CA2089165A1 - Derives diphenyluree - Google Patents

Derives diphenyluree

Info

Publication number
CA2089165A1
CA2089165A1 CA002089165A CA2089165A CA2089165A1 CA 2089165 A1 CA2089165 A1 CA 2089165A1 CA 002089165 A CA002089165 A CA 002089165A CA 2089165 A CA2089165 A CA 2089165A CA 2089165 A1 CA2089165 A1 CA 2089165A1
Authority
CA
Canada
Prior art keywords
urea
carbon atoms
group containing
compound
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002089165A
Other languages
English (en)
Inventor
David John Lythgoe
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Rhone Poulenc Rorer Ltd
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2089165A1 publication Critical patent/CA2089165A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C275/42—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by carboxyl groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C323/39—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton at least one of the nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom
    • C07C323/40—Y being a hydrogen or a carbon atom
    • C07C323/42—Y being a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/62—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton
    • C07C323/63—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CA002089165A 1990-08-15 1991-08-14 Derives diphenyluree Abandoned CA2089165A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB9017892.2 1990-08-15
GB909017892A GB9017892D0 (en) 1990-08-15 1990-08-15 New compositions of matter

Publications (1)

Publication Number Publication Date
CA2089165A1 true CA2089165A1 (fr) 1992-02-16

Family

ID=10680688

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002089165A Abandoned CA2089165A1 (fr) 1990-08-15 1991-08-14 Derives diphenyluree

Country Status (10)

Country Link
EP (1) EP0543891A1 (fr)
JP (1) JPH06500095A (fr)
AU (1) AU8411591A (fr)
CA (1) CA2089165A1 (fr)
GB (1) GB9017892D0 (fr)
IE (1) IE912889A1 (fr)
IL (1) IL99174A0 (fr)
PT (1) PT98684A (fr)
WO (1) WO1992003413A1 (fr)
ZA (1) ZA916412B (fr)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL110151A (en) * 1993-06-30 1998-10-30 Sankyo Co Amid and urea histories and pharmaceutical preparations containing them
DE19624155A1 (de) * 1996-06-18 1998-01-08 Hoechst Ag Substituierte Benzoesäurederivate, Verfahren zu ihrer Herstellung und die Anwendung der Verbindungen zur Behandlung von Krankheiten
CA2359244C (fr) 1999-01-13 2013-10-08 Bayer Corporation Diphenyle urees a substitution .omega.-carboxy aryle en tant qu'inhibiteurs de la kinase p38
US8124630B2 (en) 1999-01-13 2012-02-28 Bayer Healthcare Llc ω-carboxyaryl substituted diphenyl ureas as raf kinase inhibitors
US6290478B1 (en) * 1999-07-16 2001-09-18 Scroll Technologies Eccentric back chamber seals for scroll compressor
WO2003068229A1 (fr) 2002-02-11 2003-08-21 Bayer Pharmaceuticals Corporation N-oxydes de pyridine, de quinoline, et d'isoquinoline en tant qu'inhibiteurs de kinase
DK1478358T3 (da) 2002-02-11 2013-10-07 Bayer Healthcare Llc Sorafenibtosylat til behandling af sygdomme kendetegnet ved unormal angiogenese
PT1626714E (pt) 2003-05-20 2007-08-24 Bayer Pharmaceuticals Corp Diarilureias para doenças mediadas por pdgfr
ES2297490T3 (es) 2003-07-23 2008-05-01 Bayer Pharmaceuticals Corporation Omega-carboxiarildifenilurea fluoro sustituida para el tratamiento y prevencion de enfermadades y afecciones.

Also Published As

Publication number Publication date
IE912889A1 (en) 1992-02-26
GB9017892D0 (en) 1990-09-26
WO1992003413A1 (fr) 1992-03-05
IL99174A0 (en) 1992-07-15
PT98684A (pt) 1992-07-31
ZA916412B (en) 1992-04-29
JPH06500095A (ja) 1994-01-06
AU8411591A (en) 1992-03-17
EP0543891A1 (fr) 1993-06-02

Similar Documents

Publication Publication Date Title
US6096747A (en) Phenylaminocarbonyl derivatives and processes for their preparation
AU695507B2 (en) Metalloproteinase inhibitors
US4146631A (en) Benzamide derivatives
CA2051693C (fr) Modificateurs de l'hemoglobine allosteriques
AU702603B2 (en) 2,6-diaryl pyridazinones with immunosuppressant activity
AU652088B2 (en) Chemical compounds
IL109431A (en) Pharmaceutical compositions containing n-acyl sulfamic acid esters (or thioesters), n-acyl sulfonamides, and n-sulfonyl carbamic acid esters (or thioesters), for regulating plasma cholesterol concentration, and certain such novel compounds
AU7729696A (en) Biphenyl hydroxamate inhibitors of matrix metalloproteinases
CA2089165A1 (fr) Derives diphenyluree
US6093744A (en) N-acyl sulfamic acid esters useful as hypocholesterolemic agents
SK123993A3 (en) N,n-disubstituted arylcycloalkylamides, their salts, process for their preparation and their pharmaceutical agents
US3625987A (en) Cyano carbamoyloximes
US5159114A (en) Acat inhibitory benzanilides
US4499105A (en) Carboxyimidamide derivatives
EP0806412B1 (fr) Derives du benzene
IE58166B1 (en) Benzamides and their salts
US4985595A (en) Aminobenzamide derivatives
CA2089151A1 (fr) Derives benzamide
EP0041256A1 (fr) Dérivés de l'hexahydroisoindole, procédé de préparation et herbicides les contenant
US4382954A (en) Fungicidal N-1-substituted cyclopropyl-N-acyl-2,6-dialkylaniline
EP0365210A1 (fr) Dérivés de l'acide hydroxamique
CA2089166A1 (fr) Derives benzanilide et leur utilisation comme agents anti-antherosclerotiques
US5760087A (en) Glycylanilide derivatives, their preparation and their application in therapy
US4376731A (en) 1-Aziridine carboxylic acid derivatives with immunostimulant activity
Purchase et al. Inhibitors of acyl-CoA: cholesterol acyltransferase: novel trisubstituted ureas as hypocholesterolemic agents

Legal Events

Date Code Title Description
FZDE Discontinued