CA2173110A1 - Calciumperoxide-bicarbonate oral composition - Google Patents
Calciumperoxide-bicarbonate oral compositionInfo
- Publication number
- CA2173110A1 CA2173110A1 CA 2173110 CA2173110A CA2173110A1 CA 2173110 A1 CA2173110 A1 CA 2173110A1 CA 2173110 CA2173110 CA 2173110 CA 2173110 A CA2173110 A CA 2173110A CA 2173110 A1 CA2173110 A1 CA 2173110A1
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- Canada
- Prior art keywords
- formulation according
- oral formulation
- thc
- sodium
- oral
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/22—Peroxides; Oxygen; Ozone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/88—Two- or multipart kits
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Inorganic Chemistry (AREA)
- Epidemiology (AREA)
- Birds (AREA)
- Chemical & Material Sciences (AREA)
- Emergency Medicine (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Cosmetics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Oral compositions comprising a first calcium peroxide containing component and a second bicarbonate containing component.
Description
W 095/09603 . . 2 1 7 3 ~ ~ O PCT~US94~1120~
Calciumperoxide-bicarbonate oral composition BACKGROU~D OF T~DEDNn~ENTION
S Oral CO~ l;on~ utilizing a p~,ro~,atc cc~ on~ and a bicarbonate CO~pl:!n~ ~1 have been d;s~los,~d Thc most witely used pc.u~dc has been hydrogen p~o.udc and the pcro~dc and the bica l,o~ute have been ph~
separated prior to use. Patents d:s lo ~ "~1 on~ of this typc include U.S.
Patents 4,849,213 and 4,528,180 to Schaeff. Thesc compositions deliv benefits in the u~plaque and z~ ~;gh\c:~itis are~s. Oth bcnefits may also be provided.
While ~o.ddc e~utionC havc been d.,.clopcd, therc is still the need for r~ io~l p.<,du~ which provide for additional blefits or e~lse of n~nufilcture.
The present invcntors have found that ~.~du.,ts ba~ed on calcium p .o~udc can provide excellent pc.~u. --'A when used with a bicar~onate salt.
It is an object Ihc~fu..; of the present L...wltior. to provide a calciwn pc~A,dc bicarbonatetual~ .l~r.e~ .~si'~
A further object ofthe present i..~ t;on i~ to provide ~.~Si~;Q-'' which deliver a variety of bcnefits to the rnouth such as those tc~.;~ct ~ve.
These and other objects of the present L.. _.~t.on will become morc readily llpp&~nl from the more detailed dc~ ion and examples which follow.
C~ ~t~br 5 and ratios used herein re by weight unless olhe~ ;sc r~ Also, dl mcas~ ,.nents referred to haein src made at 25C in the compositions unless otherwise ~ cd 2S SUM~ARY OF THF- TNVFNl~O~
The prescnt ...~_..t;o4 in one of its aspects, relates to an oral C4,~5;~iQn (A) a f~rst Go~pon~ llyl;~;~lg (1) calcium peroxide present in an arnount of from about .05/ to about 10.0% ofthe first c~ -on~n~, and (2) a suitable carrier; and (B) a second CC.~?Ofieut ~m~,l;s;n~.
(1) a bi~l,onale salt present in an amount of from sbout 1.0/.
to bout 60.0/. ofthe second C4l~ , ant 3S (2) a suitable canier wherein c4..~pon ~1~ A and B are held in SCp&~le areas of a con~ r corlt~ G theco.~ c..-~ prior to use. Examples of containers suitable for use in the present invention are described in US Patents 4,849,213 and 4,528,180 to Schaeffer.
W095/09603 ~ ~ ~ t ~s 2 1 73 1 1 0 PCT/US9~/112Q4 By "oral con~rositionS" as used herein means a protuct which in the ordinary course of usage is not intentionally swallowed for purposa of systemic a~minis~ration of particular therapeutic agents, but is rather retained in thc oral cavity for a time a~ffi~ient to contact subst~ntiqlly all ofthe dental swfaces and/or 5 oral tissu for purposes of oral activity.
By ~safe and cffcctive amount~ u used herein means ~ c-~t amount of material to pro~idc thc dcsired benefit whilc bchg safc to thc hard and soft tissua of the oral cavity.
By the term ~ p- ;~, as used hcrein, is nuant that vanou~ - ~d ~
10 c~- ~pon~ can be cDr~a ~tly . , lo~od in the co- .po5 ~;OI~ of this i~t;on ~s long as the listed matcrials perform their intendcd r~ on~
By thc terrn ~cama" as. uscd hacin, is meant a vehicle which is swtable for use to apply the prescnt c~. ,pQ~:~;OA~ in the oral ca~ity.
DFT~ Fn DF-~C~PTION OF T~F r~VF~ON
lS Thc prcs~nt ,~ -lion in a certain spect imolva ~ D, r Qs i ~r containing a bic~boru-le salt c~ -~pol~c~' and a second composition aDntaining a calcium p~,.u.ddc c~ ~ncnt. ~e c~ -ti - I and optional co ~l~r ~ ~Is of the comp~Dsidons~re set forth in detail below.
Bicarbonate S~
An cssential c~ p,Dr~ 1 of the prescnt ~ t;on is a biculPDnate salt.
Plcfe.l~d salts are ~L~ali metal salts such u sodium and polA~;-~n llle most pl~f.,~d bicarbonate salt is sodium bica~bonate which is a staple itcm of co..ln-c~e. The bicarbonate is used at level of from bout 1.0/ to bout 60~/., plcf~ '1~ from about 10/ to about 30/.
2S ~alcium ~e.o~dc A second e~ ti~l co~ on~-~' of the present invention is calcium pcroA.dc. This material is used at a levd of from a~out 0.0S% to about 10/., pr~ bly from about l.û% to about S.0/
Addi~;onAI Co..~on~i~ts Water may also be present in the two c4 ~pos:l;on~ of this u.~_n~ion.
WaSer . . ' ~ in the pre~,~al;on of co--llllc.~,;all~ suitable co~s:~ior~ shouldpreferably be d~ ;r.ni7~d and free of organic impurides. Watcr gen~ COI~.;~S
from about 10/. to S0/~, p.~,f~.~bly from about 20/ to 40/~, by wdght of theto~tl.p~cte co~s~ n~ herein. These ~ ~ ou-~t~ of wata include the free water 3 5 which is addcd plus that which is introduced with other materials as with sorbitol.
The co~ CiS;1;Q~' of the present ul~e.llion may contain in addition to the abo-~-L;,t, d c~...r~o~ many othen which will be s~ .}~t de~r ~' on the WO 95/09603 ~ t~ 2 1 7 3 1 1 ~ PCTIUS9~JII20 type of composition (tOOlhp2~t~ topicaJ gds, prophylaxis pastes und thc like).
