CA2167091A1 - Acides nucleiques codant b7-2 et ctl a4/cd 28 - Google Patents
Acides nucleiques codant b7-2 et ctl a4/cd 28Info
- Publication number
- CA2167091A1 CA2167091A1 CA002167091A CA2167091A CA2167091A1 CA 2167091 A1 CA2167091 A1 CA 2167091A1 CA 002167091 A CA002167091 A CA 002167091A CA 2167091 A CA2167091 A CA 2167091A CA 2167091 A1 CA2167091 A1 CA 2167091A1
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- Prior art keywords
- peptide
- cell
- cells
- nucleic acid
- tumor
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
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Classifications
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- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/70532—B7 molecules, e.g. CD80, CD86
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2827—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2207/00—Modified animals
- A01K2207/15—Humanized animals
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
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- A—HUMAN NECESSITIES
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- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/07—Animals genetically altered by homologous recombination
- A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
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- A—HUMAN NECESSITIES
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- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/10—Mammal
- A01K2227/105—Murine
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/03—Animal model, e.g. for test or diseases
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/03—Animal model, e.g. for test or diseases
- A01K2267/0331—Animal model for proliferative diseases
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/03—Animal model, e.g. for test or diseases
- A01K2267/035—Animal model for multifactorial diseases
- A01K2267/0381—Animal model for diseases of the hematopoietic system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Zoology (AREA)
- Biochemistry (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- Wood Science & Technology (AREA)
- Oncology (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Toxicology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Plant Pathology (AREA)
- Cell Biology (AREA)
- Physics & Mathematics (AREA)
- Gastroenterology & Hepatology (AREA)
- Pulmonology (AREA)
- Transplantation (AREA)
- AIDS & HIV (AREA)
- Microbiology (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/101,624 US5942607A (en) | 1993-07-26 | 1993-07-26 | B7-2: a CTLA4/CD28 ligand |
| US10939393A | 1993-08-19 | 1993-08-19 | |
| US14777393A | 1993-11-03 | 1993-11-03 | |
| US08/147,773 | 1993-11-03 | ||
| US08/101,624 | 1993-11-03 | ||
| US08/109,393 | 1993-11-03 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2167091A1 true CA2167091A1 (fr) | 1995-02-02 |
Family
ID=27379212
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002167091A Abandoned CA2167091A1 (fr) | 1993-07-26 | 1994-07-26 | Acides nucleiques codant b7-2 et ctl a4/cd 28 |
Country Status (5)
| Country | Link |
|---|---|
| EP (1) | EP0711345A1 (fr) |
| JP (2) | JPH09500788A (fr) |
| AU (2) | AU7405294A (fr) |
| CA (1) | CA2167091A1 (fr) |
| WO (1) | WO1995003408A1 (fr) |
Families Citing this family (63)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6406696B1 (en) | 1989-10-27 | 2002-06-18 | Tolerance Therapeutics, Inc. | Methods of stimulating the immune system with anti-CD3 antibodies |
