—Automatically aligning the laser beam along the beam path, i.e. alignment of laser beam axis relative to laser beam apparatus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods
- A61B2017/00017—Electrical control of surgical instruments
- A61B2017/00022—Sensing or detecting at the treatment site
- A61B2017/00057—Light
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods
- A61B2017/00681—Aspects not otherwise provided for
- A61B2017/00694—Aspects not otherwise provided for with means correcting for movement of or for synchronisation with the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B2018/00636—Sensing and controlling the application of energy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/18—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves
- A61B18/20—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser
- A61B2018/2015—Miscellaneous features
- A61B2018/2025—Miscellaneous features with a pilot laser
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F9/00—Methods or devices for treatment of the eyes; Devices for putting in contact-lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
- A61F9/007—Methods or devices for eye surgery
- A61F9/008—Methods or devices for eye surgery using laser
- A61F2009/00844—Feedback systems
- A61F2009/00846—Eyetracking
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F9/00—Methods or devices for treatment of the eyes; Devices for putting in contact-lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
- A61F9/007—Methods or devices for eye surgery
- A61F9/008—Methods or devices for eye surgery using laser
- A61F2009/00855—Calibration of the laser system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F9/00—Methods or devices for treatment of the eyes; Devices for putting in contact-lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
- A61F9/007—Methods or devices for eye surgery
- A61F9/008—Methods or devices for eye surgery using laser
- A61F2009/00861—Methods or devices for eye surgery using laser adapted for treatment at a particular location
- A61F2009/00872—Cornea
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F9/00—Methods or devices for treatment of the eyes; Devices for putting in contact-lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
- A61F9/007—Methods or devices for eye surgery
- A61F9/008—Methods or devices for eye surgery using laser
- A61F9/009—Auxiliary devices making contact with the eyeball and coupling in laser light, e.g. goniolenses
Landscapes
- Physics & Mathematics (AREA)
- Optics & Photonics (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Surgery (AREA)
- Ophthalmology & Optometry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- General Health & Medical Sciences (AREA)
- Mechanical Engineering (AREA)
- Plasma & Fusion (AREA)
- Vascular Medicine (AREA)
- Molecular Biology (AREA)
- Medical Informatics (AREA)
- Otolaryngology (AREA)
- Electromagnetism (AREA)
- Laser Surgery Devices (AREA)
- Eye Examination Apparatus (AREA)
Abstract
Procédé et appareil permettant à un système d'alignement sur l'oeil d'obtenir un pointage plus précis, comprenant un laser de superposition exacte ou un laser de pointage permettant de localiser avec précision le point de l'oeil que doit frapper le prochain tir d'ablation par laser. Ce procédé et cet appareil impliquent en outre l'utilisation d'un dispositif d'aide au pointage, constitué d'un cadre fixe de référence destiné à localiser la naissance de l'oeil.
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/225,306 | 1994-04-08 | ||
| US08/225,306 US5645550A (en) | 1994-04-08 | 1994-04-08 | Method and apparatus for providing precise location of points on the eye |
| US31065694A | 1994-09-22 | 1994-09-22 | |
| US08/310,656 | 1994-09-22 | ||