Toothp~ctes uc thc ~cfc~d systems with toothp~ctes being thc most p.ef~..c~.
Toothp?stes contain as a major co~pon...lt an abrasive. The abrasi~c polishing material conte.~ cd for use in the present invention can be any 5 material which doa not excessively abrade dentin. These inclute, for ~ r,'e, silicas ;~ ;~ gels ant p~ s, calcium c~l~nale, t;c~
G.~hop)~o~ e tihytrate, a~lcium ~.ophosp~ t~;a~ phosphate, calcium poly.. -~h~ph~l~ inso1ublc sodium p~l~.. t~phospht4 b,t~tet alun~uu, ant resinous rbr.u.~e materials such a~ particulate .s~nc~ pi~tu~ of ur~ ant 10 formaldehyt4 . nt others such ~ J; rlQSI~d .bY Cooley et .~1. in U.S. Patent 3.070.S10. ncc~ 2S, 1962, in.cG.~,alet haein by ~ .~. Mixtura of abrasiva may also be used.
Silica dental tb"~C5, of ~nous t~, can provite thc unique .bcnefi~ of ~.,c~t;a--' dent.sl ,,1~ g u~t polishing p~fi....~nce without undul~r ~brading 15 tooth e~nd or dentin. Silica abrasivc matials are Iso ~ ~p~ n~11y r~ ';ble with source~ of soluble fiuorite ant otha ion sources. For these reasons they are ,.l~f~ .l~ for use hein.
The sDica abrasive polishing ..,alc.;db useful herein, ~ weU as the oth abrasives, 6u~c..~ have n average particle size ranging ~.~. Jbout 0.1 ant 20 30 microns, preferably S ant 15 microns. The silica ~b ~_ can be ~l~r;~ tcd silica or sDica gels such as the silica Acrogels tc~l il~ in Pader d al., U.S. Patent 3.S3~ ~0. issued March 2, 1970 and Digiulio, U.S. P~tent 3.862.307. June 21, 1975, both u,c~.~,G."t~d herein by ref~ x.~ce. ~cf~.~,t are thc silica Acl.E-ted unter the tratename ~Syloit~ by the W. R Grace ~ Conlp~ny, Davison25 Chemical Division. F~. f~.~d p~ec~,;t~d silic~ ~.~t~,.;als include those ~ Ct~
by the J. M. Huber Corporation under thc tradename ~7codent", p~li~l~ly the silica ~ng the d~ ;on ~7~dent 110~. These silica r' ~;-ICS are dc5~,.il,cd h U.S. Patcnt 4.340.583. July 29, 1982, hco~ aled herein by ref~nce.
The abrasive in thc denti~ice col..~o~itions dcsc~ d hercin is present at a 30 Icvel of from about 6% to about 70%, pr~,f~.dbly from about 15% to about 30/.
when the dcnliLice is a tooth~ e.
Flavoring agents can also be added to the dcnliL;ce and other c~mpositionc of the prescnt invention. Suitable flavoring agents include oil of t~,,~c~n, oD of pcpp~ t, oil of ~,C&..u.lt, oil of s~C~s, and oil of clove.
35 S~ t~ .g agents are also useful and include aspartarn4 r~ e saccharin, de~ ,K, levulose and sodium ~,15", 1e. Fla~roring and s ~et~ n; ~g agents are generally used in the cci~rci5ilions herein at levels of from about 0.005% to abou 2% by weight.
W095/09603 ` ~ 2 1 73 1 1 0 PCT/USg4/1120~ ~
In prcp&-ng toolt~p~ s, it is ncccss~y to add somc ~h;c~ e material to provide a dcd.~:'e co~cictency. P~cf~ d th,cl~ r lg agents arc c~l~Qnyl polymers, c~lag~n~ hydroxy-cthyl cdl~lose and water soluble ~Its of cell~)lQse cthers wch as sodiurn c&l~ cLll~l cel~ os~ and sodium ic~l,o~...cll.yl 5 hydroxyethyl c~l4~10se Natural gums such as gum karay~, gum a~abic, and gum tragacanth and pol~ r~ ide gums such u xanthan gum can also be used.
Cgllo:l~' m~ s;~m a luminum silicate or findy di~ided silica can be used ~s partof the thic~cl~g agent to furthcr u..~,.o._ texture. Tl'~ ;ng agcnts in a combined amount from 0.5% to 5.0/ by wdght of the total cc r~~ Qr may be 10 usod.
Su~ n~ arc also useful in thc compoddons of this in~c~tion and hclude many t~e.n typcs of n~lc.;~ls. Suit bk i~rfactants inciute ny w~ich are reasonably stable uld fi~nctinr over a wide pH range. ~ - hldcd are non 9 - y anionic, nonionic~ c~or~ itl~. ccic and an.phot-.;c orjganic i~.~thct;c 15 surfactants. Many of these arc d;~ lo~s~d by Gieseke et ~1. in U.S. Patent 4,051,234, S~t~n~ 27, 1988 u~cGl~atet hein in tot l by l~fe~ence.
It is ~lso tcsirablc to include a hJ-- cd o-~1 in a toolhp~ to keep it from h~dc~u.g. Suitable ~ includc glycerin, sorbitol, and oth edible polyh,JI;crlcDhc'-~t a levdoffromabout10/to bout90~/
One of the co.-~po~ phases of the present ........ -nl may be a gd without abrasive. The l ~ is the do~ l co ~po~ t of uch c~ .o.- -~
phase ant thc ~ g is provided by a material such as a c~ ...yl polyma.
Another optional Cv npOfi '~ of the c~ tion~ of this invention i~ an anionic polycall~lalc which may provide an u~tic~ effect. The anionic 25 polymeric pol~c~bvA~lat o~ t;on~lly but preferably employed herein uc weU
known, being . . '~,_d in the form of their free acids or partially or prcferably fuUy n~t,~li~ wata soluble alkali metal (e.g., preferably sodium) or ~ ~n-salts. Pl~fe~.~d are 1:4 to 4:1 copolyrners of n~leic anhydride or acid withanother poly...~. blc ethyl~ -slly unsaturated . ~A, "~r, preferably mdhyl s~inyl ether (mctko~dl.ylene) ha~ing a 1 ~le ~19~ weight (M.W.) of about 30,000 to about 1,000,000. These copolymers are available for example as Gantrez ~N 139 ~M.W. 500,000), AN 119 (M.W. 250,000) and preferably S-97 Pharmac~ti Grade (M.W. 70,000), of GAF Corporation.
