CA2086531A1 - Immunoreactive compound - Google Patents

Immunoreactive compound

Info

Publication number
CA2086531A1
CA2086531A1 CA002086531A CA2086531A CA2086531A1 CA 2086531 A1 CA2086531 A1 CA 2086531A1 CA 002086531 A CA002086531 A CA 002086531A CA 2086531 A CA2086531 A CA 2086531A CA 2086531 A1 CA2086531 A1 CA 2086531A1
Authority
CA
Canada
Prior art keywords
igm
iga
compound according
immunoreactive compound
polypeptide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002086531A
Other languages
English (en)
French (fr)
Inventor
Ebo S. Bos
Petrus J. Boon
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Akzo NV
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2086531A1 publication Critical patent/CA2086531A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/42Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57484Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6889Conjugates wherein the antibody being the modifying agent and wherein the linker, binder or spacer confers particular properties to the conjugates, e.g. peptidic enzyme-labile linkers or acid-labile linkers, providing for an acid-labile immuno conjugate wherein the drug may be released from its antibody conjugated part in an acidic, e.g. tumoural or environment
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/06Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies from serum
    • C07K16/065Purification, fragmentation
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531Production of immunochemical test materials
    • G01N33/532Production of labelled immunochemicals

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Cell Biology (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Public Health (AREA)
  • Analytical Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Pathology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Physics & Mathematics (AREA)
  • Veterinary Medicine (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Inorganic Chemistry (AREA)
  • Hospice & Palliative Care (AREA)
  • Oncology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
CA002086531A 1990-07-03 1991-06-28 Immunoreactive compound Abandoned CA2086531A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP90201781 1990-07-03
EP90201781.3 1990-07-03
PCT/EP1991/001223 WO1992000763A1 (en) 1990-07-03 1991-06-28 Immunoreactive compound

Publications (1)

Publication Number Publication Date
CA2086531A1 true CA2086531A1 (en) 1992-01-04

Family

ID=8205056

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002086531A Abandoned CA2086531A1 (en) 1990-07-03 1991-06-28 Immunoreactive compound

Country Status (7)

Country Link
EP (1) EP0537222A1 (hu)
JP (1) JPH05507924A (hu)
KR (1) KR930701201A (hu)
CA (1) CA2086531A1 (hu)
FI (1) FI925804A (hu)
HU (1) HUT63343A (hu)
WO (1) WO1992000763A1 (hu)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9824632D0 (en) * 1998-11-10 1999-01-06 Celltech Therapeutics Ltd Biological compounds

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3173342D1 (en) * 1980-03-03 1986-02-13 Milton David Goldenberg Agent for tumor localization and therapy with labeled antibodies and antibody fragments
CA1168150A (en) * 1981-12-18 1984-05-29 The Governors Of The University Of Alberta Targeting conjugates of albumin and therapeutic agents
NZ210867A (en) * 1984-01-31 1989-01-06 Litton Bionetics Inc Tumour-specific monoclonal antibodies, production thereof and use
EP0293524A1 (en) * 1987-06-02 1988-12-07 Vasocor Atherosclerotic plaque immunoassay
JPH01257263A (ja) * 1987-06-19 1989-10-13 Agouron Inst:The Sm−d抗原、sm−d抗原のクローニングとsm−d抗原使用による播種性エリテマトーデの検出
ATE82136T1 (de) * 1987-08-10 1992-11-15 Miles Inc Gereinigtes igm.
US4937183A (en) * 1988-02-03 1990-06-26 Cytogen Corporation Method for the preparation of antibody-fragment conjugates
EP0398872A1 (en) * 1988-02-12 1990-11-28 HighTech Receptor AB Immunoglobulin binding substance, subfragments, a process for preparing thereof, reagent kit and immunoglobulin binding organisms
US4983529A (en) * 1988-06-10 1991-01-08 Abbott Laboratories Immunoassay for HIV-I antigens using F(AB')2 fragments as probe
KR900005995A (ko) * 1988-10-31 1990-05-07 우메모또 요시마사 변형 인터류킨-2 및 그의 제조방법
JPH04504253A (ja) * 1989-03-27 1992-07-30 セントカー・インコーポレーテツド IgM抗体の安定化のための配合物

Also Published As

Publication number Publication date
JPH05507924A (ja) 1993-11-11
WO1992000763A1 (en) 1992-01-23
HUT63343A (en) 1993-08-30
FI925804A0 (fi) 1992-12-21
KR930701201A (ko) 1993-06-11
EP0537222A1 (en) 1993-04-21
HU9204170D0 (en) 1993-04-28
FI925804A (fi) 1992-12-21

Similar Documents

Publication Publication Date Title
AU636872B2 (en) Cross-linked antibodies and processes for their preparation
JP2942356B2 (ja) 毒素および薬剤を含む治療用複合体
US5116944A (en) Conjugates having improved characteristics for in vivo administration
AU622415B2 (en) Immunoconjugates joined by thioether bonds having reduced toxicity and improved selectivity
US4350626A (en) Antitumor hybrid and process for the preparation thereof
AU611397B2 (en) Method of purifying toxin conjugates using hydrophobic interaction chromatography
US5747446A (en) Modified polypeptides with increased biological activity
AU659427B2 (en) Site-specific conjugation of immunoglobulins and detectable labels
JPS6221000B2 (hu)
JPS62181280A (ja) トリコテセン結合体を含む抗腫瘍剤
US5354554A (en) Crosslinked antibodies and processes for their preparation
WO1994015644A1 (en) Compounds for targeting
IE67320B1 (en) Cross-linked antibodies and processes for their preparation
CA2086531A1 (en) Immunoreactive compound
US5714149A (en) Crosslinked antibodies and processes for their preparation
AU8063591A (en) Immunoreactive compound
JPH04266829A (ja) 免疫結合体を形成するための抗体の化学修飾
Trost et al. A New Immunoenzyme Tracer for Localization of Antibodies in Immunohistology: Peroxidase‐Labeled Protein A
JPH06505480A (ja) 安定化抗体断片
EP0650735A2 (en) Kit and method for pretargeting
WO1996000087A2 (en) Kit for pretargeting and novel pretargeting conjugates
Trost et al. Ein neuer enzymgekoppelter Tracer für die Immunhistologie: Peroxidase-markiertes Protein A: Anwendung zum Nachweis und zur Titration antinukleärer Antikörper
JPH0428720B2 (hu)
Hainfeld Antibody-gold cluster conjugates
AU4605401A (en) Multimeric erythropoietin with increased biological activity

Legal Events

Date Code Title Description
FZDE Dead