CA2088491A1 - Derives de substitution en 4 de n-hydrocarbylpiperidines; preparation et utilisation comme agents de blocage du calcium - Google Patents
Derives de substitution en 4 de n-hydrocarbylpiperidines; preparation et utilisation comme agents de blocage du calciumInfo
- Publication number
- CA2088491A1 CA2088491A1 CA002088491A CA2088491A CA2088491A1 CA 2088491 A1 CA2088491 A1 CA 2088491A1 CA 002088491 A CA002088491 A CA 002088491A CA 2088491 A CA2088491 A CA 2088491A CA 2088491 A1 CA2088491 A1 CA 2088491A1
- Authority
- CA
- Canada
- Prior art keywords
- compound
- ethyl
- pentylpiperidine
- phenyl
- title compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/10—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms
- C07D211/14—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
- C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/44—Oxygen atoms attached in position 4
- C07D211/46—Oxygen atoms attached in position 4 having a hydrogen atom as the second substituent in position 4
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pain & Pain Management (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Hydrogenated Pyridines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB9017224.8 | 1990-08-06 | ||
GB909017224A GB9017224D0 (en) | 1990-08-06 | 1990-08-06 | Compounds |
GB919107757A GB9107757D0 (en) | 1991-04-12 | 1991-04-12 | Compounds |
GB9107757.8 | 1991-04-12 | ||
PCT/GB1991/001340 WO1992002502A1 (fr) | 1990-08-06 | 1991-08-05 | Piperidines a substitution n-hydrocarbyle en position 4, leur preparation et leur utilisation comme agents de blocage du calcium |
Publications (1)
Publication Number | Publication Date |
---|---|
CA2088491A1 true CA2088491A1 (fr) | 1992-02-07 |
Family
ID=26297463
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002088491A Abandoned CA2088491A1 (fr) | 1990-08-06 | 1991-08-05 | Derives de substitution en 4 de n-hydrocarbylpiperidines; preparation et utilisation comme agents de blocage du calcium |
Country Status (15)
Country | Link |
---|---|
EP (1) | EP0542846A1 (fr) |
JP (1) | JPH06500093A (fr) |
KR (1) | KR930701402A (fr) |
CN (1) | CN1061963A (fr) |
AP (1) | AP279A (fr) |
AU (1) | AU8327191A (fr) |
CA (1) | CA2088491A1 (fr) |
IE (1) | IE912759A1 (fr) |
IL (1) | IL99073A0 (fr) |
MA (1) | MA22250A1 (fr) |
MX (1) | MX9100513A (fr) |
NZ (1) | NZ239268A (fr) |
PT (1) | PT98574A (fr) |
TW (1) | TW267164B (fr) |
WO (1) | WO1992002502A1 (fr) |
Families Citing this family (37)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5109002A (en) * | 1989-09-08 | 1992-04-28 | Du Pont Merck Pharmaceutical Company | Antipsychotic 1-cycloalkylpiperidines |
CZ283619B6 (cs) * | 1991-09-12 | 1998-05-13 | Smithkline Beecham P.L.C | Použití derivátů kyseliny benzoové pro výrobu farmaceutických prostředků, deriváty kyseliny benzoo vé, způsob jejich výroby a farmaceutické prostředky s jejich obsahem |
WO1993015052A1 (fr) * | 1992-01-28 | 1993-08-05 | Smithkline Beecham Plc | Composes utilises comme antagonistes des canaux calciques |
CA2110251A1 (fr) | 1992-11-30 | 1994-05-31 | Koichi Fujimoto | Derives de diarylalcane alpha-omega, leur preparation et leur utilisation dans le traitement et la prevention des maladies circulatoires et de la psychose |
GB9226111D0 (en) * | 1992-12-15 | 1993-02-10 | Smithkline Beecham Plc | Madicaments |
GB9314973D0 (en) * | 1993-07-20 | 1993-09-01 | Smithkline Beecham Plc | Medicaments |