| PCT/EP1995/001287 WO1995027453A1 (fr) | 1994-04-08 | 1995-04-07 | Procede et appareil permettant de localiser avec precision des points sur l'×il |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2187373A1 CA2187373A1 (fr) | 1995-10-19 |
| CA2187373C true CA2187373C (fr) | 2001-06-05 |
Family
ID=26919490
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002187373A Expired - Fee Related CA2187373C (fr) | 1994-04-08 | 1995-04-07 | Procede et appareil permettant de localiser avec precision des points sur l'oeil |
Country Status (5)
| Country | Link |
|---|---|
| EP (1) | EP0754019A1 (fr) |
| JP (1) | JPH10501707A (fr) |
| AU (1) | AU697055B2 (fr) |
| CA (1) | CA2187373C (fr) |
| WO (1) | WO1995027453A1 (fr) |
Families Citing this family (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5782822A (en) * | 1995-10-27 | 1998-07-21 | Ir Vision, Inc. | Method and apparatus for removing corneal tissue with infrared laser radiation |
| AU723120B2 (en) * | 1996-04-17 | 2000-08-17 | Lions Eye Institute Limited | A system for ocular ultramicrosurgery |
| AUPN929096A0 (en) * | 1996-04-17 | 1996-05-09 | Lions Eye Institute | A system for ocular ultramicrosurgery |
| DE19618883A1 (de) * | 1996-05-10 | 1997-11-20 | Jurca Optoelektronik Gmbh | Vorrichtung und Verfahren zur photorefraktiven Korrektur von Fehlsichtigkeiten |
| JP3828626B2 (ja) * | 1996-12-27 | 2006-10-04 | 株式会社ニデック | 眼科手術装置 |
| DE19710906B4 (de) * | 1997-03-15 | 2004-02-19 | Carl Zeiss | Operationsmikroskop mit einer Pupillenlageerffassungsanordnung |
| US6090102A (en) * | 1997-05-12 | 2000-07-18 | Irvision, Inc. | Short pulse mid-infrared laser source for surgery |
| US6299307B1 (en) * | 1997-10-10 | 2001-10-09 | Visx, Incorporated | Eye tracking device for laser eye surgery using corneal margin detection |
| US6283954B1 (en) | 1998-04-21 | 2001-09-04 | Visx, Incorporated | Linear array eye tracker |
| US6245059B1 (en) | 1999-04-07 | 2001-06-12 | Visx, Incorporated | Offset ablation profiles for treatment of irregular astigmation |
| US6322216B1 (en) | 1999-10-07 | 2001-11-27 | Visx, Inc | Two camera off-axis eye tracker for laser eye surgery |
| EP1767174A3 (fr) | 1999-10-21 | 2008-09-17 | Technolas GmbH Ophthalmologische Systeme | Reconnaissance et suivi de l'iris en vue d'un traitement optique |
| DE19962107A1 (de) | 1999-12-22 | 2001-06-28 | Wavelight Laser Technologie Ag | Vorrichtung für die photorefraktive Keratektomie des Auges mit Zentrierung |
| AU2001267473A1 (en) * | 2000-05-20 | 2001-12-03 | Sensomotoric Instruments Gmbh | Method and apparatus for a controlled customisation of the cornea |
| DE10196226B3 (de) | 2000-05-20 | 2012-02-23 | SensoMotoric Instruments Gesellschaft für innovative Sensorik mbH | Vorrichtung zur Bestimmung und Verminderung dynamischer Positionierungsfehler eines Ablations-Lasers während refraktiver Laserchirurgie |
| AU2002346438A1 (en) | 2002-05-30 | 2003-12-19 | Visx, Inc. | Torsional eye orientation and position |
| RU2255714C2 (ru) * | 2003-01-04 | 2005-07-10 | Государственное образовательное учреждение высшего профессионального образования "Оренбургский государственный университет" | Устройство для проведения хирургических операций |
| US7458683B2 (en) | 2003-06-16 | 2008-12-02 | Amo Manufacturing Usa, Llc | Methods and devices for registering optical measurement datasets of an optical system |
| US7766903B2 (en) | 2003-12-24 | 2010-08-03 | The Board Of Trustees Of The Leland Stanford Junior University | Patterned laser treatment of the retina |
| WO2005081955A2 (fr) | 2004-02-20 | 2005-09-09 | Visx, Incorporated | Fonction d'etalement ponctuel volumetrique destinee au diagnostic et au traitement de l'oeil |
| WO2005122872A2 (fr) | 2004-06-10 | 2005-12-29 | Optimedica Corporation | Procede et appareil de fixation ophtalmique par balayage |
