CA2014390C - Compositions therapeutiques pour le traitement ou la prevention du ronflement - Google Patents
Compositions therapeutiques pour le traitement ou la prevention du ronflement Download PDFInfo
- Publication number
- CA2014390C CA2014390C CA002014390A CA2014390A CA2014390C CA 2014390 C CA2014390 C CA 2014390C CA 002014390 A CA002014390 A CA 002014390A CA 2014390 A CA2014390 A CA 2014390A CA 2014390 C CA2014390 C CA 2014390C
- Authority
- CA
- Canada
- Prior art keywords
- composition according
- snoring
- nasal
- patients
- sodium salt
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 24
- 206010041235 Snoring Diseases 0.000 title claims abstract description 21
- 230000001225 therapeutic effect Effects 0.000 title claims abstract description 7
- 230000002265 prevention Effects 0.000 title claims abstract description 5
- 238000011282 treatment Methods 0.000 title claims description 16
- 229920002683 Glycosaminoglycan Polymers 0.000 claims abstract description 13
- 229920001287 Chondroitin sulfate Polymers 0.000 claims abstract description 7
- 229910052500 inorganic mineral Inorganic materials 0.000 claims abstract description 5
- 239000011707 mineral Substances 0.000 claims abstract description 5
- 239000003755 preservative agent Substances 0.000 claims abstract description 5
- 230000001632 homeopathic effect Effects 0.000 claims abstract description 4
- 230000002335 preservative effect Effects 0.000 claims abstract description 4
- 229940100656 nasal solution Drugs 0.000 claims description 9
- 159000000000 sodium salts Chemical class 0.000 claims description 9
- 229940059329 chondroitin sulfate Drugs 0.000 claims description 7
- SQDAZGGFXASXDW-UHFFFAOYSA-N 5-bromo-2-(trifluoromethoxy)pyridine Chemical group FC(F)(F)OC1=CC=C(Br)C=N1 SQDAZGGFXASXDW-UHFFFAOYSA-N 0.000 claims description 6
- 241000196324 Embryophyta Species 0.000 claims description 5
- 239000000470 constituent Substances 0.000 claims description 5
- 229920000447 polyanionic polymer Polymers 0.000 claims description 3
- 241000219106 Bryonia Species 0.000 claims description 2
- PNEYBMLMFCGWSK-UHFFFAOYSA-N aluminium oxide Inorganic materials [O-2].[O-2].[O-2].[Al+3].[Al+3] PNEYBMLMFCGWSK-UHFFFAOYSA-N 0.000 claims description 2
- 239000007864 aqueous solution Substances 0.000 claims description 2
- KXKPYJOVDUMHGS-OSRGNVMNSA-N chondroitin sulfate Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](OS(O)(=O)=O)[C@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](C(O)=O)O1 KXKPYJOVDUMHGS-OSRGNVMNSA-N 0.000 claims description 2
- 239000012895 dilution Substances 0.000 claims description 2
- 238000010790 dilution Methods 0.000 claims description 2
- WABPQHHGFIMREM-UHFFFAOYSA-N lead(0) Chemical compound [Pb] WABPQHHGFIMREM-UHFFFAOYSA-N 0.000 claims description 2
- 239000013543 active substance Substances 0.000 claims 2
- 229920000642 polymer Polymers 0.000 claims 2
- 241001465356 Atropa belladonna Species 0.000 claims 1
- 239000008363 phosphate buffer Substances 0.000 abstract description 3
- 235000013311 vegetables Nutrition 0.000 abstract description 3
- 238000002636 symptomatic treatment Methods 0.000 abstract description 2
- PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 abstract 1
- 239000000546 pharmaceutical excipient Substances 0.000 abstract 1
- 239000012929 tonicity agent Substances 0.000 abstract 1
- 239000000126 substance Substances 0.000 description 9
- 210000002850 nasal mucosa Anatomy 0.000 description 6
- 208000024891 symptom Diseases 0.000 description 5
- 229920002567 Chondroitin Polymers 0.000 description 4
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 description 4
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 4
- 230000000694 effects Effects 0.000 description 4
- 229920000669 heparin Polymers 0.000 description 4
- 229960002897 heparin Drugs 0.000 description 4
- 230000006872 improvement Effects 0.000 description 4
- 229940043138 pentosan polysulfate Drugs 0.000 description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 4
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 description 3
