CA2065290A1 - Chelates de metal et de composes du type hydroxy-aryle utiles pour l'imagerie rmn diagnostique - Google Patents

Chelates de metal et de composes du type hydroxy-aryle utiles pour l'imagerie rmn diagnostique

Info

Publication number
CA2065290A1
CA2065290A1 CA2065290A CA2065290A CA2065290A1 CA 2065290 A1 CA2065290 A1 CA 2065290A1 CA 2065290 A CA2065290 A CA 2065290A CA 2065290 A CA2065290 A CA 2065290A CA 2065290 A1 CA2065290 A1 CA 2065290A1
Authority
CA
Canada
Prior art keywords
iii
nitrogens
hydroxy
ligand
nmr
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA2065290A
Other languages
English (en)
Other versions
CA2065290C (fr
Inventor
Randall B. Lauffer
Scott K. Larsen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
General Hospital Corp
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2065290A1 publication Critical patent/CA2065290A1/fr
Application granted granted Critical
Publication of CA2065290C publication Critical patent/CA2065290C/fr
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
    • G01R33/48—NMR imaging systems
    • G01R33/54—Signal processing systems, e.g. using pulse sequences ; Generation or control of pulse sequences; Operator console
    • G01R33/56—Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution
    • G01R33/5601—Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution involving use of a contrast agent for contrast manipulation, e.g. a paramagnetic, super-paramagnetic, ferromagnetic or hyperpolarised contrast agent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations

Landscapes

  • Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Condensed Matter Physics & Semiconductors (AREA)
  • Signal Processing (AREA)
  • High Energy & Nuclear Physics (AREA)
  • Engineering & Computer Science (AREA)
  • General Physics & Mathematics (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)

Abstract

Une composition d'agents de contraste de résonnance magnétique nucléaire contient un complexe d'un ion métallique sélectionné et d'un ligand sélectionné. L'ion est sélectionné dans le groupe composé de gadolinium (III), fer (III), manganèse (II), manganèse (III), chrome (III), cuivre (II), dysprosium (III), terbium (III), holmium (III), erbium (III), europium (II), et europium (III); et le ligand est un composé linéaire à deux atomes d'azote comportant un groupe 2-hydroxy-aryle au niveau d'un des atomes d'azote; ou le ligand est un composé linéaire à deux atomes d'azote comportant un ou deux groupes 2-hydroxy-aryle à chaque atome d'azote; ou le ligand est un composé linéaire à trois, quatre ou cinq atomes d'azote comportant un ou deux substituants 2-hydroxy-aryle au niveau de chaque atome ou de plusieurs atomes d'azote, ou le ligand est un composé hétérocyclique comportant un anneau contenant trois ou quatre atomes d'azote, et ayant un substituant 2-hydroxy-aryle au niveau d'un ou de plusieurs atomes d'azote; ou bien le ligand est un composé hétérocyclique comportant un anneau contenant quatre atomes d'azote, et ayant un groupe carboxyle au niveau de deux atomes d'azote ainsi qu'un substituant aromatique au niveau des deux autres atomes d'azote. De plus, un procédé d'amélioration du contraste en imagerie RMN chez un patient comprend les étapes consistant à préparer un agent améliorant le contraste de RMN par mélange d'un composé de contraste de RMN de l'invention avec un support pharmaceutiquement acceptable, à introduire l'agent améliorant le contraste de RMN dans le patient, et à soumettre le patient à une imagerie par RMN.
CA002065290A 1989-08-28 1990-08-28 Chelates de metal et de composes du type hydroxy-aryle utiles pour l'imagerie rmn diagnostique Expired - Fee Related CA2065290C (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US39973789A 1989-08-28 1989-08-28
US399,737 1989-08-28
PCT/US1990/004887 WO1991003200A1 (fr) 1989-08-28 1990-08-28 Chelates metalliques d'hydroxy-aryle d'imagerie par resonnance magnetique nucleaire de diagnostic

Publications (2)

Publication Number Publication Date
CA2065290A1 true CA2065290A1 (fr) 1991-03-01
CA2065290C CA2065290C (fr) 2000-12-12

Family

ID=23580762

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002065290A Expired - Fee Related CA2065290C (fr) 1989-08-28 1990-08-28 Chelates de metal et de composes du type hydroxy-aryle utiles pour l'imagerie rmn diagnostique

Country Status (7)

Country Link
EP (1) EP0489869B1 (fr)
JP (1) JPH05503072A (fr)
AT (1) ATE173336T1 (fr)
CA (1) CA2065290C (fr)
DE (1) DE69032761T2 (fr)
HK (1) HK1012707A1 (fr)
WO (1) WO1991003200A1 (fr)