| DE69032484T4 (de) * | 1989-10-27 | 1999-09-16 | Arch Dev Corp | Zusammensetzungen und deren verwendung zur förderung der immunopotentiation |
| US6491916B1 (en) | 1994-06-01 | 2002-12-10 | Tolerance Therapeutics, Inc. | Methods and materials for modulation of the immunosuppresive activity and toxicity of monoclonal antibodies |
| AU772061B2 (en) * | 1993-07-26 | 2004-04-08 | Dana-Farber Cancer Institute, Inc. | B7-2:CTL A4/CD 28 counter receptor |
| US6084067A (en) * | 1993-07-26 | 2000-07-04 | Dana-Farber Cancer Institute | CTLA4/CD28 ligands and uses therefor |
| US6824779B1 (en) | 1993-07-26 | 2004-11-30 | Dana-Farber Cancer Institute, Inc. | Methods for inhibiting the interaction of B7-2 with its natural ligand |
| US6723705B1 (en) | 1993-08-19 | 2004-04-20 | Gentics Institute, Inc. | Tumor cells modified to express B7-2 with increased immunogenicity and uses therefor |
| US6218510B1 (en) | 1994-03-02 | 2001-04-17 | Brigham & Woman's Hospital | B7-1 and B7-2 polypeptides |
| WO1995034320A2 (fr) * | 1994-06-07 | 1995-12-21 | Regents Of The University Of Minnesota | Procedes d'inhibition des reponses des lymphocytes t specifiques a un antigene |
| WO1996014865A1 (fr) * | 1994-11-10 | 1996-05-23 | Repligen Corporation | Procedes d'inhibition de la reaction du greffon contre l'hote lors d'une greffe de moelle osseuse |
| JP4031033B2 (ja) * | 1995-05-04 | 2008-01-09 | アメリカ合衆国 | Ｔ細胞の改良トランスフェクション法 |
| US6692964B1 (en) | 1995-05-04 | 2004-02-17 | The United States Of America As Represented By The Secretary Of The Navy | Methods for transfecting T cells |
| US7067318B2 (en) | 1995-06-07 | 2006-06-27 | The Regents Of The University Of Michigan | Methods for transfecting T cells |
| US5811097A (en) * | 1995-07-25 | 1998-09-22 | The Regents Of The University Of California | Blockade of T lymphocyte down-regulation associated with CTLA-4 signaling |
| US5855887A (en) * | 1995-07-25 | 1999-01-05 | The Regents Of The University Of California | Blockade of lymphocyte down-regulation associated with CTLA-4 signaling |
| US6051227A (en) | 1995-07-25 | 2000-04-18 | The Regents Of The University Of California, Office Of Technology Transfer | Blockade of T lymphocyte down-regulation associated with CTLA-4 signaling |
| DE69713336T2 (de) * | 1996-03-30 | 2002-12-05 | Science Park Raf S P A | Verfahren zur Herstellung von aktivierten markierten tumorspezifischen T-Zellen und deren Verwendung in der Behandlung von Tumoren |
| US6491925B2 (en) | 1996-08-15 | 2002-12-10 | Emory University | Compositions and methods for cancer prophylaxis and/or treatment |
| US6077833A (en) * | 1996-12-31 | 2000-06-20 | Isis Pharmaceuticals, Inc. | Oligonucleotide compositions and methods for the modulation of the expression of B7 protein |
| US7235653B2 (en) | 1996-12-31 | 2007-06-26 | Isis Pharmaceuticals, Inc. | Oligonucleotide compositions and methods for the modulation of the expression of B7 protein |
| US6319906B1 (en) | 1996-12-31 | 2001-11-20 | Isis Pharmaceuticals | Oligonucleotide compositions and methods for the modulation of the expression of B7 protein |
| CA2194814A1 (fr) * | 1997-01-10 | 1998-07-10 | Terry L. Delovitch | Stimulation des cellules t protectrices pour prevenir les maladies auto-immunes |
| DE19808759C2 (de) * | 1998-03-02 | 2003-06-26 | Kermi Gmbh | Montagewerkzeug für Glasabschnitte |
