CA2155843C - Nouveaux derives de l'uree; preparation et utilisation - Google Patents
Nouveaux derives de l'uree; preparation et utilisation Download PDFInfo
- Publication number
- CA2155843C CA2155843C CA002155843A CA2155843A CA2155843C CA 2155843 C CA2155843 C CA 2155843C CA 002155843 A CA002155843 A CA 002155843A CA 2155843 A CA2155843 A CA 2155843A CA 2155843 C CA2155843 C CA 2155843C
- Authority
- CA
- Canada
- Prior art keywords
- alkyl
- alkoxycarbonyl
- hydrogen
- aryl
- amino
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C275/40—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by nitrogen atoms not being part of nitro or nitroso groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D263/32—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06104—Dipeptides with the first amino acid being acidic
- C07K5/06113—Asp- or Asn-amino acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0802—Tripeptides with the first amino acid being neutral
- C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
- C07K5/0806—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0821—Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Closures For Containers (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DEP4309867.3 | 1993-03-26 | ||
DE4309867A DE4309867A1 (de) | 1993-03-26 | 1993-03-26 | Neue Harnstoffderivate, ihre Herstellung und Verwendung |
PCT/EP1994/000713 WO1994022907A1 (fr) | 1993-03-26 | 1994-03-09 | Nouveaux derives d'uree, leur preparation et leur utilisation |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2155843A1 CA2155843A1 (fr) | 1994-10-13 |
CA2155843C true CA2155843C (fr) | 2004-09-21 |
Family
ID=6483938
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002155843A Expired - Fee Related CA2155843C (fr) | 1993-03-26 | 1994-03-09 | Nouveaux derives de l'uree; preparation et utilisation |
Country Status (14)
Country | Link |
---|---|
US (1) | US5703050A (fr) |
EP (1) | EP0689549B1 (fr) |
JP (1) | JP3597862B2 (fr) |
KR (1) | KR100418144B1 (fr) |
AT (1) | ATE167483T1 (fr) |
AU (1) | AU679509B2 (fr) |
CA (1) | CA2155843C (fr) |
DE (2) | DE4309867A1 (fr) |
DK (1) | DK0689549T3 (fr) |
ES (1) | ES2119187T3 (fr) |
HU (1) | HU219483B (fr) |
IL (1) | IL109135A (fr) |
WO (1) | WO1994022907A1 (fr) |
ZA (1) | ZA942124B (fr) |
Families Citing this family (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE4427979A1 (de) | 1993-11-15 | 1996-02-15 | Cassella Ag | Substituierte 5-Ring-Heterocyclen, ihre Herstellung und ihre Verwendung |
US6248713B1 (en) | 1995-07-11 | 2001-06-19 | Biogen, Inc. | Cell adhesion inhibitors |
CA2230209A1 (fr) | 1995-08-30 | 1997-03-06 | G.D. Searle & Co. | Derives de la meta-guanidine, de l'uree, de la thio-uree ou de l'acide aminobenzoique azacyclique utilises comme antagonistes de l'integrine |
JP2000516197A (ja) * | 1996-01-16 | 2000-12-05 | メルク エンド カンパニー インコーポレーテッド | インテグリンレセプターアンタゴニスト |
DE19622489A1 (de) | 1996-06-05 | 1997-12-11 | Hoechst Ag | Salze des 3-(2-(4-(4-(Amino-imino-methyl)-phenyl)-4- methyl-2,5-dioxo-imidazolidin-1-yl)-acetylamino)-3- phenyl-propionsäure-ethylesters |
US6239108B1 (en) | 1996-07-11 | 2001-05-29 | Biogen, Inc. | Cell adhesion inhibitors |
ES2285735T3 (es) | 1996-07-25 | 2007-11-16 | Biogen Idec Inc | Modelo molecular para inhibidores de vla-4. |
US6686350B1 (en) | 1996-07-25 | 2004-02-03 | Biogen, Inc. | Cell adhesion inhibitors |
YU75500A (sh) | 1998-05-28 | 2002-12-10 | Biogen Inc. | NOVI VLA-4 INHIBITORI oMePUPA-V |
US6420403B1 (en) * | 1998-10-29 | 2002-07-16 | Edwin J. Iwanowicz | Inhibitors of IMPDH enzyme |
KR100720907B1 (ko) | 1999-08-13 | 2007-05-25 | 바이오겐 아이덱 엠에이 인코포레이티드 | 세포 유착 억제제 |
ES2244474T3 (es) * | 1999-09-29 | 2005-12-16 | Ortho-Mcneil Pharmaceutical, Inc. | Isonipecotamida para el tratamiento de trastornos mediados por integrina. |
