CA2147854C - Taxanes possedant une chaine laterale avec substitution alkylique; compositions pharmaceutiques qui en renferment - Google Patents

Taxanes possedant une chaine laterale avec substitution alkylique; compositions pharmaceutiques qui en renferment Download PDF

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Publication number
CA2147854C
CA2147854C CA002147854A CA2147854A CA2147854C CA 2147854 C CA2147854 C CA 2147854C CA 002147854 A CA002147854 A CA 002147854A CA 2147854 A CA2147854 A CA 2147854A CA 2147854 C CA2147854 C CA 2147854C
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CA
Canada
Prior art keywords
solution
hydrogen
alkyl
thf
mixture
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA002147854A
Other languages
English (en)
Other versions
CA2147854A1 (fr
Inventor
Robert A. Holton
Ki-Byung Chai
Hamid Idmoumaz
Hossain Nadizadeh
Yukio Suzuki
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Florida State University
Original Assignee
Florida State University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US07/976,331 external-priority patent/US5284865A/en
Priority claimed from US08/005,229 external-priority patent/US5338872A/en
Priority claimed from US08/010,798 external-priority patent/US5399726A/en
Priority claimed from US08/026,978 external-priority patent/US5990325A/en
Priority claimed from US08/034,247 external-priority patent/US5430160A/en
Application filed by Florida State University filed Critical Florida State University
Priority claimed from PCT/US1993/010816 external-priority patent/WO1994010997A1/fr
Publication of CA2147854A1 publication Critical patent/CA2147854A1/fr
Application granted granted Critical
Publication of CA2147854C publication Critical patent/CA2147854C/fr
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Epoxy Compounds (AREA)

Abstract

xane derivatives having an alkyl substituted C13 side-chain.
CA002147854A 1992-11-13 1993-11-01 Taxanes possedant une chaine laterale avec substitution alkylique; compositions pharmaceutiques qui en renferment Expired - Fee Related CA2147854C (fr)

Applications Claiming Priority (13)

Application Number Priority Date Filing Date Title
US07/976,331 1992-11-13
US07/976,331 US5284865A (en) 1991-09-23 1992-11-13 Cyclohexyl substituted taxanes and pharmaceutical compositions containing them
US08/005,229 1993-01-15
US08/005,229 US5338872A (en) 1993-01-15 1993-01-15 Process for the preparation of 10-desacetoxybaccatin III and 10-desacetoxytaxol and derivatives thereof
US08/010,798 1993-01-29
US08/010,798 US5399726A (en) 1993-01-29 1993-01-29 Process for the preparation of baccatin III analogs bearing new C2 and C4 functional groups
US08/026,978 1993-03-05
US08/026,978 US5990325A (en) 1993-03-05 1993-03-05 Process for the preparation of 9-desoxotaxol, 9-desoxobaccatin III and analogs thereof
US08/034,247 US5430160A (en) 1991-09-23 1993-03-22 Preparation of substituted isoserine esters using β-lactams and metal or ammonium alkoxides
US08/034,247 1993-03-22
US9475693A 1993-07-20 1993-07-20
US08/094,756 1993-07-20
PCT/US1993/010816 WO1994010997A1 (fr) 1992-11-13 1993-11-01 Taxanes a chaine laterale a substitution alkyle et compositions pharmaceutiques les contenant

Publications (2)

Publication Number Publication Date
CA2147854A1 CA2147854A1 (fr) 1994-05-26
CA2147854C true CA2147854C (fr) 2006-03-21

Family

ID=36101451

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002147854A Expired - Fee Related CA2147854C (fr) 1992-11-13 1993-11-01 Taxanes possedant une chaine laterale avec substitution alkylique; compositions pharmaceutiques qui en renferment

Country Status (1)

Country Link
CA (1) CA2147854C (fr)

Also Published As

Publication number Publication date
CA2147854A1 (fr) 1994-05-26

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