CA2153071C - Derives de calcitonines - Google Patents

Derives de calcitonines Download PDF

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Publication number
CA2153071C
CA2153071C CA002153071A CA2153071A CA2153071C CA 2153071 C CA2153071 C CA 2153071C CA 002153071 A CA002153071 A CA 002153071A CA 2153071 A CA2153071 A CA 2153071A CA 2153071 C CA2153071 C CA 2153071C
Authority
CA
Canada
Prior art keywords
compound according
calcitonin
group
human
sct
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA002153071A
Other languages
English (en)
Other versions
CA2153071A1 (fr
Inventor
Virender Labroo
Tomikazu Sasaki
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Washington
Zymogenetics Inc
Original Assignee
University of Washington
Zymogenetics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Washington, Zymogenetics Inc filed Critical University of Washington
Publication of CA2153071A1 publication Critical patent/CA2153071A1/fr
Application granted granted Critical
Publication of CA2153071C publication Critical patent/CA2153071C/fr
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/57527—Calcitonin gene related peptide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/23—Calcitonins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/585—Calcitonins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Abstract

Molécules de calcitonine dérivées, compositions pharmaceutiques comprenant les dérivés calcitonines, et procédé permettant de réduire le calcium sérique chez un patient au moyen des dérivés calcitonines. Ces molécules sont caractérisées par une extrémité amino-dérivée, formée par la combinaison d'une calcitonine avec une fraction cyclique, polycyclique ou hétérocyclique. Des formes multimères de ces molécules sont également décrites.
CA002153071A 1992-12-31 1993-12-30 Derives de calcitonines Expired - Fee Related CA2153071C (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US99974992A 1992-12-31 1992-12-31
US07/999,749 1992-12-31
PCT/US1993/012692 WO1994015962A2 (fr) 1992-12-31 1993-12-30 Derives calcitonines

Publications (2)

Publication Number Publication Date
CA2153071A1 CA2153071A1 (fr) 1994-07-21
CA2153071C true CA2153071C (fr) 2000-05-30

Family

ID=25546645

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002153071A Expired - Fee Related CA2153071C (fr) 1992-12-31 1993-12-30 Derives de calcitonines

Country Status (9)

Country Link
EP (1) EP0677062A1 (fr)
JP (1) JPH08505393A (fr)
KR (1) KR100310280B1 (fr)
AU (1) AU673237B2 (fr)
CA (1) CA2153071C (fr)
FI (1) FI953255A (fr)
NO (1) NO952608L (fr)
NZ (1) NZ261052A (fr)
WO (1) WO1994015962A2 (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5962270A (en) 1996-02-06 1999-10-05 Bionebraska, Inc. Recombinant preparation of calcitonin fragments and use thereof in the preparation of calcitonin and related analogs

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3956260A (en) * 1967-11-09 1976-05-11 Ciba-Geigy Corporation Hypocalcaemic peptides and processes for their manufacture
DE1806135A1 (de) * 1967-11-09 1969-07-17 Ciba Geigy Neue hypocalcaemische Peptide und Verfahren zu ihrer Herstellung
CH523868A (de) * 1969-10-22 1972-06-15 Ciba Geigy Ag Verfahren zur Herstellung neuer Dotriacontapeptidamide und ihrer Derivate
HUT44794A (en) * 1985-12-04 1988-04-28 Sandoz Ag Process for production of calcitonine-derivatives and medical preparatives containing such compounds
EP0297159A1 (fr) * 1987-07-01 1989-01-04 Armour Pharmaceutical Company [N-Acyl, 1,7-Di-alanine]calcitonines, leur méthode de préparation, leurs compositions pharmaceutiques et emploi
ES2052642T3 (es) * 1987-07-08 1994-07-16 Mitsubishi Petrochemical Co Nuevo derivado de calcitonina y su sal.

Also Published As

Publication number Publication date
AU673237B2 (en) 1996-10-31
WO1994015962A3 (fr) 1994-09-29
KR960700273A (ko) 1996-01-19
FI953255A0 (fi) 1995-06-30
NO952608D0 (no) 1995-06-29
JPH08505393A (ja) 1996-06-11
WO1994015962A2 (fr) 1994-07-21
EP0677062A1 (fr) 1995-10-18
FI953255A (fi) 1995-06-30
NO952608L (no) 1995-08-30
AU5962994A (en) 1994-08-15
CA2153071A1 (fr) 1994-07-21
KR100310280B1 (ko) 2002-02-28
NZ261052A (en) 1997-10-24

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