Other opcrative pol~,..e,ic pol~ ~ include those ~ch as the 1:1 35 copolymas of m~leic anhydride with ahyl acrylate, }.~t.u~ late, N-vinyl-2-pyrollitone, or ethylene, thc latter being a~ for e ~le as ~9ntQ EMA No. 1103, M.W. 10,000 and EMA Grade 61, and 1:1 copolymer~
~ W095/09603 . . ~; ` t ~ 2 l 73 1 1 0 PCT/US94/11204 ., of acrylic acid ~ith mcthyl or hydroxyethyl nl~lhac.ylatc, methyl or ethyl acrylatc, " isobutyl vinyl ether or N-~nyl-2-pyrrolidone ~ tionql operative polymeric polyc~l,o~lates di~clos~ in s~ove referred to US Patent Nos 4.138.477 and 4.183.914. i..co",o~tcd herein by S ~cfc..,l-cc, includc copolyrners of maleic anhydlidc with styrcne, isoLItyl~nc or ethyl ~nyl ether, polyaaylic, polyitaconic and polymaldc acid~, and ~1 -r_11 . ylic oligc!~<~a of M W. as low as 1,000 available as Uniroyd ND-2.
Suitabtc gcnc.ally are pol~...~iLc~l olefinically or cLh,y!~~ -ally un~lu~tcd carboxylic acid~ C4 '~ g an activated carbon-to-carbon olefinic touble bond 10 and at least one cuboxyl group, that is, an acid contau~ing an olef~nic double bond which readily function s-n pol~.nc.~al.on becausc of its p.~ncc in the n~o~
e eith h thc alpha-~eta position with respect to a c~bo~yl group or s part of t te~minal n~lh~lcnc ~ouphg. Dluslradve of Qlch acits re ~ic, methaaylic, cthacrylic, alpha-chloroaaylic, aotonic, bct~-acryloxy propionic, lS sorbic, alpha-.~'c ~.l c, cir~nic, beta-a~ lt ,"~ c, itaconic, citraconic, mesacodc, glutaconic, aconitic, alpha-phcnyl-acrylic, 2-ben~yl ~ic, 2~,hh~,A~laaylic, angeDc, unbeUic, fumanc, msleic acids nd ~nhydrides.
Other di~,r~ olefinic . or.~ ~ copol~...c.~blc with such C~I~UA~I;C
,u~nG...c ~ indute ~ te, ~inyl ~' '- ;~c, dimethyl male&te ant the likc.
20 Copol~ contain "~ r ~t c~b~J~lic salt groups fot water-solubility.
The ~..;ht;c anionic pol~ ..ic polycz.bo.ylate co--.~ent i5 mainly a hydrocarbon with optional halogen nt 0-contairi~ng ~-~b.t;~u~ ant linkages ~s present in for eAarnplc ester, ether and OH groups, and whcn present is gen~lly employed in the instant co--~ i';ons h approAi.~te weight ~ of O.OS So 3%, preferably 0.05 to 2%, more pref~bly 0.1 to 2%.
Anoth optional co-..~n ~t is a fluoridc ion source. Thc sourccs of fJuorite ions, or ~uorite-providing c;o~ .uu ~dc, useful ~ t~ So this l..~ tiûn are well known in the art as anti-caries agents and p,.~,?hosp~ ~ inhbison ant also act as such agents in the p. ~ctic~ of this il..~ t;on. These co. .rou-~d~ may be 30 slightly solublc in wat or nuy be fully water-solublc. They are characterizet by their ability to release fluoritc ions in water ant by L~dGIII from ~ndcs~
reaction with other conlpo~nds of the oral preparation. Among these l.~l.,.;al5 arc ,..o~ uoride salts, such a~ soluble alkali metal, allcaline earth metal salts, for e , ~, sotium fluoride, barium ~uoride, sodium ûuor-silicatc, ammonium 35 fiuoros.lir7~ç, sodium ~uo,o~onate, sodium l~or~ rophG5lJk~ z mono- ant ti-nuofophncl l~t~e~ ant ~uorinsted sodium calcium p~opho~hn~
Alkali metal ant tin fluorite~, such as sodium and s~. r~ nuol;dc~, sodium mono-fiuo, ~yho~p~ P) and mixtures thaeof, are ylef~
w095/09603 ~ t ~ 2 1 73 1 I D PCT/US9~/1120~ ~
The amount of fluoride-providing cornr~o~nd is de~c-,dc ~I to some extent upon the type of compound, its solubility, and the type of oral p~c~,a,ation, but it must be a l~on~oYie amount, generally about 0.005 to about 3.0/. in the p,~palalion. In a dcll1irlice pl~,&ra~ion, e.g. tental gel, toothpac~e (inel..~
Calciumperoxide-bicarbonate oral composition BACKGROU~D OF T~DEDNn~ENTION
S Oral CO~ l;on~ utilizing a p~,ro~,atc cc~ on~ and a bicarbonate CO~pl:!n~ ~1 have been d;s~los,~d Thc most witely used pc.u~dc has been hydrogen p~o.udc and the pcro~dc and the bica l,o~ute have been ph~
separated prior to use. Patents d:s lo ~ "~1 on~ of this typc include U.S.
Patents 4,849,213 and 4,528,180 to Schaeff. Thesc compositions deliv benefits in the u~plaque and z~ ~;gh\c:~itis are~s. Oth bcnefits may also be provided.
While ~o.ddc e~utionC havc been d.,.clopcd, therc is still the need for r~ io~l p.<,du~ which provide for additional blefits or e~lse of n~nufilcture.
The present invcntors have found that ~.~du.,ts ba~ed on calcium p .o~udc can provide excellent pc.~u. --'A when used with a bicar~onate salt.
It is an object Ihc~fu..; of the present L...wltior. to provide a calciwn pc~A,dc bicarbonatetual~ .l~r.e~ .~si'~
A further object ofthe present i..~ t;on i~ to provide ~.~Si~;Q-'' which deliver a variety of bcnefits to the rnouth such as those tc~.;~ct ~ve.
These and other objects of the present L.. _.~t.on will become morc readily llpp&~nl from the more detailed dc~ ion and examples which follow.
C~ ~t~br 5 and ratios used herein re by weight unless olhe~ ;sc r~ Also, dl mcas~ ,.nents referred to haein src made at 25C in the compositions unless otherwise ~ cd 2S SUM~ARY OF THF- TNVFNl~O~
The prescnt ...~_..t;o4 in one of its aspects, relates to an oral C4,~5;~iQn (A) a f~rst Go~pon~ llyl;~;~lg (1) calcium peroxide present in an arnount of from about .05/ to about 10.0% ofthe first c~ -on~n~, and (2) a suitable carrier; and (B) a second CC.~?Ofieut ~m~,l;s;n~.
