CA2056435A1 - Accumulation de medicaments dans des liposomes par un gradient de proton - Google Patents

Accumulation de medicaments dans des liposomes par un gradient de proton

Info

Publication number
CA2056435A1
CA2056435A1 CA002056435A CA2056435A CA2056435A1 CA 2056435 A1 CA2056435 A1 CA 2056435A1 CA 002056435 A CA002056435 A CA 002056435A CA 2056435 A CA2056435 A CA 2056435A CA 2056435 A1 CA2056435 A1 CA 2056435A1
Authority
CA
Canada
Prior art keywords
composition according
liposome
lipid
buffer solution
pharmaceutical agent
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002056435A
Other languages
English (en)
Inventor
Thomas D. Madden
Michael J. Hope
Colin P.S. Tilcock
Pieter R. Cullis
P. Richard Harrigan
Barbara S. Mui
Marcel B. Bally
Linda Tai
Lawrence D. Mayer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Elan Pharmaceuticals LLC
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2056435A1 publication Critical patent/CA2056435A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A61K9/1277—Processes for preparing; Proliposomes
    • A61K9/1278—Post-loading, e.g. by ion or pH gradient

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Dispersion Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CA002056435A 1989-05-15 1990-05-15 Accumulation de medicaments dans des liposomes par un gradient de proton Abandoned CA2056435A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US35249789A 1989-05-15 1989-05-15
US352,497 1989-05-15
PCT/US1990/002736 WO1990014105A1 (fr) 1989-05-15 1990-05-15 Accumulation de medicaments dans des liposomes au moyen d'un gradient protonique

Publications (1)

Publication Number Publication Date
CA2056435A1 true CA2056435A1 (fr) 1990-11-16

Family

ID=23385362

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002056435A Abandoned CA2056435A1 (fr) 1989-05-15 1990-05-15 Accumulation de medicaments dans des liposomes par un gradient de proton

Country Status (5)

Country Link
EP (1) EP0472639A4 (fr)
JP (1) JPH04505616A (fr)
CA (1) CA2056435A1 (fr)
MX (1) MX9203793A (fr)
WO (1) WO1990014105A1 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005048986A1 (fr) * 2003-11-20 2005-06-02 Delex Therapeutics Inc. Compositions liposomales stables comprenant une amine lipophile contenant des agents pharmaceutiques

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK0699068T3 (da) * 1993-05-21 2002-03-11 Liposome Co Inc Reduktion af liposominducerede fysiologiske bivirkninger
US5741516A (en) * 1994-06-20 1998-04-21 Inex Pharmaceuticals Corporation Sphingosomes for enhanced drug delivery
US5543152A (en) * 1994-06-20 1996-08-06 Inex Pharmaceuticals Corporation Sphingosomes for enhanced drug delivery
US7351427B2 (en) 1998-06-18 2008-04-01 Busulipo Ab Pharmaceutical composition, a method of preparing it and a method of treatment by use thereof
HUP0303719A2 (hu) * 2000-10-16 2004-03-01 Neopharm, Inc. Mitoxantron hatóanyag-tartalmú liposzómás gyógyszerkészítmények és eljárás az előállításukra
AT500143A1 (de) * 2004-04-22 2005-11-15 Sanochemia Pharmazeutika Ag Cholinesterase-inhibitoren in liposomen sowie deren herstellung und verwendung
US20050255154A1 (en) 2004-05-11 2005-11-17 Lena Pereswetoff-Morath Method and composition for treating rhinitis
MX2007015577A (es) * 2005-06-09 2008-02-25 Biolipox Ab Metodo y composiciones para el tratamiento de trastornos inflamatorios.
MX2015005992A (es) 2012-11-20 2016-03-07 Spectrum Pharmaceuticals Inc Metodo mejorado para la preparacion de la vincristina liposomal encapsulada para el uso terapeutico.
ES2826896T3 (es) 2015-05-04 2021-05-19 Versantis AG Método para preparar vesículas con gradiente de pH transmembrana
TWI678213B (zh) 2015-07-22 2019-12-01 美商史倍壯製藥公司 用於長春新鹼硫酸鹽脂質體注射之即可使用的調配物
CN113041223B (zh) * 2019-12-26 2022-08-19 南京绿叶制药有限公司 一种局部麻醉剂脂质体制备方法
CN111729087A (zh) * 2020-07-24 2020-10-02 成都大学 一种选择性β2受体激动剂的脂质修饰物及其制备方法与用途
CA3182955A1 (en) * 2021-07-16 2023-01-16 Celator Pharmaceuticals, Inc. Methods for preparing liposomal formulations
WO2024077287A2 (fr) * 2022-10-07 2024-04-11 Mercury Bio, Inc. Méthodes de chargement actif de molécules thérapeutiques dans des vésicules extracellulaires modifiées pour administration ciblée à des cellules

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4515736A (en) * 1983-05-12 1985-05-07 The Regents Of The University Of California Method for encapsulating materials into liposomes
EP0152379A3 (fr) * 1984-02-15 1986-10-29 Ciba-Geigy Ag Procédé pour la préparation de compositions pharmaceutiques contenant des liposomes unilamellaires
US4861580A (en) * 1985-10-15 1989-08-29 The Liposome Company, Inc. Composition using salt form of organic acid derivative of alpha-tocopheral
SE8601457D0 (sv) * 1986-04-01 1986-04-01 Draco Ab Compositions of liposomes and b?712-receptor active substances for inhalation
US4781871A (en) * 1986-09-18 1988-11-01 Liposome Technology, Inc. High-concentration liposome processing method
US4891324A (en) * 1987-01-07 1990-01-02 Syntex (U.S.A.) Inc. Particle with luminescer for assays
CA1338702C (fr) * 1987-03-05 1996-11-12 Lawrence D. Mayer Formulations d'agents liposomiques-antineoplasiques a faible teneur en medicaments-lipides

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005048986A1 (fr) * 2003-11-20 2005-06-02 Delex Therapeutics Inc. Compositions liposomales stables comprenant une amine lipophile contenant des agents pharmaceutiques

Also Published As

Publication number Publication date
JPH04505616A (ja) 1992-10-01
MX9203793A (es) 1992-09-01
EP0472639A1 (fr) 1992-03-04
EP0472639A4 (en) 1992-07-01
WO1990014105A1 (fr) 1990-11-29

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Legal Events

Date Code Title Description
FZDE Discontinued
FZDE Discontinued

Effective date: 19980515

FZDE Discontinued

Effective date: 19980515