CA2159603C - Quinoleines en tant qu'inhibiteurs de la phosphodiesterase de type iv - Google Patents

Quinoleines en tant qu'inhibiteurs de la phosphodiesterase de type iv Download PDF

Info

Publication number
CA2159603C
CA2159603C CA002159603A CA2159603A CA2159603C CA 2159603 C CA2159603 C CA 2159603C CA 002159603 A CA002159603 A CA 002159603A CA 2159603 A CA2159603 A CA 2159603A CA 2159603 C CA2159603 C CA 2159603C
Authority
CA
Canada
Prior art keywords
compound
quinoline
formula
nitro
mmol
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA002159603A
Other languages
English (en)
Other versions
CA2159603A1 (fr
Inventor
Robert Stephen Wilhelm
Paul Ross Fatheree
Ronnie Lipp Chin
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Syntex USA LLC
Original Assignee
Syntex USA LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/040,731 external-priority patent/US5455252A/en
Application filed by Syntex USA LLC filed Critical Syntex USA LLC
Publication of CA2159603A1 publication Critical patent/CA2159603A1/fr
Application granted granted Critical
Publication of CA2159603C publication Critical patent/CA2159603C/fr
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/04—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to the ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/12—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/12—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D215/14—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/18—Halogen atoms or nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
CA002159603A 1993-03-31 1994-03-23 Quinoleines en tant qu'inhibiteurs de la phosphodiesterase de type iv Expired - Fee Related CA2159603C (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/040,731 1993-03-31
US08/040,731 US5455252A (en) 1993-03-31 1993-03-31 Optionally substituted 6,8-quinolines
PCT/US1994/003004 WO1994022852A1 (fr) 1993-03-31 1994-03-23 Quinoleines comme inhibiteurs de la phosphodiesterase type iv

Publications (2)

Publication Number Publication Date
CA2159603A1 CA2159603A1 (fr) 1994-10-13
CA2159603C true CA2159603C (fr) 2006-07-25

Family

ID=36707375

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002159603A Expired - Fee Related CA2159603C (fr) 1993-03-31 1994-03-23 Quinoleines en tant qu'inhibiteurs de la phosphodiesterase de type iv

Country Status (1)

Country Link
CA (1) CA2159603C (fr)

Also Published As

Publication number Publication date
CA2159603A1 (fr) 1994-10-13

Similar Documents

Publication Publication Date Title
EP0691966B1 (fr) Quinoleines comme inhibiteurs de la phosphodiesterase type iv
CA2132297C (fr) Derives pyrido[2,3-d]pyrimidine agissant comme inhibiteurs de la phosphodiesterase
US5466697A (en) 8-phenyl-1,6-naphthyridin-5-ones
AU646007B2 (en) 3-substituted-1-(aryl or arylalkyl)-2(1h)-quinolinones
NL8600596A (nl) Geneeskrachtige verbindingen, werkwijzen ter bereiding daarvan alsmede deze verbindingen als actieve component bevattende preparaten.
EP0240015B1 (fr) Dérivés de carbostyrile, procédé pour leur préparation, compositions pharmaceutiques les contenant et leur utilisation
JPH01279866A (ja) キノリン系メバロノラクトン類
US5716954A (en) Benzopyridazinone and pyridopyridazinone compounds
CA2159603C (fr) Quinoleines en tant qu'inhibiteurs de la phosphodiesterase de type iv
US5475003A (en) 8-phenylcyclopentenoquinoline and 8-phenylcyclohexenoquinoline derivatives
JPH05505619A (ja) 喘息、関節炎および関連疾患の治療におけるアザベンジミダゾール
KR940000785B1 (ko) 카르보스티릴 유도체 및 그의 염의 제조 방법
CS273190B2 (en) Method of substituted tetralin and chroman production
FI79539B (fi) Foerfarande foer framstaellning av antiallergiska fenylspiro/1,8/-naftyridindioner.
NL8105652A (nl) Heterocyclische verbindingen.
JPS63159382A (ja) １−置換ナフチリジンおよびピリドピラジン誘導体
JPS62223150A (ja) １，４−ベンゾキノン誘導体
JPH03500417A (ja) 治療用薬剤
JPS635078A (ja) 置換８−（フエニルチオ）テトラヒドロキノリン及びその塩、その製造法並びに薬剤

Legal Events

Date Code Title Description
EEER Examination request
MKLA Lapsed