(1) a bi~l,onale salt present in an amount of from sbout 1.0/.
to bout 60.0/. ofthe second C4l~ , ant 3S (2) a suitable canier wherein c4..~pon ~1~ A and B are held in SCp&~le areas of a con~ r corlt~ G theco.~ c..-~ prior to use. Examples of containers suitable for use in the present invention are described in US Patents 4,849,213 and 4,528,180 to Schaeffer.
W095/09603 ~ ~ ~ t ~s 2 1 73 1 1 0 PCT/US9~/112Q4 By "oral con~rositionS" as used herein means a protuct which in the ordinary course of usage is not intentionally swallowed for purposa of systemic a~minis~ration of particular therapeutic agents, but is rather retained in thc oral cavity for a time a~ffi~ient to contact subst~ntiqlly all ofthe dental swfaces and/or 5 oral tissu for purposes of oral activity.
By ~safe and cffcctive amount~ u used herein means ~ c-~t amount of material to pro~idc thc dcsired benefit whilc bchg safc to thc hard and soft tissua of the oral cavity.
By the term ~ p- ;~, as used hcrein, is nuant that vanou~ - ~d ~
10 c~- ~pon~ can be cDr~a ~tly . , lo~od in the co- .po5 ~;OI~ of this i~t;on ~s long as the listed matcrials perform their intendcd r~ on~
By thc terrn ~cama" as. uscd hacin, is meant a vehicle which is swtable for use to apply the prescnt c~. ,pQ~:~;OA~ in the oral ca~ity.
DFT~ Fn DF-~C~PTION OF T~F r~VF~ON
lS Thc prcs~nt ,~ -lion in a certain spect imolva ~ D, r Qs i ~r containing a bic~boru-le salt c~ -~pol~c~' and a second composition aDntaining a calcium p~,.u.ddc c~ ~ncnt. ~e c~ -ti - I and optional co ~l~r ~ ~Is of the comp~Dsidons~re set forth in detail below.
Bicarbonate S~
An cssential c~ p,Dr~ 1 of the prescnt ~ t;on is a biculPDnate salt.
Plcfe.l~d salts are ~L~ali metal salts such u sodium and polA~;-~n llle most pl~f.,~d bicarbonate salt is sodium bica~bonate which is a staple itcm of co..ln-c~e. The bicarbonate is used at level of from bout 1.0/ to bout 60~/., plcf~ '1~ from about 10/ to about 30/.
2S ~alcium ~e.o~dc A second e~ ti~l co~ on~-~' of the present invention is calcium pcroA.dc. This material is used at a levd of from a~out 0.0S% to about 10/., pr~ bly from about l.û% to about S.0/
Addi~;onAI Co..~on~i~ts Water may also be present in the two c4 ~pos:l;on~ of this u.~_n~ion.
WaSer . . ' ~ in the pre~,~al;on of co--llllc.~,;all~ suitable co~s:~ior~ shouldpreferably be d~ ;r.ni7~d and free of organic impurides. Watcr gen~ COI~.;~S
from about 10/. to S0/~, p.~,f~.~bly from about 20/ to 40/~, by wdght of theto~tl.p~cte co~s~ n~ herein. These ~ ~ ou-~t~ of wata include the free water 3 5 which is addcd plus that which is introduced with other materials as with sorbitol.
The co~ CiS;1;Q~' of the present ul~e.llion may contain in addition to the abo-~-L;,t, d c~...r~o~ many othen which will be s~ .}~t de~r ~' on the WO 95/09603 ~ t~ 2 1 7 3 1 1 ~ PCTIUS9~JII20 type of composition (tOOlhp2~t~ topicaJ gds, prophylaxis pastes und thc like).
Toothp~ctes uc thc ~cfc~d systems with toothp~ctes being thc most p.ef~..c~.
Toothp?stes contain as a major co~pon...lt an abrasive. The abrasi~c polishing material conte.~ cd for use in the present invention can be any 5 material which doa not excessively abrade dentin. These inclute, for ~ r,'e, silicas ;~ ;~ gels ant p~ s, calcium c~l~nale, t;c~
G.~hop)~o~ e tihytrate, a~lcium ~.ophosp~ t~;a~ phosphate, calcium poly.. -~h~ph~l~ inso1ublc sodium p~l~.. t~phospht4 b,t~tet alun~uu, ant resinous rbr.u.~e materials such a~ particulate .s~nc~ pi~tu~ of ur~ ant 10 formaldehyt4 . nt others such ~ J; rlQSI~d .bY Cooley et .~1. in U.S. Patent 3.070.S10. ncc~ 2S, 1962, in.cG.~,alet haein by ~ .~. Mixtura of abrasiva may also be used.
Silica dental tb"~C5, of ~nous t~, can provite thc unique .bcnefi~ of ~.,c~t;a--' dent.sl ,,1~ g u~t polishing p~fi....~nce without undul~r ~brading 15 tooth e~nd or dentin. Silica abrasivc matials are Iso ~ ~p~ n~11y r~ ';ble with source~ of soluble fiuorite ant otha ion sources. For these reasons they are ,.l~f~ .l~ for use hein.
The sDica abrasive polishing ..,alc.;db useful herein, ~ weU as the oth abrasives, 6u~c..~ have n average particle size ranging ~.~. Jbout 0.1 ant 20 30 microns, preferably S ant 15 microns. The silica ~b ~_ can be ~l~r;~ tcd silica or sDica gels such as the silica Acrogels tc~l il~ in Pader d al., U.S. Patent 3.S3~ ~0. issued March 2, 1970 and Digiulio, U.S. P~tent 3.862.307. June 21, 1975, both u,c~.~,G."t~d herein by ref~ x.~ce. ~cf~.~,t are thc silica Acl.E-ted unter the tratename ~Syloit~ by the W. R Grace ~ Conlp~ny, Davison25 Chemical Division. F~. f~.~d p~ec~,;t~d silic~ ~.~t~,.;als include those ~ Ct~
by the J. M. Huber Corporation under thc tradename ~7codent", p~li~l~ly the silica ~ng the d~ ;on ~7~dent 110~. These silica r' ~;-ICS are dc5~,.il,cd h U.S. Patcnt 4.340.583. July 29, 1982, hco~ aled herein by ref~nce.
The abrasive in thc denti~ice col..~o~itions dcsc~ d hercin is present at a 30 Icvel of from about 6% to about 70%, pr~,f~.dbly from about 15% to about 30/.
when the dcnliLice is a tooth~ e.
