CA2116198A1 - Lipid metabolism improving medicinal composition - Google Patents
Lipid metabolism improving medicinal compositionInfo
- Publication number
- CA2116198A1 CA2116198A1 CA002116198A CA2116198A CA2116198A1 CA 2116198 A1 CA2116198 A1 CA 2116198A1 CA 002116198 A CA002116198 A CA 002116198A CA 2116198 A CA2116198 A CA 2116198A CA 2116198 A1 CA2116198 A1 CA 2116198A1
- Authority
- CA
- Canada
- Prior art keywords
- cholesterol
- lipid metabolism
- lipid
- medicinal composition
- metabolism improving
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 230000037356 lipid metabolism Effects 0.000 title claims abstract description 17
- 239000000203 mixture Substances 0.000 title claims abstract description 15
- -1 phosphoric acid diester compound Chemical class 0.000 claims abstract description 15
- 150000003839 salts Chemical class 0.000 claims abstract description 8
- NBIIXXVUZAFLBC-UHFFFAOYSA-N phosphoric acid Substances OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 claims abstract description 6
- 229910000147 aluminium phosphate Inorganic materials 0.000 claims abstract description 5
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims abstract description 4
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims abstract description 3
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 abstract description 39
- 235000012000 cholesterol Nutrition 0.000 abstract description 19
- 208000031226 Hyperlipidaemia Diseases 0.000 abstract description 12
- 150000003626 triacylglycerols Chemical class 0.000 abstract description 11
- 150000002632 lipids Chemical class 0.000 abstract description 10
- 235000021588 free fatty acids Nutrition 0.000 abstract description 9
- 108010010234 HDL Lipoproteins Proteins 0.000 abstract description 8
- 102000015779 HDL Lipoproteins Human genes 0.000 abstract description 8
- 108010007622 LDL Lipoproteins Proteins 0.000 abstract description 8
- 102000007330 LDL Lipoproteins Human genes 0.000 abstract description 8
- 150000005830 nonesterified fatty acids Chemical class 0.000 abstract description 8
- 108010062497 VLDL Lipoproteins Proteins 0.000 abstract description 5
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract description 5
- 201000010099 disease Diseases 0.000 abstract description 4
- 208000026106 cerebrovascular disease Diseases 0.000 abstract 2
- 206010002383 Angina Pectoris Diseases 0.000 abstract 1
- 206010065559 Cerebral arteriosclerosis Diseases 0.000 abstract 1
- 206010020772 Hypertension Diseases 0.000 abstract 1
- 206010029164 Nephrotic syndrome Diseases 0.000 abstract 1
- 208000008589 Obesity Diseases 0.000 abstract 1
- 206010008118 cerebral infarction Diseases 0.000 abstract 1
- 206010012601 diabetes mellitus Diseases 0.000 abstract 1
- 201000005851 intracranial arteriosclerosis Diseases 0.000 abstract 1
- 208000010125 myocardial infarction Diseases 0.000 abstract 1
- 208000009928 nephrosis Diseases 0.000 abstract 1
- 231100001027 nephrosis Toxicity 0.000 abstract 1
- 235000020824 obesity Nutrition 0.000 abstract 1
- 230000036470 plasma concentration Effects 0.000 abstract 1
- 238000011321 prophylaxis Methods 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 description 21
- 241000700159 Rattus Species 0.000 description 9
- FYPMFJGVHOHGLL-UHFFFAOYSA-N probucol Chemical compound C=1C(C(C)(C)C)=C(O)C(C(C)(C)C)=CC=1SC(C)(C)SC1=CC(C(C)(C)C)=C(O)C(C(C)(C)C)=C1 FYPMFJGVHOHGLL-UHFFFAOYSA-N 0.000 description 8
- 229960003912 probucol Drugs 0.000 description 8
- 230000000694 effects Effects 0.000 description 7
- ZSJLQEPLLKMAKR-UHFFFAOYSA-N Streptozotocin Natural products O=NN(C)C(=O)NC1C(O)OC(CO)C(O)C1O ZSJLQEPLLKMAKR-UHFFFAOYSA-N 0.000 description 5
- 239000008280 blood Substances 0.000 description 5
- 210000004369 blood Anatomy 0.000 description 5
- 239000003814 drug Substances 0.000 description 5