GB9319534D0 (en) * | 1993-09-22 | 1993-11-10 | Boots Co Plc | Therapeutic agents |
WO1995024390A1 (fr) * | 1994-03-11 | 1995-09-14 | Smithkline Beecham Plc | Nouvelles piperidines substituees par phenyl(-alkyl/alkoxy)-1-aminoalkyle et pyrolidines utilisees comme antagonistes des canaux calciques |
GB9411052D0 (en) * | 1994-06-02 | 1994-07-20 | Smithkline Beecham Plc | Medicaments |
GB9411045D0 (en) * | 1994-06-02 | 1994-07-20 | Smithkline Beecham Plc | Compounds and use |
US5892047A (en) * | 1994-12-21 | 1999-04-06 | Neurosearch A/S | Process for the preparation of substituted 4-ethyl-piperidines and an intermediate for the preparation of same |
AUPN037195A0 (en) * | 1995-01-03 | 1995-01-27 | Australian Nuclear Science & Technology Organisation | Piperidine-based sigma receptor ligands |
JP3064425B2 (ja) * | 1995-09-15 | 2000-07-12 | ノイロサーチ アクティーゼルスカブ | カルシウムチャンネル・ブロッカーとしてのピペリジン化合物 |
FR2742051B1 (fr) * | 1995-12-06 | 1998-02-06 | Synthelabo | Utilisation de composes ayant une affinite pour le site de liaison du (3h)ifenprodil pour la fabrication de medicaments utiles dans la prevention et le traitement des neuropathies |
ZA9610738B (en) | 1995-12-22 | 1997-06-24 | Warner Lambert Co | Subtype selective nmda receptor ligands and the use thereof |
ZA9610745B (en) * | 1995-12-22 | 1997-06-24 | Warner Lambert Co | 4-Subsituted piperidine analogs and their use as subtype selective nmda receptor antagonists |
ZA9610741B (en) | 1995-12-22 | 1997-06-24 | Warner Lambert Co | 4-Substituted piperidine analogs and their use as subtype selective nmda receptor antagonists |
ZA9610736B (en) * | 1995-12-22 | 1997-06-27 | Warner Lambert Co | 2-Substituted piperidine analogs and their use as subtypeselective nmda receptor antagonists |
AU713236B2 (en) * | 1996-02-15 | 1999-11-25 | Sankyo Company Limited | Diarly alkane derivatives containing an alicyclic group, their preparation and their theraputic and prophylactic uses |
WO1998006396A1 (fr) * | 1996-08-12 | 1998-02-19 | Merck & Co., Inc. | Inhibiteurs de la thrombine |
US6251919B1 (en) | 1998-02-27 | 2001-06-26 | Warner-Lambert | Heterocyclic substituted aniline calcium channel blockers |
US6166052A (en) * | 1998-03-11 | 2000-12-26 | Warner-Lambert Company | Heteroaryl alkyl alpha substituted peptidylamine calcium channel blockers |
US6011035A (en) * | 1998-06-30 | 2000-01-04 | Neuromed Technologies Inc. | Calcium channel blockers |
JP4932994B2 (ja) * | 1999-04-07 | 2012-05-16 | ユニバーシテイ・オブ・バージニア・パテント・フアウンデーシヨン | 抗癌性カルシウムチャンネル遮断薬 |
GB9917406D0 (en) | 1999-07-23 | 1999-09-22 | Smithkline Beecham Plc | Compounds |
EP1318988A2 (fr) | 2000-09-11 | 2003-06-18 | Sepracor, Inc. | Ligands pour les recepteurs de monoamine et transporteurs, et procedes d'utilisation de ces derniers (neurotransmission) |
US7294637B2 (en) | 2000-09-11 | 2007-11-13 | Sepracor, Inc. | Method of treating addiction or dependence using a ligand for a monamine receptor or transporter |
SE0103818D0 (sv) | 2001-11-15 | 2001-11-15 | Astrazeneca Ab | Chemical compounds |
SE0203828D0 (sv) * | 2002-12-20 | 2002-12-20 | Astrazeneca Ab | Chemical compounds |
AR042628A1 (es) * | 2002-12-20 | 2005-06-29 | Astrazeneca Ab | Derivados de piperidina como moduladores del receptor ccr5 |
SE0301369D0 (sv) | 2003-05-09 | 2003-05-09 | Astrazeneca Ab | Chemical compounds |
DK1641775T3 (da) | 2003-07-03 | 2009-04-20 | Euro Celtique Sa | 2-pyridinalkynderivater, der er anvendelige til behandling af smerter |
