CA2143756C - N-cyano-n'-pyridylguanidines, antagonistes de la serotonine - Google Patents
N-cyano-n'-pyridylguanidines, antagonistes de la serotonine Download PDFInfo
- Publication number
- CA2143756C CA2143756C CA002143756A CA2143756A CA2143756C CA 2143756 C CA2143756 C CA 2143756C CA 002143756 A CA002143756 A CA 002143756A CA 2143756 A CA2143756 A CA 2143756A CA 2143756 C CA2143756 C CA 2143756C
- Authority
- CA
- Canada
- Prior art keywords
- cyano
- stands
- halogen
- pharmaceutically
- hydroxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Biomedical Technology (AREA)
- Psychiatry (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB9219472.9 | 1992-09-15 | ||
| GB929219472A GB9219472D0 (en) | 1992-09-15 | 1992-09-15 | Chemical compounds |
| PCT/DK1993/000291 WO1994006770A1 (fr) | 1992-09-15 | 1993-09-13 | N-cyano-n'-pyridyleguanidines en tant qu'antagonistes de la serotonine |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2143756A1 CA2143756A1 (fr) | 1994-03-31 |
| CA2143756C true CA2143756C (fr) | 2003-11-11 |
Family
ID=10721912
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002143756A Expired - Lifetime CA2143756C (fr) | 1992-09-15 | 1993-09-13 | N-cyano-n'-pyridylguanidines, antagonistes de la serotonine |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US5563160A (fr) |
| EP (1) | EP0660823B1 (fr) |
| JP (1) | JP3485567B2 (fr) |
| KR (1) | KR100292592B1 (fr) |
| AT (1) | ATE141262T1 (fr) |
| AU (1) | AU670816B2 (fr) |
| CA (1) | CA2143756C (fr) |
| DE (1) | DE69304076T2 (fr) |
| DK (1) | DK0660823T3 (fr) |
| ES (1) | ES2092835T3 (fr) |
| FI (1) | FI109118B (fr) |
| GB (1) | GB9219472D0 (fr) |
| GR (1) | GR3021015T3 (fr) |
| NZ (1) | NZ255330A (fr) |
| RU (1) | RU2141951C1 (fr) |
| WO (1) | WO1994006770A1 (fr) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5696140A (en) * | 1992-09-15 | 1997-12-09 | Leo Pharmaceutical Products Ltd. | N-cyano-N'-pyridylguanidines as serotonin antagonists |
| US5869497A (en) * | 1996-03-15 | 1999-02-09 | Eli Lilly And Company | Method of treating or ameliorating the symptoms of common cold or allergic rhinitis |
| EP0795328A1 (fr) * | 1996-03-15 | 1997-09-17 | Pfizer Inc. | Utilisation de dérivés de naphtalène pour le traitement de cancer des poumons |
| GB9711124D0 (en) * | 1997-05-29 | 1997-07-23 | Leo Pharm Prod Ltd | Novel cyanoguanidines |
| GB9711122D0 (en) * | 1997-05-29 | 1997-07-23 | Leo Pharm Prod Ltd | Novel cyanoguanidines |
| GB9711126D0 (en) * | 1997-05-29 | 1997-07-23 | Leo Pharm Prod Ltd | Cyanoamidines |
| GB9711119D0 (en) * | 1997-05-29 | 1997-07-23 | Leo Pharm Prod Ltd | Novel cyanoguanidines |
| GB9711123D0 (en) * | 1997-05-29 | 1997-07-23 | Leo Pharm Prod Ltd | Novel cyanoguanidines |
| GB9711127D0 (en) | 1997-05-29 | 1997-07-23 | Leo Pharm Prod Ltd | Novel cyanoguanidines |
| GB9711125D0 (en) | 1997-05-29 | 1997-07-23 | Leo Pharm Prod Ltd | Novel cyanoguanidines |