- ZSJLQEPLLKMAKR-GKHCUFPYSA-N streptozocin Chemical compound O=NN(C)C(=O)N[C@H]1[C@@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O ZSJLQEPLLKMAKR-GKHCUFPYSA-N 0.000 description 5
- 229960001052 streptozocin Drugs 0.000 description 5
- 239000000126 substance Substances 0.000 description 5
- MDYZKJNTKZIUSK-UHFFFAOYSA-N tyloxapol Chemical compound O=C.C1CO1.CC(C)(C)CC(C)(C)C1=CC=C(O)C=C1 MDYZKJNTKZIUSK-UHFFFAOYSA-N 0.000 description 5
- 206010003210 Arteriosclerosis Diseases 0.000 description 4
- 208000011775 arteriosclerosis disease Diseases 0.000 description 4
- 239000003795 chemical substances by application Substances 0.000 description 4
- 229940079593 drug Drugs 0.000 description 4
- 238000000034 method Methods 0.000 description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 4
- 108010023302 HDL Cholesterol Proteins 0.000 description 3
- 102000004895 Lipoproteins Human genes 0.000 description 3
- 108090001030 Lipoproteins Proteins 0.000 description 3
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
- 239000012153 distilled water Substances 0.000 description 3
- 150000003904 phospholipids Chemical class 0.000 description 3
- 238000002360 preparation method Methods 0.000 description 3
- 239000003826 tablet Substances 0.000 description 3
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 2
- 241000700157 Rattus norvegicus Species 0.000 description 2
- MSCCTZZBYHQMQJ-AZAGJHQNSA-N Tocopheryl nicotinate Chemical compound C([C@@](OC1=C(C)C=2C)(C)CCC[C@H](C)CCC[C@H](C)CCCC(C)C)CC1=C(C)C=2OC(=O)C1=CC=CN=C1 MSCCTZZBYHQMQJ-AZAGJHQNSA-N 0.000 description 2
- 239000002253 acid Substances 0.000 description 2
- 239000003708 ampul Substances 0.000 description 2
- 230000007423 decrease Effects 0.000 description 2
- 239000011521 glass Substances 0.000 description 2
- 239000004615 ingredient Substances 0.000 description 2
- 230000000069 prophylactic effect Effects 0.000 description 2
- 238000011552 rat model Methods 0.000 description 2
- 235000021055 solid food Nutrition 0.000 description 2
- 241000894007 species Species 0.000 description 2
- 229950009883 tocopheryl nicotinate Drugs 0.000 description 2
- 210000003462 vein Anatomy 0.000 description 2
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 description 1
- 241000725101 Clea Species 0.000 description 1
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 1
- 239000011627 DL-alpha-tocopherol Substances 0.000 description 1
- 235000001815 DL-alpha-tocopherol Nutrition 0.000 description 1
- 239000004129 EU approved improving agent Substances 0.000 description 1
- 239000002211 L-ascorbic acid Substances 0.000 description 1
- 235000000069 L-ascorbic acid Nutrition 0.000 description 1
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 1
- 229930195725 Mannitol Natural products 0.000 description 1
- 206010027304 Menopausal symptoms Diseases 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- PVNIIMVLHYAWGP-UHFFFAOYSA-N Niacin Chemical compound OC(=O)C1=CC=CN=C1 PVNIIMVLHYAWGP-UHFFFAOYSA-N 0.000 description 1
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical class [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 1
- 229920002472 Starch Polymers 0.000 description 1
- 150000007513 acids Chemical class 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 229910052783 alkali metal Inorganic materials 0.000 description 1
- 229910052784 alkaline earth metal Inorganic materials 0.000 description 1
- 230000001437 anti-cataract Effects 0.000 description 1
- 239000002260 anti-inflammatory agent Substances 0.000 description 1
- 229940124599 anti-inflammatory drug Drugs 0.000 description 1
- 239000003699 antiulcer agent Substances 0.000 description 1
- 229960005070 ascorbic acid Drugs 0.000 description 1
- 229940115445 ascorbyl tocopheryl phosphate Drugs 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 238000010876 biochemical test Methods 0.000 description 1