Flavoring agents can also be added to the dcnliL;ce and other c~mpositionc of the prescnt invention. Suitable flavoring agents include oil of t~,,~c~n, oD of pcpp~ t, oil of ~,C&..u.lt, oil of s~C~s, and oil of clove.
35 S~ t~ .g agents are also useful and include aspartarn4 r~ e saccharin, de~ ,K, levulose and sodium ~,15", 1e. Fla~roring and s ~et~ n; ~g agents are generally used in the cci~rci5ilions herein at levels of from about 0.005% to abou 2% by weight.
W095/09603 ` ~ 2 1 73 1 1 0 PCT/USg4/1120~ ~
In prcp&-ng toolt~p~ s, it is ncccss~y to add somc ~h;c~ e material to provide a dcd.~:'e co~cictency. P~cf~ d th,cl~ r lg agents arc c~l~Qnyl polymers, c~lag~n~ hydroxy-cthyl cdl~lose and water soluble ~Its of cell~)lQse cthers wch as sodiurn c&l~ cLll~l cel~ os~ and sodium ic~l,o~...cll.yl 5 hydroxyethyl c~l4~10se Natural gums such as gum karay~, gum a~abic, and gum tragacanth and pol~ r~ ide gums such u xanthan gum can also be used.
Cgllo:l~' m~ s;~m a luminum silicate or findy di~ided silica can be used ~s partof the thic~cl~g agent to furthcr u..~,.o._ texture. Tl'~ ;ng agcnts in a combined amount from 0.5% to 5.0/ by wdght of the total cc r~~ Qr may be 10 usod.
Su~ n~ arc also useful in thc compoddons of this in~c~tion and hclude many t~e.n typcs of n~lc.;~ls. Suit bk i~rfactants inciute ny w~ich are reasonably stable uld fi~nctinr over a wide pH range. ~ - hldcd are non 9 - y anionic, nonionic~ c~or~ itl~. ccic and an.phot-.;c orjganic i~.~thct;c 15 surfactants. Many of these arc d;~ lo~s~d by Gieseke et ~1. in U.S. Patent 4,051,234, S~t~n~ 27, 1988 u~cGl~atet hein in tot l by l~fe~ence.
It is ~lso tcsirablc to include a hJ-- cd o-~1 in a toolhp~ to keep it from h~dc~u.g. Suitable ~ includc glycerin, sorbitol, and oth edible polyh,JI;crlcDhc'-~t a levdoffromabout10/to bout90~/
One of the co.-~po~ phases of the present ........ -nl may be a gd without abrasive. The l ~ is the do~ l co ~po~ t of uch c~ .o.- -~
phase ant thc ~ g is provided by a material such as a c~ ...yl polyma.
Another optional Cv npOfi '~ of the c~ tion~ of this invention i~ an anionic polycall~lalc which may provide an u~tic~ effect. The anionic 25 polymeric pol~c~bvA~lat o~ t;on~lly but preferably employed herein uc weU
known, being . . '~,_d in the form of their free acids or partially or prcferably fuUy n~t,~li~ wata soluble alkali metal (e.g., preferably sodium) or ~ ~n-salts. Pl~fe~.~d are 1:4 to 4:1 copolyrners of n~leic anhydride or acid withanother poly...~. blc ethyl~ -slly unsaturated . ~A, "~r, preferably mdhyl s~inyl ether (mctko~dl.ylene) ha~ing a 1 ~le ~19~ weight (M.W.) of about 30,000 to about 1,000,000. These copolymers are available for example as Gantrez ~N 139 ~M.W. 500,000), AN 119 (M.W. 250,000) and preferably S-97 Pharmac~ti Grade (M.W. 70,000), of GAF Corporation.
Other opcrative pol~,..e,ic pol~ ~ include those ~ch as the 1:1 35 copolymas of m~leic anhydride with ahyl acrylate, }.~t.u~ late, N-vinyl-2-pyrollitone, or ethylene, thc latter being a~ for e ~le as ~9ntQ EMA No. 1103, M.W. 10,000 and EMA Grade 61, and 1:1 copolymer~
~ W095/09603 . . ~; ` t ~ 2 l 73 1 1 0 PCT/US94/11204 ., of acrylic acid ~ith mcthyl or hydroxyethyl nl~lhac.ylatc, methyl or ethyl acrylatc, " isobutyl vinyl ether or N-~nyl-2-pyrrolidone ~ tionql operative polymeric polyc~l,o~lates di~clos~ in s~ove referred to US Patent Nos 4.138.477 and 4.183.914. i..co",o~tcd herein by S ~cfc..,l-cc, includc copolyrners of maleic anhydlidc with styrcne, isoLItyl~nc or ethyl ~nyl ether, polyaaylic, polyitaconic and polymaldc acid~, and ~1 -r_11 . ylic oligc!~<~a of M W. as low as 1,000 available as Uniroyd ND-2.
Suitabtc gcnc.ally are pol~...~iLc~l olefinically or cLh,y!~~ -ally un~lu~tcd carboxylic acid~ C4 '~ g an activated carbon-to-carbon olefinic touble bond 10 and at least one cuboxyl group, that is, an acid contau~ing an olef~nic double bond which readily function s-n pol~.nc.~al.on becausc of its p.~ncc in the n~o~
e eith h thc alpha-~eta position with respect to a c~bo~yl group or s part of t te~minal n~lh~lcnc ~ouphg. Dluslradve of Qlch acits re ~ic, methaaylic, cthacrylic, alpha-chloroaaylic, aotonic, bct~-acryloxy propionic, lS sorbic, alpha-.~'c ~.l c, cir~nic, beta-a~ lt ,"~ c, itaconic, citraconic, mesacodc, glutaconic, aconitic, alpha-phcnyl-acrylic, 2-ben~yl ~ic, 2~,hh~,A~laaylic, angeDc, unbeUic, fumanc, msleic acids nd ~nhydrides.
Other di~,r~ olefinic . or.~ ~ copol~...c.~blc with such C~I~UA~I;C
,u~nG...c ~ indute ~ te, ~inyl ~' '- ;~c, dimethyl male&te ant the likc.
20 Copol~ contain "~ r ~t c~b~J~lic salt groups fot water-solubility.
The ~..;ht;c anionic pol~ ..ic polycz.bo.ylate co--.~ent i5 mainly a hydrocarbon with optional halogen nt 0-contairi~ng ~-~b.t;~u~ ant linkages ~s present in for eAarnplc ester, ether and OH groups, and whcn present is gen~lly employed in the instant co--~ i';ons h approAi.~te weight ~ of O.OS So 3%, preferably 0.05 to 2%, more pref~bly 0.1 to 2%.