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US8623822B2 (en) 2002-03-01 2014-01-07 Bracco Suisse Sa KDR and VEGF/KDR binding peptides and their use in diagnosis and therapy
US7261876B2 (en) 2002-03-01 2007-08-28 Bracco International Bv Multivalent constructs for therapeutic and diagnostic applications
EP1587944A4 (fr) 2002-03-01 2007-03-21 Dyax Corp Peptides de liaison kdr et vegf/kdr et leur utilisation a des fins diagnostiques et therapeutiques
US7794693B2 (en) 2002-03-01 2010-09-14 Bracco International B.V. Targeting vector-phospholipid conjugates
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US20120045393A1 (en) 2009-03-17 2012-02-23 Linder Karen E Lhrh-ii peptide analogs
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US20110077396A1 (en) * 2009-09-30 2011-03-31 General Electric Company Intermediates for hydroxylated contrast enhancement agents
US8378134B2 (en) 2009-09-30 2013-02-19 General Electric Company Hydroxylated contrast enhancement agents
US8722020B2 (en) * 2010-03-31 2014-05-13 General Electric Company Hydroxylated contrast enhancement agents
JP6297440B2 (ja) * 2013-07-31 2018-03-20 キヤノンメディカルシステムズ株式会社 造影剤
WO2015038968A1 (fr) 2013-09-13 2015-03-19 The General Hospital Corporation Sondes de liaison à la fibrine activables
US20150344523A1 (en) 2014-05-05 2015-12-03 California Institute Of Technology Mutant akt-specific capture agents, compositions, and methods of using and making
US10471162B2 (en) 2014-06-20 2019-11-12 The General Hospital Corporation Collagen targeted imaging probes
EP3270951B1 (fr) 2015-03-16 2020-09-09 California Institute of Technology Agents de capture spécifiques de la neurotoxine botulique, compositions et méthodes d'utilisation et de préparation associées
CN104910030B (zh) * 2015-05-14 2018-03-23 石家庄杰克化工有限公司 一种高纯度乙醇胺类氨羧螯合剂的合成工艺
EP3101012A1 (fr) 2015-06-04 2016-12-07 Bayer Pharma Aktiengesellschaft Nouveaux composés de chélate de gadolinium pour une utilisation dans l'imagerie par résonance magnétique
US10598671B2 (en) 2015-07-15 2020-03-24 Indi Molecular, Inc. IL-17F-specific capture agents, compositions, and methods of using and making
US9829474B2 (en) * 2015-10-16 2017-11-28 General Electric Company Acetate complexes and methods for acetate quantification
US20170319722A1 (en) 2016-04-04 2017-11-09 Indi Molecular, Inc. Cd8-specific capture agents, compositions, and methods of using and making
EP3519425B1 (fr) 2016-09-29 2024-02-28 Indi Molecular, Inc. Compositions pour la détection, l'inhibition et l'imagerie de l'indoléamine 2,3-dioxygénase 1 (ido1) et leurs méthodes de production et d'utilisation
EP3535278A4 (fr) 2016-11-01 2020-06-24 Ohio State Innovation Foundation Procédés d'iodation de biomolécules
JP7034160B2 (ja) 2016-11-28 2022-03-11 バイエル・ファルマ・アクティエンゲゼルシャフト 磁気共鳴画像法に使用するための高緩和度ガドリニウムキレート化合物
EP3638687A1 (fr) 2017-06-15 2020-04-22 Indi Molecular, Inc. Agents de capture spécifiques d'il-17f et il-17a, compositions et procédés d'utilisation et de production
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US11638764B2 (en) 2018-11-08 2023-05-02 Indi Molecular, Inc. Theranostic capture agents, compositions, and methods of using and making
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WO2020236969A1 (fr) 2019-05-20 2020-11-26 Indi Molecular, Inc. Compositions et procédés se rapportant à la détection, à l'inhibition et à l'imagerie de l'indoléamine 2,3-dioxygénase 1 (ido1)
WO2020236952A1 (fr) 2019-05-20 2020-11-26 Ohio State Innovation Foundation Complexes d'apohémoglobine-haptoglobine et leurs procédés d'utilisation
US11414460B2 (en) 2019-07-19 2022-08-16 Institute For Systems Biology KRAS-specific capture agents, compositions, and methods of making and using
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WO2022098745A1 (fr) 2020-11-03 2022-05-12 Indi Molecular, Inc. Compositions, systèmes d'administration et méthodes utiles dans la thérapie antitumorale

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Also Published As

Publication number Publication date
WO1991003200A1 (fr) 1991-03-21
EP0489869A4 (en) 1993-03-17
HK1012707A1 (en) 1999-08-06
ATE173336T1 (de) 1998-11-15
DE69032761T2 (de) 1999-04-22
EP0489869B1 (fr) 1998-11-11
JPH05503072A (ja) 1993-05-27
CA2065290C (fr) 2000-12-12
EP0489869A1 (fr) 1992-06-17
DE69032761D1 (de) 1998-12-17

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