CA2093667A1 - Anticorps monoclonaux murins et leur utilisation - Google Patents
Anticorps monoclonaux murins et leur utilisationInfo
- Publication number
- CA2093667A1 CA2093667A1 CA2093667A CA2093667A CA2093667A1 CA 2093667 A1 CA2093667 A1 CA 2093667A1 CA 2093667 A CA2093667 A CA 2093667A CA 2093667 A CA2093667 A CA 2093667A CA 2093667 A1 CA2093667 A1 CA 2093667A1
- Authority
- CA
- Canada
- Prior art keywords
- monoclonal antibodies
- mouse monoclonal
- relates
- diagnosis
- cancer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
- A61K47/6851—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/57407—Specifically defined cancers
- G01N33/57419—Specifically defined cancers of colon
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/57407—Specifically defined cancers
- G01N33/57446—Specifically defined cancers of stomach or intestine
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/57407—Specifically defined cancers
- G01N33/57449—Specifically defined cancers of ovaries
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
- G01N33/57492—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites involving compounds localized on the membrane of tumor or cancer cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Urology & Nephrology (AREA)
- Biomedical Technology (AREA)
- Cell Biology (AREA)
- Hematology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Oncology (AREA)
- Organic Chemistry (AREA)
- Hospice & Palliative Care (AREA)
- Food Science & Technology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
Abstract
L'invention se rapporte à des anticorps monoclonaux et à leur utilisation. En particulier, l'invention se rapporte à trois anticorps monoclonaux, appelés B1, B3 et B5, et qui sont utiles pour le traitement et le diagnostic de nombreuses formes de cancer.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/596,289 US5242813A (en) | 1990-10-12 | 1990-10-12 | Mouse monoclonal antibodies specific for normal primate tissue, malignant human cultural cell lines human tumors |
US596,289 | 1990-10-12 | ||
PCT/US1991/007226 WO1992007271A1 (fr) | 1990-10-12 | 1991-10-09 | Anticorps monoclonaux de souris |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2093667A1 true CA2093667A1 (fr) | 1992-04-13 |
CA2093667C CA2093667C (fr) | 2000-02-15 |
Family
ID=24386733
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002093667A Expired - Fee Related CA2093667C (fr) | 1990-10-12 | 1991-10-09 | Anticorps monoclonaux murins et leur utilisation |
Country Status (11)
Country | Link |
---|---|
US (2) | US5242813A (fr) |
EP (1) | EP0552296B1 (fr) |
JP (1) | JP2651046B2 (fr) |
AT (1) | ATE161582T1 (fr) |
AU (1) | AU650302B2 (fr) |
CA (1) | CA2093667C (fr) |
DE (1) | DE69128543T2 (fr) |
DK (1) | DK0552296T3 (fr) |
ES (1) | ES2113891T3 (fr) |
GR (1) | GR3026219T3 (fr) |
WO (1) | WO1992007271A1 (fr) |
Families Citing this family (27)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ATE171207T1 (de) * | 1990-10-12 | 1998-10-15 | Us Health | Monoklonaler antikörper |
US5608039A (en) * | 1990-10-12 | 1997-03-04 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Single chain B3 antibody fusion proteins and their uses |
US5242813A (en) * | 1990-10-12 | 1993-09-07 | The United States Of America As Represented By The Department Of Health And Human Services | Mouse monoclonal antibodies specific for normal primate tissue, malignant human cultural cell lines human tumors |