- 230000037396 body weight Effects 0.000 description 1
- 159000000007 calcium salts Chemical class 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 210000000170 cell membrane Anatomy 0.000 description 1
- 239000002537 cosmetic Substances 0.000 description 1
- 238000000354 decomposition reaction Methods 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 235000005911 diet Nutrition 0.000 description 1
- 230000037213 diet Effects 0.000 description 1
- 235000014113 dietary fatty acids Nutrition 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 239000003995 emulsifying agent Substances 0.000 description 1
- 239000000194 fatty acid Substances 0.000 description 1
- 229930195729 fatty acid Natural products 0.000 description 1
- 150000004665 fatty acids Chemical class 0.000 description 1
- 239000000706 filtrate Substances 0.000 description 1
- 230000004927 fusion Effects 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- 201000001421 hyperglycemia Diseases 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 230000000302 ischemic effect Effects 0.000 description 1
- 239000008101 lactose Substances 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 159000000003 magnesium salts Chemical class 0.000 description 1
- 239000000594 mannitol Substances 0.000 description 1
- 235000010355 mannitol Nutrition 0.000 description 1
- 235000001968 nicotinic acid Nutrition 0.000 description 1
- 239000011664 nicotinic acid Substances 0.000 description 1
- 239000007935 oral tablet Substances 0.000 description 1
- 229940096978 oral tablet Drugs 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 230000008506 pathogenesis Effects 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 239000002831 pharmacologic agent Substances 0.000 description 1
- 229940093429 polyethylene glycol 6000 Drugs 0.000 description 1
- XAEFZNCEHLXOMS-UHFFFAOYSA-M potassium benzoate Chemical compound [K+].[O-]C(=O)C1=CC=CC=C1 XAEFZNCEHLXOMS-UHFFFAOYSA-M 0.000 description 1
- 230000003389 potentiating effect Effects 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 229940043274 prophylactic drug Drugs 0.000 description 1
- 230000009103 reabsorption Effects 0.000 description 1
- 238000007789 sealing Methods 0.000 description 1
- 159000000000 sodium salts Chemical class 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 229940124597 therapeutic agent Drugs 0.000 description 1
- 229940126585 therapeutic drug Drugs 0.000 description 1
- 238000011285 therapeutic regimen Methods 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 230000002792 vascular Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/665—Phosphorus compounds having oxygen as a ring hetero atom, e.g. fosfomycin
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP73814/1993 | 1993-03-31 | ||
| JP7381493 | 1993-03-31 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2116198A1 true CA2116198A1 (en) | 1994-10-01 |
Family
ID=13529009
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002116198A Abandoned CA2116198A1 (en) | 1993-03-31 | 1994-02-22 | Lipid metabolism improving medicinal composition |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US5474991A (forum.php) |
| EP (1) | EP0617963B1 (forum.php) |
| KR (1) | KR100272483B1 (forum.php) |
| AT (1) | ATE141508T1 (forum.php) |
| CA (1) | CA2116198A1 (forum.php) |
| DE (1) | DE69400382T2 (forum.php) |
| ES (1) | ES2091057T3 (forum.php) |
| TW (1) | TW252918B (forum.php) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5866147A (en) * | 1995-05-15 | 1999-02-02 | Avon Products, Inc. | Ascorbyl-phosphoryl-cholesterol |
| CA2244535A1 (en) * | 1995-05-15 | 2000-01-30 | Avon Products, Inc. | Novel uses for ascorbyl-phosphoryl-cholesterol in topical compositions |
| US6162450A (en) * | 1995-05-15 | 2000-12-19 | Avon Products, Inc. | Uses of ascorbyl-phosphoryl-cholesterol and compositions for practicing same |
