CA2070813A1 - Une methode permettant de determiner la concentration d'anticoagulants - Google Patents
Une methode permettant de determiner la concentration d'anticoagulantsInfo
- Publication number
- CA2070813A1 CA2070813A1 CA2070813A CA2070813A CA2070813A1 CA 2070813 A1 CA2070813 A1 CA 2070813A1 CA 2070813 A CA2070813 A CA 2070813A CA 2070813 A CA2070813 A CA 2070813A CA 2070813 A1 CA2070813 A1 CA 2070813A1
- Authority
- CA
- Canada
- Prior art keywords
- anticoagulatory
- thrombin
- concentration
- active components
- anticoagulants
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000003146 anticoagulant agent Substances 0.000 title abstract 2
- 229940127219 anticoagulant drug Drugs 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 230000002429 anti-coagulating effect Effects 0.000 abstract 4
- 108090000190 Thrombin Proteins 0.000 abstract 3
- 239000000203 mixture Substances 0.000 abstract 3
- 229960004072 thrombin Drugs 0.000 abstract 3
- 108010039209 Blood Coagulation Factors Proteins 0.000 abstract 2
- 102000015081 Blood Coagulation Factors Human genes 0.000 abstract 2
- 238000003556 assay Methods 0.000 abstract 2
- 230000015572 biosynthetic process Effects 0.000 abstract 2
- 239000003114 blood coagulation factor Substances 0.000 abstract 2
- 239000003153 chemical reaction reagent Substances 0.000 abstract 2
- 239000000126 substance Substances 0.000 abstract 2
- GONFBOIJNUKKST-UHFFFAOYSA-N 5-ethylsulfanyl-2h-tetrazole Chemical compound CCSC=1N=NNN=1 GONFBOIJNUKKST-UHFFFAOYSA-N 0.000 abstract 1
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 abstract 1
- 101000712605 Theromyzon tessulatum Theromin Proteins 0.000 abstract 1
- 229940122388 Thrombin inhibitor Drugs 0.000 abstract 1
- 239000012190 activator Substances 0.000 abstract 1
- 229910001628 calcium chloride Inorganic materials 0.000 abstract 1
- 239000001110 calcium chloride Substances 0.000 abstract 1
- 230000015271 coagulation Effects 0.000 abstract 1
- 238000005345 coagulation Methods 0.000 abstract 1
- 238000011534 incubation Methods 0.000 abstract 1
- 230000005764 inhibitory process Effects 0.000 abstract 1
- 150000003904 phospholipids Chemical class 0.000 abstract 1
- 239000003868 thrombin inhibitor Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/56—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving blood clotting factors, e.g. involving thrombin, thromboplastin, fibrinogen
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/81—Protease inhibitors
- G01N2333/815—Protease inhibitors from leeches, e.g. hirudin, eglin
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/90—Enzymes; Proenzymes
- G01N2333/914—Hydrolases (3)
- G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
- G01N2333/974—Thrombin
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2400/00—Assays, e.g. immunoassays or enzyme assays, involving carbohydrates
- G01N2400/10—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- G01N2400/38—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence, e.g. gluco- or galactomannans, e.g. Konjac gum, Locust bean gum, Guar gum
- G01N2400/40—Glycosaminoglycans, i.e. GAG or mucopolysaccharides, e.g. chondroitin sulfate, dermatan sulfate, hyaluronic acid, heparin, heparan sulfate, and related sulfated polysaccharides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Immunology (AREA)
- Analytical Chemistry (AREA)
- Molecular Biology (AREA)
- Physics & Mathematics (AREA)
- Neurosurgery (AREA)
- Hematology (AREA)
- Biophysics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- External Artificial Organs (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US60934090A | 1990-11-05 | 1990-11-05 | |
| US609,340 | 1990-11-05 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2070813A1 true CA2070813A1 (fr) | 1992-05-06 |
