US4546105A - Pyrrolylaminopiperidines, compositions thereof and methods of use - Google Patents
Pyrrolylaminopiperidines, compositions thereof and methods of use Download PDFInfo
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- US4546105A US4546105A US06/647,309 US64730984A US4546105A US 4546105 A US4546105 A US 4546105A US 64730984 A US64730984 A US 64730984A US 4546105 A US4546105 A US 4546105A
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- pyrrol
- piperidin
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
Definitions
- the compounds of the present invention have the general formula ##STR3## where R is hydrogen, loweralkyl, Arloweralkyl, cycloalkylloweralkyl, loweralkanoyl and thienylloweralkyl; R 1 is hydrogen, loweralkyl, loweralkylcarbonyl, loweralkoxycarbonyl, loweralkylthiocarbonyl ##STR4## cyano, loweralkylaminocarbonyl, diloweralkylaminocarbonyl, cycloalkylcarbonyl, cycloalkylloweralkylcarbonyl and loweralkenylcarbonyl; R 2 is hydrogen, halogen and --CH 3 ; and the pharmaceutically acceptable salts thereof.
- Particularly preferred compounds of the invention are those of Compound I where R is phenylethyl; R 1 is loweralkoxycarbonyl, loweralkylcarbonyl and cyano; and R 2 is hydrogen.
- lower means the group it is describing contains 1 to 6 carbon atoms.
- alkyl refers to a straight or branched chain hydrocarbon containing no unsaturation, e.g. methyl, ethyl, propyl, tertiary-butyl, isopropyl, etc.
- Arloweralkyl refers to a monovalent substituent which consists of an aryl group, e.g.
- phenyl, p-nitrophenyl, o-toluyl, m-methoxyphenyl, etc. linked through a lower alkylene group having its free valence bond from a carbon of the lower alkylene group and having a formula of ##STR5## where Z is hydrogen, halogen, CF 3 , NO 2 , NH 2 , loweralkyl, and loweralkoxy.
- alkylene refers to a bivalent radical of the lower branched or unbranched alkyl group it is derived from having valence bonds from two terminal carbons thereof, e.g., ethylene (--CH 2 CH 2 --), propylene (--CH 2 CH 2 CH 2 --), isopropylene ##STR6## etc.
- alkoxy refers to a monovalent substituent which consists of an alkyl group linked through an ether oxygen having its free valence bond from the ether oxygen, e.g. methoxy, ethoxy, isopropoxy, butoxy, etc.
- halogen refers to a member of the family consisting of fluorine, chlorine, bromine and iodine.
- cycloalkylloweralkyl refers to a monovalent substituent consisting of a saturated hydrocarbon group possessing at least one carbocyclic ring of 3 to 7 carbon atoms, e.g. cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cycloheptyl, etc., linked through a lower alkyl group.
- alkenyl refers to a straight or branched chain hydrocarbon containing one unsaturated or double bond, e.g. CH 2 ⁇ CH--, ##STR7## etc.
- thienylloweralkyl means ##STR8##
- a substituted 1-aminopyrrole of the formula ##STR9## is selected.
- Compound II is typically prepared in the manner described in Flitsch et al., Chem. Ber. 102, 3268-3276 (1969) which describes the preparation of 1-aminopyrrole and substituted 1-aminopyrroles.
- Compound II is condensed with Compound III having the formula ##STR10## by heating at 80° to 120° C. for 2 to 24 hours in the presence of an inert solvent, e.g. benzene, toluene, cyclohexane, etc., followed by reduction with an agent such as sodium borohydride in a solvent such as isopropanol at 60°-80° to form a condensation product of the invention having the formula ##STR11##
- an inert solvent e.g. benzene, toluene, cyclohexane, etc.
- Compound IV is reacted under conventional substitution reaction conditions, typically in the presence of a polar solvent, e.g. dimethylformamide, dichloromethane, chloroform, etc. a base, such as for example K 2 CO 3 , Na 2 CO 3 , NaHCO 3 , etc., at a temperature of 25° to 60° C.
- a polar solvent e.g. dimethylformamide, dichloromethane, chloroform, etc.
- a base such as for example K 2 CO 3 , Na 2 CO 3 , NaHCO 3 , etc.
- Compound IV is reacted with an isocyanate compound of the formula R 5 --N ⁇ C ⁇ O (X) where R 5 is (C 1 -C 6 ) alkyl to form a compound of the invention having the formula ##STR18##
- a nonpolar solvent e.g. benzene, toluene, xylene, etc.
- Compound XI in turn can be further N-substituted in a conventional manner of alkylation, such as for example by treatment of the sodium salt thereof (from sodium metal or sodium hydride) with an alkyl iodide, e.g. methyliodide, or dimethylsulfate.
- Compounds of the present invention are useful as analgesic agents due to their ability to alleviate pain in mammals.
- the activity of the compounds is demonstrated in the 2-phenyl-1,4-benzoquinone-induced writhing test in mice, a standard assay for analgesia [Proc. Soc. Exptl. Biol. Med. 95, 729 (1957)].
- analgesic activity of some of the compounds expressed in a dosage of the compounds which exhibit either (a) a 50% effective dose inhibition (ED 50 ) or (b) a percent inhibition is given in Table I.
- Effective amounts of the compounds of the present invention may be administered to a subject by one of various methods, for example, orally as in capsules or tablets, parenterally in the form of sterile solutions or suspensions, and in some cases intravenously in the form of sterile solutions.
- the compounds of the invention while effective themselves, may be formulated and administered in the form of their pharmaceutically acceptable acid addition salts for purposes of stability, convenience of crystallization, increased solubility and the like.
- Preferred pharmaceutically acceptable acid addition salts include those derived from inorganic acids such as hydrochloric, hydrobromic, sulfuric, nitric, phosphoric, perchloric acids and the like as well as organic acids such as tartaric, citric, succinic, maleic, fumaric acids and the like.
- the compounds of the present invention may be administered orally, for example, with an inert diluent or with an edible carrier. They may be enclosed in gelatin capsules or compressed into tablets.
- the compounds may be incorporated with excipients and used in the form of tablets, troches, capsules, elixirs, suspensions, syrups, wafers, chewing gums and the like.
- These preparations should contain at least 4% of the pyrrolylaminopiperidines and related compounds of the invention, the active ingredient, but may be varied depending upon the particular form and may conveniently be between 4% to about 70% of the weight of the unit.
- the amount of the compound present in such compositions is such that a suitable dosage will be obtained.
- Preferred compositions and preparations according to the present invention are prepared so that an oral dosage unit form contains between 5.0-300 milligrams of the pyrrolylaminopiperidines and related compounds of the invention.
- the tablets, pills, capsules, troches and the like may also contain the following adjuvants: a binder such as microcrystalline cellulose, gum tragacanth or gelatin; an excipient such as starch or lactose, a disintegrating agent such as alginic acid, Primogel, corn starch and the like; a lubricant such as magnesium stearate or Sterotex; a glidant such as colloidal silicon dioxide; and a sweetening agent such as sucrose or saccharin may be added or a flavoring agent such as peppermint, methyl salicylate or orange flavoring.
- a binder such as microcrystalline cellulose, gum tragacanth or gelatin
- an excipient such as starch or lactose, a disintegrating agent such as alginic acid, Primogel, corn starch and the like
- a lubricant such as magnesium stearate or Sterotex
- a glidant such as colloidal silicon dioxide
- dosage unit forms may contain other various materials which modify the physical form of the dosage unit, for example, as coatings.
- tablets or pills may be coated with sugar, shellac, or other enteric coating agents.
- a syrup may contain, in addition to the present compounds, sucrose as a sweetening agent and certain preservatives, dyes and colorings and flavors. Materials used in preparing these various compositions should be pharmaceutically pure and non-toxic in the amounts used.
- the compounds of the present invention may be incorporated into a solution or suspension. These preparations should contain at least 0.1% of the pyrrolylaminopiperidines and related compounds of the invention, but may be varied to be between 0.1 and about 50% of the weight thereof. The amount of the inventive compound present in such compositions is such that a suitable dosage will be obtained. Preferred compositions and preparations according to the present invention are prepared so that a parenteral dosage unit contains between 5.0 to 100 milligrams of the pyrrolylaminopiperidine and related compounds of the invention.
- the solutions or suspensions may also include the following adjuvants: a sterile diluent such as water for injection, saline solution, fixed oils, polyethylene glycols, glycerine, propylene glycol or other synthetic solvents; antibacterial agents such as benzyl alcohol or methyl paraben; antioxidants such as ascorbic acid or sodium bisulfite; chelating agents such as ethylene diaminetetraacetic acid, buffers such as acetates, citrates or phosphates and agents for the adjustment of tonicity such as sodium chloride or dextrose.
- a sterile diluent such as water for injection, saline solution, fixed oils, polyethylene glycols, glycerine, propylene glycol or other synthetic solvents
- antibacterial agents such as benzyl alcohol or methyl paraben
- antioxidants such as ascorbic acid or sodium bisulfite
- chelating agents such as ethylene diaminetetraacetic acid, buffers such
- the oxalate was formed by adding ethereal oxalic acid but did not crystallize.