| AUPR549901A0 (en) * | 2001-06-06 | 2001-07-12 | Vital Health Sciences Pty Ltd | Topical formulation containing tocopheryl phosphates |
| CN1262274C (zh) * | 2000-11-14 | 2006-07-05 | 生命健康科学有限公司 | 磷酸盐衍生物复合物 |
| EP1420797A4 (en) * | 2001-07-27 | 2005-03-02 | Vital Health Sciences Pty Ltd | DERMAL THERAPY USING PHOSPHATE DERIVATIVES OF ELECTRONIC TRANSFER AGENTS |
| BR0215102A (pt) * | 2001-12-13 | 2004-11-03 | Vital Health Sciences Pty Ltd | Transporte transdermal de compostos, formulação tópica, método para melhorar a absorção da pele, método para a terapia de reposição hormonal, uso de um ou mais derivados de fosfato de um composto hidróxi farmacêutico em um sistema de aplicação transdermal, sistema de aplicação transdermal, método para aplicação de um composto hidróxi farmacêutico a um indivìduo e para melhorar a eficácia de uma formulação |
| AU2003225277A1 (en) * | 2002-05-02 | 2003-11-17 | Robert Harris | Lipid removal from the body |
| AU2002950713A0 (en) * | 2002-08-09 | 2002-09-12 | Vital Health Sciences Pty Ltd | Carrier |
| BRPI0406484A (pt) * | 2003-01-17 | 2005-12-06 | Vital Health Sciences Pty Ltd | Método de inibição da ocorrência de uma ou mais das seguintes condições: a proliferação de monócitos/macrófagos; ou a proliferação de células do músculo liso; ou a expressão de receptores de cd36; ou a absorção de lipoproteìna de baixa densidade - ldl oxidada, método de alìvio de sintomas de tratamento ou prevenção de aterosclerose; de diabetes; do mal de alzheimer, método de inibição da ocorrência da formação de placas no sistema vascular, método de alìvio da inflamação associada a ocorrência de uma ou de mais das seguintes condições: a proliferação de monócitos, a proliferação de células do músculo liso, a expressão de ldl oxidadas ou de receptor descontaminante, composição farmacêutica, uso de uma quantidade eficaz de um ou mais derivados ou fosfato de um ou mais agentes de transferência de elétrons conjuntamente com um veìculo ou um diluente apropriado, uso de uma quantidade eficaz de um ou mais derivados de fosfato de (alfa)-tocoferol conjuntamente com um veìculo ou um diluente apropriado e uso de uma quantidade eficaz de um ou mais derivados de fosfato de um ou mais agentes de transferência de elétrons selecionados do grupo que consiste em fosfato mono-tocoferila, fosfato de di-tocoferila e as misturas destes conjuntamente com um veìculo ou um diluente apropriado |
| AU2003901815A0 (en) * | 2003-04-15 | 2003-05-01 | Vital Health Sciences Pty Ltd | Phosphate derivatives |
| JP4847437B2 (ja) | 2004-03-03 | 2011-12-28 | バイタル ヘルス サイエンシズ プロプライアタリー リミティド | アルカロイド製剤 |
| KR20070108383A (ko) * | 2005-03-03 | 2007-11-09 | 바이탈 헬스 사이언시즈 피티와이 리미티드 | 지질 저하성 화합물 |
| WO2006092024A1 (en) * | 2005-03-03 | 2006-09-08 | Vital Health Sciences Pty Ltd | Compounds having anti-cancer properties |
| US9168216B2 (en) * | 2005-06-17 | 2015-10-27 | Vital Health Sciences Pty. Ltd. | Carrier comprising one or more di and/or mono-(electron transfer agent) phosphate derivatives or complexes thereof |
| JP2009520697A (ja) * | 2005-12-23 | 2009-05-28 | バイタル ヘルス サイエンシズ プロプライアタリー リミティド | サイトカイン調節性を有する化合物 |
| WO2011094814A1 (en) | 2010-02-05 | 2011-08-11 | Phosphagenics Limited | Carrier comprising non-neutralised tocopheryl phosphate |
| CA2794734C (en) | 2010-03-30 | 2017-12-12 | Phosphagenics Limited | Transdermal delivery patch |
| US9561243B2 (en) | 2011-03-15 | 2017-02-07 | Phosphagenics Limited | Composition comprising non-neutralised tocol phosphate and a vitamin A compound |
| JP6882321B2 (ja) | 2015-12-09 | 2021-06-02 | フォスファージニクス リミテッド | 医薬製剤 |
| EP3558903B1 (en) | 2016-12-21 | 2024-07-03 | Avecho Biotechnology Limited | Process for phosphorylating a complex alcohol |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS59219295A (ja) * | 1983-05-30 | 1984-12-10 | Senjiyu Seiyaku Kk | リン酸ジエステルまたはその塩およびそれらの製造法 |
