CA2116453A1 - Disease associated human autoantibodies specific for human thyroid peroxidase - Google Patents

Disease associated human autoantibodies specific for human thyroid peroxidase

Info

Publication number
CA2116453A1
CA2116453A1 CA002116453A CA2116453A CA2116453A1 CA 2116453 A1 CA2116453 A1 CA 2116453A1 CA 002116453 A CA002116453 A CA 002116453A CA 2116453 A CA2116453 A CA 2116453A CA 2116453 A1 CA2116453 A1 CA 2116453A1
Authority
CA
Canada
Prior art keywords
antibody
thyroid peroxidase
human thyroid
tpo
human
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002116453A
Other languages
English (en)
French (fr)
Inventor
Basil Rapoport
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
NICHOLS INSTITUTE DIAGNOSTIC
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/US1992/006283 external-priority patent/WO1993003146A1/en
Application filed by Individual filed Critical Individual
Publication of CA2116453A1 publication Critical patent/CA2116453A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/40Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004Oxidoreductases (1.)
    • C12N9/0065Oxidoreductases (1.) acting on hydrogen peroxide as acceptor (1.11)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/156Polymorphic or mutational markers
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/158Expression markers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CA002116453A 1991-08-28 1992-08-28 Disease associated human autoantibodies specific for human thyroid peroxidase Abandoned CA2116453A1 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US75057991A 1991-08-28 1991-08-28
US07/750,579 1991-08-28
PCT/US1992/006283 WO1993003146A1 (en) 1991-07-30 1992-07-30 Disease associated b-cell epitopes of tpo and use thereof
WOPCT/US92/06283 1992-07-30

Publications (1)

Publication Number Publication Date
CA2116453A1 true CA2116453A1 (en) 1993-03-18

Family

ID=26784910

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002116453A Abandoned CA2116453A1 (en) 1991-08-28 1992-08-28 Disease associated human autoantibodies specific for human thyroid peroxidase

Country Status (8)

Country Link
US (1) US7196181B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
EP (1) EP0668918A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
JP (1) JPH07506960A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
AU (1) AU2555792A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
CA (1) CA2116453A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
FI (1) FI940732L (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
NO (1) NO940668D0 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
WO (1) WO1993005072A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI940732L (fi) 1991-08-28 1994-04-28 Nichols Inst Diagnostics Ihmisen tyroidiperoksidaasille spesifiset autovasta-aineet
GB2265713A (en) * 1992-05-16 1993-10-06 R S R Limited Assay for autoantibodies against thyroglobulin or thyroid peroxidase
AU2004261980A1 (en) * 2003-08-01 2005-02-10 Genentech, Inc. Antibody CDR polypeptide sequences with restricted diversity
GB0621513D0 (en) * 2006-10-30 2006-12-06 Domantis Ltd Novel polypeptides and uses thereof
CN105087512A (zh) * 2014-05-13 2015-11-25 苏州偲聚生物材料有限公司 可用于检测甲状腺疾病的蛋白质及该蛋白质的部分肽
US11327074B2 (en) 2018-07-02 2022-05-10 Siemens Healthcare Diagnostics Inc. Thyroid peroxidase autoantibody immunoassay

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4098876A (en) 1976-10-26 1978-07-04 Corning Glass Works Reverse sandwich immunoassay
US4376110A (en) 1980-08-04 1983-03-08 Hybritech, Incorporated Immunometric assays using monoclonal antibodies
NZ209308A (en) * 1983-08-30 1991-08-27 Genentech Inc Vaccine against hsv involving a truncated membrane-free derivative of a membrane-bound protein
AU6161390A (en) * 1989-07-31 1991-03-11 Basil Rapaport Recombinant human thyroid peroxidase
CA2024562C (en) 1989-09-05 2000-09-26 Shinya Yamashita Cho cells transformed with a recombinant plasmid expressing human thyroid peroxidase and preparation thereof
FI940391L (fi) * 1991-07-30 1994-03-28 Nichols Inst Diagnostics Ihmisen tyroidiperoksidaasin B-soluepitoopit ja niiden käyttö
FI940732L (fi) 1991-08-28 1994-04-28 Nichols Inst Diagnostics Ihmisen tyroidiperoksidaasille spesifiset autovasta-aineet
US5998153A (en) 1992-05-19 1999-12-07 The Regents Of The University Of Michigan Thyroid peroxidase epitopic regions
GB9622772D0 (en) 1996-11-01 1997-01-08 Rsr Ltd Monitoring reactivity of thyroid peroxidase autoantibodies

Also Published As

Publication number Publication date
NO940668D0 (no) 1994-02-25
FI940732A7 (fi) 1994-04-28
AU2555792A (en) 1993-04-05
WO1993005072A1 (en) 1993-03-18
FI940732A0 (fi) 1994-02-16
JPH07506960A (ja) 1995-08-03
US7196181B1 (en) 2007-03-27
FI940732L (fi) 1994-04-28
NO940668L (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1994-04-29
EP0668918A1 (en) 1995-08-30
EP0668918A4 (en) 1994-11-28

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Legal Events

Date Code Title Description
FZDE Discontinued