- DLGJWSVWTWEWBJ-HGGSSLSASA-N chondroitin Chemical compound CC(O)=N[C@@H]1[C@H](O)O[C@H](CO)[C@H](O)[C@@H]1OC1[C@H](O)[C@H](O)C=C(C(O)=O)O1 DLGJWSVWTWEWBJ-HGGSSLSASA-N 0.000 description 3
- 229920002674 hyaluronan Polymers 0.000 description 3
- 229960003160 hyaluronic acid Drugs 0.000 description 3
- -1 keratosulfates Polymers 0.000 description 3
- 239000008213 purified water Substances 0.000 description 3
- 239000004094 surface-active agent Substances 0.000 description 3
- 238000002560 therapeutic procedure Methods 0.000 description 3
- 229920001221 xylan Polymers 0.000 description 3
- 150000004823 xylans Chemical class 0.000 description 3
- CNIIGCLFLJGOGP-UHFFFAOYSA-N 2-(1-naphthalenylmethyl)-4,5-dihydro-1H-imidazole Chemical compound C=1C=CC2=CC=CC=C2C=1CC1=NCCN1 CNIIGCLFLJGOGP-UHFFFAOYSA-N 0.000 description 2
- 241001106067 Atropa Species 0.000 description 2
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 2
- 229920001499 Heparinoid Polymers 0.000 description 2
- 241000208829 Sambucus Species 0.000 description 2
- HUCJFAOMUPXHDK-UHFFFAOYSA-N Xylometazoline Chemical compound CC1=CC(C(C)(C)C)=CC(C)=C1CC1=NCCN1 HUCJFAOMUPXHDK-UHFFFAOYSA-N 0.000 description 2
- 239000002253 acid Substances 0.000 description 2
- 239000004480 active ingredient Substances 0.000 description 2
- 230000002421 anti-septic effect Effects 0.000 description 2
- 229940064004 antiseptic throat preparations Drugs 0.000 description 2
- 239000000872 buffer Substances 0.000 description 2
- 210000000845 cartilage Anatomy 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- 230000008034 disappearance Effects 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 235000008995 european elder Nutrition 0.000 description 2
- 239000003889 eye drop Substances 0.000 description 2
- 229940012356 eye drops Drugs 0.000 description 2
- 239000002554 heparinoid Substances 0.000 description 2
- 229940025770 heparinoids Drugs 0.000 description 2
- 239000007923 nasal drop Substances 0.000 description 2
- 229940100662 nasal drops Drugs 0.000 description 2
- VUXSPDNLYQTOSY-UHFFFAOYSA-N phenylmercuric borate Chemical compound OB(O)O[Hg]C1=CC=CC=C1 VUXSPDNLYQTOSY-UHFFFAOYSA-N 0.000 description 2
- 229960000247 phenylmercuric borate Drugs 0.000 description 2
- 229920001282 polysaccharide Polymers 0.000 description 2
- 239000005017 polysaccharide Substances 0.000 description 2
- 150000004804 polysaccharides Chemical class 0.000 description 2
- LWIHDJKSTIGBAC-UHFFFAOYSA-K potassium phosphate Substances [K+].[K+].[K+].[O-]P([O-])([O-])=O LWIHDJKSTIGBAC-UHFFFAOYSA-K 0.000 description 2
- 238000012545 processing Methods 0.000 description 2
- 230000009467 reduction Effects 0.000 description 2
- 230000029058 respiratory gaseous exchange Effects 0.000 description 2
- 201000002859 sleep apnea Diseases 0.000 description 2
- 239000011780 sodium chloride Substances 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- BYJAVTDNIXVSPW-UHFFFAOYSA-N tetryzoline Chemical compound N1CCN=C1C1C2=CC=CC=C2CCC1 BYJAVTDNIXVSPW-UHFFFAOYSA-N 0.000 description 2
- 210000001519 tissue Anatomy 0.000 description 2
- 239000005526 vasoconstrictor agent Substances 0.000 description 2
- FHYNZKLNCPUNEU-UHFFFAOYSA-N 4-[(3,4-dihydroxyphenyl)methyl]-3-[(4-hydroxyphenyl)methyl]oxolan-2-one Chemical compound C1=CC(O)=CC=C1CC1C(=O)OCC1CC1=CC=C(O)C(O)=C1 FHYNZKLNCPUNEU-UHFFFAOYSA-N 0.000 description 1
- 150000005168 4-hydroxybenzoic acids Chemical class 0.000 description 1
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 description 1
- 241000251468 Actinopterygii Species 0.000 description 1
- BTBUEUYNUDRHOZ-UHFFFAOYSA-N Borate Chemical compound [O-]B([O-])[O-] BTBUEUYNUDRHOZ-UHFFFAOYSA-N 0.000 description 1
- GHXZTYHSJHQHIJ-UHFFFAOYSA-N Chlorhexidine Chemical class C=1C=C(Cl)C=CC=1NC(N)=NC(N)=NCCCCCCN=C(N)N=C(N)NC1=CC=C(Cl)C=C1 GHXZTYHSJHQHIJ-UHFFFAOYSA-N 0.000 description 1
- 206010012335 Dependence Diseases 0.000 description 1
- 229920000045 Dermatan sulfate Polymers 0.000 description 1
- 229920002307 Dextran Polymers 0.000 description 1
- 240000000731 Fagus sylvatica Species 0.000 description 1