- the resultant oil was basified, extracted with dichloromethane and dried to give 3.2 g of an oil. This oil was chromatographed on a high pressure liquid chromatograph (HPLC) using 11/2% diethylamine in acetonitrile.
- HPLC high pressure liquid chromatograph
- the resultant 1.5 g of free base was converted to the maleate (1.9 g) by adding ethereal maleic acid and recrystallized from absolute ethanol/ether to give 1.8 g, m.p. 146°-147° C. of N-(1-methylpiperidin-4-yl)-N-(1H-pyrrol-1-yl)propanamide maleate.
- the oil was dissolved in 100 ml of isopropyl alcohol and 25 ml of methanol. To the solution was added NaBH 4 (2.6 g, 68 mmole) and the resultant mixture was refluxed for 2 hours. The mixture was cooled, evaporated with ethyl acetate/ether. The organic extract was washed with water, dried, filtered and evaporated to yield 12 g of an oil. The oil was purified by high pressure liquid chromatography (silica, 1% ethanol/ethylacetate) to give 9.6 g (94%) of an oil of 1-[2-(4-chlorophenyl)ethyl]-4-(1H-pyrrol-1-yl)aminopiperidine which solidified at room temperature upon standing.
- This oil was purified by HPLC (silica gel, ethyl acetate) to give 3.3 g (62%) of an oil. This oil was distilled to give 2.3 g (43%) of N-[1-(n-butyl)piperidin-4-yl]-N-(1H-pyrrol-1-yl)carbamic acid ethyl ester (b.p. 130°-140° C. @ 0.2 mm; m.p. 42°-43° C.).
- This oil was purified by HPLC (silica, 20% ethyl acetate in dichloromethane) to give 3.4 g (78%) of an oil.
- This oil was converted to the maleate salt as in Example 1 and recrystallized from isopropanol-ether to give 4 g (64%) of N-[1-(n-butyl)piperidin-4-yl]-N-(1H-pyrrol-1-yl)-propanamide maleate, mp 131°-132° C.
- This oil was purified by HPLC (silica gel, 20% ethyl acetate in dichloromethane) to give 4 g (67%) of an oil.
- This oil was converted to the hydrochloride salt as in Example 2 and was recrystallized from isopropanol to give 4.3 g (63%) of N- ⁇ 1-[2-(2-thienyl)ethyl]piperidin-4-yl ⁇ -N-(1H-pyrrol-1-yl)propanamide hydrochloride, d 276°-277° C.
- This solid was purified by HPLC (silica gel, 20% ethyl acetate in dichloromethane) to give 4 g (64%) of a solid mp 104°-106° C.
- This material was converted to the hydrochloride salt as in Example 2 and was recrystallized from isopropanol to give 4 g (57%) of N- ⁇ 1-[2-(2-thienyl)ethyl]piperidin-4-yl ⁇ -N-(1H-pyrrol- 1yl)carbamic acid ethyl ester hydrochloride, d 212°-213° C.
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Abstract
This invention relates to pyrrolylaminopiperidines and related compounds of the formula ##STR1## where R is hydrogen, loweralkyl, Arloweralkyl, cycloalkylloweralkyl, loweralkenyl and thienylloweralkyl; R1 loweralkyl, hydrogen, loweralkylcarbonyl, loweralkoxycarbonyl, loweralkylthiocarbonyl of the formula ##STR2## cyano, loweralkylaminocarbonyl, diloweralkylaminocarbonyl, cycloalkylcarbonyl, cycloalkylloweralkylcarbonyl and loweralkenylcarbonyl; R2 is hydrogen, halogen and methyl; and the pharmaceutically acceptable acid addition salts thereof.
Description
To the best of our knowledge the compounds of the present invention have not heretofore been described or suggested.
The compounds of the present invention have the general formula ##STR3## where R is hydrogen, loweralkyl, Arloweralkyl, cycloalkylloweralkyl, loweralkanoyl and thienylloweralkyl; R1 is hydrogen, loweralkyl, loweralkylcarbonyl, loweralkoxycarbonyl, loweralkylthiocarbonyl ##STR4## cyano, loweralkylaminocarbonyl, diloweralkylaminocarbonyl, cycloalkylcarbonyl, cycloalkylloweralkylcarbonyl and loweralkenylcarbonyl; R2 is hydrogen, halogen and --CH3 ; and the pharmaceutically acceptable salts thereof.
Particularly preferred compounds of the invention are those of Compound I where R is phenylethyl; R1 is loweralkoxycarbonyl, loweralkylcarbonyl and cyano; and R2 is hydrogen.
In the above definitions and as used hereinafter, the term "lower" means the group it is describing contains 1 to 6 carbon atoms. The term "alkyl" refers to a straight or branched chain hydrocarbon containing no unsaturation, e.g. methyl, ethyl, propyl, tertiary-butyl, isopropyl, etc. The term "Arloweralkyl" refers to a monovalent substituent which consists of an aryl group, e.g. phenyl, p-nitrophenyl, o-toluyl, m-methoxyphenyl, etc., linked through a lower alkylene group having its free valence bond from a carbon of the lower alkylene group and having a formula of ##STR5## where Z is hydrogen, halogen, CF3, NO2, NH2, loweralkyl, and loweralkoxy. The term "alkylene" refers to a bivalent radical of the lower branched or unbranched alkyl group it is derived from having valence bonds from two terminal carbons thereof, e.g., ethylene (--CH2 CH2 --), propylene (--CH2 CH2 CH2 --), isopropylene ##STR6## etc. The term "alkoxy" refers to a monovalent substituent which consists of an alkyl group linked through an ether oxygen having its free valence bond from the ether oxygen, e.g. methoxy, ethoxy, isopropoxy, butoxy, etc. The term "halogen" refers to a member of the family consisting of fluorine, chlorine, bromine and iodine. The term "cycloalkylloweralkyl" refers to a monovalent substituent consisting of a saturated hydrocarbon group possessing at least one carbocyclic ring of 3 to 7 carbon atoms, e.g. cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cycloheptyl, etc., linked through a lower alkyl group. The term "alkenyl" refers to a straight or branched chain hydrocarbon containing one unsaturated or double bond, e.g. CH2 ═CH--, ##STR7## etc. The term "thienylloweralkyl" means ##STR8##
The compounds of the present invention are prepared in the following manner. The substituents R, R1 and R2 are as defined above unless indicated otherwise.
A substituted 1-aminopyrrole of the formula ##STR9## is selected. Compound II is typically prepared in the manner described in Flitsch et al., Chem. Ber. 102, 3268-3276 (1969) which describes the preparation of 1-aminopyrrole and substituted 1-aminopyrroles.
Compound II is condensed with Compound III having the formula ##STR10## by heating at 80° to 120° C. for 2 to 24 hours in the presence of an inert solvent, e.g. benzene, toluene, cyclohexane, etc., followed by reduction with an agent such as sodium borohydride in a solvent such as isopropanol at 60°-80° to form a condensation product of the invention having the formula ##STR11##
Compound IV is reacted under conventional substitution reaction conditions, typically in the presence of a polar solvent, e.g. dimethylformamide, dichloromethane, chloroform, etc. a base, such as for example K2 CO3, Na2 CO3, NaHCO3, etc., at a temperature of 25° to 60° C. for 2 to 24 hours, with an acid halide having the formula ##STR12## where Hal is a halogen and R3 is loweralkyl of 1 to 5 carbon atoms [(C1 -C5)-alkyl], cycloalkyl and loweralkenyl of 1 to 5 carbon atoms [(C1 -C5)-alkenyl] to form a compound of the invention having a formula ##STR13## The carbonyl group of compound V in turn can be reduced in a conventional manner, e.g. with borane-tetrahydrofuran complex at a temperature of -30° C. to 0° C. for a time of 1 minute to 60 minutes, with zinc amalgam in hydrochloric acid, hydrogen in the presence of a catalyst, such as Pd, etc., to provide Compound I, where R1 is loweralkyl of 1 to 6 carbon atoms, when R3 is (C1 -C5) alkyl or (C1 -C5) alkenyl; or to provide Compound I where R1 is loweralkylcycloalkyl when R3 is cycloalkyl. Compound V, where R3 is (C1 -C5) alkyl, is reacted in the manner reported in Bull. Soc. Chim. Belg. 87, (3), 229-238 (1978) with p-methoxyphenylthionophosphine sulfide dimer to form a compound of the invention having the formula ##STR14##
Compound IV is reacted under conventional substitution reaction conditions with a halocyanide of the formula Hal-CN, where Hal is a halogen, e.g. Br, to form a compound of the invention having the formula ##STR15## Typically the reaction is carried out in a polar solvent, e.g. dimethylformamide, chloroform, dichloromethane, etc. at a temperature of 25° to 60° C. for 2 to 24 hours.
Compound IV is reacted, under conventional substitution reaction conditions, in a polar solvent at 25° to 60° C. for 2 to 24 hours with a haloformate ester of the formula ##STR16## where Hal is a halogen and R4 is a (C1 -C6) alkyl to form a compound of the invention having the formula ##STR17##
Compound IV is reacted with an isocyanate compound of the formula R5 --N═C═O (X) where R5 is (C1 -C6) alkyl to form a compound of the invention having the formula ##STR18## Typically this reaction is carried out in a nonpolar solvent, e.g. benzene, toluene, xylene, etc., at a temperature of 50° to 80° C. for 4 to 24 hours. Compound XI in turn can be further N-substituted in a conventional manner of alkylation, such as for example by treatment of the sodium salt thereof (from sodium metal or sodium hydride) with an alkyl iodide, e.g. methyliodide, or dimethylsulfate.