| US6852847B1 (en) | 1998-03-19 | 2005-02-08 | Heska Corporation | Canine and feline B7-2 nucleic acid molecules and uses thereof |
| US7279168B2 (en) * | 1998-05-01 | 2007-10-09 | Texas A & M University System | Recombinant virus expressing foreign DNA encoding feline CD86 and uses thereof |
| US7078512B2 (en) | 1998-05-01 | 2006-07-18 | Schering-Plough Animal Health Corporation | Nucleic acid encoding feline CD86 |
| AP1590A (en) * | 1998-12-23 | 2006-03-14 | Pfizer | Human monoclonal antibodies to CTLA-4. |
| US7109003B2 (en) | 1998-12-23 | 2006-09-19 | Abgenix, Inc. | Methods for expressing and recovering human monoclonal antibodies to CTLA-4 |
| EE05627B1 (et) | 1998-12-23 | 2013-02-15 | Pfizer Inc. | CTLA-4 vastased inimese monoklonaalsed antikehad |
| CN1360596A (zh) | 1999-02-12 | 2002-07-24 | 遗传研究所有限公司 | 与b7分子发生反应的人源化免疫球蛋白及应用该免疫球蛋白的治疗方法 |
| US6972125B2 (en) | 1999-02-12 | 2005-12-06 | Genetics Institute, Llc | Humanized immunoglobulin reactive with B7-2 and methods of treatment therewith |
| ATE464910T1 (de) | 1999-04-30 | 2010-05-15 | Univ Pennsylvania | Humane cd80-mutante und zusammensetzungen und methoden zu deren herstellung und verwendung |
| WO2001012658A2 (fr) * | 1999-08-11 | 2001-02-22 | Isis Innovations Limited | Acides nucleiques, polypeptides, analyses, moyens et techniques therapeutiques |
| BR0013581A (pt) | 1999-08-23 | 2002-07-02 | Dana Faber Cancer Inst Inc | Pd-1, um receptor para b7-4, e usos para isto |
| US6936704B1 (en) * | 1999-08-23 | 2005-08-30 | Dana-Farber Cancer Institute, Inc. | Nucleic acids encoding costimulatory molecule B7-4 |
| US7605238B2 (en) | 1999-08-24 | 2009-10-20 | Medarex, Inc. | Human CTLA-4 antibodies and their uses |
| CN1371416B (zh) | 1999-08-24 | 2012-10-10 | 梅达里克斯公司 | 人ctla-4抗体及其应用 |
| CA2411828A1 (fr) | 2000-06-23 | 2002-01-03 | Maxygen, Inc. | Nouvelles molecules costimulatrices |
| US7183376B2 (en) | 2000-06-23 | 2007-02-27 | Maxygen, Inc. | Variant B7 co-stimulatory molecules |
| NZ522844A (en) | 2000-06-28 | 2005-02-25 | Brigham & Womens Hospital | PD-L2 molecules: novel PD-1 ligands and methods to identify compounds to modulate T cell activation |
| US6635750B1 (en) | 2000-07-20 | 2003-10-21 | Millennium Pharmaceuticals, Inc. | B7-H2 nucleic acids, members of the B7 family |
| AR036993A1 (es) | 2001-04-02 | 2004-10-20 | Wyeth Corp | Uso de agentes que modulan la interaccion entre pd-1 y sus ligandos en la submodulacion de respuestas inmunologicas |
| US7638326B2 (en) | 2002-01-03 | 2009-12-29 | The Trustees Of The University Of Pennsylvania | Activation and expansion of T-cells using an engineered multivalent signaling platform |
| US7638325B2 (en) | 2002-01-03 | 2009-12-29 | The Trustees Of The University Of Pennsylvania | Activation and expansion of T-cells using an engineered multivalent signaling platform |
| US7745140B2 (en) | 2002-01-03 | 2010-06-29 | The Trustees Of The University Of Pennsylvania | Activation and expansion of T-cells using an engineered multivalent signaling platform as a research tool |
| EP1503794B9 (fr) | 2002-04-12 | 2012-09-19 | Medarex, Inc. | Methodes de traitement dans lesquelles sont utilises des anticorps du ctla-4 |
| JP4511943B2 (ja) | 2002-12-23 | 2010-07-28 | ワイス エルエルシー | Ｐｄ−１に対する抗体およびその使用 |
| US7897582B2 (en) | 2003-05-23 | 2011-03-01 | Isis Pharmaceuticals, Inc. | Oligonucleotide compositions and methods for the modulation of the expression of B7 protein |
