CA2140278A1 - Enrichissement et determination des cellules foetales dans le sang maternel pour hybridation in situ - Google Patents
Enrichissement et determination des cellules foetales dans le sang maternel pour hybridation in situInfo
- Publication number
- CA2140278A1 CA2140278A1 CA002140278A CA2140278A CA2140278A1 CA 2140278 A1 CA2140278 A1 CA 2140278A1 CA 002140278 A CA002140278 A CA 002140278A CA 2140278 A CA2140278 A CA 2140278A CA 2140278 A1 CA2140278 A1 CA 2140278A1
- Authority
- CA
- Canada
- Prior art keywords
- fetal
- cells
- enriched
- fetal cells
- maternal
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 230000001605 fetal effect Effects 0.000 title abstract 7
- 230000008774 maternal effect Effects 0.000 title abstract 6
- 210000004369 blood Anatomy 0.000 title abstract 3
- 239000008280 blood Substances 0.000 title abstract 3
- 238000007901 in situ hybridization Methods 0.000 title abstract 2
- 210000004027 cell Anatomy 0.000 abstract 8
- 230000002068 genetic effect Effects 0.000 abstract 4
- 108010044495 Fetal Hemoglobin Proteins 0.000 abstract 3
- 230000005856 abnormality Effects 0.000 abstract 3
- WZUVPPKBWHMQCE-UHFFFAOYSA-N Haematoxylin Chemical compound C12=CC(O)=C(O)C=C2CC2(O)C1C1=CC=C(O)C(O)=C1OC2 WZUVPPKBWHMQCE-UHFFFAOYSA-N 0.000 abstract 2
- 210000003743 erythrocyte Anatomy 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 102000004641 Fetal Proteins Human genes 0.000 abstract 1
- 108010003471 Fetal Proteins Proteins 0.000 abstract 1
- 101000738771 Homo sapiens Receptor-type tyrosine-protein phosphatase C Proteins 0.000 abstract 1
- 102000011782 Keratins Human genes 0.000 abstract 1
- 108010076876 Keratins Proteins 0.000 abstract 1
- 208000002693 Multiple Abnormalities Diseases 0.000 abstract 1
- 101710160107 Outer membrane protein A Proteins 0.000 abstract 1
- 102100037422 Receptor-type tyrosine-protein phosphatase C Human genes 0.000 abstract 1
- 238000007792 addition Methods 0.000 abstract 1
- 238000005576 amination reaction Methods 0.000 abstract 1
- 238000002669 amniocentesis Methods 0.000 abstract 1
- 230000003321 amplification Effects 0.000 abstract 1
- 210000004252 chorionic villi Anatomy 0.000 abstract 1
- 238000012217 deletion Methods 0.000 abstract 1
- 230000037430 deletion Effects 0.000 abstract 1
- 238000000432 density-gradient centrifugation Methods 0.000 abstract 1
- -1 e.g. Proteins 0.000 abstract 1
- 210000002257 embryonic structure Anatomy 0.000 abstract 1
- YQGOJNYOYNNSMM-UHFFFAOYSA-N eosin Chemical compound [Na+].OC(=O)C1=CC=CC=C1C1=C2C=C(Br)C(=O)C(Br)=C2OC2=C(Br)C(O)=C(Br)C=C21 YQGOJNYOYNNSMM-UHFFFAOYSA-N 0.000 abstract 1
- 230000004720 fertilization Effects 0.000 abstract 1
- 210000003754 fetus Anatomy 0.000 abstract 1
- 238000012296 in situ hybridization assay Methods 0.000 abstract 1
- 238000000338 in vitro Methods 0.000 abstract 1
- 239000012678 infectious agent Substances 0.000 abstract 1
- 210000000265 leukocyte Anatomy 0.000 abstract 1
- 210000004698 lymphocyte Anatomy 0.000 abstract 1
- 108020004999 messenger RNA Proteins 0.000 abstract 1
- 238000003199 nucleic acid amplification method Methods 0.000 abstract 1
- 238000007899 nucleic acid hybridization Methods 0.000 abstract 1
- 210000005259 peripheral blood Anatomy 0.000 abstract 1
- 239000011886 peripheral blood Substances 0.000 abstract 1