Compounds of the present invention are useful as analgesic agents due to their ability to alleviate pain in mammals. The activity of the compounds is demonstrated in the 2-phenyl-1,4-benzoquinone-induced writhing test in mice, a standard assay for analgesia [Proc. Soc. Exptl. Biol. Med. 95, 729 (1957)].
The analgesic activity of some of the compounds expressed in a dosage of the compounds which exhibit either (a) a 50% effective dose inhibition (ED50) or (b) a percent inhibition is given in Table I.
TABLE I
__________________________________________________________________________
(ED.sub.50)
(ED.sub.50)
Subcutaneous
Oral Dose Sub-
Dose in
in Mg/kg cutaneous
Mg/kg of
of Body
% Dose
Compound Body Weight
Weight
(Decrease)
(Mg/kg)
__________________________________________________________________________
N--[1-(2-phenethyl)
0.35 1.4 -- --
piperidin-4-yl]-
N--(1H--pyrrol-1-yl)
propanamide
hydrochloride
N--[1-(2-phenethyl)
1.2 9.5 -- --
piperidin-4-yl)]-
N--(1H--pyrrol-1-yl)-
acetamide
hydrochloride
N--[1-(2-phenethyl)
2.4 5.6 -- --
piperidin-4-yl]-
N--(1H--pyrrol-1-yl)
carbamic acid
ethyl ester
hydrochloride
N--[1-(2-phenethyl)
0.65 7.7 -- --
piperidin-4-yl]-N--
(1H--pyrrol-1-yl)
carbamic acid methyl
ester hydrochloride
N--[1-(2-phenethyl)
2.4 -- -- --
piperidin-4-yl]-
N--(1H--pyrrol-1-yl)
cyanamide
hydrochloride
N--{1-[2-(4- -- -- 76 40
chlorophenyl)ethyl]
piperidin-4-yl}-N--
(1H--pyrrol-1-yl)
propanamide
N--[1-(n-butyl)
-- -- 20 20
piperidin-4-yl]-N--
(1H--pyrrol-1-yl)
carbamic acid ethyl
ester
N--[1-(n-butyl)
-- -- 45 10
piperidin-4-yl]-
N--(1H--pyrrol-1-yl)
propanamide
maleate
1-(2-phenethyl)-
-- -- 49 10
4-(1H--pyrrol-1-yl)
aminopiperidine
maleate
N--{1-[2-(4-methoxy-
-- -- 27 10
phenyl)ethyl]piperidin-
4-yl}-N--(1H--pyrrol-1-yl)
propanamide
N--{1-[2-(4-methoxy-
-- -- 51 10
phenyl)ethyl]piperidin-
4-yl}-N--(1H--pyrrol-
1-yl)cyanamide
hydrochloride
1-(2-phenethyl)-4-
-- -- 53 10
[N--(n-propyl)-N--(1H--
pyrrol-1-yl)]amino-
piperidine oxalate
N--[1-(2-phenyl-
-- -- 30 10
propyl)-piperidin-
4-yl]-N--(1H--pyrrol-
1-yl)propanamide
hydrochloride
N--[1-(2-phenyl-
-- -- 42 10
propyl)piperidin-4-
yl]-N--(1H--pyrrol-1-
yl)carbamic acid
ethyl ester
N--[1-(2-phenethyl)
-- -- 100 10
piperidin-4-yl]-N--
(1H--pyrrol-1-yl)
acrylamide
hydrochloride
N--[1-(2-phenethyl)
-- -- 100 10
piperidin-4-yl]-N--
(1H--pyrrol-1-yl)-N'--
methylurea
hydrochloride
N--[1-(2-phenethyl)
-- -- 65 10
piperidin-4-yl]-N--
(1H--pyrrol-1-yl)
cyclobutanecarboxylic
acid amide
hydrochloride
N--{1-[2-(2-thienyl)
-- -- 54 10
ethyl]piperidin-4-
yl}-N--(1H--pyrrol-1-
yl)carbamic acid
ethyl ester
hydrochloride
N--[1-(2-phenethyl)
-- -- 99 10
piperidin-4-yl]-
N--(1H--pyrrol-1-yl)
propanethioamide
hydrochloride
__________________________________________________________________________
Effective amounts of the compounds of the present invention may be administered to a subject by one of various methods, for example, orally as in capsules or tablets, parenterally in the form of sterile solutions or suspensions, and in some cases intravenously in the form of sterile solutions. The compounds of the invention, while effective themselves, may be formulated and administered in the form of their pharmaceutically acceptable acid addition salts for purposes of stability, convenience of crystallization, increased solubility and the like.
Preferred pharmaceutically acceptable acid addition salts include those derived from inorganic acids such as hydrochloric, hydrobromic, sulfuric, nitric, phosphoric, perchloric acids and the like as well as organic acids such as tartaric, citric, succinic, maleic, fumaric acids and the like.
The compounds of the present invention may be administered orally, for example, with an inert diluent or with an edible carrier. They may be enclosed in gelatin capsules or compressed into tablets. For the purpose of oral therapeutic administration, the compounds may be incorporated with excipients and used in the form of tablets, troches, capsules, elixirs, suspensions, syrups, wafers, chewing gums and the like. These preparations should contain at least 4% of the pyrrolylaminopiperidines and related compounds of the invention, the active ingredient, but may be varied depending upon the particular form and may conveniently be between 4% to about 70% of the weight of the unit. The amount of the compound present in such compositions is such that a suitable dosage will be obtained. Preferred compositions and preparations according to the present invention are prepared so that an oral dosage unit form contains between 5.0-300 milligrams of the pyrrolylaminopiperidines and related compounds of the invention.
The tablets, pills, capsules, troches and the like may also contain the following adjuvants: a binder such as microcrystalline cellulose, gum tragacanth or gelatin; an excipient such as starch or lactose, a disintegrating agent such as alginic acid, Primogel, corn starch and the like; a lubricant such as magnesium stearate or Sterotex; a glidant such as colloidal silicon dioxide; and a sweetening agent such as sucrose or saccharin may be added or a flavoring agent such as peppermint, methyl salicylate or orange flavoring. When the dosage unit form is a capsule, it may contain, in addition to material of the above type, a liquid carrier such as a fatty oil. Other dosage unit forms may contain other various materials which modify the physical form of the dosage unit, for example, as coatings. Thus, tablets or pills may be coated with sugar, shellac, or other enteric coating agents. A syrup may contain, in addition to the present compounds, sucrose as a sweetening agent and certain preservatives, dyes and colorings and flavors. Materials used in preparing these various compositions should be pharmaceutically pure and non-toxic in the amounts used.
For the purpose of parenteral therapeutic administration, the compounds of the present invention may be incorporated into a solution or suspension. These preparations should contain at least 0.1% of the pyrrolylaminopiperidines and related compounds of the invention, but may be varied to be between 0.1 and about 50% of the weight thereof. The amount of the inventive compound present in such compositions is such that a suitable dosage will be obtained. Preferred compositions and preparations according to the present invention are prepared so that a parenteral dosage unit contains between 5.0 to 100 milligrams of the pyrrolylaminopiperidine and related compounds of the invention.
The solutions or suspensions may also include the following adjuvants: a sterile diluent such as water for injection, saline solution, fixed oils, polyethylene glycols, glycerine, propylene glycol or other synthetic solvents; antibacterial agents such as benzyl alcohol or methyl paraben; antioxidants such as ascorbic acid or sodium bisulfite; chelating agents such as ethylene diaminetetraacetic acid, buffers such as acetates, citrates or phosphates and agents for the adjustment of tonicity such as sodium chloride or dextrose. The parenteral preparations can be enclosed in ampules, disposable syringes or multiple dose vials made of glass or plastic.
The following examples are for illustrative purposes and are not to be construed as limiting the invention disclosed herein. All temperatures are given in degrees centigrade unless indicated otherwise.
