CA2058441A1 - R-h-gm-csf cristallise et methode de preparation - Google Patents

R-h-gm-csf cristallise et methode de preparation

Info

Publication number
CA2058441A1
CA2058441A1 CA2058441A CA2058441A CA2058441A1 CA 2058441 A1 CA2058441 A1 CA 2058441A1 CA 2058441 A CA2058441 A CA 2058441A CA 2058441 A CA2058441 A CA 2058441A CA 2058441 A1 CA2058441 A1 CA 2058441A1
Authority
CA
Canada
Prior art keywords
csf
crystalline
preparation
crystals
making
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA2058441A
Other languages
English (en)
Other versions
CA2058441C (fr
Inventor
Paul Reichert
Gerald S. Hammond
Hung V. Le
Tattanahalli L. Nagabhushan
Paul P. Trotta
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Sharp and Dohme LLC
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2058441A1 publication Critical patent/CA2058441A1/fr
Application granted granted Critical
Publication of CA2058441C publication Critical patent/CA2058441C/fr
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/53—Colony-stimulating factor [CSF]
    • C07K14/535—Granulocyte CSF; Granulocyte-macrophage CSF
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/14—Lymphokine; related peptides
    • Y10S930/145—Colony stimulating factor

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Toxicology (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Steroid Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Crystals, And After-Treatments Of Crystals (AREA)
  • Glass Compositions (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Silicates, Zeolites, And Molecular Sieves (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Mechanical Treatment Of Semiconductor (AREA)

Abstract

La présente invention porte sur une forme cristalline du facteur stimulant les colonies de granulocytes-macrophages humain recombinant (r-h-GM-CSF) et sur des méthodes pour obtenir ces cristaux.
CA002058441A 1989-06-06 1990-06-04 R-h-gm-csf cristallise et methode de preparation Expired - Fee Related CA2058441C (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US362,187 1989-06-06
US07/362,187 US5109119A (en) 1989-06-06 1989-06-06 Crystalline r-h-gm-csf and method

Publications (2)

Publication Number Publication Date
CA2058441A1 true CA2058441A1 (fr) 1990-12-07
CA2058441C CA2058441C (fr) 1997-12-16

Family

ID=23425041

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002058441A Expired - Fee Related CA2058441C (fr) 1989-06-06 1990-06-04 R-h-gm-csf cristallise et methode de preparation

Country Status (14)

Country Link
US (2) US5109119A (fr)
EP (3) EP0402070B1 (fr)
JP (1) JP2572160B2 (fr)
KR (1) KR960004454B1 (fr)
AT (1) ATE110113T1 (fr)
AU (1) AU644083B2 (fr)
CA (1) CA2058441C (fr)
DE (1) DE69011586T2 (fr)
DK (1) DK0402070T3 (fr)
FI (1) FI915709A0 (fr)
HK (1) HK184996A (fr)
HU (1) HU209871B (fr)
NO (1) NO914771D0 (fr)
WO (1) WO1990015151A1 (fr)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69031914T2 (de) * 1989-08-11 1998-07-30 Amrad Corp. Ltd., Kew, Victoria Rezeptor für granulozyten-macrophagen-koloniestimulierungsfaktor und seine derivate
EP0955365A3 (fr) 1992-06-09 2000-12-20 Chiron Corporation Cristallisation du M-CSF
US5581476A (en) * 1993-01-28 1996-12-03 Amgen Inc. Computer-based methods and articles of manufacture for preparing G-CSF analogs
US6004549A (en) * 1994-12-14 1999-12-21 Schering Corporation Crystalline protein controlled release compositions
US6646110B2 (en) * 2000-01-10 2003-11-11 Maxygen Holdings Ltd. G-CSF polypeptides and conjugates
US6831158B2 (en) * 2000-01-10 2004-12-14 Maxygen Holdings Ltd. G-CSF conjugates
US6555660B2 (en) * 2000-01-10 2003-04-29 Maxygen Holdings Ltd. G-CSF conjugates
PE20020394A1 (es) * 2000-08-18 2002-06-21 Agouron Pharma Compuestos de pirazol y composiciones farmaceuticas que los contienen, que modulan y/o inhiben la actividad de erab/hadh2
MXPA04000231A (es) * 2001-07-11 2004-05-04 Maxygen Holdings Ltd Conjugados del factor de estimulacion de colonias de granulocitos.
US7765302B2 (en) * 2003-06-30 2010-07-27 Nortel Networks Limited Distributed call server supporting communication sessions in a communication system and method
EP1768700B1 (fr) * 2004-07-16 2010-12-15 Nektar Therapeutics Conjugues comprenant gm-csf et un polymer
CA2607844C (fr) 2005-06-01 2012-07-10 Maxygen Holdings Ltd. Polypeptides g-csf pegyles et procedes de production correspondants
WO2007102946A2 (fr) * 2006-01-23 2007-09-13 Amgen Inc. Polypeptides cristallins
US20160303242A1 (en) 2013-12-09 2016-10-20 Durect Corporation Pharmaceutically Active Agent Complexes, Polymer Complexes, and Compositions and Methods Involving the Same

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU588819B2 (en) * 1984-10-29 1989-09-28 Immunex Corporation Cloning of human granulocyte-macrophage colony stimulating factor gene
IL77080A (en) * 1984-11-20 1998-02-08 Schering Biotech Corp Polypeptides showing activity of human growth factor of macrophage granulocyte and eosinophils Vectors and cells transformed for their preparation and pharmaceutical preparations containing or
JP2595216B2 (ja) * 1986-12-12 1997-04-02 日清製粉株式会社 α―アミラーゼインヒビターの結晶の製造方法
US4912200A (en) * 1987-05-11 1990-03-27 Schering Corporation Extraction of granulocyte macrophage colony stimulating factor from bacteria
DE68921186T2 (de) * 1988-05-31 1995-06-14 Cetus Oncology Corp Verfahren zur gewinnung von heterologe proteine enthaltenden refraktilkörpern aus mikrobiellen wirten.

Also Published As

Publication number Publication date
FI915709A0 (fi) 1991-12-04
HU209871B (en) 1994-11-28
AU5834890A (en) 1991-01-07
WO1990015151A1 (fr) 1990-12-13
JP2572160B2 (ja) 1997-01-16
EP0402070A1 (fr) 1990-12-12
EP0561429A1 (fr) 1993-09-22
NO914771L (no) 1991-12-04
AU644083B2 (en) 1993-12-02
KR920700293A (ko) 1992-02-19
EP0402070B1 (fr) 1994-08-17
HUT58822A (en) 1992-03-30
NO914771D0 (no) 1991-12-04
KR960004454B1 (ko) 1996-04-06
US5109119A (en) 1992-04-28
US5616555A (en) 1997-04-01
HU904835D0 (en) 1992-02-28
ATE110113T1 (de) 1994-09-15
DE69011586T2 (de) 1995-03-02
JPH04502014A (ja) 1992-04-09
DK0402070T3 (da) 1994-09-12
CA2058441C (fr) 1997-12-16
DE69011586D1 (de) 1994-09-22
EP0476022A1 (fr) 1992-03-25
HK184996A (en) 1996-10-11

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Legal Events

Date Code Title Description
EEER Examination request
MKLA Lapsed