CA2167091A1 - B7-2: ctl a4/cd 28 counter receptor - Google Patents
B7-2: ctl a4/cd 28 counter receptorInfo
- Publication number
- CA2167091A1 CA2167091A1 CA002167091A CA2167091A CA2167091A1 CA 2167091 A1 CA2167091 A1 CA 2167091A1 CA 002167091 A CA002167091 A CA 002167091A CA 2167091 A CA2167091 A CA 2167091A CA 2167091 A1 CA2167091 A1 CA 2167091A1
- Authority
- CA
- Canada
- Prior art keywords
- peptide
- cell
- cells
- nucleic acid
- tumor
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
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- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
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- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
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- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
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- C—CHEMISTRY; METALLURGY
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- C07K—PEPTIDES
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- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2827—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
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- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
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- A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
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- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
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- A01K2227/10—Mammal
- A01K2227/105—Murine
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- A—HUMAN NECESSITIES
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- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
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- A—HUMAN NECESSITIES
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- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/03—Animal model, e.g. for test or diseases
- A01K2267/0331—Animal model for proliferative diseases
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/03—Animal model, e.g. for test or diseases
- A01K2267/035—Animal model for multifactorial diseases
- A01K2267/0381—Animal model for diseases of the hematopoietic system
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
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- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
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- Biotechnology (AREA)
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- Biomedical Technology (AREA)
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- Transplantation (AREA)
- Plant Pathology (AREA)
- Microbiology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Pulmonology (AREA)
- Cell Biology (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Physics & Mathematics (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/101,624 US5942607A (en) | 1993-07-26 | 1993-07-26 | B7-2: a CTLA4/CD28 ligand |
| US10939393A | 1993-08-19 | 1993-08-19 | |
| US14777393A | 1993-11-03 | 1993-11-03 | |
| US08/109,393 | 1993-11-03 | ||
| US08/147,773 | 1993-11-03 | ||
| US08/101,624 | 1993-11-03 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2167091A1 true CA2167091A1 (en) | 1995-02-02 |
Family
ID=27379212
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002167091A Abandoned CA2167091A1 (en) | 1993-07-26 | 1994-07-26 | B7-2: ctl a4/cd 28 counter receptor |
Country Status (5)
| Country | Link |
|---|---|
| EP (1) | EP0711345A1 (de) |
| JP (2) | JPH09500788A (de) |
| AU (2) | AU7405294A (de) |
| CA (1) | CA2167091A1 (de) |
| WO (1) | WO1995003408A1 (de) |
Families Citing this family (63)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6406696B1 (en) | 1989-10-27 | 2002-06-18 | Tolerance Therapeutics, Inc. | Methods of stimulating the immune system with anti-CD3 antibodies |
| JP2546544B2 (ja) * | 1989-10-27 | 1996-10-23 | アーチ ディベラップメント コーポレイション | 免疫強化を促進するための方法と組成物 |
| US6491916B1 (en) | 1994-06-01 | 2002-12-10 | Tolerance Therapeutics, Inc. | Methods and materials for modulation of the immunosuppresive activity and toxicity of monoclonal antibodies |
| US6723705B1 (en) | 1993-08-19 | 2004-04-20 | Gentics Institute, Inc. | Tumor cells modified to express B7-2 with increased immunogenicity and uses therefor |
| US6084067A (en) | 1993-07-26 | 2000-07-04 | Dana-Farber Cancer Institute | CTLA4/CD28 ligands and uses therefor |
| AU772061B2 (en) * | 1993-07-26 | 2004-04-08 | Dana-Farber Cancer Institute, Inc. | B7-2:CTL A4/CD 28 counter receptor |
| US6824779B1 (en) | 1993-07-26 | 2004-11-30 | Dana-Farber Cancer Institute, Inc. | Methods for inhibiting the interaction of B7-2 with its natural ligand |
