CA2070433A1 - Method and kit for immunoassay of propeptide of osteocalcin and proosteocalcin - Google Patents
Method and kit for immunoassay of propeptide of osteocalcin and proosteocalcinInfo
- Publication number
- CA2070433A1 CA2070433A1 CA 2070433 CA2070433A CA2070433A1 CA 2070433 A1 CA2070433 A1 CA 2070433A1 CA 2070433 CA2070433 CA 2070433 CA 2070433 A CA2070433 A CA 2070433A CA 2070433 A1 CA2070433 A1 CA 2070433A1
- Authority
- CA
- Canada
- Prior art keywords
- antibody
- osteocalcin
- propeptide
- specifically recognizing
- human
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 238000000034 method Methods 0.000 title claims abstract description 138
- 102000004067 Osteocalcin Human genes 0.000 title claims abstract description 110
- 108090000573 Osteocalcin Proteins 0.000 title claims abstract description 110
- 238000003018 immunoassay Methods 0.000 title description 2
- 238000007689 inspection Methods 0.000 claims abstract description 42
- 101001086210 Homo sapiens Osteocalcin Proteins 0.000 claims description 56
- 102000055149 human BGLAP Human genes 0.000 claims description 56
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- 150000001413 amino acids Chemical group 0.000 claims description 27
- 239000000126 substance Substances 0.000 claims description 23
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- XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 description 1
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- SHUZOJHMOBOZST-UHFFFAOYSA-N phylloquinone Natural products CC(C)CCCCC(C)CCC(C)CCCC(=CCC1=C(C)C(=O)c2ccccc2C1=O)C SHUZOJHMOBOZST-UHFFFAOYSA-N 0.000 description 1
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- AHTFMWCHTGEJHA-UHFFFAOYSA-N s-(2,5-dioxooxolan-3-yl) ethanethioate Chemical compound CC(=O)SC1CC(=O)OC1=O AHTFMWCHTGEJHA-UHFFFAOYSA-N 0.000 description 1
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- LASOLDQRFPFANT-UHFFFAOYSA-N tris(2-nitrophenyl) phosphate Chemical compound [O-][N+](=O)C1=CC=CC=C1OP(=O)(OC=1C(=CC=CC=1)[N+]([O-])=O)OC1=CC=CC=C1[N+]([O-])=O LASOLDQRFPFANT-UHFFFAOYSA-N 0.000 description 1
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Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/78—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin or cold insoluble globulin [CIG]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6887—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids from muscle, cartilage or connective tissue
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Hematology (AREA)
- Biochemistry (AREA)
- Urology & Nephrology (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Analytical Chemistry (AREA)
- Microbiology (AREA)
- Cell Biology (AREA)
- General Physics & Mathematics (AREA)
- Physics & Mathematics (AREA)
- Pathology (AREA)
- Food Science & Technology (AREA)
- Biotechnology (AREA)
- Endocrinology (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP264935/1990 | 1990-10-04 | ||
| JP26493590 | 1990-10-04 | ||
| JP17476891A JPH05232109A (ja) | 1990-10-04 | 1991-06-20 | ヒト・オステオカルシンプロ蛋白の測定方法 |
| JP174768/1991 | 1991-06-20 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2070433A1 true CA2070433A1 (en) | 1992-04-05 |
Family
ID=26496260
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA 2070433 Abandoned CA2070433A1 (en) | 1990-10-04 | 1991-10-03 | Method and kit for immunoassay of propeptide of osteocalcin and proosteocalcin |
Country Status (4)
| Country | Link |
|---|---|
| EP (1) | EP0504423A1 (enExample) |
| JP (1) | JPH05232109A (enExample) |
| CA (1) | CA2070433A1 (enExample) |
| WO (1) | WO1992006377A1 (enExample) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1311691B1 (en) | 2000-08-23 | 2006-10-04 | Enobia Pharma Inc. | Method and compositions for promoting osteogenesis |
| US20060134694A1 (en) * | 2004-12-22 | 2006-06-22 | Intel Corporation | Methods of protein profiling by thiolation |
| JP5280916B2 (ja) * | 2008-03-31 | 2013-09-04 | タカラバイオ株式会社 | 抗ラットオステオカルシンモノクローナル抗体 |
| CN112162099A (zh) * | 2020-09-28 | 2021-01-01 | 安徽大千生物工程有限公司 | 基于胶乳增强免疫比浊法测定n-mid的试剂盒及其制备方法 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5767858A (en) * | 1980-10-15 | 1982-04-24 | Takeda Chem Ind Ltd | Immunochemical measurement method for human chorionic gonadotropin and production of antibody |
| JPS57124253A (en) * | 1981-01-26 | 1982-08-03 | Toyobo Co Ltd | Immunological measuring method for adrenocorticotropic hormone precursor |
| JPS6157856A (ja) * | 1984-08-29 | 1986-03-24 | Chemo Sero Therapeut Res Inst | ホルモンの測定方法 |
| JPS62159046A (ja) * | 1985-12-31 | 1987-07-15 | Chemo Sero Therapeut Res Inst | ホルモンのサブユニツトの測定方法 |
| JPS62185169A (ja) * | 1986-02-12 | 1987-08-13 | Daiichi Rajio Isotope Kenkyusho:Kk | 多目的免疫化学的測定法および試薬 |
| JPH022935A (ja) * | 1988-06-20 | 1990-01-08 | Tosoh Corp | アンジオテンシンの測定法 |
| DE3833936C1 (enExample) * | 1988-10-05 | 1989-09-21 | Henning Berlin Gmbh Chemie- Und Pharmawerk, 1000 Berlin, De | |
| EP0410004B1 (en) * | 1989-02-10 | 1996-05-08 | Teijin Limited | Immunoassay of human osteocalcin, reagent and kit therefor |
-
1991
- 1991-06-20 JP JP17476891A patent/JPH05232109A/ja active Pending
- 1991-10-03 CA CA 2070433 patent/CA2070433A1/en not_active Abandoned
- 1991-10-03 EP EP91917334A patent/EP0504423A1/en not_active Withdrawn
- 1991-10-03 WO PCT/JP1991/001330 patent/WO1992006377A1/ja not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| WO1992006377A1 (en) | 1992-04-16 |
| EP0504423A1 (en) | 1992-09-23 |
| EP0504423A4 (enExample) | 1994-04-13 |
| JPH05232109A (ja) | 1993-09-07 |
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