US5889157A (en) * | 1990-10-12 | 1999-03-30 | The United States Of America As Represented By The Department Of Health And Human Services | Humanized B3 antibody fragments, fusion proteins, and uses thereof |
US5981726A (en) * | 1990-10-12 | 1999-11-09 | The United States Of America As Represented By The Department Of Health And Human Services | Chimeric and mutationally stabilized tumor-specific B1, B3 and B5 antibody fragments; immunotoxic fusion proteins; and uses thereof |
US5877289A (en) * | 1992-03-05 | 1999-03-02 | The Scripps Research Institute | Tissue factor compositions and ligands for the specific coagulation of vasculature |
US6749853B1 (en) | 1992-03-05 | 2004-06-15 | Board Of Regents, The University Of Texas System | Combined methods and compositions for coagulation and tumor treatment |
US6036955A (en) * | 1992-03-05 | 2000-03-14 | The Scripps Research Institute | Kits and methods for the specific coagulation of vasculature |
US6004555A (en) * | 1992-03-05 | 1999-12-21 | Board Of Regents, The University Of Texas System | Methods for the specific coagulation of vasculature |
US6093399A (en) * | 1992-03-05 | 2000-07-25 | Board Of Regents, The University Of Texas System | Methods and compositions for the specific coagulation of vasculature |
US5489525A (en) * | 1992-10-08 | 1996-02-06 | The United States Of America As Represented By The Department Of Health And Human Services | Monoclonal antibodies to prostate cells |
US5597569A (en) * | 1993-10-25 | 1997-01-28 | Bristol-Myers Squibb Company | Bryodin 2 a ribosome-inactivating protein isolated from the plant Bryonia dioica |
DE19547324C2 (de) * | 1995-12-19 | 1997-10-16 | Behringwerke Ag | Humanes Muzin (MUC8) |
AU755706B2 (en) * | 1998-03-20 | 2002-12-19 | Genzyme Corporation | Methods to provoke anti-cancer immune responses |
KR100785718B1 (ko) | 1998-05-19 | 2007-12-18 | 리서치 디벨럽먼트 파운데이션 | 트리테르펜 조성물 |
AU7701100A (en) * | 1999-09-03 | 2001-04-10 | Millennium Pharmaceuticals, Inc. | Compositions, kits, and methods for identification, assessment, prevention, and therapy of ovarian cancer |
US20020182619A1 (en) * | 2000-11-08 | 2002-12-05 | Millennium Pharmaceuticals, Inc. | Compositions, kits, and methods for identification, assessment, prevention, and therapy of ovarian cancer |
US20060148732A1 (en) * | 2000-11-17 | 2006-07-06 | Gutterman Jordan U | Inhibition of NF-kappaB by triterpene compositions |
DE60238435D1 (de) * | 2001-10-26 | 2011-01-05 | Scripps Research Inst | Gezielte thrombose durch gewebefaktor polypeptiden |
BR0312692A (pt) | 2002-07-15 | 2007-06-26 | Univ Texas | anticorpos selecionados e peptìdeos de duramicina que se ligam a fosfolipìdios aniÈnicos e aminofosfolipìdios e seus usos no tratamento de infecções virais e cáncer |
EP2219672B1 (fr) | 2007-11-09 | 2016-02-17 | Peregrine Pharmaceuticals, Inc. | Compositions d'anticorps anti-vegf et procédés correspondants |
KR101133243B1 (ko) * | 2009-10-29 | 2012-04-06 | 국립암센터 | 암의 진단 및 치료를 위한 eIF3m의 용도 |
WO2011138391A1 (fr) | 2010-05-06 | 2011-11-10 | Novartis Ag | Compositions et méthodes d'utilisation d'anticorps multivalents thérapeutiques de faible densité de la protéine apparentée à la lipoprotéine 6 (lrp6) |
CA2798432A1 (fr) | 2010-05-06 | 2011-11-10 | Novartis Ag | Compositions et procedes d'utilisation d'anticorps therapeutiques diriges contre la proteine 6 liee a la lipoproteine de basse densite (lrp6) |