EP1162194A1 (fr) * | 2000-06-06 | 2001-12-12 | Aventis Pharma Deutschland GmbH | Dérivés de (thio)-urée inhibiteurs du facteur VIIa, procédé de leur préparation et leur utilisation |
US6875743B1 (en) | 2000-11-28 | 2005-04-05 | Biogen, Inc. | Cell adhesion inhibitors |
DE10063008A1 (de) * | 2000-12-16 | 2002-06-20 | Merck Patent Gmbh | Carbonsäureamidderivate |
JP2004529918A (ja) * | 2001-04-09 | 2004-09-30 | オーソ−マクニール・フアーマシユーチカル・インコーポレーテツド | インテグリンに由来する疾患の治療のためのキナゾリンおよびキナゾリン類似化合物 |
EP1270551A1 (fr) * | 2001-06-26 | 2003-01-02 | Aventis Pharma Deutschland GmbH | Dérivés d'urée avec une activité antiprotéolytique |
CN113717079B (zh) * | 2021-09-30 | 2023-03-31 | 内蒙古康普药业有限公司 | 一种甲氧氯普胺双胺新杂质的制备方法 |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5051405A (en) * | 1989-10-10 | 1991-09-24 | Rhone-Poulenc Rorer Pharmaceuticals Inc. | Anti-thrombotic peptides and pseudopeptides |
US5053392A (en) * | 1989-12-01 | 1991-10-01 | Rhone-Poulenc Rorer Pharmaceuticals Inc. | Novel arginine, glycine, aspartic acid derivatives as platelet-aggregation inhibitors |
DE4009506A1 (de) * | 1990-03-24 | 1991-09-26 | Hoechst Ag | Hydantoinderivate |
JPH06505978A (ja) * | 1991-02-05 | 1994-07-07 | スミスクライン・ビーチャム・コーポレイション | 芳香族エステルまたはアミドを含有する抗凝集性ペプチド |
US5321034A (en) * | 1991-05-07 | 1994-06-14 | Merck & Co., Inc. | Fibrinogen receptor antagonists |
DK0513675T3 (da) * | 1991-05-13 | 1996-09-30 | Fujisawa Pharmaceutical Co | Hidtil ukendt peptidforbindelse samt fremgangsmåde til fremstilling deraf |
DE4126277A1 (de) * | 1991-08-08 | 1993-02-11 | Cassella Ag | Hydantoinderivate |
US5272162A (en) * | 1992-07-02 | 1993-12-21 | G. D. Searle & Co. | Platelet aggregation inhibitors |
US5314902A (en) * | 1993-01-27 | 1994-05-24 | Monsanto Company | Urea derivatives useful as platelet aggregation inhibitors |
-
1993
- 1993-03-26 DE DE4309867A patent/DE4309867A1/de not_active Withdrawn
-
1994
- 1994-03-09 US US08/513,815 patent/US5703050A/en not_active Expired - Lifetime
- 1994-03-09 EP EP94911129A patent/EP0689549B1/fr not_active Expired - Lifetime
- 1994-03-09 KR KR1019950704123A patent/KR100418144B1/ko not_active IP Right Cessation
- 1994-03-09 CA CA002155843A patent/CA2155843C/fr not_active Expired - Fee Related
- 1994-03-09 HU HU9502792A patent/HU219483B/hu not_active IP Right Cessation
- 1994-03-09 DK DK94911129T patent/DK0689549T3/da active
- 1994-03-09 ES ES94911129T patent/ES2119187T3/es not_active Expired - Lifetime
- 1994-03-09 DE DE59406279T patent/DE59406279D1/de not_active Expired - Lifetime
- 1994-03-09 AU AU63754/94A patent/AU679509B2/en not_active Ceased
- 1994-03-09 JP JP52159194A patent/JP3597862B2/ja not_active Expired - Lifetime
- 1994-03-09 WO PCT/EP1994/000713 patent/WO1994022907A1/fr active IP Right Grant
- 1994-03-09 AT AT94911129T patent/ATE167483T1/de not_active IP Right Cessation
- 1994-03-25 ZA ZA942124A patent/ZA942124B/xx unknown
- 1994-03-25 IL IL10913594A patent/IL109135A/en active IP Right Grant
Also Published As
Publication number | Publication date |
---|---|
DE59406279D1 (de) | 1998-07-23 |
CA2155843A1 (fr) | 1994-10-13 |
KR960701087A (ko) | 1996-02-24 |
HU9502792D0 (en) | 1995-11-28 |
ES2119187T3 (es) | 1998-10-01 |
IL109135A (en) | 1999-03-12 |
AU679509B2 (en) | 1997-07-03 |
HUT73409A (en) | 1996-07-29 |
DE4309867A1 (de) | 1994-09-29 |
AU6375494A (en) | 1994-10-24 |
EP0689549B1 (fr) | 1998-06-17 |
HU219483B (hu) | 2001-04-28 |
DK0689549T3 (da) | 1999-02-01 |
JP3597862B2 (ja) | 2004-12-08 |
US5703050A (en) | 1997-12-30 |
ZA942124B (en) | 1994-11-10 |
JPH08508267A (ja) | 1996-09-03 |
ATE167483T1 (de) | 1998-07-15 |
KR100418144B1 (ko) | 2004-05-07 |
EP0689549A1 (fr) | 1996-01-03 |
IL109135A0 (en) | 1994-06-24 |
WO1994022907A1 (fr) | 1994-10-13 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
EEER | Examination request | ||
MKLA | Lapsed |