| CA2070813C CA2070813C (fr) | 1996-10-29 |
Family
ID=24440379
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002070813A Expired - Fee Related CA2070813C (fr) | 1990-11-05 | 1991-10-30 | Une methode permettant de determiner la concentration d'anticoagulants |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US5702912A (fr) |
| EP (1) | EP0509086B1 (fr) |
| JP (1) | JP3094165B2 (fr) |
| AT (1) | ATE121139T1 (fr) |
| AU (1) | AU650941B2 (fr) |
| CA (1) | CA2070813C (fr) |
| DE (1) | DE69108896T2 (fr) |
| DK (1) | DK0509086T3 (fr) |
| ES (1) | ES2073908T3 (fr) |
| WO (1) | WO1992007954A1 (fr) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4203980A1 (de) * | 1992-02-11 | 1993-08-12 | Max Planck Gesellschaft | Verfahren zur bestimmung von hirudin und synthetischen thrombininhibitoren |
| AT397391B (de) * | 1992-05-15 | 1994-03-25 | Immuno Ag | Verwendung von prothrombinfragmenten |
| US5308755A (en) * | 1992-06-08 | 1994-05-03 | Research Corporation Technologies, Inc. | Method for measuring heparin |
| RU2153506C2 (ru) * | 1993-09-30 | 2000-07-27 | Сейкагаку когио кабусики кайся | Дерматансульфат или его соль, противотромбозные средства, способ предупреждения или лечения тромбозов, способ предупреждения или лечения синдрома рассеянной интраваскулярной коагуляции, способ лечения инфаркта миокарда |
| AU711702B2 (en) * | 1995-03-23 | 1999-10-21 | Cambridge University Technical Services Limited | Vectors for gene delivery |
| US6010911A (en) * | 1997-04-30 | 2000-01-04 | Medtronic, Inc. | Apparatus for performing a heparin-independent high sensitivity platelet function evaluation technique |
| US5985582A (en) * | 1997-12-09 | 1999-11-16 | Sigma-Aldrich Co. | Thrombin-based assay for antithrombin III |
| WO1999038997A1 (fr) * | 1998-01-30 | 1999-08-05 | Yoshitomi Pharmaceutical Industries, Ltd. | Procede de mesure de l'activite du cofacteur ii de l'heparine et boite de reactifs y relative |
| US6194394B1 (en) * | 1998-07-01 | 2001-02-27 | Sigma-Aldrich Co. | Coagulation controls for prothrombin time (PT) and activated partial thromboplastin time (APTT) assays |
| DE19904674A1 (de) * | 1999-02-04 | 2000-08-31 | Haemosys Gmbh | Verfahren zur Bestimmung der Konzentration von Thrombininhibitoren |
| EP1045250A1 (fr) * | 1999-04-12 | 2000-10-18 | INSTRUMENTATION LABORATORY S.p.A. | Test pour l'évaluation de la fonctionnalité du système thrombine/antithrombine |
| AUPP971299A0 (en) | 1999-04-12 | 1999-05-06 | South Eastern Sydney Area Health Service | Procoagulant assay |
| JP2003524187A (ja) * | 2000-02-23 | 2003-08-12 | ベッスト−テスト アンパーツゼルスカブ | 体液、例えば尿におけるマーカーと血液凝固活性とを相互関連づけるための方法 |
| US6680177B2 (en) * | 2001-12-07 | 2004-01-20 | Cardiovascular Diagnostics, Inc. | Low molecular weight heparin assay, system and reagent therefor |
| DE10330900B4 (de) * | 2003-07-01 | 2006-09-14 | Leibniz-Institut Für Polymerforschung Dresden E.V. | Biomaterial mit einem modularen Beschichtungssystem zur Anwendung in Medizinprodukten mit direktem Blutkontakt |
| CA2566411A1 (fr) * | 2004-05-11 | 2005-11-24 | Heptest Laboratories, Inc. | Compositions, kit et procede en une etape permettant de surveiller des composes possedant des activites d'antifacteur xa et/ou d'antifacteur iia |
| CA2567137A1 (fr) | 2004-05-17 | 2005-12-08 | Medtronic, Inc. | Systeme de determination de l'heparine au point de service |
| BRPI0511603A (pt) * | 2004-05-27 | 2008-01-02 | Avigen Inc | método para o tratamento de distúrbios do sangramento com a utilização de polissacarìdeos sulfatados |
| DE102005038418A1 (de) * | 2005-08-12 | 2007-02-15 | Dade Behring Marburg Gmbh | Faktor Xa-basierter Heparinassay unter Verwendung einer Heparin-modifizierenden Komponente |
| DE102006035580A1 (de) * | 2006-07-27 | 2008-02-14 | Csl Behring Gmbh | Bestimmung der biologischen Aktivität von Heparin in AT III-haltigen Präparationen |
