CA2167282A1 - Apoptose avec regulation - Google Patents

Apoptose avec regulation

Info

Publication number
CA2167282A1
CA2167282A1 CA002167282A CA2167282A CA2167282A1 CA 2167282 A1 CA2167282 A1 CA 2167282A1 CA 002167282 A CA002167282 A CA 002167282A CA 2167282 A CA2167282 A CA 2167282A CA 2167282 A1 CA2167282 A1 CA 2167282A1
Authority
CA
Canada
Prior art keywords
ligand
binding
cells
domain
protein
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002167282A
Other languages
English (en)
Inventor
Gerald R. Crabtree
Stuart L. Schreiber
David M. Spencer
Thomas J. Wandless
Peter Belshaw
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Harvard College
Leland Stanford Junior University
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/US1994/001617 external-priority patent/WO1994018317A1/fr
Application filed by Individual filed Critical Individual
Publication of CA2167282A1 publication Critical patent/CA2167282A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/7051—T-cell receptor (TcR)-CD3 complex
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/03—Fusion polypeptide containing a localisation/targetting motif containing a transmembrane segment
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/035—Fusion polypeptide containing a localisation/targetting motif containing a signal for targeting to the external surface of a cell, e.g. to the outer membrane of Gram negative bacteria, GPI- anchored eukaryote proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/09—Fusion polypeptide containing a localisation/targetting motif containing a nuclear localisation signal
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/20—Fusion polypeptide containing a tag with affinity for a non-protein ligand
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/40—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation
    • C07K2319/42—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation containing a HA(hemagglutinin)-tag
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/40—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation
    • C07K2319/43—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation containing a FLAG-tag
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/71—Fusion polypeptide containing domain for protein-protein interaction containing domain for transcriptional activaation, e.g. VP16
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/71—Fusion polypeptide containing domain for protein-protein interaction containing domain for transcriptional activaation, e.g. VP16
    • C07K2319/715—Fusion polypeptide containing domain for protein-protein interaction containing domain for transcriptional activaation, e.g. VP16 containing a domain for ligand dependent transcriptional activation, e.g. containing a steroid receptor domain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/80—Fusion polypeptide containing a DNA binding domain, e.g. Lacl or Tet-repressor
    • C07K2319/81—Fusion polypeptide containing a DNA binding domain, e.g. Lacl or Tet-repressor containing a Zn-finger domain for DNA binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/90—Fusion polypeptide containing a motif for post-translational modification

Abstract

On a développé un processus général de dimérisation ou d'oligomérisation régulée (pouvant être induite) de protéines intracellulaires. Des procédés et des substances sont décrites, lesquels permettent d'amorcer de manière régulable l'apoptose (mort cellulaire programmée) dans des cellules produites par technique génétique.
CA002167282A 1993-07-16 1994-07-18 Apoptose avec regulation Abandoned CA2167282A1 (fr)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US9349993A 1993-07-16 1993-07-16
US08/093,499 1993-07-16
US17914394A 1994-01-07 1994-01-07
US08/179,143 1994-01-07
PCT/US1994/001617 WO1994018317A1 (fr) 1993-02-12 1994-02-14 Transcription regulee de genes cibles et d'autres evenements biologiques
WOPCT/US94/01617 1994-02-14

Publications (1)

Publication Number Publication Date
CA2167282A1 true CA2167282A1 (fr) 1995-01-26

Family

ID=27377531

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002167282A Abandoned CA2167282A1 (fr) 1993-07-16 1994-07-18 Apoptose avec regulation

Country Status (6)

