CA2021500A1 - Methode pour stimuler la proliferation de lymphocytes dans le sang peripherique - Google Patents
Methode pour stimuler la proliferation de lymphocytes dans le sang peripheriqueInfo
- Publication number
- CA2021500A1 CA2021500A1 CA2021500A CA2021500A CA2021500A1 CA 2021500 A1 CA2021500 A1 CA 2021500A1 CA 2021500 A CA2021500 A CA 2021500A CA 2021500 A CA2021500 A CA 2021500A CA 2021500 A1 CA2021500 A1 CA 2021500A1
- Authority
- CA
- Canada
- Prior art keywords
- peripheral blood
- blood lymphocytes
- stimulating proliferation
- subpopulations
- starting
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000000034 method Methods 0.000 title abstract 3
- 210000005105 peripheral blood lymphocyte Anatomy 0.000 title abstract 3
- 230000035755 proliferation Effects 0.000 title abstract 2
- 230000004936 stimulating effect Effects 0.000 title 1
- 230000001413 cellular effect Effects 0.000 abstract 2
- 230000000527 lymphocytic effect Effects 0.000 abstract 2
- 238000012258 culturing Methods 0.000 abstract 1
- 210000005259 peripheral blood Anatomy 0.000 abstract 1
- 239000011886 peripheral blood Substances 0.000 abstract 1
- 239000000758 substrate Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0636—T lymphocytes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/461—Cellular immunotherapy characterised by the cell type used
- A61K39/4611—T-cells, e.g. tumor infiltrating lymphocytes [TIL], lymphokine-activated killer cells [LAK] or regulatory T cells [Treg]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
- A61K39/4643—Vertebrate antigens
- A61K39/4644—Cancer antigens
- A61K39/464402—Receptors, cell surface antigens or cell surface determinants
- A61K39/464411—Immunoglobulin superfamily
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0646—Natural killers cells [NK], NKT cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K2035/124—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells the cells being hematopoietic, bone marrow derived or blood cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/30—Organic components
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/30—Organic components
- C12N2500/44—Thiols, e.g. mercaptoethanol
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/23—Interleukins [IL]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/30—Hormones
- C12N2501/33—Insulin
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/50—Cell markers; Cell surface determinants
- C12N2501/515—CD3, T-cell receptor complex
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- Biotechnology (AREA)
- Cell Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Microbiology (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Hematology (AREA)
- Medicinal Chemistry (AREA)
- Mycology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Oncology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US38394289A | 1989-07-21 | 1989-07-21 | |
US383,942 | 1989-07-21 |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2021500A1 true CA2021500A1 (fr) | 1991-01-22 |
CA2021500C CA2021500C (fr) | 1995-06-13 |
Family
ID=23515405
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002021500A Expired - Lifetime CA2021500C (fr) | 1989-07-21 | 1990-07-19 | Methode pour stimuler la proliferation de lymphocytes dans le sang peripherique |
Country Status (7)
Country | Link |
---|---|
EP (1) | EP0409655A3 (fr) |
JP (1) | JP3056230B2 (fr) |
AU (1) | AU633940B2 (fr) |
CA (1) | CA2021500C (fr) |
GR (1) | GR1001034B (fr) |
IE (1) | IE902662A1 (fr) |
ZA (1) | ZA905735B (fr) |
Families Citing this family (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2981486B2 (ja) * | 1988-06-14 | 1999-11-22 | メディカル・バイオロジー・インスティチュート | 哺乳動物の免疫系研究方法 |
AU663711B2 (en) * | 1991-04-05 | 1995-10-19 | Regents Of The University Of Minnesota | Method of enhancing the immunotherapeutic activity of immune cells by depletion/positive selection of cell subsets |
US5725855A (en) * | 1991-04-05 | 1998-03-10 | The United States Of America As Represented By The Department Of Health And Human Services | Method of treating tumors with CD8+ -depleted or CD4+ T cell subpopulations |
IE922233A1 (en) * | 1991-07-10 | 1993-01-13 | Augusto C Ochoa | Short-term anti-cd3 stimulation of lymphocytes to increase¹their in vivo activity |
WO1995032729A1 (fr) * | 1994-05-31 | 1995-12-07 | Augusto Carlos Ochoa | Stimulation anti-cd3 a court terme des lymphocytes destinee a en accroitre l'activite in vivo |