| EP1918718A1 (fr) | 2006-10-31 | 2008-05-07 | Roche Diagnostics GmbH | Procédés et dispositifs destinés à la détermination électrochimique d'inhibiteurs du facteur Xa dans des échantillons sanguins |
| US20120178114A1 (en) * | 2007-08-10 | 2012-07-12 | Subc, Inc. | Methods and devices for detecting thrombin generation |
| EP2471945A1 (fr) * | 2010-12-30 | 2012-07-04 | Siemens Healthcare Diagnostics Products GmbH | Procédé de détermination d'inhibiteurs de coagulation |
| JP6087775B2 (ja) * | 2013-09-13 | 2017-03-01 | 薫 梅野 | ハンドバイブレーターおよびハンドバイブレーター用連結具 |
| WO2018128002A1 (fr) * | 2017-01-06 | 2018-07-12 | ソニー株式会社 | Analyseur de système de coagulation sanguine, système d'analyse de système de coagulation sanguine, procédé d'analyse de système de coagulation sanguine, programme d'analyse de système de coagulation sanguine, prédicteur de volume hémorragique, système de prédiction de volume hémorragique, procédé de prédiction de volume hémorragique et programme de prédiction de volume hémorragique |
| CN110514851A (zh) * | 2019-08-28 | 2019-11-29 | 深圳麦科田生物医疗技术有限公司 | 血小板抑制率的检测方法和检测试剂盒 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2812943C3 (de) * | 1978-03-23 | 1981-05-14 | Boehringer Mannheim Gmbh, 6800 Mannheim | Verfahren und Reagens zur Bestimmung der biologischen Aktivität von Heparin im Plasma |
| DE3005540A1 (de) * | 1980-02-14 | 1981-08-20 | Boehringer Mannheim Gmbh, 6800 Mannheim | Verfahren und reagens zur bestimmung der biologischen aktivitaet von heparin im plasma |
| WO1982001377A1 (fr) * | 1980-10-09 | 1982-04-29 | Lill Helmut | Procede de determination d'une bm ('binding moderately') antithrombine |
| US4473639A (en) * | 1982-09-15 | 1984-09-25 | Miles Laboratories, Inc. | Reagent strip test for antithrombin-III |
| US4851336A (en) * | 1985-09-05 | 1989-07-25 | Yin E Thye | Composition, kit, and method for assaying heparinano a method for making the composition |
| DE3536903A1 (de) * | 1985-10-16 | 1987-04-16 | Boehringer Mannheim Gmbh | Verfahren zur photometrischen bestimmung von protein c |
| IT1230744B (it) * | 1989-07-07 | 1991-10-29 | Instrumentation Lab Spa | Metodo per la determinazione della attivita' funzionale della proteina s nel plasma umano. |
| NL8902406A (nl) * | 1989-09-27 | 1991-04-16 | Hendrik Coenraad Hemker Prof D | Werkwijze voor het bepalen van de endogene trombinepotentiaal van plasma, en bloed alsmede een bij deze werkwijze te gebruiken kit. |
-
1991
- 1991-10-30 AT AT92900357T patent/ATE121139T1/de not_active IP Right Cessation
- 1991-10-30 CA CA002070813A patent/CA2070813C/fr not_active Expired - Fee Related
- 1991-10-30 DE DE69108896T patent/DE69108896T2/de not_active Expired - Lifetime
- 1991-10-30 EP EP92900357A patent/EP0509086B1/fr not_active Expired - Lifetime
- 1991-10-30 ES ES92900357T patent/ES2073908T3/es not_active Expired - Lifetime
- 1991-10-30 DK DK92900357.2T patent/DK0509086T3/da active
- 1991-10-30 WO PCT/US1991/008117 patent/WO1992007954A1/fr active IP Right Grant
- 1991-10-30 JP JP04501268A patent/JP3094165B2/ja not_active Expired - Lifetime
-
1992
- 1992-01-09 AU AU10154/92A patent/AU650941B2/en not_active Ceased
-
1995
- 1995-11-30 US US08/564,986 patent/US5702912A/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| AU650941B2 (en) | 1994-07-07 |
| JP3094165B2 (ja) | 2000-10-03 |
| DE69108896D1 (de) | 1995-05-18 |
| EP0509086B1 (fr) | 1995-04-12 |
| EP0509086A1 (fr) | 1992-10-21 |
| JPH05503223A (ja) | 1993-06-03 |
| WO1992007954A1 (fr) | 1992-05-14 |
| DK0509086T3 (da) | 1995-07-03 |
| AU1015492A (en) | 1992-06-25 |
| ATE121139T1 (de) | 1995-04-15 |
| DE69108896T2 (de) | 1995-08-24 |
| CA2070813C (fr) | 1996-10-29 |
| US5702912A (en) | 1997-12-30 |
| ES2073908T3 (es) | 1995-08-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| MKLA | Lapsed |