CA2147854A1 - Taxanes possedant une chaine laterale avec substitution alkylique; compositions pharmaceutiques qui en renferment - Google Patents
Taxanes possedant une chaine laterale avec substitution alkylique; compositions pharmaceutiques qui en renfermentInfo
- Publication number
- CA2147854A1 CA2147854A1 CA002147854A CA2147854A CA2147854A1 CA 2147854 A1 CA2147854 A1 CA 2147854A1 CA 002147854 A CA002147854 A CA 002147854A CA 2147854 A CA2147854 A CA 2147854A CA 2147854 A1 CA2147854 A1 CA 2147854A1
- Authority
- CA
- Canada
- Prior art keywords
- hydrogen
- alkyl
- alkenyl
- heteroaryl
- alkynyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000000217 alkyl group Chemical group 0.000 title abstract 18
- 229940123237 Taxane Drugs 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 20
- 239000001257 hydrogen Substances 0.000 abstract 20
- 125000003342 alkenyl group Chemical group 0.000 abstract 16
- 125000000304 alkynyl group Chemical group 0.000 abstract 15
- 150000002431 hydrogen Chemical group 0.000 abstract 15
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 15
- 125000003118 aryl group Chemical group 0.000 abstract 14
- 125000001072 heteroaryl group Chemical group 0.000 abstract 14
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 4
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 abstract 2
- IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 abstract 2
- 125000004432 carbon atom Chemical group C* 0.000 abstract 2
- 125000000325 methylidene group Chemical group [H]C([H])=* 0.000 abstract 2
- 125000003566 oxetanyl group Chemical group 0.000 abstract 2
- 125000004043 oxo group Chemical group O=* 0.000 abstract 2
- 125000006239 protecting group Chemical group 0.000 abstract 2
- -1 t-butoxy Chemical group 0.000 abstract 2
- DKPFODGZWDEEBT-QFIAKTPHSA-N taxane Chemical class C([C@]1(C)CCC[C@@H](C)[C@H]1C1)C[C@H]2[C@H](C)CC[C@@H]1C2(C)C DKPFODGZWDEEBT-QFIAKTPHSA-N 0.000 abstract 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 125000004423 acyloxy group Chemical group 0.000 abstract 1
- 230000000719 anti-leukaemic effect Effects 0.000 abstract 1
- 239000000063 antileukemic agent Substances 0.000 abstract 1
- 239000002246 antineoplastic agent Substances 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 125000000547 substituted alkyl group Chemical group 0.000 abstract 1
- 125000003396 thiol group Chemical group [H]S* 0.000 abstract 1
Classifications
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Epoxy Compounds (AREA)
Applications Claiming Priority (13)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/976,331 | 1992-11-13 | ||
| US07/976,331 US5284865A (en) | 1991-09-23 | 1992-11-13 | Cyclohexyl substituted taxanes and pharmaceutical compositions containing them |
| US08/005,229 | 1993-01-15 | ||
| US08/005,229 US5338872A (en) | 1993-01-15 | 1993-01-15 | Process for the preparation of 10-desacetoxybaccatin III and 10-desacetoxytaxol and derivatives thereof |
| US08/010,798 | 1993-01-29 | ||
| US08/010,798 US5399726A (en) | 1993-01-29 | 1993-01-29 | Process for the preparation of baccatin III analogs bearing new C2 and C4 functional groups |
| US08/026,978 | 1993-03-05 | ||
| US08/026,978 US5990325A (en) | 1993-03-05 | 1993-03-05 | Process for the preparation of 9-desoxotaxol, 9-desoxobaccatin III and analogs thereof |
| US08/034,247 US5430160A (en) | 1991-09-23 | 1993-03-22 | Preparation of substituted isoserine esters using β-lactams and metal or ammonium alkoxides |
| US08/034,247 | 1993-03-22 | ||
| US9475693A | 1993-07-20 | 1993-07-20 | |
| US08/094,756 | 1993-07-20 | ||
| PCT/US1993/010816 WO1994010997A1 (fr) | 1992-11-13 | 1993-11-01 | Taxanes a chaine laterale a substitution alkyle et compositions pharmaceutiques les contenant |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2147854A1 true CA2147854A1 (fr) | 1994-05-26 |
| CA2147854C CA2147854C (fr) | 2006-03-21 |
Family
ID=36101451
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002147854A Expired - Fee Related CA2147854C (fr) | 1992-11-13 | 1993-11-01 | Taxanes possedant une chaine laterale avec substitution alkylique; compositions pharmaceutiques qui en renferment |
Country Status (1)
| Country | Link |
|---|---|
| CA (1) | CA2147854C (fr) |
-
1993
- 1993-11-01 CA CA002147854A patent/CA2147854C/fr not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| CA2147854C (fr) | 2006-03-21 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| MKLA | Lapsed |