A solution of 1-aminopyrrole (4.2 g, 0.05 mol) and 1-methyl-4-piperidone (6.9 g, 0.06 mol) in cyclohexane was refluxed overnight (about 16 hours) over 4 Å molecular sieves. After 3 hours, an additional 1 g of 1-methyl-4-piperidone was added. The molecular sieves were filtered off and the cyclohexane removed by evaporation under reduced pressure. The resulting oil was dissolved in isopropanol and 5 g of sodium borohydride added. The mixture was stirred at reflux for three hours, then methanol was added, the heat was removed, and stirring continued until the mixture had cooled to room temperature. The solvent was removed by evaporation under reduced pressure to give a residue to which water was added. This mixture was extracted with dichloromethane, the dichloromethane solution was dried with saturated sodium chloride solution and magnesium sulfate, and the dichloromethane evaporated in vacuo to give 7 g (78%) of 1-methyl-4-(1H-pyrrol-1-yl)aminopiperidine. To a cooled solution of 1-methyl-4-(1H-pyrrol-1-yl)aminopiperidine (5.4 g, 0.03 mol) and triethylamine (3.35 g, 0.033 mol) in CHCl3 (100 ml) was added dropwise a solution of propionyl chloride (3.07 g, 0.033 mol) in CHCl3 (100 ml). The reaction mixture was stirred at ice bath temperature for one hour, then at room temperature overnight (about 16 hours). The chloroform solution was washed with water, dried with saturated sodium chloride and magnesium sulfate, and the chloroform removed to give 4.8 g of an oil. The oxalate was formed by adding ethereal oxalic acid but did not crystallize. The resultant oil was basified, extracted with dichloromethane and dried to give 3.2 g of an oil. This oil was chromatographed on a high pressure liquid chromatograph (HPLC) using 11/2% diethylamine in acetonitrile. The resultant 1.5 g of free base was converted to the maleate (1.9 g) by adding ethereal maleic acid and recrystallized from absolute ethanol/ether to give 1.8 g, m.p. 146°-147° C. of N-(1-methylpiperidin-4-yl)-N-(1H-pyrrol-1-yl)propanamide maleate. The recovered starting material was reacted again with propionyl chloride (0.7 g) in CH2 Cl2 (20 ml) with sodium bicarbonate (1 g) at room temperature overnight. Work-up gave an oil which was dissolved in ether, and an ether solution of maleic acid added to give the maleate salt. Recrystallization from absolute ethanol/ether gave an additional 1.5 g of product of N-(1-methylpiperidin-4-yl)-N-(1H-pyrrol-1-yl)propanamide maleate, mp 146°-147° C., combined yield 3.3 g (9.39 mmole), 31.3% yield from 1-methyl-4-(1H-pyrrol-1-yl)aminopiperidine.
ANALYSIS: Calculated for C13 H21 N3 O.C4 H4 O4 : 58.09%C; 7.18%H; 11.96%N; Found: 58.29%C; 7.02%H; 12.05%N.
A solution of 1-aminopyrrole (6 g, 73 mmole) and 1-(2-phenethyl)-4-piperidone (16 g, 80 mmole) in 250 ml benzene was stirred six hours at reflux. The reaction mixture was cooled, filtered and evaporated to 20 g of an oil. This oil was dissolved in 200 ml isopropanol and 50 ml methanol and stirred two hours at reflux with NaBH4 (6 g, 0.16 mole). The reaction mixture was cooled and evaporated to a semi-solid which was stirred with water and extracted with ether. The organic extract was washed with water, saturated NaCl and was dried (anhydrous MgSO4), filtered and evaporated to 20 g of an oil. This oil was purified by HPLC to give 17 g (86%) of an oil comprising 1-(2-phenethyl)-4-(1H-pyrrol-1-yl)aminopiperidine. To a solution of 1-(2-phenethyl)-4-(1H-pyrrol-1-yl)aminopiperidine (4.5 g, 17 mmole) in 150 ml dichloromethane containing sodium bicarbonate (2.8 g, 33 mmoles) was added a solution of propionyl chloride (1.8 g, 10 mmole) in 10 ml dichloromethane. After stirring two days at ambient temperature, the reaction mixture was evaporated to an oil that was stirred with water and extracted with ethyl acetate. The organic extract was washed with water and saturated NaCl and was dried (anhydrous MgSO4), filtered and evaporated to 5.4 g of an oil. This oil was converted to the hydrochloride salt by adding ethereal hydrogen chloride and recrystallized from isopropanol/methanol to give 5.1 g (84%) of N-[1-(2-phenethyl)-piperidin-4-yl]-N-(1H-pyrrol-1-yl)propanamide hydrochloride, d 270° C.
ANALYSIS: Calculated for C20 H27 N3 O.HCl: 66.37%C; 7.80%H; 11.61%N; Found: 66.53%C; 7.80%H; 11.58%N;
To a solution of 1-(2-phenethyl)-4-(1H-pyrrol-1-yl)aminopiperidine of Example 11 (4.5 g, 17 mmole) in 200 ml dichloromethane containing sodium bicarbonate (2.8 g, 33 mmole) was added a solution of acetyl chloride (1.5 g, 19 mmole) in 20 ml dichloromethane. After stirring twenty hours at ambient temperature, the mixture was evaporated to a solid that was stirred with water and extracted with ethyl acetate-ether. The organic extract was washed with water and saturated NaCl and was dried (anhydrous MgSO4), filtered and evaporated to 5.4 g of a solid. This material was converted to the hydrochloride as in Example 2 and recrystallized from isopropanol-methanol to give 4.8 g (83%) of N-[1-(2-phenethyl)piperidin-4-yl]-N-(1H-pyrrol-1-yl)acetamide hydrochloride, d 278° C.
ANALYSIS: Calculated for C19 H25 N3 O.HCl: 65.59%C; 7.53%H; 12.08%N; Found: 65.42%C; 7.48%H; 12.00%N.
To a solution of 1-(2-phenethyl)-4-(1H-pyrrol-1-yl)aminopiperidine of Example 11 (4.1 g. 15 mmole) in 150 ml dichloromethane containing sodium bicarbonate (2.6 g, 30 mmole) was added a solution of ethyl chloroformate (1.9 g, 18 mmole) in 20 ml dichloromethane. After stirring twenty hours at ambient temperature, the mixture was evaporated to a solid that was stirred with water and extracted with ethyl acetate-ether. The organic extract was washed with water and saturated NaCl and was dried (anhydrous MgSO4), filtered and evaporated to 5.2 g of a solid. 3.5 g of the solid was converted to the hydrochloride salt as in Example 2 then recrystallized from isopropanol to give 2.6 g (67%) of N-[1-(2-phenethyl)piperidin-4-yl]-N-(1H-pyrrol-1-yl)carbamic acid ethyl ester hydrochloride.
ANALYSIS: Calculated for C20 H27 N3 O2.HCl: 63.55%C; 7.47%H; 11.12%N; Found: 63.93%C; 7.58%H; 11.32%N.
To a solution of 1-(2-phenethyl)-4-(1H-pyrrol-1-yl)aminopiperidine of Example 11 (4 g, 15 mmole) in 150 ml dichloromethane containing sodium bicarbonate (2.5 g, 30 mmole) was added a solution of methyl chloroformate (1.6 g, 17 mmole) in 20 ml dichloromethane. After stirring twenty hours at ambient temperature, the reaction mixture was evaporated, stirred with water and extracted with ethyl acetate-ether. The organic extract was washed with water, saturated NaCl and was dried (anhydrous MgSO4), filtered and evaporated to an oil (4.7 g) that was purified by HPLC (silica gel, ethyl acetate/hexane/diethylamine-50/50/1) to give 3.7 g (76%) of a solid. This solid was converted to the hydrochloride salt as in Example 2 and recrystallized from isopropanol to give 3.6 g (67%) of N-[1-(2-phenethyl)-piperidin-4-yl]-N-(1H-pyrrol-1-yl)-carbamic acid methyl ester hydrochloride, d 222°-223° C.
ANALYSIS: Calculated for C19 H25 N3 O2.HCl: 62.71%C; 7.20%H; 11.55%N; Found: 62.46%C; 7.35%H; 11.45%N.
To a solution of 1-(2-phenethyl)-4-(1H-pyrrol-1-yl)aminopiperidine of Example 11, (4 g, 15 mmole) in 150 ml dichloromethane containing 2.5 g (30 mmole) sodium bicarbonate was slowly added a solution of cyanogen bromide (1.8 g, 17 mmole) in 25 ml dichloromethane. After stirring twenty hours at ambient temperature, the reaction mixture was evaporated, stirred with water and extracted into ethyl acetate-ether. The organic extract was washed with water, saturated NaCl and was dried (anhydrous MgSO4), filtered and evaporated to 5 g of an oil. This oil was converted to the hydrochloride salt as in Example 2 and recrystallized twice from isopropanol to give 2.7 g (55%) of N-[1-(2-phenethyl)-piperidin-4-yl]-N-(1H-pyrrol-1-yl)cyanamide hydrochloride, d 211°-212° C.
ANALYSIS: Calculated for C18 H22 N4.HCl: 65.34%C; 7.01%H; 16.94%N; Found: 65.04%C; 6.94%H; 17.06%N.
A mixture of 1-[2-(4-chlorophenyl)ethyl]-4-piperidone (8 g, 33.6 mmole) and 1-aminopyrrole (2.7 g, 33.6 mmole) in 100 ml of benzene was stirred at reflux for 6 hours. An additional 0.5 g of 1-aminopyrrole was added and reflux was continued for 2 hours whereafter an additional 0.5 g of 1-aminopyrrole was added and refluxing was continued overnight (about 16 hours). An additional 0.5 g of 1-aminopyrrole was added followed by refluxing for 6 hours. The resultant mixture was evaporated to yield 13 g of an oil. The oil was dissolved in 100 ml of isopropyl alcohol and 25 ml of methanol. To the solution was added NaBH4 (2.6 g, 68 mmole) and the resultant mixture was refluxed for 2 hours. The mixture was cooled, evaporated with ethyl acetate/ether. The organic extract was washed with water, dried, filtered and evaporated to yield 12 g of an oil. The oil was purified by high pressure liquid chromatography (silica, 1% ethanol/ethylacetate) to give 9.6 g (94%) of an oil of 1-[2-(4-chlorophenyl)ethyl]-4-(1H-pyrrol-1-yl)aminopiperidine which solidified at room temperature upon standing.
