CA2186526C - Procede et produit de regulation de la sensibilite des cellules a des signaux externes - Google Patents

Procede et produit de regulation de la sensibilite des cellules a des signaux externes

Info

Publication number
CA2186526C
CA2186526C CA002186526A CA2186526A CA2186526C CA 2186526 C CA2186526 C CA 2186526C CA 002186526 A CA002186526 A CA 002186526A CA 2186526 A CA2186526 A CA 2186526A CA 2186526 C CA2186526 C CA 2186526C
Authority
CA
Canada
Prior art keywords
mekk
protein
leu
glu
ser
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA002186526A
Other languages
English (en)
Other versions
CA2186526A1 (fr
Inventor
Gary L. Johnson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
National Jewish Health
Original Assignee
National Jewish Center for Immunology and Respiratory Medicine
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/US1994/004178 external-priority patent/WO1994024159A1/fr
Application filed by National Jewish Center for Immunology and Respiratory Medicine filed Critical National Jewish Center for Immunology and Respiratory Medicine
Priority claimed from PCT/US1994/011690 external-priority patent/WO1995028421A1/fr
Publication of CA2186526A1 publication Critical patent/CA2186526A1/fr
Application granted granted Critical
Publication of CA2186526C publication Critical patent/CA2186526C/fr
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

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  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Container Filling Or Packaging Operations (AREA)

Abstract

L'invention concerne des protéines MEKK isolées, des molécules d'acides nucléiques ayant des séquences qui codent de telles protéines, ainsi que des anticorpss dressés contre de telles protéines. La présente invention concerne également des procédés d'utilisation de telles protéines pour la régulation de la transduction de signaux dans une cellule. La présente invention concerne également des compositions thérapeutiques comprenant ces protéines ou des molécules d'acide nucléique qui codent ces protéines ainsi que leur utilisation pour le traitement d'animaux présentant des problèmes d'ordre médical tel qu'un cancer, une inflammation, des dysfonctionnements neurologiques, des maladies auto-immunes, des réactions allergiques et des maladies hormonales. Lorsque MEKK est exprimée, elle se phosphorylise et active les MEKs y compris MEK-1, MEK-2 et JEK.
CA002186526A 1994-04-15 1994-10-14 Procede et produit de regulation de la sensibilite des cellules a des signaux externes Expired - Fee Related CA2186526C (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
PCT/US1994/004178 WO1994024159A1 (fr) 1993-04-15 1994-04-15 Procede et produit de regulation de la reactivite cellulaire a des signaux externes
WOPCT/US94/04178 1994-04-15
PCT/US1994/011690 WO1995028421A1 (fr) 1993-04-15 1994-10-14 Procede et produit de regulation de la sensibilite des cellules a des signaux externes

Publications (2)

Publication Number Publication Date
CA2186526A1 CA2186526A1 (fr) 1995-10-26
CA2186526C true CA2186526C (fr) 1999-12-14

Family

ID=22242467

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002186526A Expired - Fee Related CA2186526C (fr) 1994-04-15 1994-10-14 Procede et produit de regulation de la sensibilite des cellules a des signaux externes

Country Status (5)

Country Link
JP (2) JP3980635B2 (fr)
AT (1) ATE319821T1 (fr)
AU (1) AU703070B2 (fr)
CA (1) CA2186526C (fr)
DE (1) DE69434650T2 (fr)

Also Published As

Publication number Publication date
JP3980635B2 (ja) 2007-09-26
AU8017794A (en) 1995-11-10
JP3980609B2 (ja) 2007-09-26
DE69434650T2 (de) 2006-11-09
ATE319821T1 (de) 2006-03-15
DE69434650D1 (de) 2006-05-04
JPH09511906A (ja) 1997-12-02
CA2186526A1 (fr) 1995-10-26
JP2006051026A (ja) 2006-02-23
AU703070B2 (en) 1999-03-11

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