CA2133744A1 - 1,4 naphthoquinone derivatives with anti-protozoal and anti-parasitic activity - Google Patents

1,4 naphthoquinone derivatives with anti-protozoal and anti-parasitic activity

Info

Publication number
CA2133744A1
CA2133744A1 CA002133744A CA2133744A CA2133744A1 CA 2133744 A1 CA2133744 A1 CA 2133744A1 CA 002133744 A CA002133744 A CA 002133744A CA 2133744 A CA2133744 A CA 2133744A CA 2133744 A1 CA2133744 A1 CA 2133744A1
Authority
CA
Canada
Prior art keywords
group
formula
compound
compounds
optionally substituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002133744A
Other languages
English (en)
French (fr)
Inventor
Alan T. Hudson
Clive L. Yeates
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wellcome Foundation Ltd
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2133744A1 publication Critical patent/CA2133744A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
    • C07D295/205—Radicals derived from carbonic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/10—Anthelmintics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/32—Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C271/34—Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of rings other than six-membered aromatic rings with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CA002133744A 1992-04-06 1993-04-05 1,4 naphthoquinone derivatives with anti-protozoal and anti-parasitic activity Abandoned CA2133744A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB929207517A GB9207517D0 (en) 1992-04-06 1992-04-06 Heterocyclic compounds
GB9207517.5 1992-04-06

Publications (1)

Publication Number Publication Date
CA2133744A1 true CA2133744A1 (en) 1993-10-14

Family

ID=10713546

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002133744A Abandoned CA2133744A1 (en) 1992-04-06 1993-04-05 1,4 naphthoquinone derivatives with anti-protozoal and anti-parasitic activity

Country Status (16)

Country Link
EP (1) EP0634996A1 (ko)
JP (1) JPH07505388A (ko)
KR (1) KR950700874A (ko)
CN (1) CN1083048A (ko)
AU (1) AU3899293A (ko)
CA (1) CA2133744A1 (ko)
CZ (1) CZ242994A3 (ko)
FI (1) FI944657A (ko)
GB (1) GB9207517D0 (ko)
HU (1) HUT68937A (ko)
IL (1) IL105322A0 (ko)
MX (1) MX9301962A (ko)
NO (1) NO943737L (ko)
SK (1) SK120994A3 (ko)
WO (1) WO1993020044A1 (ko)
ZA (1) ZA932458B (ko)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013093937A2 (en) * 2011-09-16 2013-06-27 Alkem Laboratories Ltd. ''3-(5-methyl-2-oxo-l, 3-dioxol-4-yl) methyloxy-2- trans-[(4-chloro phenyl) cyclohexyl] [1,4]naphthaquinone"-atovaquone prodrug
KR20190020774A (ko) 2016-06-20 2019-03-04 더 스크립스 리서치 인스티튜트 항말라리아 조성물 및 이의 용도

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4485116A (en) * 1981-10-16 1984-11-27 Hudson Alan T Antiprotozoal compounds
GB8310141D0 (en) * 1983-04-14 1983-05-18 Wellcome Found Naphthoquinone derivatives
EP0362996B1 (en) * 1988-08-16 1994-04-27 The Wellcome Foundation Limited Naphthoquinones for the treatment and prophylaxis of pneumocystis carinii infections

Also Published As

Publication number Publication date
CZ242994A3 (en) 1995-06-14
KR950700874A (ko) 1995-02-20
HU9402850D0 (en) 1995-01-30
CN1083048A (zh) 1994-03-02
JPH07505388A (ja) 1995-06-15
ZA932458B (en) 1994-10-05
MX9301962A (es) 1993-11-01
NO943737L (no) 1994-11-29
NO943737D0 (no) 1994-10-05
SK120994A3 (en) 1995-07-11
HUT68937A (en) 1995-08-28
FI944657A0 (fi) 1994-10-05
AU3899293A (en) 1993-11-08
WO1993020044A1 (en) 1993-10-14
IL105322A0 (en) 1993-08-18
FI944657A (fi) 1994-12-02
EP0634996A1 (en) 1995-01-25
GB9207517D0 (en) 1992-05-20

Similar Documents

Publication Publication Date Title
US7879886B2 (en) Iron binding agents
HU181238B (en) Process for preparing amine derivatives of di-o-/n-higher alkyl or -alkenyl/-propandiols
US20060100225A1 (en) Heteroaryl guanidines; inhibitors of viral replication
US9994577B2 (en) Azepanyl-derivatives and pharmaceutical compositions comprising the same with antiparasitic activity
CA3189252A1 (en) High penetration prodrug compositions and pharmaceutical composition thereof for treatment of pulmonary conditions
CA1329621C (en) Naphthoquinones in the treatment or prophylaxis of pneumocystis carinii infections
EP0366066B1 (en) Compounds and formulations for use in methods for the treatment and prophylaxis of pneumocystis cariniipneumonia and other diseases
US6987114B1 (en) Antiviral pyrimidinedione derivatives and process for the preparation thereof
CA2133744A1 (en) 1,4 naphthoquinone derivatives with anti-protozoal and anti-parasitic activity
CA2150234E (en) Combination of atovaquone with proguanil for the treatment of protozoal infections
GB2148296A (en) 1,2-dithiolan derivatives, process for their production pharmaceutical compositions containing them and their use
JP4355450B2 (ja) ベンフルメトール誘導体、その中間体および寄生原生動物および吸虫に対するその使用
US4857529A (en) Interferon inducing, anti-vaccinia, and/or anti-influenza compositions
AP315A (en) Heterocyclic compounds.
US6762316B1 (en) Preparation of substituted cyclopentane and cyclopentene compounds and certain intermediates
US20230225984A1 (en) Mono- and bis-nitrosylated alkyl polyols for therapeutic use
JPH0859471A (ja) 抗マラリア剤
JPH11310530A (ja) 一酸化窒素産生抑制剤
US8389569B2 (en) Polyspirane compounds, application thereof in the treatment of malaria or toxoplasmosis and method for preparing same
US3639602A (en) 2 4-di-(4-arylpiperazino)-3-pentanones for treating schistosomiasis
CA2053246A1 (en) Amonafide salts
CA1150268A (en) Decaprenylamine derivatives
JPH11228408A (ja) 抗マラリア剤
JPH07309757A (ja) βアミロイド蛋白神経細胞毒性低減剤

Legal Events

Date Code Title Description
FZDE Discontinued