| US6218510B1 (en) * | 1994-03-02 | 2001-04-17 | Brigham & Woman's Hospital | B7-1 and B7-2 polypeptides |
| JPH10501815A (ja) * | 1994-06-07 | 1998-02-17 | リージェンツ・オブ・ザ・ユニバーシティ・オブ・ミネソタ | 抗原特異的ｔ細胞応答の阻害方法 |
| WO1996014865A1 (en) * | 1994-11-10 | 1996-05-23 | Repligen Corporation | Methods for inhibiting graft versus host disease in bone marrow transplantation |
| US6692964B1 (en) | 1995-05-04 | 2004-02-17 | The United States Of America As Represented By The Secretary Of The Navy | Methods for transfecting T cells |
| US7067318B2 (en) | 1995-06-07 | 2006-06-27 | The Regents Of The University Of Michigan | Methods for transfecting T cells |
| JP4031033B2 (ja) * | 1995-05-04 | 2008-01-09 | アメリカ合衆国 | Ｔ細胞の改良トランスフェクション法 |
| US5811097A (en) * | 1995-07-25 | 1998-09-22 | The Regents Of The University Of California | Blockade of T lymphocyte down-regulation associated with CTLA-4 signaling |
| US6051227A (en) * | 1995-07-25 | 2000-04-18 | The Regents Of The University Of California, Office Of Technology Transfer | Blockade of T lymphocyte down-regulation associated with CTLA-4 signaling |
| US5855887A (en) * | 1995-07-25 | 1999-01-05 | The Regents Of The University Of California | Blockade of lymphocyte down-regulation associated with CTLA-4 signaling |
| DE69713336T2 (de) * | 1996-03-30 | 2002-12-05 | Science Park Raf S P A | Verfahren zur Herstellung von aktivierten markierten tumorspezifischen T-Zellen und deren Verwendung in der Behandlung von Tumoren |
| US6491925B2 (en) | 1996-08-15 | 2002-12-10 | Emory University | Compositions and methods for cancer prophylaxis and/or treatment |
| US7235653B2 (en) | 1996-12-31 | 2007-06-26 | Isis Pharmaceuticals, Inc. | Oligonucleotide compositions and methods for the modulation of the expression of B7 protein |
| US6077833A (en) * | 1996-12-31 | 2000-06-20 | Isis Pharmaceuticals, Inc. | Oligonucleotide compositions and methods for the modulation of the expression of B7 protein |
| US6319906B1 (en) | 1996-12-31 | 2001-11-20 | Isis Pharmaceuticals | Oligonucleotide compositions and methods for the modulation of the expression of B7 protein |
| CA2194814A1 (en) | 1997-01-10 | 1998-07-10 | Terry L. Delovitch | Stimulation of protective t cells to prevent autoimmune disease |
| DE19808759C2 (de) * | 1998-03-02 | 2003-06-26 | Kermi Gmbh | Montagewerkzeug für Glasabschnitte |
| US6852847B1 (en) | 1998-03-19 | 2005-02-08 | Heska Corporation | Canine and feline B7-2 nucleic acid molecules and uses thereof |
| US7078512B2 (en) * | 1998-05-01 | 2006-07-18 | Schering-Plough Animal Health Corporation | Nucleic acid encoding feline CD86 |
| US7279168B2 (en) * | 1998-05-01 | 2007-10-09 | Texas A & M University System | Recombinant virus expressing foreign DNA encoding feline CD86 and uses thereof |
| US7109003B2 (en) | 1998-12-23 | 2006-09-19 | Abgenix, Inc. | Methods for expressing and recovering human monoclonal antibodies to CTLA-4 |
| DE69942037D1 (de) | 1998-12-23 | 2010-04-01 | Amgen Fremont Inc | Humane monoklonale antikörper gegen ctla-4 |
| US6682736B1 (en) | 1998-12-23 | 2004-01-27 | Abgenix, Inc. | Human monoclonal antibodies to CTLA-4 |
| US6972125B2 (en) | 1999-02-12 | 2005-12-06 | Genetics Institute, Llc | Humanized immunoglobulin reactive with B7-2 and methods of treatment therewith |
| EP1159300A2 (de) | 1999-02-12 | 2001-12-05 | Genetics Institute, Inc. | Humanisierte immunoglobuline gerichtet gegen b7 moleküle und behandlungsmethoden damit |
| WO2000066162A1 (en) | 1999-04-30 | 2000-11-09 | The Trustees Of The University Of Pennsylvania | Mutant human cd80 and compositions for and methods of making and using the same |
| AU6458400A (en) * | 1999-08-11 | 2001-03-13 | Isis Innovation Limited | Nucleic acid, polypeptides, assays, therapeutic methods and means |
| EP2360254A1 (de) | 1999-08-23 | 2011-08-24 | Dana-Farber Cancer Institute, Inc. | Screeningverfahren zur Isolierung von Anti-pd1 Antikörper und deren Verwendungen |
| US6936704B1 (en) | 1999-08-23 | 2005-08-30 | Dana-Farber Cancer Institute, Inc. | Nucleic acids encoding costimulatory molecule B7-4 |
| NZ517202A (en) | 1999-08-24 | 2004-05-28 | Medarex Inc | Human CTLA-4 antibodies and their uses |
| US7605238B2 (en) | 1999-08-24 | 2009-10-20 | Medarex, Inc. | Human CTLA-4 antibodies and their uses |
| EP1360290A2 (de) | 2000-06-23 | 2003-11-12 | Maxygen, Inc. | Costimulierende moleküle |
| US7183376B2 (en) | 2000-06-23 | 2007-02-27 | Maxygen, Inc. | Variant B7 co-stimulatory molecules |
| US20020164600A1 (en) * | 2000-06-28 | 2002-11-07 | Gordon Freeman | PD-L2 molecules: novel PD-1 ligands and uses therefor |