Anoth optional co-..~n ~t is a fluoridc ion source. Thc sourccs of fJuorite ions, or ~uorite-providing c;o~ .uu ~dc, useful ~ t~ So this l..~ tiûn are well known in the art as anti-caries agents and p,.~,?hosp~ ~ inhbison ant also act as such agents in the p. ~ctic~ of this il..~ t;on. These co. .rou-~d~ may be 30 slightly solublc in wat or nuy be fully water-solublc. They are characterizet by their ability to release fluoritc ions in water ant by L~dGIII from ~ndcs~
reaction with other conlpo~nds of the oral preparation. Among these l.~l.,.;al5 arc ,..o~ uoride salts, such a~ soluble alkali metal, allcaline earth metal salts, for e , ~, sotium fluoride, barium ~uoride, sodium ûuor-silicatc, ammonium 35 fiuoros.lir7~ç, sodium ~uo,o~onate, sodium l~or~ rophG5lJk~ z mono- ant ti-nuofophncl l~t~e~ ant ~uorinsted sodium calcium p~opho~hn~
Alkali metal ant tin fluorite~, such as sodium and s~. r~ nuol;dc~, sodium mono-fiuo, ~yho~p~ P) and mixtures thaeof, are ylef~
w095/09603 ~ t ~ 2 1 73 1 I D PCT/US9~/1120~ ~
The amount of fluoride-providing cornr~o~nd is de~c-,dc ~I to some extent upon the type of compound, its solubility, and the type of oral p~c~,a,ation, but it must be a l~on~oYie amount, generally about 0.005 to about 3.0/. in the p,~palalion. In a dcll1irlice pl~,&ra~ion, e.g. tental gel, toothpac~e (inel..~
5 crcarn), an amount of such co,-~po~ d which rcleases up to about 5,000 ppm of F-ion by weight of thè pn,p,u ~lion is eonr:de~r~ satisfactory. Any suitable n~inimum amount of such co~ o~ may bc used, but it is preferablc to employ ~ rt~t cc ~ -A to rdease about 300 to 2,000 ppm, more p~efe~r'y ~bout 800 to bout 1,500 ppm of ~uontc ion. Typically, in the cases of L~c li metall n~u-;d~c~ and 10 stannous fluorite, this ~ ~pC!G- ~1 i5 present in ut unount up to sbout 2~/ by weight, basod on the weight of the p..,~ l Dn, nt prefcrably in the r nge of a~out 0.05% to 1%. In the case of sotium - o~n~lwop~ e, thc co may bc present in an amount of about 0.1-3%, more typicdly sbout 0.76%.
Other anti calculus agents arc mctal ions such a3 zinc d;~loxd in U.S.
15 Patent 4.Q22 880. May 10, 1977 to V~nson inc~.~orated herein by r~f~.~c. Still other-s re pol~n.c.s such as those dc~.i1~cd in U.S. Patent 4.661.341. hpril 28,1987 to n~ncd;.,~ and U.S. Patent 3.429.963. Febm~ry 2S, 1969 to Shedlo~ky, both of which re ,nco,~,alcd herein by ref~. cc. Such metalS ~re used in an amount of from about 0.01% to about S%, prefer~bly bout 0.1~/. to bout 2%, 20 while such pol~care used in so~t~ of from ~bout 0.1% to bout 10 pref bly from about 0.5% to about S%. l Still other anti calculus agents ~re ~".ophGs~ salts such as ti- and tetra-aL~cali metal p~,-ophGsy~ rs nd others ~ os,~d in U.S. Patent 4,999,184, March 12, 1991, to Parran et al., inco~ dt~d herein by ~f~c.
Othcr optional co~ ~r~ for use in the present ~?o~ io~ are non-cationic wat insoluble agents wch ~s l.;closan. Such materi~ls are ~ lo~d in U.S. 4,022,899 to Vmson et al., i~ o~ated herein by ref~r~
MF rHOD OF MANUFACI URE
The eGlnp~ l;on~ of the present --~n~ion can be p.cp~d using the method des~il cd rollo~lg the F--- ?
COMPOSITION U~F.
The prcsent invention in its method aspoct involves appl~ g to the oral cavity safe and effective ~mount~ of the col ~rosi1ionc Generally, ~m~unts of atleast about I gram ofthe co, ~pos ~;nn is effective.
Given below are ~ rl~ scn~ative of the present idvention. They descnbe and d~, or.~l~ate pr~ f~ d embo~imcnts within the ill~rehlioll's s~cope.
~ wo 95,09603 2 ~ 7 3 ~ ~ O PCTJUS9~/11204 The ~ "!e ~ are given solcly for the purpose of illu~L.alion and are not to be c~nstrued as ~ n~;on~ of this i~.ie.ltion. Many ~ lion5 thereof are possible without dcp~ R from the inve~t;on's spirit and scope.
F~MpT F. I
S Given below are co~po, ~;o~ re".~.l1dtive ofthe present ;~ lion:
B~ ale Co..~?Gsition Co.. -~)o~ t p~ t.~/Q) Sorbitol 40 040 Sodium Bic~l,ol~lc 20.000 Silica lS.000 Wata 10.000 r~y~ 7.000 SASS 4.000 Sodium Carbonate 1.000 IS Flavor 1.000 CMC 0.8S0 Saccharin 0.S17 rl02 0.350 Fluorite 0.243 Blue Dye 0.000 TOTAL loo.ooo m Pt..,~idc CO..~ ;nn~
Given below are four c~lcium ~,. idc compc~:~ion~ which are uscful for 25 usc with thc above bicarbonatc co~-~po5i';c'n OPTION#I !NT.% OPTION#2 WT.%
Sodium Fluoritc 0.243 Sodium Fluoridc 0.243 Saccharin 0.33 Saccharin 0.33 Citric Acid 0.2 Citric Acid 0.2 Sotium Citratc5.59 Sodium CitrateS.S9 C9~ m Pt.o.udcl.S Calcium Pero~dc 1.S
T~ -~inc 3 T,;~ ol--.~inc 3 Carbopol 9S6 3 Carbopol 956 3 Flavor 0.963 Flavor 0.963 Glyccrin 85.174 PEG-6 85.174 TOT~L 100.000 100-000 WO 95/09603 t t ~ r ~ C; 2 l 7 3 1 1 0P~T/USg~/11204 OPTION#3 Wl` ~/o OPTION#4 ~j Sodium Fluoride 0.243 Sodium Fluoride 0.243 Saccharin 0.33 Saccharin 0.33 Calcium Pero,d.dc 1.5 C~lri~m Pcr~,~.dc l.S
~olc ~r 407 20 Poloxamer 407 20 (Pluronic 127) CE 1~ . 127) Flavor 0.963 Flavor 0.963 Glyc~nn 76.964 PEG-6 76 964 TOTAL 100.000 TOT~L 100.000 Prior to use, the bicsrbonate composition and the calcium peroxide composition must be held in separate areas o a container cont~nln~ the components. Examples.of containers suitable for use in the present invention are described in US Patents 4,849,213 and 4,528,180 to Schaeffer.