EP0910624B1 (fr) * | 1996-04-17 | 2004-09-22 | Albert, Winfried, Dr. | Procede de production et de multiplication de lymphocytes |
US6511848B2 (en) | 1996-04-17 | 2003-01-28 | Winfried Albert | Process for producing and multiplying lymphocytes |
JP4186013B2 (ja) * | 1996-07-15 | 2008-11-26 | 暉彬 関根 | ウイルス感染症の治療・予防剤、その調製方法 |
SE511143C2 (sv) | 1997-12-30 | 1999-08-09 | Sca Hygiene Paper Ab | Metod att framställa ett papper uppvisande en tredimensionellt mönster |
JP2001354575A (ja) | 2000-06-09 | 2001-12-25 | Human Tekku:Kk | 癌の再発予防法および癌の再発予防用活性化リンパ球を含む製剤、ならびにそれらの細胞の凍結および加工委・受託システム |
JP4917201B2 (ja) * | 2000-12-04 | 2012-04-18 | 株式会社リンフォテック | 臍帯血移植後の腫瘍および各種感染症の予防・治療用製剤、臍帯血移植後の移植臍帯血幹細胞の生着促進用製剤、臍帯血移植後の腫瘍および各種感染症の予防・治療用製剤ならびに臍帯血移植後の移植臍帯血幹細胞の生着促進用製剤の製造方法。 |
WO2002069990A1 (fr) * | 2001-03-05 | 2002-09-12 | Lymphotec Inc. | Methode de traitement d'une tumeur et systeme servant a la proliferation et au traitement de lymphocytes activees destinees a une utilisation parallele a la therapie tpd |
DE10120505A1 (de) * | 2001-04-26 | 2002-11-07 | Rudolf Wank | Verwendung von stimulierten mononukleären Zellen des peripheren Blutes zur Behandlung von Krebserkrankungen |
CN100591760C (zh) | 2002-03-25 | 2010-02-24 | 宝生物工程株式会社 | 制备细胞毒性淋巴细胞的方法 |
JP4562353B2 (ja) * | 2002-04-08 | 2010-10-13 | 株式会社リンフォテック | Hla一致他人由来活性化リンパ球を含有してなる腫瘍・感染症および自己免疫疾患の予防・治療用製剤 |
US20070025961A1 (en) | 2003-06-03 | 2007-02-01 | Kenzo Bamba | Composition for stabilizing survival of transplanted hematopoietic stem cell, kit for obtaining the composition, method of stabilizing survival of transplanted hematopoietic stem cell, human monoclonal antibody or human polyclonal antibody and method of producing the same, gene encoding human monoclonal antibody and transf |
US8927273B2 (en) | 2003-08-22 | 2015-01-06 | Takara Bio Inc. | Process for producing cytotoxic lymphocytes |
JP2006143709A (ja) * | 2004-10-20 | 2006-06-08 | Lymphotec:Kk | 薬剤耐性原生生物感染症の治療もしくは予防用製剤、該製剤の調製用キットおよび調製方法、薬剤耐性原生生物感染症の治療方法 |
KR101279172B1 (ko) * | 2005-08-17 | 2013-06-27 | 다카라 바이오 가부시키가이샤 | 림프구의 제조 방법 |
EP2390363A1 (fr) * | 2006-06-02 | 2011-11-30 | GlaxoSmithKline Biologicals s.a. | Procédé d'identification si un patient est réactif ou non à l'immunothérapie basé sur l'expression différentielle du gène PRF1 |
KR101133185B1 (ko) * | 2008-07-29 | 2012-04-06 | 서울대학교병원 | 자연살해세포의 증식방법 |
JP7158682B2 (ja) * | 2016-12-27 | 2022-10-24 | 住友化学株式会社 | 染色体の異常の検出方法および誘発性を評価する方法 |
AU2019215034C1 (en) | 2018-02-01 | 2022-01-06 | Nkmax Co., Ltd. | Method of producing natural killer cells and composition for treating cancer |
WO2021085504A1 (fr) | 2019-11-01 | 2021-05-06 | 京都府公立大学法人 | Récepteur d'anticorps de lympocyte b et son utilisation |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2529321B2 (ja) * | 1986-04-28 | 1996-08-28 | エンドトロニックス インコーポレーテッド | 白血球を培養する方法 |
AU7873187A (en) * | 1986-08-08 | 1988-02-24 | University Of Minnesota | Method of culturing leukocytes |
DE3634017A1 (de) * | 1986-10-06 | 1988-04-14 | Max Planck Gesellschaft | Verfahren zur aktivierung und vermehrung von t-zellen, insbesondere von deren subpopulationen |
AU4485089A (en) * | 1988-10-21 | 1990-05-14 | Brigham And Women's Hospital | Activation and growth of human tumor-infiltrating lymphocytes using antibodies to cd3 or tcr |
-
1990
- 1990-07-18 GR GR900100551A patent/GR1001034B/el not_active IP Right Cessation
- 1990-07-19 CA CA002021500A patent/CA2021500C/fr not_active Expired - Lifetime
- 1990-07-20 IE IE266290A patent/IE902662A1/en unknown
- 1990-07-20 ZA ZA905735A patent/ZA905735B/xx unknown
- 1990-07-20 JP JP2190897A patent/JP3056230B2/ja not_active Expired - Lifetime
- 1990-07-20 EP EP19900307983 patent/EP0409655A3/en not_active Withdrawn
- 1990-07-20 AU AU59182/90A patent/AU633940B2/en not_active Ceased
Also Published As
Publication number | Publication date |
---|---|
CA2021500C (fr) | 1995-06-13 |
JP3056230B2 (ja) | 2000-06-26 |
IE902662A1 (en) | 1991-02-27 |
GR900100551A (fr) | 1991-12-10 |
ZA905735B (en) | 1992-03-25 |
GR1001034B (el) | 1993-03-31 |
EP0409655A2 (fr) | 1991-01-23 |
AU633940B2 (en) | 1993-02-11 |
EP0409655A3 (en) | 1992-04-15 |
JPH0380076A (ja) | 1991-04-04 |
AU5918290A (en) | 1991-01-24 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
EEER | Examination request | ||
MKLA | Lapsed | ||
MKEC | Expiry (correction) |
Effective date: 20121202 |