| EP1771140B1 (fr) | 2004-06-28 | 2013-01-30 | Topcon Medical Laser Systems, Inc. | Dispositif de therapie ophtalmique optique |
| US7507203B2 (en) | 2004-09-21 | 2009-03-24 | Digital Signal Corporation | System and method for remotely monitoring physiological functions |
| DE102005046130A1 (de) * | 2005-09-27 | 2007-03-29 | Bausch & Lomb Inc. | System und Verfahren zur Behandlung eines Auges eines Patienten, das mit hoher Geschwindigkeit arbeitet |
| DE102005054691A1 (de) | 2005-11-16 | 2007-05-24 | Bausch & Lomb Inc. | Verfahren und Vorrichtung zur Bestimmung der Sehschärfe eines Auges |
| US9681985B2 (en) | 2005-12-01 | 2017-06-20 | Topcon Medical Laser Systems, Inc. | System and method for minimally traumatic ophthalmic photomedicine |
| WO2007070853A2 (fr) | 2005-12-14 | 2007-06-21 | Digital Signal Corporation | Systeme et procede pour le suivi du deplacement de globe oculaire |
| US8081670B2 (en) | 2006-02-14 | 2011-12-20 | Digital Signal Corporation | System and method for providing chirped electromagnetic radiation |
| EP2043572B1 (fr) | 2006-06-30 | 2014-12-31 | Aquesys Inc. | Appareils destinés à soulager la pression dans un organe |
| US7496174B2 (en) | 2006-10-16 | 2009-02-24 | Oraya Therapeutics, Inc. | Portable orthovoltage radiotherapy |
| US7620147B2 (en) | 2006-12-13 | 2009-11-17 | Oraya Therapeutics, Inc. | Orthovoltage radiotherapy |
| US8568393B2 (en) | 2007-03-13 | 2013-10-29 | Topcon Medical Laser Systems, Inc. | Computer guided patterned laser trabeculoplasty |
| US8363783B2 (en) * | 2007-06-04 | 2013-01-29 | Oraya Therapeutics, Inc. | Method and device for ocular alignment and coupling of ocular structures |
| US8512236B2 (en) | 2008-01-11 | 2013-08-20 | Oraya Therapeutics, Inc. | System and method for positioning and stabilizing an eye |
| EP2231277B1 (fr) | 2007-12-23 | 2017-08-30 | Carl Zeiss Meditec, Inc. | Dispositifs permettant de détecter, contrôler et prévoir l'administration d'un rayonnement |
| US7801271B2 (en) | 2007-12-23 | 2010-09-21 | Oraya Therapeutics, Inc. | Methods and devices for orthovoltage ocular radiotherapy and treatment planning |
| US8717545B2 (en) | 2009-02-20 | 2014-05-06 | Digital Signal Corporation | System and method for generating three dimensional images using lidar and video measurements |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3902036A (en) * | 1974-05-02 | 1975-08-26 | Western Electric Co | Control system using multiplexed laser beams |
| US4396285A (en) * | 1980-08-25 | 1983-08-02 | Coherent, Inc. | Laser system and its method of use |
| WO1987005205A1 (fr) * | 1986-03-08 | 1987-09-11 | G. Rodenstock Instrumente Gmbh | Installation a laser pour l'examen et le traitement de l'oeil |
| US4848340A (en) * | 1988-02-10 | 1989-07-18 | Intelligent Surgical Lasers | Eyetracker and method of use |
| IL89874A0 (en) * | 1989-04-06 | 1989-12-15 | Nissim Nejat Danon | Apparatus for computerized laser surgery |
| DE4320579C2 (de) * | 1992-06-15 | 2000-06-15 | Topcon Corp | Operationsmikroskop |
-
1995
- 1995-04-07 CA CA002187373A patent/CA2187373C/fr not_active Expired - Fee Related
- 1995-04-07 EP EP95916614A patent/EP0754019A1/fr not_active Withdrawn
- 1995-04-07 JP JP7526074A patent/JPH10501707A/ja active Pending
- 1995-04-07 AU AU23053/95A patent/AU697055B2/en not_active Ceased
- 1995-04-07 WO PCT/EP1995/001287 patent/WO1995027453A1/fr not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| WO1995027453A1 (fr) | 1995-10-19 |
| EP0754019A1 (fr) | 1997-01-22 |
| AU697055B2 (en) | 1998-09-24 |
| AU2305395A (en) | 1995-10-30 |
| JPH10501707A (ja) | 1998-02-17 |
| CA2187373A1 (fr) | 1995-10-19 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| MKLA | Lapsed |