| US7960355B2 (en) | 2003-05-23 | 2011-06-14 | Isis Pharmaceuticals, Inc. | Compositions and methods for the modulation of the expression of B7 protein |
| US20050234002A1 (en) * | 2004-01-23 | 2005-10-20 | Mourich Dan V | Antisense oligomers and methods for inducing immune tolerance and immunosuppression |
| ES2653570T3 (es) | 2004-05-27 | 2018-02-07 | The Trustees Of The University Of Pennsylvania | Células presentadoras de antígeno artificiales novedosas y usos de las mismas |
| HUE030877T2 (en) | 2005-06-08 | 2017-06-28 | Dana Farber Cancer Inst Inc | Methods and Compositions for the Treatment of Permanent Infections and Cancer by Inhibition of Programmed Cell Death (PD-1) Synthesis |
| US8663634B2 (en) | 2005-07-11 | 2014-03-04 | Macrogenics, Inc. | Methods for the treatment of autoimmune disorders using immunosuppressive monoclonal antibodies with reduced toxicity |
| US8110194B2 (en) | 2005-12-07 | 2012-02-07 | Medarex, Inc. | CTLA-4 antibody dosage escalation regimens |
| WO2007147090A2 (fr) | 2006-06-14 | 2007-12-21 | Macrogenics, Inc. | Procédés de traitement de troubles auto-immuns utilisant des anticorps monoclonaux à toxicité réduite |
| US8501907B2 (en) | 2007-08-10 | 2013-08-06 | Janssen Biotech, Inc. | Immunoglobulin cleavage fragments as disease indicators and compositions for detecting and binding such |
| US9598491B2 (en) | 2008-11-28 | 2017-03-21 | Emory University | Methods for the treatment of infections and tumors |
| CA2764373C (fr) | 2009-06-05 | 2019-11-19 | Cellular Dynamics International, Inc. | Reprogrammation de cellules t et de cellules hematophietiques |
| US20120269834A1 (en) * | 2010-11-19 | 2012-10-25 | Robert Jordan | Immunoglobulin cleavage fragment vaccine compositions |
| JP6368308B2 (ja) * | 2012-09-07 | 2018-08-01 | トラスティーズ・オブ・ダートマス・カレッジ | 癌の診断および治療のためのｖｉｓｔａ調節剤 |
| EP3483276B1 (fr) * | 2013-09-23 | 2021-03-31 | Wilson Wolf Manufacturing Corporation | Procédés améliorés de modification génétique de cellules animales |
| WO2017009842A2 (fr) | 2015-07-16 | 2017-01-19 | Biokine Therapeutics Ltd. | Compositions et méthodes pour le traitement du cancer |
| EP4043076A4 (fr) * | 2019-10-08 | 2024-01-03 | Genefrontier Corp | Peptide cyclique possédant une activité inhibitrice de ctla-4 et application de celui-ci |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2580812A1 (fr) | 1991-06-27 | 1993-01-07 | Bristol-Myers Squibb Company | Recepteur ctla, proteines hybrides qui le contiennent et ses applications |
-
1994
- 1994-07-26 EP EP94924017A patent/EP0711345A1/fr not_active Withdrawn
- 1994-07-26 WO PCT/US1994/008423 patent/WO1995003408A1/fr active Application Filing
- 1994-07-26 JP JP7505397A patent/JPH09500788A/ja not_active Withdrawn
- 1994-07-26 CA CA002167091A patent/CA2167091A1/fr not_active Abandoned
- 1994-07-26 AU AU74052/94A patent/AU7405294A/en not_active Abandoned
-
1998
- 1998-12-08 AU AU96991/98A patent/AU9699198A/en not_active Abandoned
-
2008
- 2008-09-17 JP JP2008237969A patent/JP2009060905A/ja not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| AU7405294A (en) | 1995-02-20 |
| EP0711345A1 (fr) | 1996-05-15 |
| AU9699198A (en) | 1999-02-18 |
| WO1995003408A1 (fr) | 1995-02-02 |
| JPH09500788A (ja) | 1997-01-28 |
| JP2009060905A (ja) | 2009-03-26 |
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