- 230000008707 rearrangement Effects 0.000 abstract 1
- 238000005070 sampling Methods 0.000 abstract 1
- 238000010186 staining Methods 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
- 230000005945 translocation Effects 0.000 abstract 1
- 210000002993 trophoblast Anatomy 0.000 abstract 1
- 230000000007 visual effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6809—Methods for determination or identification of nucleic acids involving differential detection
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6804—Nucleic acid analysis using immunogens
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6841—In situ hybridisation
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
- G01N33/56966—Animal cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/156—Polymorphic or mutational markers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/158—Expression markers
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/36—Gynecology or obstetrics
- G01N2800/368—Pregnancy complicated by disease or abnormalities of pregnancy, e.g. preeclampsia, preterm labour
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Immunology (AREA)
- Analytical Chemistry (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biomedical Technology (AREA)
- Pathology (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Cell Biology (AREA)
- General Physics & Mathematics (AREA)
- Medicinal Chemistry (AREA)
- Food Science & Technology (AREA)
- Virology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US91596592A | 1992-07-17 | 1992-07-17 | |
| US915,965 | 1992-07-17 | ||
| PCT/US1993/006828 WO1994002646A1 (fr) | 1992-07-17 | 1993-07-19 | Enrichissement et identification de cellules foetales dans le sang maternel pour l'hybridation in situ |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2140278A1 true CA2140278A1 (fr) | 1994-02-03 |
| CA2140278C CA2140278C (fr) | 2009-03-17 |
Family
ID=25436486
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002140278A Expired - Lifetime CA2140278C (fr) | 1992-07-17 | 1993-07-19 | Enrichissement et determination des cellules foetales dans le sang maternel pour hybridation in situ |
Country Status (6)
| Country | Link |
|---|---|
| EP (1) | EP0662152A1 (fr) |
| JP (1) | JPH07509136A (fr) |
| AU (1) | AU4685593A (fr) |
| BR (1) | BR9306867A (fr) |
| CA (1) | CA2140278C (fr) |
| WO (1) | WO1994002646A1 (fr) |
Families Citing this family (45)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5457024A (en) * | 1993-01-22 | 1995-10-10 | Aprogenex, Inc. | Isolation of fetal erythrocytes |
| US6136540A (en) * | 1994-10-03 | 2000-10-24 | Ikonisys Inc. | Automated fluorescence in situ hybridization detection of genetic abnormalities |
| US5501954A (en) * | 1994-06-13 | 1996-03-26 | Genzyme Corporation | Method of detecting cellular material |
| GB9422504D0 (en) | 1994-11-08 | 1995-01-04 | Robertson Patricia M B | Blood testing |
| US5750339A (en) * | 1994-11-30 | 1998-05-12 | Thomas Jefferson University | Methods for identifying fetal cells |
| US5998596A (en) * | 1995-04-04 | 1999-12-07 | The United States Of America As Represented By The Department Of Health And Human Services | Inhibition of protein kinase activity by aptameric action of oligonucleotides |