To a solution of 1-[2-(4-chlorophenyl)ethyl]-4-(1H-pyrrol-1-yl)aminopiperidine of Example 7a, (3.6 g, 12 mmole) in 100 ml dichloromethane containing sodium bicarbonate (2.5 g, 30 mmole) was added a solution of ethyl chloroformate (1.6 g, 15 mmole) in 20 ml of dichloromethane. The reaction mixture was stirred three hours at ambient temperature, then was evaporated, stirred with water and extracted with ethyl acetate-ether. The organic extracts were washed with water, saturated NaCl and were dried (anhydrous MgSO4), filtered and evaporated to 4 g of an oil. This oil was purified by HPLC (silica gel; dichloromethane/ethyl acetate/diethylamine:100/20/1) to give 3.4 g of a solid. This material was converted to the hydrochloride salt as in Example 2 and recrystallized from isopropanol to give 2.8 g (58%) of N-{1-[2-(4-chlorophenyl)ethyl]piperidin-4-yl}-N-(1H-pyrrol-1-yl)carbamic acid ethyl ester hydrochloride, d 253°-254° C.
ANALYSIS: Calculated for C20 H26 ClN3 O2.HCL: 58.25%C; 6.60%H; 10.19%N; Found: 58.44%C; 6.58%H; 10.28%N.
To a solution of 1-[2-(4-chlorophenyl)ethyl]-4-(1H-pyrrol-1-yl)aminopiperidine of Example 7a, (5 g, 16 mmole) in 150 ml dichloromethane containing sodium bicarbonate (3 g, 36 mmole) was added a solution of propionyl chloride (1.7 g, 18 mmole) in 20 ml dichloromethane. After stirring four hours at ambient temperature, the reaction mixture was washed with water, saturated sodium chloride and was dried (anhydrous MgSO4), filtered and evaporated to give 6 g of a solid. This material was purified by HPLC (silica gel, 20% ethyl acetate/dichloromethane) to give 3.6 g (61%) of a solid, mp 80°-85° C. This was recrystallized from isopropyl ether/petroleum ether (1:1) to give 2.5 g (42%) of N-{1-[2-(4-chlorophenyl)ethyl]piperidin-4-yl}-N-(1H-pyrrol-1-yl)propanamide, mp 85°-86° C.
ANALYSIS: Calculated for C20 H26 ClN3 O: 66.74%C; 7.28%H; 11.68%N; Found: 66.54%C; 7.11%H; 12.00%N.
A solution of 1-butyl-4-piperidone (6.2 g, 40 mmole) and 1-aminopyrrole (3.3 g, 40 mmole) in 100 ml of toluene was stirred at reflux overnight (about 16 hours). The mixture was cooled and then evaporated to an oil, which in turn was dissolved in 75 ml of isopropanol, and 22 ml of ethanol. To the solution was added NaBH4 (3.8 g, 100 mole). The mixture was stirred at 70° C. for 2 hours and then evaporated, stirred with water and extracted with ethyl acetate-ether. The organic extract was washed with water and saturated NaCl solution, dried (anhydrous MgSO4), filtered and evaporated to 13 g of an oil. This oil was purified by high pressure liquid chromatography (silica, 1% diethylamine/ethyl acetate) to give 8.2 g of an oil of 1-(n-butyl)-4-(1H-pyrrol-1-yl)aminopiperidine.
To a solution of 1-(n-butyl)-4-(1H-pyrrol-1-yl)aminopiperidine of Example 9a, (4 g, 18 mmole) in 100 ml dichloromethane containing sodium bicarbonate (3 g, 36 mmole) was added a solution of ethyl chloroformate (2.3 g, 20 mmole) in 20 ml dichloromethane. After stirring three hours at ambient temperature the reaction mixture was evaporated, stirred with water and extracted with ethyl acetate. The organic extract was washed with water and saturated NaCl and was dried (anhydrous MgSO4), filtered and evaporated to give 4.8 g of an oil. This oil was purified by HPLC (silica gel, ethyl acetate) to give 3.3 g (62%) of an oil. This oil was distilled to give 2.3 g (43%) of N-[1-(n-butyl)piperidin-4-yl]-N-(1H-pyrrol-1-yl)carbamic acid ethyl ester (b.p. 130°-140° C. @ 0.2 mm; m.p. 42°-43° C.).
ANALYSIS: Calculated for C16 H27 N3 O2 : 65.49%C; 9.28%H; 14.32%N; Found: 65.26%C; 9.04%H; 14.05%N.
To a solution of 1-(n-butyl)-4-(1H-pyrrol-1-yl)aminopiperidine of Example 9a, (3.5 g, 16 mmole) in 150 ml dichloromethane containing sodium bicarbonate (4 g, 48 mmole) was added a solution of propionyl chloride (1.6 g, 17 mmole) in 25 ml dichloromethane. After stirring five hours at ambient temperature, the reaction mixture was evaporated, stirred with water and extracted with ether. The organic extract was washed with water, saturated NaCl and was dried (anhydrous MgSO4), filtered and evaporated to 4 g of an oil. This oil was purified by HPLC (silica, 20% ethyl acetate in dichloromethane) to give 3.4 g (78%) of an oil. This oil was converted to the maleate salt as in Example 1 and recrystallized from isopropanol-ether to give 4 g (64%) of N-[1-(n-butyl)piperidin-4-yl]-N-(1H-pyrrol-1-yl)-propanamide maleate, mp 131°-132° C.
ANALYSIS: Calculated for C16 H27 N3 O.C4 H4 O4 : 61.05%C; 7.94%H; 10.68%N; Found: 61.14%C; 7.91%H; 10.66%N.
A mixture of 1-(β-phenethyl)-4-piperidone (12.4 g, 61 mmole) and 1-aminopyrrole (5 g, 61 mmole) in 100 ml benzene was stirred seven hours at reflux. After cooling, the mixture was evaporated, dissolved in 100 ml isopropanol and 25 ml methanol, and to this solution was added sodium borohydride (4.6 g, 121 mmole). The mixture stirred two hours at 70° C. then was cooled, evaporated, stirred with water and extracted into ethyl acetate-ether. The organic extract was washed with water, saturated NaCl and was dried (anhydrous MgSO4), filtered and evaporated to 17 g of an oil. This oil was purified by HPLC (silica, ethyl acetate) to give 14 g (85%) of a solid, mp 45°-47° C. Two grams of this material was converted to the maleate salt as in Example 1 and recrystallized from isopropanol-ether to give 2.5 g of 1-(2-phenethyl)-4-(1H-pyrrol-1-yl)aminopiperidine maleate, mp 147°-148° C.
ANALYSIS: Calculated for C17 H23 N3.C4 H4 O4 : 65.43%C; 7.06%H; 10.90%N; Found: 65.29%C; 7.07%H; 10.88%N.
A solution of 1-[2-(4-methoxyphenyl)ethyl]-4-piperidone (15 g, 64 mmole) and 1-aminopyrrole (6 g, 73 mmole) in 125 ml of benzene was stirred at 120° C. for 20 hours. The resultant solution was evaporated, dissolved in 125 ml of isopropanol and 50 ml of methanol and then NaBH4 (6 g, 158 mmole) was added. The resultant mixture was stirred 3 hours at 75° C., cooled, evaporated, stirred with water and then extracted with ethyl acetate-ether. The organic extract was washed with water and saturated NaCl solution, dried, (anhydrous MgSO4), filtered and evaporated to 19.7 g of an oil. This oil was purified by high pressure liquid chromatography (silica, 3% methanol/dichloromethane) to give 14.7 g (76.6%) of a solid. 0.5 g of this solid was recrystallized from isopropyl ether to give 0.1 g of 1-[2-(4-methoxyphenyl)ethyl]-4-(1H-pyrrol-1-yl)aminopiperidine.
ANALYSIS: Calculated for C18 H25 N3 O: 72.20%C; 8.42%H; 14.04%N; Found: 72.51%C; 8.40%H; 14.10%N;
To a solution of 1-[2-(4-methoxyphenyl)ethyl]-4-(1H-pyrrol-1-yl)aminopiperidine of Example 12a, (3.6 g, 12 mmole) in 100 ml dichloromethane containing sodium bicarbonate (2 g, 24 mmole) was added a solution of propionyl chloride (1.1 g, 12 mmole) in 20 ml dichloromethane. After stirring two hours at ambient temperature, the reaction mixture was evaporated, stirred with water and extracted into ethyl acetate-ether. The organic extract was washed with water and saturated NaCl and was dried (anhydrous MgSO4), filtered and evaporated to give 4 g of a solid. This material was recrystallized from isopropyl etherpetroleum ether (1:1) to give 2.8 g (65%) of N-{1-[2-(4-methoxyphenyl)ethyl]piperidin-4-yl}-N-(1H-pyrrol-1-yl)propanamide, mp 83°-84° C.
ANALYSIS: Calculated for C21 H29 N3 O2 : 70.95%C; 8.22%H; 11.82%N; Found: 70.98%C; 8.24%H; 11.76%N.