- 235000010099 Fagus sylvatica Nutrition 0.000 description 1
- 206010022998 Irritability Diseases 0.000 description 1
- 241000124008 Mammalia Species 0.000 description 1
- 229910002651 NO3 Inorganic materials 0.000 description 1
- NHNBFGGVMKEFGY-UHFFFAOYSA-N Nitrate Chemical compound [O-][N+]([O-])=O NHNBFGGVMKEFGY-UHFFFAOYSA-N 0.000 description 1
- 241000283973 Oryctolagus cuniculus Species 0.000 description 1
- 206010033307 Overweight Diseases 0.000 description 1
- 206010035664 Pneumonia Diseases 0.000 description 1
- 206010041349 Somnolence Diseases 0.000 description 1
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 1
- 230000002159 abnormal effect Effects 0.000 description 1
- 150000007513 acids Chemical class 0.000 description 1
- 238000001467 acupuncture Methods 0.000 description 1
- 230000002009 allergenic effect Effects 0.000 description 1
- 125000000129 anionic group Chemical group 0.000 description 1
- 230000002429 anti-coagulating effect Effects 0.000 description 1
- 239000003146 anticoagulant agent Substances 0.000 description 1
- 229940127219 anticoagulant drug Drugs 0.000 description 1
- 239000003443 antiviral agent Substances 0.000 description 1
- 238000013459 approach Methods 0.000 description 1
- 235000019568 aromas Nutrition 0.000 description 1
- 229960000686 benzalkonium chloride Drugs 0.000 description 1
- CADWTSSKOVRVJC-UHFFFAOYSA-N benzyl(dimethyl)azanium;chloride Chemical compound [Cl-].C[NH+](C)CC1=CC=CC=C1 CADWTSSKOVRVJC-UHFFFAOYSA-N 0.000 description 1
- KGBXLFKZBHKPEV-UHFFFAOYSA-N boric acid Chemical compound OB(O)O KGBXLFKZBHKPEV-UHFFFAOYSA-N 0.000 description 1
- 239000004327 boric acid Substances 0.000 description 1
- 210000004556 brain Anatomy 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 239000000969 carrier Substances 0.000 description 1
- 239000003093 cationic surfactant Substances 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 210000002808 connective tissue Anatomy 0.000 description 1
- ZPWVASYFFYYZEW-UHFFFAOYSA-L dipotassium hydrogen phosphate Chemical compound [K+].[K+].OP([O-])([O-])=O ZPWVASYFFYYZEW-UHFFFAOYSA-L 0.000 description 1
- 229910000396 dipotassium phosphate Inorganic materials 0.000 description 1
- 235000019797 dipotassium phosphate Nutrition 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000035475 disorder Diseases 0.000 description 1
- 206010013663 drug dependence Diseases 0.000 description 1
- 230000008030 elimination Effects 0.000 description 1
- 238000003379 elimination reaction Methods 0.000 description 1
- 208000001780 epistaxis Diseases 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 230000007717 exclusion Effects 0.000 description 1
- 239000004744 fabric Substances 0.000 description 1
- 230000003480 fibrinolytic effect Effects 0.000 description 1
- 238000011207 functional examination Methods 0.000 description 1
- 235000011187 glycerol Nutrition 0.000 description 1
- 230000035876 healing Effects 0.000 description 1
- WJRBRSLFGCUECM-UHFFFAOYSA-N hydantoin Chemical compound O=C1CNC(=O)N1 WJRBRSLFGCUECM-UHFFFAOYSA-N 0.000 description 1
- 230000000887 hydrating effect Effects 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 150000002730 mercury Chemical class 0.000 description 1
- 229910000402 monopotassium phosphate Inorganic materials 0.000 description 1
- 235000019796 monopotassium phosphate Nutrition 0.000 description 1
- 210000004877 mucosa Anatomy 0.000 description 1
- 210000004400 mucous membrane Anatomy 0.000 description 1
- 229960005016 naphazoline Drugs 0.000 description 1
- 208000011309 nasal bleeding Diseases 0.000 description 1
- 210000003928 nasal cavity Anatomy 0.000 description 1
- 210000000492 nasalseptum Anatomy 0.000 description 1
- 230000014508 negative regulation of coagulation Effects 0.000 description 1
- 230000000422 nocturnal effect Effects 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 210000001331 nose Anatomy 0.000 description 1
- 230000009965 odorless effect Effects 0.000 description 1
- 239000002304 perfume Substances 0.000 description 1
- 230000002688 persistence Effects 0.000 description 1