SG11201401717VA (en) | 2011-11-04 | 2014-05-29 | Novartis Ag | Low density lipoprotein-related protein 6 (lrp6) - half life extender constructs |
UY36449A (es) | 2014-12-19 | 2016-07-29 | Novartis Ag | Composiciones y métodos para anticuerpos dirigidos a bmp6 |
US11434269B2 (en) | 2016-06-15 | 2022-09-06 | Novartis Ag | Methods for treating disease using inhibitors of bone morphogenetic protein 6 (BMP6) |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0044167A3 (fr) * | 1980-07-14 | 1982-04-21 | The Regents Of The University Of California | Agent cytotoxique dirigé par un anticorps |
US4713352A (en) * | 1981-08-31 | 1987-12-15 | Sloan-Kettering Institute For Cancer Reseach | Monoclonal antibody panel for early diagnosis and therapy of renal carcinoma |
JPS5843926A (ja) * | 1981-09-08 | 1983-03-14 | Suntory Ltd | 選択性制癌剤 |
CA1215331A (fr) * | 1983-03-04 | 1986-12-16 | Tsann M. Chu | Anticorps monolconaux contre les cellules de cancer du sein et utilisation desdits anticorps pour le diagnostic et le traitement |
US4699783A (en) * | 1983-03-11 | 1987-10-13 | Terman David S | Products and methods for treatment of cancer |
EP0184369B1 (fr) * | 1984-12-05 | 1992-04-01 | The Salk Institute For Biological Studies | Anticorps monoclonal spécifique de l'antigène de surface cellulaire de tumeur mammaire |
IL94872A (en) * | 1989-06-30 | 1995-03-30 | Oncogen | Monoclonal or chimeric antibodies that react with human carcinoma, recombinant proteins that contain their anti-binding site, pharmaceutical preparations and kits that contain the |
ATE171207T1 (de) * | 1990-10-12 | 1998-10-15 | Us Health | Monoklonaler antikörper |
US5242813A (en) * | 1990-10-12 | 1993-09-07 | The United States Of America As Represented By The Department Of Health And Human Services | Mouse monoclonal antibodies specific for normal primate tissue, malignant human cultural cell lines human tumors |
-
1990
- 1990-10-12 US US07/596,289 patent/US5242813A/en not_active Expired - Lifetime
-
1991
- 1991-10-09 DK DK91920282.0T patent/DK0552296T3/da active
- 1991-10-09 ES ES91920282T patent/ES2113891T3/es not_active Expired - Lifetime
- 1991-10-09 AU AU89050/91A patent/AU650302B2/en not_active Ceased
- 1991-10-09 CA CA002093667A patent/CA2093667C/fr not_active Expired - Fee Related
- 1991-10-09 AT AT91920282T patent/ATE161582T1/de not_active IP Right Cessation
- 1991-10-09 JP JP3518456A patent/JP2651046B2/ja not_active Expired - Fee Related
- 1991-10-09 DE DE69128543T patent/DE69128543T2/de not_active Expired - Fee Related
- 1991-10-09 EP EP91920282A patent/EP0552296B1/fr not_active Expired - Lifetime
- 1991-10-09 WO PCT/US1991/007226 patent/WO1992007271A1/fr active IP Right Grant
-
1994
- 1994-12-22 US US08/363,203 patent/US5612032A/en not_active Expired - Lifetime
-
1998
- 1998-02-25 GR GR980400398T patent/GR3026219T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
DE69128543T2 (de) | 1998-07-16 |
WO1992007271A1 (fr) | 1992-04-30 |
DK0552296T3 (da) | 1998-04-27 |
AU650302B2 (en) | 1994-06-16 |
ES2113891T3 (es) | 1998-05-16 |
EP0552296A4 (en) | 1994-02-16 |
EP0552296B1 (fr) | 1997-12-29 |
JPH05508553A (ja) | 1993-12-02 |
ATE161582T1 (de) | 1998-01-15 |
GR3026219T3 (en) | 1998-05-29 |
DE69128543D1 (de) | 1998-02-05 |
US5242813A (en) | 1993-09-07 |
CA2093667C (fr) | 2000-02-15 |
JP2651046B2 (ja) | 1997-09-10 |
US5612032A (en) | 1997-03-18 |
AU8905091A (en) | 1992-05-20 |
EP0552296A1 (fr) | 1993-07-28 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
EEER | Examination request | ||
MKLA | Lapsed |