To a solution of 1-[2-(4-methoxyphenyl)ethyl]-4-ethyl-4-(1H-pyrrol-1-yl)aminopiperidine of Example 12a (4 g, 13.4 mmole) in 150 ml dichloromethane containing sodium bicarbonate (3.4 g, 40 mmole) was added a solution of cyanogen bromide (1.6 g, 14.7 mmole) in 25 ml dichloromethane. After stirring twenty hours at ambient temperature, the reaction mixture was evaporated, stirred with water and extracted with ether. The organic extract was washed with water and saturated NaCl and was dried (anhydrous MgSO4), filtered and evaporated to 5 g of an oil. The oil was converted to the hydrochloride salt as in Example 2 and was recrystallized from isopropanol-ether to give 2.8 g (58%) of N-{1-[2-(4-methoxyphenyl)ethyl]piperidin-4-yl}-N-(1H-pyrrol-1-yl)cyanamide hydrochloride, d 227°-229° C.
ANALYSIS: Calculated for C19 H24 N4 O.HCl: 63.23%C; 6.98%H; 15.53%N; Found: 63.17%C; 6.92%H; 15.42%N.
To a solution of borane-tetrahydrofuran (THF) complex (0.97M in THF, 86 mmole, 86 ml), cooled with an ice bath, was slowly added a solution of N-[1-(2-phenethyl)piperidin-4-yl]-N-(1H-pyrrol-1-yl)propanamide of Example 2, (7 g, 22 mmole) in 25 ml tetrahydrofuran. After stirring three hours at ambient temperature the reaction mixture was cooled and excess borane was quenched by slow addition of 3N HCl. The mixture was then basified with sodium carbonate and the oil which separated was extracted with ethyl acetate-ether. The organic extract was washed with water and saturated NaCl and was dried (anhydrous MgSO4), filtered and evaporated to give 8 g of a solid, mp 121°-123° C. A mixture of this solid in 175 ml 3N HCl was stirred three hours at 105° C., then was cooled, diluted with water and basified with sodium carbonate. The oil which separated was extracted with ethyl-acetate ether. The organic extract was washed with water, saturated NaCl and was dried (anhydrous MgSO4), filtered and evaporated to give 7 g of an oil. This oil was purified by HPLC (silica, ethyl acetate) to give 5 g (75%) of an oil. This oil was converted to the oxalate salt as in Example 1 and was recrystallized from isopropanol to give 5.5 g (64%) of 1-(2-phenethyl)-4-[N-(n-propyl)-N-(1H-pyrrol-1-yl)]aminopiperidine oxalate, d 188°-190° C.
ANALYSIS: Calculated for C20 H29 N3.C2 H2 O4 : 65.81%C; 7.78%H; 10.47%N; Found: 65.88%C; 7.71%H; 10.36%N.
A solution of 1-aminopyrrole (6 g, 73.1 mmole) and 1-(2-phenylpropyl)-4-piperidone (13.8 g, 63.5 mmole) in 100 ml of benzene was stirred at reflux for 3 hours. The resultant mixture was evaporated, dissolved in 100 ml of isopropanol and 25 ml of ethanol and to the resultant solution was added NaBH4 (4.8 g, 0.13 mole). The resultant mixture was stirred 2 hours at 70° C. and then kept at room temperature for 3 days. The mixture was evaporated, stirred with water and extracted with ether. The organic extract was washed with water and saturated NaCl solution and was dried (anhydrous MgSO4), filtered and evaporated to 18 g of an oil. This oil was purified by high pressure liquid chromatography (silica, 3% methanol/dichloromethane) to give 14 g (77.8%) of an oil which on cooling yielded a solid of 1-(2-phenylpropyl)-4-(1H-pyrrol-1-yl)aminopiperidine, m.p. 72°-74° C.
To a solution of 1-(2-phenylpropyl)-4-(1H-pyrrol-1-yl)aminopiperidine of Example 15a, (3.5 g, 12.3 mmole) in 100 ml dichloromethane containing sodium bicarbonate (3.1 g, 37 mmole) was added a solution of propionyl chloride (1.3 g, 13.6 mmole) in 20 ml dichloromethane. After stirring six hours at ambient temperature the reaction mixture was evaporated, stirred with water and extracted into ether. The organic extract was washed with water, saturated sodium chloride and was dried (anhydrous MgSO4), filtered and evaporated to give 5 g of an oil. This oil was converted to the hydrochloride salt as in Example 2 and was recrystallized from isopropanol-ether to give 4.1 g (89%) of N-[1-(2-phenylpropyl)piperidin-4-yl]-N-(1H-pyrrol-1-yl)propanamide hydrochloride, d 258°-259° C.
ANALYSIS: Calculated for C21 H29 N3 O.HCl: 67.09%C; 8.04%H; 11.18%N; Found: 67.14%C; 7.98%H; 11.15%N.
To a solution of 1-(2-phenylpropyl)-4-(1H-pyrrol-1-yl)aminopiperidine of Example 15a (3.5 g, 13.2 mmole) in 100 ml dichloromethane containing sodium bicarbonate (4 g, 48 mmole) was added a solution of ethyl chloroformate (1.6 g, 15 mmole) in 20 ml dichloromethane. After stirring twenty hours at ambient temperature, the reaction mixture was evaporated, stirred with water and extracted into ether. The organic extract was washed with water, saturated NaCl and was dried (anhydrous MgSO4), filtered and evaporated to give 4.5 g of an oil. The oil was purified by HPLC (silica gel, ethyl acetate) to give 3.6 g (82%) of an oil. This oil was converted to the hydrochloride salt as in Example 2 then recrystallized from isopropanol-ether to give 3.1 g (64%) of N-[1-(2-phenylpropyl)piperidin-4-yl]-N-(1H-pyrrol-1-yl)carbamic acid ethyl ester hydrochloride
ANALYSIS: Calculated for C21 H29 N3 O2.HCl: 64.35%C; 7.72%H; 10.72%N; Found: 64.26%C; 7.76%H; 10.54%N.
To a solution of 1-(2-phenethyl)-4-(1H-pyrrol-1-yl) aminopiperidine of Example 11 (5 g, 10 mmole) in 150 ml dichloromethane containing sodium bicarbonate (3 g, 36 mmole) was added a solution of butyl chloroformate (2.8 g, 20 mmole) in 20 ml dichloromethane. After stirring twenty hours at ambient temperature, the reaction mixture was evaporated, stirred with water and extracted with ether. The organic extract was washed with water and saturated sodium chloride and was dried (anhydrous MgSO4), filtered and evaporated to give 7 g of an oil. This oil was purified by HPLC (silica gel, 10% ethyl acetate in dichloromethane) to give 5.2 g (75%) of a solid mp 60° C. This material was converted to the hydrochloride salt as in Example 2 and was recrystallized from isopropanol-ether to give 3.2 g (42%) of N-[1-(2-phenethyl)piperidin-4-yl]-N-(1H-pyrrol-1-yl)carbamic acid-(n-butyl)-ester hydrochloride, d 216°-217° C.
ANALYSIS: Calculated for C22 H31 N3 O2.HCl: 65.09%C; 7.95%H; 10.35%N; Found: 65.37%C; 7.96%H; 10.38%N.
To a solution of 1-(2-phenethyl)-4-(1H-pyrrol-1-yl)aminopiperidine of Example 11 (4 g, b 14.8 mmole) in 150 ml dichloromethane containing sodium bicarbonate (4 g, 48 mmole) was added a solution of acryloyl chloride (1.5 g, 17 mmole) in 20 ml dichloromethane. After stirring twenty hours at ambient temperature the reaction mixture was evaporated, stirred with water and extracted with ethyl acetate-ether. The organic extract was washed with water and saturated sodium chloride and was dried (anhydrous MgSO4), filtered and evaporated to 4.8 g of a solid. This material was purified by HPLC (silica gel, 20% ethyl acetate in dichloromethane) to give 3.3 g (69%) of a solid. This material was converted to the hydrochloride salt as in Example 2 and was recrystallized from isopropanol to give 3.2 g (60%) of N-[1-(2-phenethyl)piperidin-4-yl]-N-(1H-pyrrol-1-yl)acrylamide hydrochloride, d 278°-279° C.
ANALYSIS: Calculated for C20 H25 N3 O.HCl: 66.74%C; 7.28%H; 11.68%N; Found: 66.64%C; 7.28%H; 11.76%N.
A solution of 1-(2-phenethyl)-4-(1H-pyrrol-1-yl)aminopiperidine of Example 11 (3.5 g, 13 mmole) and methyl isocyanate (0.8 g, 14 mmole) in 125 ml benzene was stirred at 50° C. for four hours, then was cooled and evaporated to a solid. This material was dissolved in warm isopropanol and converted to the hydrochloride salt as in Example 2. Upon cooling, the product precipitated and was collected to give 3.6 g (76%) of a solid, d 250°-251° C. This material was again recrystallized from isopropanol to give 3.2 g (68%) of N-[1-(2-phenethyl)piperidin-4-yl]-N-(1H-pyrrol-1-yl)-N'-methylurea hydrochloride, d 252°-253° C.
