CA2130100A1 - Signaux d'internalisation par recepteurs - Google Patents
Signaux d'internalisation par recepteursInfo
- Publication number
- CA2130100A1 CA2130100A1 CA 2130100 CA2130100A CA2130100A1 CA 2130100 A1 CA2130100 A1 CA 2130100A1 CA 2130100 CA2130100 CA 2130100 CA 2130100 A CA2130100 A CA 2130100A CA 2130100 A1 CA2130100 A1 CA 2130100A1
- Authority
- CA
- Canada
- Prior art keywords
- present
- alanine
- residues
- amino acid
- sequence
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1002—Tetrapeptides with the first amino acid being neutral
- C07K5/1016—Tetrapeptides with the first amino acid being neutral and aromatic or cycloaliphatic
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
- C12N15/625—DNA sequences coding for fusion proteins containing a sequence coding for a signal sequence
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/06—Fusion polypeptide containing a localisation/targetting motif containing a lysosomal/endosomal localisation signal
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/35—Nature of the modification
- C12N2310/351—Conjugate
- C12N2310/3513—Protein; Peptide
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Medicinal Chemistry (AREA)
- Immunology (AREA)
- Plant Pathology (AREA)
- Analytical Chemistry (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Cell Biology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US84485292A | 1992-03-03 | 1992-03-03 | |
US844,852 | 1992-03-03 |
Publications (1)
Publication Number | Publication Date |
---|---|
CA2130100A1 true CA2130100A1 (fr) | 1993-09-16 |
Family
ID=25293794
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA 2130100 Abandoned CA2130100A1 (fr) | 1992-03-03 | 1993-03-01 | Signaux d'internalisation par recepteurs |
Country Status (4)
Country | Link |
---|---|
EP (1) | EP0672132A1 (fr) |
JP (1) | JPH07508400A (fr) |
CA (1) | CA2130100A1 (fr) |
WO (1) | WO1993018185A1 (fr) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5807746A (en) * | 1994-06-13 | 1998-09-15 | Vanderbilt University | Method for importing biologically active molecules into cells |
WO1996021416A2 (fr) * | 1994-12-30 | 1996-07-18 | Chiron Corporation | Procedes et compostions de traitement de tumeurs solides in vivo |
ES2137620T3 (es) | 1995-06-21 | 1999-12-16 | Tecnogen Scpa | Ligandos peptidicos para la region constante de las inmunoglobulinas. |
GB0112652D0 (en) | 2001-05-24 | 2001-07-18 | Inst Of Molecul & Cell Biology | Internalisation of virus into cells |
WO2015200357A2 (fr) * | 2014-06-23 | 2015-12-30 | Immunomic Therapeutics, Inc. | Acides nucléiques pour le traitement d'allergies à l'arachide |
-
1993
- 1993-03-01 EP EP93907023A patent/EP0672132A1/fr not_active Withdrawn
- 1993-03-01 CA CA 2130100 patent/CA2130100A1/fr not_active Abandoned
- 1993-03-01 WO PCT/US1993/001669 patent/WO1993018185A1/fr not_active Application Discontinuation
- 1993-03-01 JP JP5515747A patent/JPH07508400A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
EP0672132A1 (fr) | 1995-09-20 |
WO1993018185A1 (fr) | 1993-09-16 |
JPH07508400A (ja) | 1995-09-21 |
EP0672132A4 (fr) | 1995-05-23 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
KR0178022B1 (ko) | 단백질-다가양이온 결합체 | |
Siomi et al. | A nuclear localization domain in the hnRNP A1 protein. | |
JPH11510386A (ja) | 輸送蛋白質およびそれらの使用 | |
Zaitsev et al. | H1 and HMG17 extracted from calf thymus nuclei are efficient DNA carriers in gene transfer | |
Niidome et al. | Gene transfer into hepatoma cells mediated by galactose-modified α-helical peptides | |
WO1999039742A1 (fr) | Fusion de liposome et vehicule d'administration | |
JP2002525066A (ja) | 核酸の特異的な細胞の局在化のための転写法 | |
JPH08504573A (ja) | 過剰増殖性細胞の複製阻害方法 | |
Niidome et al. | Influence of lipophilic groups in cationic α‐helical peptides on their abilities to bind with DNA and deliver genes into cells | |
CA2266429A1 (fr) | Proteines d'interaction de type herisson et utilisations s'y rapportant | |
CA2130100A1 (fr) | Signaux d'internalisation par recepteurs | |
WO1999042593A1 (fr) | Compositions et procedes servant a sensibiliser et a inhiber la croissance de cellules cancereuses humaines | |
CA2390104C (fr) | Procede de transfert de substances moleculaires au moyen de proteines procaryotiques liant des acides nucleiques | |
EA006874B1 (ru) | Полипептид, обладающий активностью rap [белка, ассоциированного с rip (взаимодействующим с рецептором белком)], кодирующая его последовательность днк и способы их получения и использования | |
Peränen et al. | Expression, purification, and properties of Rab8 function in actin cortical skeleton organization and polarized transport | |
Kubota et al. | Effects of chimeric mutants of human immunodeficiency virus type 1 Rev and human T-cell leukemia virus type I Rex on nucleolar targeting signals | |
CN114364704B (zh) | 修饰的piggybac转座酶多肽、编码其的多核苷酸、引入载体、试剂盒、将靶序列整合到细胞基因组中的方法以及生产细胞的方法 | |
Kilpatrick et al. | Effects of deletion of the cytoplasmic domain upon surface expression and membrane stability of a viral envelope glycoprotein. | |
CA2481399A1 (fr) | Peptides, compositions pharmaceutiques contenant ces peptides pour le traitement du cancer | |
KR19990008319A (ko) | 섬유아세포 성장 인자 15 | |
EP0772620B1 (fr) | Oligonucleotides anti-messagers et reversion par le recepteur de l'urokinase du phenotype invasif de fibroblastes humains transformes par l'inhibition de l'expression du gene recepteur d'urokinase par oligonucleotides anti-messagers | |
Dai et al. | Construction of an EGF receptor-mediated histone H1 0-based gene delivery system | |
CA2228378A1 (fr) | Adn complementaire de cytidine deaminase utilise comme marqueur positif pouvant etre selectionne pour le transfert de gene, la therapie genique et la synthese de proteine | |
CA2118373C (fr) | Methode d'inversion du phenotype de cellules transformees par le facteur de transcription irf-i | |
AU747522B2 (en) | Nucleic acid sequence and method for selectively expressing a protein in a target cell or tissue |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FZDE | Dead |