Country Link
JP (1) JPH09503645A (fr)
AU (1) AU696991B2 (fr)
CA (1) CA2167282A1 (fr)
FI (1) FI960165A (fr)
HU (1) HUT73100A (fr)
WO (1) WO1995002684A1 (fr)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4470226B2 (ja) * 1994-08-18 2010-06-02 アリアド・ファーマシューティカルズ・インコーポレイテッド 新規な多量体化剤
WO1996012796A1 (fr) * 1994-10-25 1996-05-02 The Board Of Trustees Of The Leland Stanford Junior University Transformation de l'etat de cellules produites par genie genetique
WO1996041865A1 (fr) * 1995-06-07 1996-12-27 Ariad Gene Therapeutics, Inc. Regulation d'evenements biologiques fondee sur la rapamycine
US6187757B1 (en) 1995-06-07 2001-02-13 Ariad Pharmaceuticals, Inc. Regulation of biological events using novel compounds
EP0907750B1 (fr) * 1996-04-26 2002-09-18 Massachusetts Institute Of Technology Methode de criblage a l'aide de trois hybrides
JPH10234372A (ja) * 1997-02-27 1998-09-08 Boehringer Mannheim Corp キメラ受容体を有する細胞とその作成方法、並びに その利用
AU6692298A (en) * 1997-03-07 1998-09-22 Ariad Gene Therapeutics, Inc. New applications of gene therapy technology
US6274602B1 (en) 1998-06-03 2001-08-14 Gpi Nil Holdings, Inc. Heterocyclic thioester and ketone hair growth compositions and uses
US6187796B1 (en) 1998-06-03 2001-02-13 Gpi Nil Holdings, Inc. Sulfone hair growth compositions and uses
US6187784B1 (en) 1998-06-03 2001-02-13 Gpi Nil Holdings, Inc. Pipecolic acid derivative hair growth compositions and uses
US6271244B1 (en) 1998-06-03 2001-08-07 Gpi Nil Holdings, Inc. N-linked urea or carbamate of heterocyclic thioester hair growth compositions and uses
US5945441A (en) 1997-06-04 1999-08-31 Gpi Nil Holdings, Inc. Pyrrolidine carboxylate hair revitalizing agents
PT1016714E (pt) 1997-06-27 2003-09-30 Ono Pharmaceutical Co Novo adn plasmidico que compreende adn do gene reporter e sua utilizacao
US6982082B1 (en) 1997-08-27 2006-01-03 President And Fellows Of Harvard College Gene therapy by cell specific targeting
US6153383A (en) * 1997-12-09 2000-11-28 Verdine; Gregory L. Synthetic transcriptional modulators and uses thereof
FR2774289B1 (fr) * 1998-02-03 2002-05-24 Goemar Lab Sa Medicament pour le traitement des dereglements de l'apoptose
US6984635B1 (en) 1998-02-13 2006-01-10 Board Of Trustees Of The Leland Stanford Jr. University Dimerizing agents, their production and use
AU3454799A (en) * 1998-03-30 1999-10-18 Baylor College Of Medicine Regulated apoptosis using chemically induced dimerization of apoptosis factors
CA2330611A1 (fr) 1998-05-22 1999-12-02 The Board Of Trustees Of The Leland Stanford Junior University Molecules bifonctionnelles et therapies basees sur celles-ci
JP2002516843A (ja) 1998-06-03 2002-06-11 ジー・ピー・アイ ニイル ホールディングス インコーポレィティッド ヘテロサイクリックエステルおよびアミド発毛組成物およびその使用
US6172087B1 (en) 1998-06-03 2001-01-09 Gpi Nil Holding, Inc. N-oxide of heterocyclic ester, amide, thioester, or ketone hair growth compositions and uses
DK1115862T3 (da) * 1998-09-23 2009-11-16 Zymogenetics Inc Cytokinreceptor Zalpha11
GB9914650D0 (en) * 1999-06-24 1999-08-25 Angyogene Pharmaceuticals Ltd Chimeric proteins mediating targeted apoptosis
GB9915074D0 (en) * 1999-06-28 1999-08-25 Cortecs Plc Ligand-binding composition
EP1229924A4 (fr) 1999-11-19 2004-12-15 Univ Leland Stanford Junior Molecules bifonctionnelles ciblees et therapies basees sur celles-ci
US7220552B1 (en) 1999-11-19 2007-05-22 The Board Of Trustees Of The Leland Stanford Junior University Bifunctional molecules and their use in the disruption of protein-protein interactions
US6887842B1 (en) 1999-11-19 2005-05-03 The Board Of Trustees Of The Leland Stanford Junior University Modulating a pharmacokinetic property of a drug by administering a bifunctional molecule containing the drug
JP4963142B2 (ja) 2000-12-14 2012-06-27 学校法人慶應義塾 遺伝子型と表現型の対応付け分子とその構成要素、および対応付け分子の製造方法と利用方法
CN100522967C (zh) 2002-02-01 2009-08-05 阿里亚德基因治疗公司 含磷化合物及其应用
US7638331B2 (en) 2004-01-02 2009-12-29 The Administration of the Tulane Rducation Fund Directed apoptosis in COX-2 overexpressing cancer cells through expression targeted gene delivery
US7968762B2 (en) 2004-07-13 2011-06-28 Van Andel Research Institute Immune-compromised transgenic mice expressing human hepatocyte growth factor (hHGF)
JP2009528545A (ja) 2006-03-02 2009-08-06 ザ ユーエービー リサーチ ファウンデーション マイコバクテリウム属の疾患検出、処置、および薬物開発
EP2258858A1 (fr) 2009-06-05 2010-12-08 Universitätsklinikum Freiburg Modèle animal pour le cancer transgénique pour LSD1
US10634668B2 (en) 2012-09-13 2020-04-28 Takara Bio Usa, Inc. Modifiable chemical inducers of proximity and methods of using the same
EP3008192B1 (fr) 2013-06-11 2019-07-17 Takara Bio USA, Inc. Microvésicules enrichies en protéines et leurs procédés de fabrication et d'utilisation
EP3443001A4 (fr) 2016-04-11 2020-04-29 Obsidian Therapeutics, Inc. Systèmes de biocircuits régulés
US10828330B2 (en) 2017-02-22 2020-11-10 IO Bioscience, Inc. Nucleic acid constructs comprising gene editing multi-sites and uses thereof
WO2021079656A1 (fr) * 2019-10-24 2021-04-29 国立大学法人千葉大学 Procédé de mesure de l'activité d'une enzyme de métabolisation de lipides dans une cellule, et substance destinée à être utilisée dans la mesure de l'activité d'une enzyme de métabolisation de lipides dans une cellule
CN116179608B (zh) * 2023-01-05 2024-03-01 昆明理工大学 一种dsRNA在免疫缺陷中华蜜蜂模型构建中的应用

Also Published As

Publication number Publication date
AU696991B2 (en) 1998-09-24
FI960165A (fi) 1996-01-26
JPH09503645A (ja) 1997-04-15
HUT73100A (en) 1996-06-28
WO1995002684A1 (fr) 1995-01-26
AU7336394A (en) 1995-02-13
HU9600083D0 (en) 1996-03-28
FI960165A0 (fi) 1996-01-15

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Legal Events

Date Code Title Description
EEER Examination request
FZDE Discontinued
FZDE Discontinued

Effective date: 20080821