ANALYSIS: Calculated for C19 H26 N4 O.HCl: 62.88%C; 7.50%H; 15.44%N; Found: 62.99%C; 7.55%H; 15.31%N.
A solution of 1-(2-thienylethyl)-4-piperidone (24.6 g, 0.12 mole) and 1-aminopyrrole (12 g, 0.15 mole) in 200 ml of benzene was stirred at reflux for 4 hours. The resultant mixture was cooled and evaporated to an oil which in turn was dissolved in 200 ml of isopropanol and 50 ml of methanol. To the resultant solution was added NaBH4 (9.1 g, 0.24 mole). The mixture was stirred at 80° C. for 2 hours, cooled, evaporated, stirred with water and then extracted with ethyl acetate-ether. The organic extract was washed twice with water and saturated NaCl solution and was dried (anhydrous MgSO4), filtered and evaporated to 33 g of an oil of 1-[2-(2-thienyl)ethyl]-4-(1H-pyrrol-1-yl)aminopiperidine.
To a solution of 1-[2-(2-thienyl)ethyl]-4-(1H-pyrrol-1-yl)aminopiperidine of Example 20a (5 g, 18 mmole) in 150 ml dichloromethane containing sodium bicarbonate (5 g, 60 mmole) was added a solution of propionyl chloride (2 g, 22 mmole) in 20 ml dichloromethane. After stirring two hours at ambient temperature, the reaction mixture was evaporated, stirred with water and extracted into ethyl acetate-ether. The organic extract was washed with water and saturated sodium chloride and was dried (anhydrous MgSO4), filtered and evaporated to give 6.2 g of an oil. This oil was purified by HPLC (silica gel, 20% ethyl acetate in dichloromethane) to give 4 g (67%) of an oil. This oil was converted to the hydrochloride salt as in Example 2 and was recrystallized from isopropanol to give 4.3 g (63%) of N-{1-[2-(2-thienyl)ethyl]piperidin-4-yl}-N-(1H-pyrrol-1-yl)propanamide hydrochloride, d 276°-277° C.
ANALYSIS: Calculated for C18 H25 N3 OS.HCl: 58.75%C; 7.12 %H; 11.42%N; Found: 58.82%C; 7.15%H; 11.17%N.
To a solution of 1-(2-phenethyl)-4-(1H-pyrrol-1-yl)aminopiperidine of Example 11 (4.4 g, 16 mmole) in 150 ml dichloromethane containing sodium bicarbonate (5 g, 60 mmole) was added a solution of cyclobutanecarboxylic acid chloride (2.1 g, 18 mmole) in 25 ml dichloromethane. After stirring twenty hours at ambient temperature, the reaction mixture was evaporated, stirred with water and extracted with ether. The organic extract was washed with water and saturated sodium chloride and was dried (anhydrous MgSO4), filtered and evaporated to 6.5 g of a solid. This material was purified by HPLC (silica gel, 25% ethyl acetate in dichloromethane) to give 5.2 g (91%) of a solid mp 103°-105° C. This material was converted to the hydrochloride salt as in Example 2 in warm isopropanol and, upon cooling, yielded 5.0 g (79%) of N-[1-(2-phenethyl)piperidin-4-yl]-N-(1H-pyrrol-1-yl)cyclobutanecarboxylic acid amide hydrochloride, d 264°- 265° C.
ANALYSIS: Calculated for C22 H29 N3 O.HCl: 68.11%C; 7.79%H; 10.83%N; Found: 68.24%C; 7.68%H; 10.78%N.
To a solution of 1-[2-(2-thienyl)ethyl]-4-(1H-pyrrol-1-yl)aminopiperidine of Example 20a (5 g, 18 mmole) in 150 ml dichloromethane containing sodium bicarbonate (5 g, 60 mmole) was added a solution of ethyl chloroformate (2.4 g, 22 mmole) in 20 ml dichloromethane. After stirring twenty hours at ambient temperature, the reaction mixture was evaporated, stirred with water and extracted with ethyl acetate-ether. The organic extract was washed with water and saturated sodium chloride and was dried (anhydrous MgSO4), filtered and evaporated to give 6.3 g of a solid. This solid was purified by HPLC (silica gel, 20% ethyl acetate in dichloromethane) to give 4 g (64%) of a solid mp 104°-106° C. This material was converted to the hydrochloride salt as in Example 2 and was recrystallized from isopropanol to give 4 g (57%) of N-{1-[2-(2-thienyl)ethyl]piperidin-4-yl}-N-(1H-pyrrol- 1yl)carbamic acid ethyl ester hydrochloride, d 212°-213° C.
ANALYSIS: Calculated for C18 H25 N3 O2 S.HCl: 56.31%C; 6.83%H; 10.95%N; Found: 56.22%C; 6.85%H; 10.86%N.
A mixture of N-[1-(2-phenethyl)piperidin-4-yl]-N-(1H-pyrrol-1-yl)propanamide of Example 2 (4.2 g, 13 mmole) and p-methoxyphenylthionophosphine sulfide dimer (2.2 g, 6.5 mmole) in 25 ml dioxane was stirred at 70° C. for two hours then was cooled, stirred with 500 ml water and was extracted with ethyl acetate. The organic extract was washed with water and saturated NaCl and was dried (anhydrous MgSO4), filtered and evaporated to 6 g of an oil. This oil was converted to the hydrochloride salt as in Example 2 and was recrystallized from isopropanol to give 2.1 g (43%) N-[1-(2-phenethyl)piperidin-4-yl]-N-(1H-pyrrol-1-yl)propanethioamide hydrochloride, d 252°-253° C.
ANALYSIS: Calculated for C20 H27 N3 S.HCl: 63.55%C; 7.47%H; 11.12%N; Found: 63.65%C; 7.39%H; 11.01%N.
To a solution of 1-(2-phenethyl)-4-(1H-pyrrol-1-yl)aminopiperidine (4 g, 15 mmole) in 150 ml of dichloromethane containing sodium bicarbonate (4 g, 48 mmole), was added a solution of cyclopropanecarboxylic acid chloride (1.8 g, 17 mmole) in 20 ml of dichloromethane. After stirring for two hours at ambient temperature, the reaction mixture was washed with water and saturated sodium chloride solution, dried over anhydrous magnesium sulfate, filtered and evaporated. The residue was purified by high performance liquid chromatography (silica gel, 20% ethyl acetate in dichloromethane) to give 3.3 g (66%) of product. The product was dissolved in 100 ml of warm isopropanol and converted to the hydrochloride salt, mp 282° C. dec.
ANALYSIS: Calculated for C21 H27 N3 O.HCl: 67.45%C; 7.55%H; 11.24%N; Found: 67.44%C; 7.45%H; 11.04%N.
To a solution of 1-(2-phenethyl)-4-(2-methyl-1H-pyrrol-1-yl)aminopiperidine (4 g, 14.1 mmole) in 125 ml of dichlormethane containing sodium bicarbonate (5 g, 60 mmole), was added a solution of ethyl chloroformate (1.8 g, 16.6 mmole) in 25 ml of dichloromethane. After stirring five hours at ambient temperature, the reaction mixture was washed with water, dried over anhydrous magnesium sulfate, filtered and evaporated. The residue was purified by high performance liquid chromatography (silica gel, 20% ethyl acetate in dichloromethane) to give 3 g (60%) of product, mp 489°-50° C. The product was dissolved in 75 ml of warm isopropanol and converted to the hydrochloride salt. The salt, which crystallized upon dilution with ether, had a mp of 212°-214° C., dec.
ANALYSIS: Calculated for C21 H29 N3 O2.HCl: 64.35%C; 7.72%H; 10.72%N; Found: 64.48%C; 7.66%H; 10.56%N.
To a solution of N-[1-(2-phenethyl)piperidin-4-yl]-N-(1H-pyrrol-1-yl)acetamide (3.5 g, 11.2 mmole) in 25 ml of dioxane was added 4-methoxyphenylthionophosphine sulfide dimer (1.9 g, 5.6 mmole). The reaction mixture was stirred at 80° C. for two hours, cooled, stirred with water and extracted with ethyl acetate. The organic extract was washed with water and saturated sodium chloride solution, dried over anhydrous magnesium sulfate, filtered and evaporated. The residue was dissolved in ethyl acetate and converted to the hydrochloride salt. The salt was collected and rebasified with sodium carbonate solution to give a solid. The solid was purified by high performance liquid chromatography (silica gel, 10% ethyl acetate in dichloromethane) to give 2.8 g (76%) of product, mp 120°-122° C. The product was dissolved in 100 ml of warm isopropanol and converted to the hydrochloride salt, mp 268°-270° C.
ANALYSIS: Calculated for C19 H25 N3 S.HCl: 62.70%C; 7.20%H; 11.55%N; Found: 62.89%C; 7.16%H; 11.43%N.
To a solution of 1-(2-phenethyl)-4-(2-methyl-1H-pyrrol-1-yl)aminopiperidine (5 g, 17.6 mmole) in 125 ml of dichloromethane containing sodium bicarbonate (5 g, 60 mmole), was added a solution of acetyl chloride (1.7 g, 21.6 mmole) in 25 ml of dichloromethane. After stirring twenty hours at ambient temperature, the reaction mixture was washed with water, dried over anhydrous magnesium sulfate, filtered and evaporated. The residue was purified by high performance liquid chromatography (silica gel, 20% ethyl acetate in dichloromethane) to give 3.7 g (65%) of product. The product was converted to the hydrochloride salt, which had mp 269°-270° C., dec., after recrystallization from isopropanol-ether.