| CN1153064C (zh) * | 1996-04-05 | 2004-06-09 | 约翰斯·霍普金斯大学 | 富集稀少细胞的方法 |
| FR2751989B1 (fr) * | 1996-08-01 | 1998-10-30 | Soc D Rech Et De Dev En Activa | Methode d'identification de cellules eucaryotes par fixation desdites cellules sur un support et support pour mettre en oeuvre ladite methode |
| US5731156A (en) * | 1996-10-21 | 1998-03-24 | Applied Imaging, Inc. | Use of anti-embryonic hemoglobin antibodies to identify fetal cells |
| JP2001513776A (ja) * | 1997-02-28 | 2001-09-04 | ユニバーシティ オブ アイオワ リサーチ ファウンデーション | ＬＰＳ関連障害の処置における非メチル化ＣｐＧジヌクレオチドを含む核酸の使用 |
| GB9807045D0 (en) * | 1998-04-01 | 1998-06-03 | Rudi Knut | Nucleic acid detection method |
| EP1078257A4 (fr) | 1998-05-09 | 2007-07-18 | Iconisys Inc | Procede et systeme informatises de diagnostic d'une cellule rare, y compris une cellule foetale |
| US7901887B2 (en) | 1998-05-09 | 2011-03-08 | Ikonisys, Inc. | Automated cancer diagnostic methods using fish |
| WO2000026666A2 (fr) * | 1998-10-29 | 2000-05-11 | Cell Works Inc. | Caracterisation de cellules individuelles par des marqueurs multiples |
| US6221596B1 (en) * | 1999-05-17 | 2001-04-24 | Motobit Ltd. | System and method for identifying and isolating rare cells from a mixed population of cells |
| US6690470B1 (en) * | 1999-11-04 | 2004-02-10 | Arcturus Engineering, Inc. | Automated laser capture microdissection |
| US7346200B1 (en) | 1999-11-18 | 2008-03-18 | Ikonisys, Inc. | Method and apparatus for computer controlled cell based diagnosis |
| US20060073509A1 (en) * | 1999-11-18 | 2006-04-06 | Michael Kilpatrick | Method for detecting and quantitating multiple subcellular components |
| US6692965B1 (en) * | 1999-11-23 | 2004-02-17 | Chromocell Corporation | Isolation of living cells and preparation of cell lines based on detection and quantification of preselected cellular ribonucleic acid sequences |
| GB0009784D0 (en) | 2000-04-20 | 2000-06-07 | Simeg Limited | Methods for clinical diagnosis |
| US7083924B2 (en) | 2000-07-10 | 2006-08-01 | Btg International Limited | Diagnostic method for the identification of foetal DNA in a material sample |
| GB0016742D0 (en) * | 2000-07-10 | 2000-08-30 | Simeg Limited | Diagnostic method |
| WO2002074055A2 (fr) | 2001-03-19 | 2002-09-26 | Ikonisys, Inc. | Systeme et procede pour accentuer le contraste d'une image produite par un microscope a epifluorescence |
| US10156501B2 (en) | 2001-11-05 | 2018-12-18 | Life Technologies Corporation | Automated microdissection instrument for determining a location of a laser beam projection on a worksurface area |
| CA2445204C (fr) | 2002-10-16 | 2014-08-12 | Streck Laboratories, Inc. | Methode et dispositif de prelevement et de conservation de cellules aux fins d'analyse |
| KR20150005720A (ko) | 2004-02-18 | 2015-01-14 | 크로모셀 코포레이션 | 신호 프로브를 이용하는 방법 및 물질 |
| WO2006119569A1 (fr) * | 2005-05-11 | 2006-11-16 | Genetic Technologies Limtied | Procedes d’enrichissement de cellules fœtales |
| WO2008019299A2 (fr) | 2006-08-04 | 2008-02-14 | Ikonisys, Inc. | Méthode de traitement d'image pour un système de microscope |
| JP2009072198A (ja) * | 2008-10-24 | 2009-04-09 | Chromocell Corp | ｍＲＮＡ結合プローブを用いる生存細胞の選択および単離 |
| US11634747B2 (en) | 2009-01-21 | 2023-04-25 | Streck Llc | Preservation of fetal nucleic acids in maternal plasma |