| US6635750B1 (en) * | 2000-07-20 | 2003-10-21 | Millennium Pharmaceuticals, Inc. | B7-H2 nucleic acids, members of the B7 family |
| AR036993A1 (es) | 2001-04-02 | 2004-10-20 | Wyeth Corp | Uso de agentes que modulan la interaccion entre pd-1 y sus ligandos en la submodulacion de respuestas inmunologicas |
| US7638326B2 (en) | 2002-01-03 | 2009-12-29 | The Trustees Of The University Of Pennsylvania | Activation and expansion of T-cells using an engineered multivalent signaling platform |
| US7745140B2 (en) | 2002-01-03 | 2010-06-29 | The Trustees Of The University Of Pennsylvania | Activation and expansion of T-cells using an engineered multivalent signaling platform as a research tool |
| WO2003057171A2 (en) | 2002-01-03 | 2003-07-17 | The Trustees Of The University Of Pennsylvania | Activation and expansion of t-cells using an engineered multivalent signaling platform |
| EP1503794B9 (de) | 2002-04-12 | 2012-09-19 | Medarex, Inc. | Behandlungsverfahren unter verwendung von ctla-4 antikörpern |
| AU2003288675B2 (en) | 2002-12-23 | 2010-07-22 | Medimmune Limited | Antibodies against PD-1 and uses therefor |
| US7960355B2 (en) | 2003-05-23 | 2011-06-14 | Isis Pharmaceuticals, Inc. | Compositions and methods for the modulation of the expression of B7 protein |
| US7897582B2 (en) | 2003-05-23 | 2011-03-01 | Isis Pharmaceuticals, Inc. | Oligonucleotide compositions and methods for the modulation of the expression of B7 protein |
| EP1713332A4 (de) * | 2004-01-23 | 2010-08-18 | Avi Biopharma Inc | Antisense-oligomere und verfahren zur induktion von immuntoleranz und immunosuppression |
| WO2005118788A2 (en) | 2004-05-27 | 2005-12-15 | The Trustees Of The University Of Pennsylvania | Novel artificial antigen presenting cells and uses therefor |
| LT2397156T (lt) | 2005-06-08 | 2017-02-27 | Dana-Farber Cancer Institute, Inc. | Būdai ir kompozicijos, skirti nuolatinių infekcijų ir vėžio gydymui inhibuojant užprogramuotos ląstelės mirties-1 (pd-1) kelią |
| SG177944A1 (en) | 2005-07-11 | 2012-02-28 | Macrogenics Inc | Methods for the treatment of autoimmune disorders using immunosuppressive monoclonal antibodies with reduced toxicity |
| NZ568016A (en) | 2005-12-07 | 2011-12-22 | Medarex Inc | CTLA-4 antibody dosage escalation regimens |
| WO2007147090A2 (en) | 2006-06-14 | 2007-12-21 | Macrogenics, Inc. | Methods for the treatment of autoimmune disorders using monoclonal antibodies with reduced toxicity |
| US8501907B2 (en) | 2007-08-10 | 2013-08-06 | Janssen Biotech, Inc. | Immunoglobulin cleavage fragments as disease indicators and compositions for detecting and binding such |
| US9598491B2 (en) | 2008-11-28 | 2017-03-21 | Emory University | Methods for the treatment of infections and tumors |
| CA2952805C (en) | 2009-06-05 | 2021-06-01 | Cellular Dynamics International, Inc. | Reprogramming t cells and hematopoietic cells |
| BR112013012389A2 (pt) * | 2010-11-19 | 2019-09-24 | Janssen Biotech Inc | composições de vacina de fragmentos de clivagem de imunoglobina |
| EP3552628A1 (de) * | 2012-09-07 | 2019-10-16 | The Trustees Of Dartmouth College | Vista-modulatoren zur diagnose und behandlung von krebs |
| SG10202101481YA (en) | 2013-09-23 | 2021-03-30 | Wilson Wolf Mfg Corporation | Improved methods of genetically modifying animal cells |
| CN116196426A (zh) | 2015-07-16 | 2023-06-02 | 百欧肯治疗有限公司 | 治疗癌症的组合物及方法 |
| US20240092836A1 (en) * | 2019-10-08 | 2024-03-21 | Genefrontier Corporation | Cyclic peptide having ctla-4 inhibitory activity and use thereof |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| AU661854B2 (en) | 1991-06-27 | 1995-08-10 | Bristol-Myers Squibb Company | CTL4A receptor, fusion proteins containing it and uses thereof |
-
1994
- 1994-07-26 WO PCT/US1994/008423 patent/WO1995003408A1/en active Application Filing
- 1994-07-26 JP JP7505397A patent/JPH09500788A/ja not_active Withdrawn
- 1994-07-26 AU AU74052/94A patent/AU7405294A/en not_active Abandoned
- 1994-07-26 EP EP94924017A patent/EP0711345A1/de not_active Withdrawn
- 1994-07-26 CA CA002167091A patent/CA2167091A1/en not_active Abandoned
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1998
- 1998-12-08 AU AU96991/98A patent/AU9699198A/en not_active Abandoned
-
2008
- 2008-09-17 JP JP2008237969A patent/JP2009060905A/ja not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| AU9699198A (en) | 1999-02-18 |
| AU7405294A (en) | 1995-02-20 |
| JP2009060905A (ja) | 2009-03-26 |
| WO1995003408A1 (en) | 1995-02-02 |
| JPH09500788A (ja) | 1997-01-28 |
| EP0711345A1 (de) | 1996-05-15 |
Similar Documents
| Publication | Publication Date | Title |
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