CA2142708A1 - Agents antibacteriens a base de cation-2-heteroarylphenyl-carbapeneme - Google Patents

Agents antibacteriens a base de cation-2-heteroarylphenyl-carbapeneme

Info

Publication number
CA2142708A1
CA2142708A1 CA002142708A CA2142708A CA2142708A1 CA 2142708 A1 CA2142708 A1 CA 2142708A1 CA 002142708 A CA002142708 A CA 002142708A CA 2142708 A CA2142708 A CA 2142708A CA 2142708 A1 CA2142708 A1 CA 2142708A1
Authority
CA
Canada
Prior art keywords
ring
alkyl
substituted
defined above
group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002142708A
Other languages
English (en)
Inventor
Frank Dininno
Susan M. Schmitt
Ravindra N. Guthikonda
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US07/937,618 external-priority patent/US5342933A/en
Priority claimed from US07/937,632 external-priority patent/US5292879A/en
Application filed by Individual filed Critical Individual
Publication of CA2142708A1 publication Critical patent/CA2142708A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/10—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D477/12—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
    • C07D477/14—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 3

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

rbapenems of formula (I) are useful antibacterial agents.\!
CA002142708A 1992-08-28 1993-08-19 Agents antibacteriens a base de cation-2-heteroarylphenyl-carbapeneme Abandoned CA2142708A1 (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US07/937,618 US5342933A (en) 1992-08-28 1992-08-28 Cationic-2-heteroarylphenyl-carbapenem antibacterial agents
US937,618 1992-08-28
US937,632 1992-08-28
US07/937,632 US5292879A (en) 1992-08-28 1992-08-28 Intermediates for preparing cationic-2-heteroaryl-phenyl-carbapenem antibacterial agents

Publications (1)

Publication Number Publication Date
CA2142708A1 true CA2142708A1 (fr) 1994-03-17

Family

ID=27130104

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002142708A Abandoned CA2142708A1 (fr) 1992-08-28 1993-08-19 Agents antibacteriens a base de cation-2-heteroarylphenyl-carbapeneme

Country Status (5)

Country Link
EP (1) EP0656900A4 (fr)
JP (1) JPH08500835A (fr)
AU (1) AU5082993A (fr)
CA (1) CA2142708A1 (fr)
WO (1) WO1994005669A1 (fr)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020137940A1 (en) 1997-12-16 2002-09-26 Smithkline Beecham P.L.C. 5-[4-[2-(N-methyl-N-(2-pyridyl)amino)ethoxy]benzyl]thiazolidine-2, 4-dione, maleic acid salt, hydrate as pharmaceutical
US6664278B2 (en) 1997-12-16 2003-12-16 Smithkline Beecham P.L.C. Hydrate of 5-[4-[2-(N-methyl-N-(2-pyridil)amino)ethoxy]benzyl]thiazolidine-2,4-dione maleic acid salt
GB9726568D0 (en) 1997-12-16 1998-02-11 Smithkline Beecham Plc Novel pharmaceutical
AU3536699A (en) 1998-04-27 1999-11-16 Ihara Chemical Industry Co. Ltd. 3-arylphenyl sulfide derivatives and insecticides and miticides

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4543257A (en) * 1977-10-19 1985-09-24 Merck & Co., Inc. 1-Carba-2-penem-3-carboxylic acid
US4978659A (en) * 1987-02-02 1990-12-18 Merck & Co., Inc. 2-(Heteroaryliumalkyl)phenyl carbapenem antibacterial agents
US5143914A (en) * 1991-06-25 1992-09-01 Merck & Co., Inc. 2-heteroarylphenyl-carbapenem antibacterial agents

Also Published As

Publication number Publication date
AU5082993A (en) 1994-03-29
WO1994005669A1 (fr) 1994-03-17
EP0656900A4 (fr) 1995-09-06
EP0656900A1 (fr) 1995-06-14
JPH08500835A (ja) 1996-01-30

Similar Documents

Publication Publication Date Title
EP0414493A2 (fr) Agents antibactériens dérivés de 2-(hétérocyclylalkyl)phényl-carbapénème
WO1994009002A1 (fr) Agents antibacteriens a base de 2-(aza-9-fluorenonyl)carbapenem
CA2052971A1 (fr) Agents antibacteriens a base de 2-heteroarylphenylcarbapeneme
CA2142708A1 (fr) Agents antibacteriens a base de cation-2-heteroarylphenyl-carbapeneme
JP2509771B2 (ja) ２−（９−フルオレノニル）−カルバペネム抗菌剤
US5153186A (en) 2-benzocoumarinyl-carbapenems
US5292879A (en) Intermediates for preparing cationic-2-heteroaryl-phenyl-carbapenem antibacterial agents
US5162314A (en) 2-benzocoumarinyl carbapenems
US5409920A (en) 2-(3-pyridyl)-carbapenem antibacterial agents
EP0467434A1 (fr) 2-Biphenyl-carbapénèmes antibactériens
US5192758A (en) 2-biphenyl-carbapenem antibacterial agents
US5177202A (en) 2-phenanthrenyl-carbapenems
US5182384A (en) 2-benzocoumarinyl carbapenems
US5216146A (en) 2-benzocoumarinyl-carbapenems
US5247074A (en) (2-substituted phenyl) carbapenems
US5342933A (en) Cationic-2-heteroarylphenyl-carbapenem antibacterial agents
JP2500286B2 (ja) ２−ヘテロアリ―ルフェニル−カルバペネム抗菌剤
US5382575A (en) (N-pyridiniumphenyl)-carbapenems
US5276149A (en) 2-(N-imidazoliumphenyl)-carbapenems
EP0515217A1 (fr) Benzocoumarinyl-2-carbapénèmes
CA2045432A1 (fr) Agents antibacteriens a base de 2-phenanthrenyl carbapeneme
EP0538017A1 (fr) (N-imidazoliumphényl)-2-carbapénèmes
EP0509756A1 (fr) Carbapénèmes 2-phénanthridonyles contenant des substituants cationisables
WO1994028719A1 (fr) Carbapenems pontes utilises comme composes antibacteriens
EP0538018A1 (fr) N-Pyridiniumphényl)-carbapénèmes

Legal Events

Date Code Title Description
FZDE Dead