ANALYSIS: Calculated for C20 H27 N3 O.HCl: 66.37%C; 7.80%H; 11.61%N; Found: 66.26%C; 7.70%H; 11.53%N.
Claims (24)
1. A compound having the formula ##STR19## where R is Arloweralkyl of the formula ##STR20## where Z is hydrogen, loweralkyl, loweralkoxy, halogen, CF3, NH2, cycloalkylloweralkyl, loweralkenyl or thienylloweralkyl; R1 is loweralkylcarbonyl, loweralkoxycarbonyl, loweralkylthiocarbonyl, or cycloalkylcarbonyl; R2 is hydrogen, halogen or --CH3 ; and the pharmaceutically acceptable addition salts thereof.
2. The compound as defined in claim 1 wherein R is ##STR21##
3. The compound as defined in claim 2 wherein R1 is lower alkoxycarbonyl, loweralkylcarbonyl, loweralkylthiocarbonyl or cycloalkylcarbonyl.
4. The compound as defined in claim 3 wherein R2 is hydrogen.
5. The compound as defined in claim 2 which is N-[1-(2-phenethyl)piperidin-4-yl]-N-(1H-pyrrol-1-yl)cyclopropane carboxylic acid amide or a pharmaceutically acceptable addition salt thereof.
6. The compound as defined in claim 3 which is N-(2-methyl-1H-pyrrol-1-yl)-N-[1-(2-phenethyl)piperidin-4-yl]carbamic acid ethyl ester or a pharmaceutically acceptable addition salt thereof.
7. The compound as defined in claim 2 which is N-[1-(2-phenethyl)piperidin-4-yl]-N-(1H-pyrrol-1-yl)ethanethioamide or a pharmaceutically acceptable addition salt thereof.
8. The compound as defined in claim 3 which is N-(2-methyl-1H-pyrrol-1-yl)-N-[1-(2-phenethyl)piperidin-4-yl]acetamide or a pharmaceutically acceptable addition salt thereof.
9. An analgesic composition which comprises an effective pain alleviating amount of a compound of the formula ##STR22## where R is loweralkyl, Arloweralkyl of the formula ##STR23## where Z is hydrogen, loweralkyl, loweralkoxy, halogen, CF3, NO2, NH2, cycloalkylloweralkyl, loweralkenyl or thienylloweralkyl; R1 is loweralkylcarbonyl, loweralkoxycarbonyl, loweralkylthiocarbonyl, or cycloalkylcarbonyl; R2 is hydrogen, halogen or --CH3 ; and the pharmaceutically acceptable addition salts thereof.
10. The composition as defined in claim 9 wherein R is ##STR24##
11. The composition as defined in claim 10 wherein R1 is lower alkoxycarbonyl, loweralkylcarbonyl, loweralkylthiocarbonyl or cycloalkylcarbonyl.
12. The composition as defined in claim 11 wherein R2 is hydrogen.
13. The composition as defined in claim 10 which comprises N-[1-(2-phenethyl)piperidin-4-yl]-N-(1H-pyrrol-1-yl)cyclopropane carboxylic acid amide or a pharmaceutically acceptable addition salt thereof.
14. The composition as defined in claim 11 which comprises N-(2-methyl-1H-pyrrol-1-yl)-N-[1-(2-phenethyl)piperidin-1-yl]carbamic acid ethyl ester or a pharmaceutically acceptable addition salt thereof.
15. The composition as defined in claim 10 which comprises N-[1-(2-phenethyl)piperidin-4-yl]-N-(1H-pyrrol-1-yl)ethanethioamide or a pharmaceutically acceptable addition salt thereof.
16. The composition as defined in claim 11 which comprises N-(2-methyl-1H-pyrrol-1-yl)-N-[1-(2-phenethyl)piperidin-4-yl]acetamide or a pharmaceutically acceptable addition salt thereof.
17. A method of alleviating pain in a mammal which comprises administering to a mammal in need thereof an effective pain relieving amount of a compound having the formula ##STR25## where R is loweralkyl, Arloweralkyl of the formula ##STR26## where Z is hydrogen, loweralkyl, loweralkoxy, halogen, CF3, NO2, NH2, cycloalkylloweralkyl, loweralkenyl or thienylloweralkyl; R1 is loweralkylcarbonyl, loweralkoxycarbonyl, loweralkylthiocarbonyl, or cycloalkylcarbonyl; R2 is hydrogen, halogen or --CH3 ; and the pharmaceutically acceptable addition salt thereof.
18. The method as defined in claim 17 wherein R is ##STR27##
19. The method as defined in claim 18 wherein R1 is loweralkoxycarbonyl, loweralkylcarbonyl, loweralkylthiocarbonyl or cycloalkylcarbonyl.
20. The method as defined in claim 19 wherein R2 is hydrogen.
21. The method as defined in claim 18 wherein said compound is N-[1-(2-phenethyl)piperidin-4-yl]-N-(1H-pyrrol-1-yl)cyclopropane carboxylic acid amide or a pharmaceutically acceptable addition salt thereof.
22. The method as defined in claim 19 wherein said compound is N-(2-methyl-1H-pyrrol-1-yl)-N-[1-(2-phenethyl)piperidin-4-yl]carbamic acid ethyl ester or a pharmaceutically acceptable addition salt thereof.
23. The method as defined in claim 18 wherein said compound is N-[1-(2-phenethyl)piperidin-4-yl]-N-(1H-pyrrol-1-yl)ethanethioamide or a pharmaceutically acceptable addition salt thereof.
24. The method as defined in claim 19 wherein said compound is N-(2-methyl-1H-pyrrol-1-yl)-N-[1-(2-phenethyl)piperidin-4-yl]acetamide or a pharmaceutically acceptable addition salt thereof.
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0277794A2 (en) * | 1987-02-02 | 1988-08-10 | Ohmeda Pharmaceutical Products Division Inc. | N-heterocyclic-N-(4-piperidyl) amides |
| US4912109A (en) * | 1987-02-02 | 1990-03-27 | Boc, Inc. | N-heterocyclic-N-(4-piperidinyl) amides and pharmaceutical compositions and methods employing such compounds |
| US4916142A (en) * | 1987-02-02 | 1990-04-10 | Boc, Inc. | N-heterocyclic-N-(4-piperidinyl)amides and pharmaceutical compositions and their use as analgesics |
| US4954506A (en) * | 1987-02-02 | 1990-09-04 | Boc, Inc. | N-heterocyclic-N-(4-piperidinyl)amides and pharmaceutical compositions and methods employing such compounds |
| AP279A (en) * | 1990-08-06 | 1993-08-01 | Smithkline & French Laboratories Ltd | 4 substituted piperidine derivatives, processes for their preparation pharmaceutical compositions containing them and their use in therapy. |
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| US4452803A (en) * | 1983-09-19 | 1984-06-05 | Hoechst-Roussel Pharmaceuticals, Inc. | Pyrrolylaminopiperidines |
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| DE2429923A1 (en) * | 1973-06-21 | 1975-01-16 | Sterling Drug Inc | 1- (ARYLAMINO) -PYRROLE AND 1- (ARYLIMINO) -PYRROLE, THE PROCESS FOR THEIR MANUFACTURING AND THE MEANS IN WHICH THESE COMPOUNDS ARE CONTAINED |
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Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0277794A2 (en) * | 1987-02-02 | 1988-08-10 | Ohmeda Pharmaceutical Products Division Inc. | N-heterocyclic-N-(4-piperidyl) amides |
| US4791112A (en) * | 1987-02-02 | 1988-12-13 | The Boc Group, Inc. | N-heterocyclic-N-(4-piperidyl)amides and pharmaceutical compositions and methods employing such compounds |
| EP0277794A3 (en) * | 1987-02-02 | 1989-10-25 | Boc, Inc. | N-heterocyclic-n-(4-piperidyl) amides |
| US4912109A (en) * | 1987-02-02 | 1990-03-27 | Boc, Inc. | N-heterocyclic-N-(4-piperidinyl) amides and pharmaceutical compositions and methods employing such compounds |
| US4916142A (en) * | 1987-02-02 | 1990-04-10 | Boc, Inc. | N-heterocyclic-N-(4-piperidinyl)amides and pharmaceutical compositions and their use as analgesics |
| AU598905B2 (en) * | 1987-02-02 | 1990-07-05 | Baxter International Inc. | N-heterocyclic-n-(4-piperidyl)amides and pharmaceutical compositions and methods employing such compounds |
| US4954506A (en) * | 1987-02-02 | 1990-09-04 | Boc, Inc. | N-heterocyclic-N-(4-piperidinyl)amides and pharmaceutical compositions and methods employing such compounds |
| AP279A (en) * | 1990-08-06 | 1993-08-01 | Smithkline & French Laboratories Ltd | 4 substituted piperidine derivatives, processes for their preparation pharmaceutical compositions containing them and their use in therapy. |
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