| EP1087785A2 (fr) * | 1998-06-15 | 2001-04-04 | Arch Development Corporation | Combinaison de facteurs radiotherapeutiques et anti-angiogeniques |
| US6255323B1 (en) | 1999-04-09 | 2001-07-03 | Shionogi Bioresearch Corp. | Cyanoguanidine compounds |
| AU4841700A (en) | 1999-05-12 | 2000-11-21 | Nitromed, Inc. | Nitrosated and nitrosylated potassium channel activators, compositions and methods of use |
| AU1494702A (en) | 2000-11-21 | 2002-06-03 | Leo Pharma As | Cyanoguanidine prodrugs |
| US20030045515A1 (en) * | 2001-05-24 | 2003-03-06 | Lise Binderup | Combination medicament for treatment of neoplastic diseases |
| RU2292344C2 (ru) | 2001-05-24 | 2007-01-27 | Лео Фарма А/С | Производные пиридилцианогуанидинов и фармацевтическая композиция на их основе |
| GB0217920D0 (en) * | 2002-04-23 | 2002-09-11 | Aventis Pharm Prod Inc | Interleukin-4 Gene Expression inhibitors |
| US7253193B2 (en) | 2002-05-17 | 2007-08-07 | Leo Pharma A/S | Cyanoguanidine prodrugs |
| JP4935073B2 (ja) | 2003-10-14 | 2012-05-23 | 味の素株式会社 | エーテル誘導体 |
| DE102004008141A1 (de) * | 2004-02-19 | 2005-09-01 | Abbott Gmbh & Co. Kg | Guanidinverbindungen und ihre Verwendung als Bindungspartner für 5-HT5-Rezeptoren |
| CA2594508C (fr) | 2004-12-22 | 2013-10-01 | Leo Pharma A/S | Composes de 1-cyanoguanidine |
| EP1917244A2 (fr) | 2005-08-24 | 2008-05-07 | Abbott GmbH & Co. KG | Composes guanidine a substitution hetaryl et utilisation en tant que partenaires de liaison pour des recepteurs de 5-ht5 |
| US8173677B2 (en) | 2007-09-26 | 2012-05-08 | Gemin X Pharmaceuticals Canada Inc. | Compositions and methods for effecting NAD+ levels using a nicotinamide phosphoribosyl transferase inhibitor |
| EP2197443A4 (fr) * | 2007-09-26 | 2014-01-01 | Gemin X Pharmaceuticals Canada Inc | Compositions et procédés pour influer sur les teneurs en nad+ en utilisant un inhibiteur de nicotinamide phosphoribosyle transférase |
| CA2751495C (fr) | 2009-02-06 | 2013-08-20 | Tianjin Hemay Bio-Tech Co., Ltd. | Compositions pharmaceutiques contenant des pyridyl-cyanoguanidines, leurs methodes de preparation et utilisations |
| US8912184B1 (en) | 2010-03-01 | 2014-12-16 | Alzheimer's Institute Of America, Inc. | Therapeutic and diagnostic methods |
| WO2012031199A1 (fr) * | 2010-09-03 | 2012-03-08 | Forma Therapeutics, Inc. | Composés et compositions de guanidine pour l'inhibition de nampt |
| EP2634173A4 (fr) | 2010-10-26 | 2014-04-02 | Tianjin Hemay Bio Tech Co Ltd | Composé polymorphe de n-(6-(4-chlorophénoxy)hexyl)-n'-cyano-n''-(4-pyridyl)guanidine, et préparation de celui-ci et utilisation de celui-ci |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1489879A (en) * | 1974-12-20 | 1977-10-26 | Leo Pharm Prod Ltd | N'-cyano-n'-3-pyridylguanidines |
| GB2242628A (en) * | 1990-04-06 | 1991-10-09 | Sandoz Ltd | Asthma prophylactic use of K+ channel activators |
-
1992
- 1992-09-15 GB GB929219472A patent/GB9219472D0/en active Pending