Other anti calculus agents arc mctal ions such a3 zinc d;~loxd in U.S.
15 Patent 4.Q22 880. May 10, 1977 to V~nson inc~.~orated herein by r~f~.~c. Still other-s re pol~n.c.s such as those dc~.i1~cd in U.S. Patent 4.661.341. hpril 28,1987 to n~ncd;.,~ and U.S. Patent 3.429.963. Febm~ry 2S, 1969 to Shedlo~ky, both of which re ,nco,~,alcd herein by ref~. cc. Such metalS ~re used in an amount of from about 0.01% to about S%, prefer~bly bout 0.1~/. to bout 2%, 20 while such pol~care used in so~t~ of from ~bout 0.1% to bout 10 pref bly from about 0.5% to about S%. l Still other anti calculus agents ~re ~".ophGs~ salts such as ti- and tetra-aL~cali metal p~,-ophGsy~ rs nd others ~ os,~d in U.S. Patent 4,999,184, March 12, 1991, to Parran et al., inco~ dt~d herein by ~f~c.
Othcr optional co~ ~r~ for use in the present ~?o~ io~ are non-cationic wat insoluble agents wch ~s l.;closan. Such materi~ls are ~ lo~d in U.S. 4,022,899 to Vmson et al., i~ o~ated herein by ref~r~
MF rHOD OF MANUFACI URE
The eGlnp~ l;on~ of the present --~n~ion can be p.cp~d using the method des~il cd rollo~lg the F--- ?
COMPOSITION U~F.
The prcsent invention in its method aspoct involves appl~ g to the oral cavity safe and effective ~mount~ of the col ~rosi1ionc Generally, ~m~unts of atleast about I gram ofthe co, ~pos ~;nn is effective.
Given below are ~ rl~ scn~ative of the present idvention. They descnbe and d~, or.~l~ate pr~ f~ d embo~imcnts within the ill~rehlioll's s~cope.
~ wo 95,09603 2 ~ 7 3 ~ ~ O PCTJUS9~/11204 The ~ "!e ~ are given solcly for the purpose of illu~L.alion and are not to be c~nstrued as ~ n~;on~ of this i~.ie.ltion. Many ~ lion5 thereof are possible without dcp~ R from the inve~t;on's spirit and scope.
F~MpT F. I
S Given below are co~po, ~;o~ re".~.l1dtive ofthe present ;~ lion:
B~ ale Co..~?Gsition Co.. -~)o~ t p~ t.~/Q) Sorbitol 40 040 Sodium Bic~l,ol~lc 20.000 Silica lS.000 Wata 10.000 r~y~ 7.000 SASS 4.000 Sodium Carbonate 1.000 IS Flavor 1.000 CMC 0.8S0 Saccharin 0.S17 rl02 0.350 Fluorite 0.243 Blue Dye 0.000 TOTAL loo.ooo m Pt..,~idc CO..~ ;nn~
Given below are four c~lcium ~,. idc compc~:~ion~ which are uscful for 25 usc with thc above bicarbonatc co~-~po5i';c'n OPTION#I !NT.% OPTION#2 WT.%
Sodium Fluoritc 0.243 Sodium Fluoridc 0.243 Saccharin 0.33 Saccharin 0.33 Citric Acid 0.2 Citric Acid 0.2 Sotium Citratc5.59 Sodium CitrateS.S9 C9~ m Pt.o.udcl.S Calcium Pero~dc 1.S
T~ -~inc 3 T,;~ ol--.~inc 3 Carbopol 9S6 3 Carbopol 956 3 Flavor 0.963 Flavor 0.963 Glyccrin 85.174 PEG-6 85.174 TOT~L 100.000 100-000 WO 95/09603 t t ~ r ~ C; 2 l 7 3 1 1 0P~T/USg~/11204 OPTION#3 Wl` ~/o OPTION#4 ~j Sodium Fluoride 0.243 Sodium Fluoride 0.243 Saccharin 0.33 Saccharin 0.33 Calcium Pero,d.dc 1.5 C~lri~m Pcr~,~.dc l.S
~olc ~r 407 20 Poloxamer 407 20 (Pluronic 127) CE 1~ . 127) Flavor 0.963 Flavor 0.963 Glyc~nn 76.964 PEG-6 76 964 TOTAL 100.000 TOT~L 100.000 Prior to use, the bicsrbonate composition and the calcium peroxide composition must be held in separate areas o a container cont~nln~ the components. Examples.of containers suitable for use in the present invention are described in US Patents 4,849,213 and 4,528,180 to Schaeffer.
Claims (8)
1. An oral composition comprising:
(a) a first dentifrice composition comprising:
(i) an effective amount of calcium peroxide; and (ii) a suitable carrier;
(b) a second dentifrice composition comprising:
(i) an effective amount of a bicarbonate salt; and (ii) a suitable carrier.
wherein components (a) and (b) are held in separate areas of a container containing the components prior to use.
(a) a first dentifrice composition comprising:
(i) an effective amount of calcium peroxide; and (ii) a suitable carrier;
(b) a second dentifrice composition comprising:
(i) an effective amount of a bicarbonate salt; and (ii) a suitable carrier.
wherein components (a) and (b) are held in separate areas of a container containing the components prior to use.
2. An oral formulation according to Claim 1 wherein one or both compositions A and B contain an abrasive.
3. An oral formulation according to either of Claims 1 or 2 wherein one or both of compositions A and B contain a soluble fluoride ion source.
4. An oral formulation according to any of Claims 1-3 wherein the bicarbonate salt in composition B is sodium bicarbonate.
5. An oral formulation according to any of Claims 1-4 wherein one or both of compositions A and B contain an effective amount of anticalculus agent.
6. An oral formulation according to Claim 5 wherein the anticalculus agent is a pyrophosphate salt or a polyphosphate salt.
7. An oral formulation according to any of Claims 1-5 wherein one or both of compositions A and B contain an antimicrobial agent.
