CA2163095A1 - Methode de traitement a l'aide de derives du tropane biologiquement actifs - Google Patents

Methode de traitement a l'aide de derives du tropane biologiquement actifs

Info

Publication number
CA2163095A1
CA2163095A1 CA002163095A CA2163095A CA2163095A1 CA 2163095 A1 CA2163095 A1 CA 2163095A1 CA 002163095 A CA002163095 A CA 002163095A CA 2163095 A CA2163095 A CA 2163095A CA 2163095 A1 CA2163095 A1 CA 2163095A1
Authority
CA
Canada
Prior art keywords
aryltropane
derivative
group
uptake
tropane
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002163095A
Other languages
English (en)
Inventor
Huw M. L. Davies
Steven R. Childers
Barbara Bennett
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wake Forest University
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/063,431 external-priority patent/US6008227A/en
Application filed by Individual filed Critical Individual
Publication of CA2163095A1 publication Critical patent/CA2163095A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Epidemiology (AREA)
  • Psychiatry (AREA)
  • Emergency Medicine (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

lective blockade of DA and 5-HT uptake sites with 3-aryltropane derivatives.\!
CA002163095A 1993-05-18 1994-04-04 Methode de traitement a l'aide de derives du tropane biologiquement actifs Abandoned CA2163095A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/063,431 1993-05-18
US08/063,431 US6008227A (en) 1992-03-13 1993-05-18 Process for blocking 5-HT and dopamine uptake with biologically active tropane derivatives

Publications (1)

Publication Number Publication Date
CA2163095A1 true CA2163095A1 (fr) 1994-11-24

Family

ID=22049138

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002163095A Abandoned CA2163095A1 (fr) 1993-05-18 1994-04-04 Methode de traitement a l'aide de derives du tropane biologiquement actifs

Country Status (5)

Country Link
EP (1) EP0697871A4 (fr)
JP (1) JP2906085B2 (fr)
AU (1) AU673265B2 (fr)
CA (1) CA2163095A1 (fr)
WO (1) WO1994026274A1 (fr)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6100275A (en) * 1995-10-13 2000-08-08 Neurosearch A/S 8-azabicyclo[3.2.1.]oct-2-ene derivatives, their preparation and use
US7105678B2 (en) 1995-11-03 2006-09-12 Organix, Inc. Boat tropanes
CA2285516C (fr) * 1999-05-12 2010-12-07 President And Fellows Of Harvard College Agents d'imagerie pour transporteur de dopamine
GB9920074D0 (en) * 1999-08-24 1999-10-27 Babraham Inst Animal model and uses thereof
US7459464B2 (en) * 2002-05-30 2008-12-02 Neurosearch A/S Triple monoamine reuptake inhibitors for the treatment of chronic pain
WO2007028770A1 (fr) * 2005-09-05 2007-03-15 Neurosearch A/S Inhibiteurs du recaptage du neurotransmetteur monoamine pour une neuroprotection chez des patients souffrant d'une maladie mentale avancée

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3813404A (en) * 1972-11-15 1974-05-28 Sterling Drug Inc Tropane-2-carboxylates and derivatives
US5262428A (en) * 1992-03-13 1993-11-16 Wake Forest University Biologically active tropane derivatives
US5288872A (en) * 1992-03-13 1994-02-22 Wake Forest University Compounds for treatment of neurodegenerative diseases
AU672052B2 (en) * 1992-12-23 1996-09-19 Neurosearch A/S Antidepressant and antiparkinsonian compounds

Also Published As

Publication number Publication date
AU6767194A (en) 1994-12-12
JP2906085B2 (ja) 1999-06-14
AU673265B2 (en) 1996-10-31
JPH08510238A (ja) 1996-10-29
EP0697871A1 (fr) 1996-02-28
WO1994026274A1 (fr) 1994-11-24
EP0697871A4 (fr) 1998-04-22

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Legal Events

Date Code Title Description
FZDE Dead