-
1993
- 1993-09-13 KR KR1019950700625A patent/KR100292592B1/ko not_active IP Right Cessation
- 1993-09-13 JP JP50770994A patent/JP3485567B2/ja not_active Expired - Lifetime
- 1993-09-13 EP EP93919045A patent/EP0660823B1/fr not_active Expired - Lifetime
- 1993-09-13 US US08/397,266 patent/US5563160A/en not_active Expired - Lifetime
- 1993-09-13 CA CA002143756A patent/CA2143756C/fr not_active Expired - Lifetime
- 1993-09-13 ES ES93919045T patent/ES2092835T3/es not_active Expired - Lifetime
- 1993-09-13 AT AT93919045T patent/ATE141262T1/de active
- 1993-09-13 NZ NZ255330A patent/NZ255330A/en not_active IP Right Cessation
- 1993-09-13 DE DE69304076T patent/DE69304076T2/de not_active Expired - Lifetime
- 1993-09-13 RU RU95105437A patent/RU2141951C1/ru active
- 1993-09-13 DK DK93919045.0T patent/DK0660823T3/da active
- 1993-09-13 AU AU49456/93A patent/AU670816B2/en not_active Expired
- 1993-09-13 WO PCT/DK1993/000291 patent/WO1994006770A1/fr active IP Right Grant
-
1995
- 1995-03-14 FI FI951189A patent/FI109118B/fi not_active IP Right Cessation
-
1996
- 1996-09-12 GR GR960402367T patent/GR3021015T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ES2092835T3 (es) | 1996-12-01 |
| RU2141951C1 (ru) | 1999-11-27 |
| GR3021015T3 (en) | 1996-12-31 |
| JPH08501539A (ja) | 1996-02-20 |
| RU95105437A (ru) | 1996-10-27 |
| KR950702964A (ko) | 1995-08-23 |
| CA2143756A1 (fr) | 1994-03-31 |
| DE69304076D1 (de) | 1996-09-19 |
| DE69304076T2 (de) | 1997-04-03 |
| NZ255330A (en) | 1997-06-24 |
| FI109118B (fi) | 2002-05-31 |
| KR100292592B1 (ko) | 2001-09-17 |
| AU670816B2 (en) | 1996-08-01 |
| AU4945693A (en) | 1994-04-12 |
| GB9219472D0 (en) | 1992-10-28 |
| JP3485567B2 (ja) | 2004-01-13 |
| EP0660823B1 (fr) | 1996-08-14 |
| EP0660823A1 (fr) | 1995-07-05 |
| US5563160A (en) | 1996-10-08 |
| FI951189A (fi) | 1995-03-14 |
| FI951189A0 (fi) | 1995-03-14 |
| WO1994006770A1 (fr) | 1994-03-31 |
| DK0660823T3 (da) | 1996-09-23 |
| ATE141262T1 (de) | 1996-08-15 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CA2143756C (fr) | N-cyano-n'-pyridylguanidines, antagonistes de la serotonine | |
| AU733142B2 (en) | Cyanoguanidines as cell proliferation inhibitors | |
| US5696140A (en) | N-cyano-N'-pyridylguanidines as serotonin antagonists | |
| US6197797B1 (en) | Cyanoguanidines as cell proliferation inhibitors | |
| AU733093B2 (en) | Cyanoguanidines as cell proliferation inhibitors | |
| AU733000B2 (en) | Cyanoguanidines as cell proliferation inhibitors | |
| AU733096B2 (en) | Cyanoguanidines as cell proliferation inhibitors | |
| DE60001581T2 (de) | Ethylthiophen-thioharnstoff-derivate und ihre verwendung | |
| US6303641B1 (en) | Cyanoamidines as cell proliferation inhibitors | |
| CZ9904238A3 (cs) | Kyanoguanidiny jako inhibitory buněčné proliferace | |
| CZ419199A3 (cs) | Kyanoguanidiny jako inhibitory buněčné proliferace |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request |