TW200610761A (en) | 2004-04-23 | 2006-04-01 | Astrazeneca Ab | Chemical compounds |
SE0401656D0 (sv) * | 2004-06-24 | 2004-06-24 | Astrazeneca Ab | Chemical compounds |
FR2872416B1 (fr) | 2004-07-01 | 2006-09-22 | Oreal | Utilisation de derives de piperidine pour lutter contre les rides |
NZ567629A (en) | 2005-09-23 | 2011-08-26 | Ms Science Corp | Piperazine derivatives useful in the treatment of discorders of the central nervous system |
ES2355607T3 (es) | 2006-01-27 | 2011-03-29 | M's Science Corporation | Derivados de piperidina y piperazina. |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4031221A (en) * | 1974-06-17 | 1977-06-21 | American Hoechst Corporation | Method of treating pain and hypertension |
EP0077427B1 (fr) * | 1981-10-15 | 1985-05-22 | Synthelabo | Dérivés de pipéridine, leur procédé de préparation et leur application en thérapeutique |
US4546105A (en) * | 1984-09-04 | 1985-10-08 | Hoechst-Roussel Pharmaceuticals Inc. | Pyrrolylaminopiperidines, compositions thereof and methods of use |
DE3441929A1 (de) * | 1984-11-16 | 1986-05-28 | Basf Ag, 6700 Ludwigshafen | Verfahren zur herstellung von substituierten piperidinen |
DE3529994A1 (de) * | 1985-08-22 | 1987-02-26 | Hoechst Ag | Indolinonderivate, verfahren zu ihrer herstellung, sie enthaltende arzneimittel und deren verwendung |
DK623586A (da) * | 1985-12-27 | 1987-06-28 | Eisai Co Ltd | Piperidinderivater eller salte deraf og farmaceutiske kompositioner indeholdende forbindelserne |
MY104343A (en) * | 1987-11-23 | 1994-03-31 | Janssen Pharmaceutica Nv | Novel pyridizinamine deravatives |
FR2636946B1 (fr) * | 1988-09-23 | 1990-11-02 | Lipha | ((diarylmethoxy)alcoyl)-1 pyrrolidines et piperidines, procedes de preparation et medicaments les contenant |
WO1990006303A1 (fr) * | 1988-12-02 | 1990-06-14 | Pfizer Inc. | Derives arylpiperidine |
-
1991
- 1991-08-02 MX MX9100513A patent/MX9100513A/es unknown
- 1991-08-02 IE IE275991A patent/IE912759A1/en unknown
- 1991-08-04 IL IL99073A patent/IL99073A0/xx unknown
- 1991-08-05 PT PT98574A patent/PT98574A/pt not_active Application Discontinuation
- 1991-08-05 EP EP91914558A patent/EP0542846A1/fr not_active Withdrawn
- 1991-08-05 AU AU83271/91A patent/AU8327191A/en not_active Abandoned
- 1991-08-05 TW TW080106121A patent/TW267164B/zh active
- 1991-08-05 JP JP3513952A patent/JPH06500093A/ja active Pending
- 1991-08-05 MA MA22529A patent/MA22250A1/fr unknown
- 1991-08-05 WO PCT/GB1991/001340 patent/WO1992002502A1/fr not_active Application Discontinuation
- 1991-08-05 CN CN91105945A patent/CN1061963A/zh active Pending
- 1991-08-05 CA CA002088491A patent/CA2088491A1/fr not_active Abandoned
- 1991-08-05 KR KR1019930700352A patent/KR930701402A/ko not_active Application Discontinuation
- 1991-08-05 NZ NZ239268A patent/NZ239268A/xx unknown
- 1991-08-06 AP APAP/P/1991/000313A patent/AP279A/en active
Also Published As
Publication number | Publication date |
---|---|
MX9100513A (es) | 1992-04-01 |
IE912759A1 (en) | 1992-02-12 |
AU8327191A (en) | 1992-03-02 |
KR930701402A (ko) | 1993-06-11 |
EP0542846A1 (fr) | 1993-05-26 |
IL99073A0 (en) | 1992-07-15 |
PT98574A (pt) | 1992-06-30 |
MA22250A1 (fr) | 1992-04-01 |
JPH06500093A (ja) | 1994-01-06 |
WO1992002502A1 (fr) | 1992-02-20 |
TW267164B (fr) | 1996-01-01 |
AP279A (en) | 1993-08-01 |
AP9100313A0 (en) | 1991-10-31 |
NZ239268A (en) | 1994-06-27 |
CN1061963A (zh) | 1992-06-17 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FZDE | Discontinued |