| US20100304978A1 (en) * | 2009-01-26 | 2010-12-02 | David Xingfei Deng | Methods and compositions for identifying a fetal cell |
| EP2398912B1 (fr) | 2009-02-18 | 2017-09-13 | Streck Inc. | Conservation des acides nucléiques extracellulaires |
| EA027314B1 (ru) | 2010-11-09 | 2017-07-31 | Арседи Байотек Апс | Способы выделения фетальной клетки с эндотелиальными и эпителиальными свойствами и набор для их осуществления |
| US9956281B2 (en) | 2011-05-04 | 2018-05-01 | Streck, Inc. | Inactivated virus compositions and methods of preparing such compositions |
| WO2014201138A1 (fr) * | 2013-06-11 | 2014-12-18 | Stelling James R | Procédé pour la détection d'anomalies fœtales |
| US10091984B2 (en) | 2013-07-24 | 2018-10-09 | Streck, Inc. | Compositions and methods for stabilizing circulating tumor cells |
| US9709556B2 (en) | 2013-12-11 | 2017-07-18 | Analiza, Inc. | Devices and methods for determining and/or isolating circulating cancer cells |
| US20150160246A1 (en) | 2013-12-11 | 2015-06-11 | Analiza, Inc. | Devices and methods for determining and/or isolating cells such as circulating cancer or fetal cells |
| US11168351B2 (en) | 2015-03-05 | 2021-11-09 | Streck, Inc. | Stabilization of nucleic acids in urine |
| ES2974904T3 (es) * | 2015-04-30 | 2024-07-02 | Sakura Finetek Usa Inc | Métodos para reducir la evaporación durante temperatura elevada |
| US20170145475A1 (en) | 2015-11-20 | 2017-05-25 | Streck, Inc. | Single spin process for blood plasma separation and plasma composition including preservative |
| CA2983930C (fr) * | 2016-04-15 | 2023-05-02 | Sakura Finetek U.S.A., Inc. | Procedes de reduction de l'evaporation en cas de temperatures elevees |
| US11506655B2 (en) | 2016-07-29 | 2022-11-22 | Streck, Inc. | Suspension composition for hematology analysis control |
| CN112980779B (zh) * | 2021-05-20 | 2021-08-24 | 广州凯普医药科技有限公司 | 一种从孕妇宫颈脱落细胞中分离胎盘滋养层细胞的方法 |
| WO2023178295A1 (fr) | 2022-03-18 | 2023-09-21 | Ludwig Institute For Cancer Research Ltd | Procédés et systèmes d'analyse de chromatines |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4727021A (en) * | 1984-06-01 | 1988-02-23 | Sloan-Kettering Institute For Cancer Research | Human monoclonal antibodies to cytokeratin |
| WO1990002173A1 (fr) * | 1988-08-31 | 1990-03-08 | Research Development Foundation | Methode d'hybridation in situ realisable en une seule etape |
| JPH04505556A (ja) * | 1989-03-07 | 1992-10-01 | シンジェン，インコーポレイテッド | 細胞の検出または分離のための浮遊状態におけるインシトゥハイブリッド形成法 |
| US5153117A (en) * | 1990-03-27 | 1992-10-06 | Genetype A.G. | Fetal cell recovery method |
-
1993
- 1993-07-19 EP EP93917297A patent/EP0662152A1/fr not_active Withdrawn
- 1993-07-19 CA CA002140278A patent/CA2140278C/fr not_active Expired - Lifetime
- 1993-07-19 AU AU46855/93A patent/AU4685593A/en not_active Abandoned
- 1993-07-19 BR BR9306867A patent/BR9306867A/pt not_active Application Discontinuation
- 1993-07-19 WO PCT/US1993/006828 patent/WO1994002646A1/fr not_active Application Discontinuation
- 1993-07-19 JP JP6504652A patent/JPH07509136A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| WO1994002646A1 (fr) | 1994-02-03 |
| AU4685593A (en) | 1994-02-14 |
| CA2140278C (fr) | 2009-03-17 |
| EP0662152A1 (fr) | 1995-07-12 |
| BR9306867A (pt) | 1998-12-08 |
| JPH07509136A (ja) | 1995-10-12 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request |