| JPS62205091A (ja) * | 1986-03-04 | 1987-09-09 | Senjiyu Seiyaku Kk | 新規なリン酸ジエステルならびにその塩、その製造法およびそれを含有する製剤 |
| JPH0781138B2 (ja) * | 1986-12-02 | 1995-08-30 | 株式会社資生堂 | 抗酸化剤 |
| JP2526059B2 (ja) * | 1987-04-28 | 1996-08-21 | 千寿製薬株式会社 | 抗潰瘍剤 |
| PH25859A (en) * | 1988-01-11 | 1991-12-02 | Takeda Chemical Industries Ltd | Composition for treatment of ischemic disorder |
| UA19385A1 (uk) * | 1989-04-27 | 1997-12-25 | Сендзю Фармасьютікал Ко. Лтд. | Фофоліпідhі похідhі та композиція, яка має аhтиоксидаhтhу та іhгібуючу активhість щодо пероксидів ліпідів |
| US5053222A (en) * | 1989-06-07 | 1991-10-01 | Shiseido Company Ltd. | Hair cosmetic composition |
| US5231090A (en) * | 1990-07-30 | 1993-07-27 | University Of Miami | Treatment for hypercholesterolemia |
| CA2099346A1 (en) * | 1992-07-17 | 1994-01-18 | Shinji Ohmori | Lipid metabolism improving composition |
-
1994
- 1994-02-19 TW TW083101420A patent/TW252918B/zh active
- 1994-02-22 CA CA002116198A patent/CA2116198A1/en not_active Abandoned
- 1994-03-22 US US08/215,814 patent/US5474991A/en not_active Expired - Fee Related
- 1994-03-27 AT AT94104839T patent/ATE141508T1/de not_active IP Right Cessation
- 1994-03-27 ES ES94104839T patent/ES2091057T3/es not_active Expired - Lifetime
- 1994-03-27 DE DE69400382T patent/DE69400382T2/de not_active Expired - Fee Related
- 1994-03-27 EP EP94104839A patent/EP0617963B1/en not_active Expired - Lifetime
- 1994-03-31 KR KR1019940006835A patent/KR100272483B1/ko not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| KR100272483B1 (ko) | 2000-11-15 |
| EP0617963A1 (en) | 1994-10-05 |
| DE69400382D1 (de) | 1996-09-26 |
| DE69400382T2 (de) | 1996-12-19 |
| KR940021059A (ko) | 1994-10-17 |
| ATE141508T1 (de) | 1996-09-15 |
| TW252918B (forum.php) | 1995-08-01 |
| US5474991A (en) | 1995-12-12 |
| EP0617963B1 (en) | 1996-08-21 |
| ES2091057T3 (es) | 1996-10-16 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CA2116198A1 (en) | Lipid metabolism improving medicinal composition | |
| US4255449A (en) | Method of treating abnormal lipoprote in ratios | |
| JP4746726B2 (ja) | フェノフィブレートとビタミンｅの組成物およびその 治療上の用途 | |
| US4602005A (en) | Tigogenin cellobioside for treating hypercholesterolemia and atherosclerosis | |
| EP0321128B1 (en) | Fatty acid compositions | |
| EP2701697B1 (en) | Oxidative retinal diseases | |
| EP0324387B1 (en) | Composition for treatment of ischemic disorder in organs | |
| US20030153541A1 (en) | Novel anticholesterol compositions and method for using same | |
| FI88583B (fi) | Foerfarande foer framstaellning av fettemulsioner, som innehaoller prostaglandin i2 | |
| CA2152693A1 (en) | Therapeutic composition for pancreatitis | |
| WO1992003130A1 (en) | Use of aryl hydroxyurea compounds for the treatment of atherosclerosis | |
| AU2004290925B2 (en) | Pharmaceutical compositions for the treatment of renal dysfunction, disease or disorder, in particular in diabetic patients | |
| KR100846641B1 (ko) | 동맥경화 억제 방법 및 조성물 | |
| US5378692A (en) | Method of lowering lipids | |
| EP1704857B1 (en) | Probucol spiroquinone or probucol diphenoquinone for use in the treatment of low hdl cholesterolemia | |
| JP2714678B2 (ja) | 虚血性臓器障害予防・治療剤 | |
| US5478815A (en) | Liver protectant tocophery-ascorbyl-phosphate | |
| MXPA96006009A (en) | Use of 8,9-dehydroestrone as an antioxide | |
| HAYASHI et al. | Fundamental studies on physiological and pharmacological actions of L-ascorbate 2-sulfate. I. On the hypolipidemic effects | |
| HK40035235A (en) | Oxidative retinal diseases | |
| Day | Pharmacologic regulation of serum lipoproteins | |
| HK1195018B (en) | Oxidative retinal diseases | |
| HK1195018A (en) | Oxidative retinal diseases | |
| JPH0640918A (ja) | 動脈硬化性疾患治療剤 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| FZDE | Discontinued |