8. An oral formulation according to any of Claims 1-7 wherein the antimicrobial agent is triclosan.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US13097593A | 1993-10-04 | 1993-10-04 | |
| US130,975 | 1993-10-04 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2173110A1 true CA2173110A1 (en) | 1995-04-13 |
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ID=22447292
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA 2173110 Abandoned CA2173110A1 (en) | 1993-10-04 | 1994-10-03 | Calciumperoxide-bicarbonate oral composition |
Country Status (11)
| Country | Link |
|---|---|
| EP (1) | EP0722311A1 (en) |
| JP (1) | JPH09503508A (en) |
| CN (1) | CN1136772A (en) |
| AU (1) | AU7964494A (en) |
| BR (1) | BR9407743A (en) |
| CA (1) | CA2173110A1 (en) |
| CZ (1) | CZ98796A3 (en) |
| HU (1) | HUT74081A (en) |
| PE (1) | PE30695A1 (en) |
| PL (1) | PL313796A1 (en) |
| WO (1) | WO1995009603A1 (en) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0839517A3 (en) * | 1996-11-01 | 2003-10-01 | Unilever N.V. | Dental product |
| US5939052A (en) * | 1996-11-21 | 1999-08-17 | The Procter & Gamble Company | Dentifrice compositions containing polyphosphate and fluoride |
| US6713049B1 (en) | 1999-11-12 | 2004-03-30 | The Procter & Gamble Company | Oral compositions providing optimal surface conditioning |
| US6190644B1 (en) * | 1996-11-21 | 2001-02-20 | The Procter & Gamble Company | Dentifrice compositions containing polyphosphate and monofluorophosphate |
| US5849269A (en) * | 1996-11-26 | 1998-12-15 | The Procter & Gamble Company | Oral compositions containing fluoride, pyrophosphate, peroxide, and nonionic and/or amphoteric surfactants |
| ID22137A (en) * | 1997-01-15 | 1999-09-09 | Unilever Nv | DENTAL BLEACHING METHOD |
| US5902568A (en) * | 1997-01-15 | 1999-05-11 | Chesebrough-Pond's Usa Co., Division Of Conopco, Inc. | Method for whitening teeth |
| JP3860471B2 (en) | 1999-11-12 | 2006-12-20 | ザ プロクター アンド ギャンブル カンパニー | Improved stannous oral composition |
| US20040146466A1 (en) | 1999-11-12 | 2004-07-29 | The Procter & Gamble Company | Method of protecting teeth against erosion |
| US10470985B2 (en) | 1999-11-12 | 2019-11-12 | The Procter & Gamble Company | Method of protecting teeth against erosion |
| MXPA02004783A (en) | 1999-11-12 | 2002-08-30 | Procter & Gamble | Improved dual phase stannous oral compositions. |
| WO2004016237A1 (en) * | 2002-08-15 | 2004-02-26 | The Procter & Gamble Company | A method of whitening teeth |
| US8524200B2 (en) | 2002-09-11 | 2013-09-03 | The Procter & Gamble Company | Tooth whitening products |
| US10123953B2 (en) | 2012-06-21 | 2018-11-13 | The Procter & Gamble Company | Reduction of tooth staining derived from cationic antimicrobials |
| WO2014187845A1 (en) * | 2013-05-24 | 2014-11-27 | Solvay Sa | Non-oxidizer particles |
| JP2019532965A (en) * | 2016-10-20 | 2019-11-14 | スリーエム イノベイティブ プロパティズ カンパニー | Method and kit for removing tartar using non-enzymatic hydrogen peroxide decomposition catalyst |
| US11191709B2 (en) | 2019-04-26 | 2021-12-07 | The Procter & Gamble Company | Reduction of tooth staining derived from cationic antimicrobials |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1209319A (en) * | 1967-12-20 | 1970-10-21 | Anneliese Scheller | Improved toothpaste |
| US4528180A (en) * | 1983-03-01 | 1985-07-09 | Schaeffer Hans A | Dental preparation, article and method for storage and delivery thereof |
| US4603045A (en) * | 1985-02-27 | 1986-07-29 | Smigel Irwin E | Toothpaste for bonded (composite filling material) as well as natural teeth |
| US4837008A (en) * | 1985-04-09 | 1989-06-06 | Peroxydent Group | Periodontal composition and method |
| CA1257545A (en) * | 1985-05-23 | 1989-07-18 | Hans A. Schaeffer | Dental composition, method of preparation thereof and container therefor |
| ATE92303T1 (en) * | 1987-03-10 | 1993-08-15 | Peroxydent Group | PERIODONTIC COMPOSITION AND PROCESS. |
| US5085853A (en) * | 1991-06-24 | 1992-02-04 | Chesebrough-Pond's U.S.A., Division Of Conopco, Inc. | Flavor for peroxide-bicarbonate oral compositions |
| US5217710A (en) * | 1992-03-05 | 1993-06-08 | Chesebrough-Pond's Usa Co. | Stabilized peroxide gels containing fluoride |
| US5252312A (en) * | 1992-09-30 | 1993-10-12 | Chesebrough-Pond's Usa Co., Division Of Conopco, Inc. | Package effervescible composition |
-
1994
- 1994-10-03 CN CN 94194378 patent/CN1136772A/en active Pending
- 1994-10-03 CZ CZ96987A patent/CZ98796A3/en unknown
- 1994-10-03 JP JP7510963A patent/JPH09503508A/en active Pending
- 1994-10-03 CA CA 2173110 patent/CA2173110A1/en not_active Abandoned
- 1994-10-03 WO PCT/US1994/011204 patent/WO1995009603A1/en not_active Application Discontinuation
- 1994-10-03 HU HU9600867A patent/HUT74081A/en unknown
- 1994-10-03 AU AU79644/94A patent/AU7964494A/en not_active Abandoned
- 1994-10-03 BR BR9407743A patent/BR9407743A/en not_active Application Discontinuation
- 1994-10-03 EP EP94930567A patent/EP0722311A1/en not_active Ceased
- 1994-10-03 PL PL31379694A patent/PL313796A1/en unknown
- 1994-10-04 PE PE1994252105A patent/PE30695A1/en not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| JPH09503508A (en) | 1997-04-08 |
| WO1995009603A1 (en) | 1995-04-13 |
| CZ98796A3 (en) | 1996-09-11 |
| AU7964494A (en) | 1995-05-01 |
| EP0722311A1 (en) | 1996-07-24 |
| CN1136772A (en) | 1996-11-27 |
| HU9600867D0 (en) | 1996-05-28 |
| BR9407743A (en) | 1997-02-12 |
| PE30695A1 (en) | 1995-10-23 |
| HUT74081A (en) | 1996-10-28 |
| PL313796A1 (en) | 1996-07-22 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| FZDE | Dead |