- 230000000079 pharmacotherapeutic effect Effects 0.000 description 1
- 210000003800 pharynx Anatomy 0.000 description 1
- PDTFCHSETJBPTR-UHFFFAOYSA-N phenylmercuric nitrate Chemical compound [O-][N+](=O)O[Hg]C1=CC=CC=C1 PDTFCHSETJBPTR-UHFFFAOYSA-N 0.000 description 1
- 229940096825 phenylmercury Drugs 0.000 description 1
- DCNLOVYDMCVNRZ-UHFFFAOYSA-N phenylmercury(.) Chemical compound [Hg]C1=CC=CC=C1 DCNLOVYDMCVNRZ-UHFFFAOYSA-N 0.000 description 1
- DLNKOYKMWOXYQA-APPZFPTMSA-N phenylpropanolamine Chemical class C[C@@H](N)[C@H](O)C1=CC=CC=C1 DLNKOYKMWOXYQA-APPZFPTMSA-N 0.000 description 1
- 229920000728 polyester Polymers 0.000 description 1
- GNSKLFRGEWLPPA-UHFFFAOYSA-M potassium dihydrogen phosphate Chemical compound [K+].OP(O)([O-])=O GNSKLFRGEWLPPA-UHFFFAOYSA-M 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 230000000750 progressive effect Effects 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 125000001453 quaternary ammonium group Chemical group 0.000 description 1
- 230000007115 recruitment Effects 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 239000008132 rose water Substances 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 238000005070 sampling Methods 0.000 description 1
- 210000001584 soft palate Anatomy 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 208000011117 substance-related disease Diseases 0.000 description 1
- 150000003467 sulfuric acid derivatives Chemical class 0.000 description 1
- 230000001629 suppression Effects 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- 229920001059 synthetic polymer Polymers 0.000 description 1
- 230000009885 systemic effect Effects 0.000 description 1
- 231100000057 systemic toxicity Toxicity 0.000 description 1
- 230000009967 tasteless effect Effects 0.000 description 1
- 229960000337 tetryzoline Drugs 0.000 description 1
- 239000002023 wood Substances 0.000 description 1
- 229960000833 xylometazoline Drugs 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/35—Caprifoliaceae (Honeysuckle family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/42—Cucurbitaceae (Cucumber family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/81—Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Biotechnology (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Botany (AREA)
- Alternative & Traditional Medicine (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Plant Substances (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR8905029A FR2645745B1 (fr) | 1989-04-12 | 1989-04-12 | Compositions therapeutiques pour le traitement ou la prevention du ronflement |
| FR8905029 | 1989-04-12 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2014390A1 CA2014390A1 (fr) | 1990-10-12 |
| CA2014390C true CA2014390C (fr) | 2001-08-14 |
Family
ID=9380780
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002014390A Expired - Lifetime CA2014390C (fr) | 1989-04-12 | 1990-04-11 | Compositions therapeutiques pour le traitement ou la prevention du ronflement |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US5516765A (de) |
| EP (1) | EP0392888B1 (de) |
| AT (1) | ATE80304T1 (de) |
| CA (1) | CA2014390C (de) |
| DE (1) | DE69000295T2 (de) |
| DK (1) | DK0392888T3 (de) |
| ES (1) | ES2053131T3 (de) |
| FR (1) | FR2645745B1 (de) |
| GR (1) | GR3006445T3 (de) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5817644A (en) * | 1991-07-03 | 1998-10-06 | Hyal Pharmaceutical Corporation | Targeting of dosages of medicine and therapeutic agents |
| US5804211A (en) * | 1996-06-05 | 1998-09-08 | Health Pharm Usa, Inc. | Composition and method for suppressing or eliminating snoring |
| DE19754940A1 (de) * | 1997-12-12 | 1999-06-17 | Siedler Siegfried | Herstellung und Verarbeitung von Pflanzenauszügen, Extrakten und ätherischen Ölen |
| US6790465B2 (en) * | 2000-12-01 | 2004-09-14 | Snore-Fix, Inc. | Composition and method for treating snoring |
| US20030022206A1 (en) * | 2001-05-16 | 2003-01-30 | Kay Robert A. | Method of characterizing a homeopathic preparation |
| FR2859105B1 (fr) * | 2003-09-02 | 2006-01-20 | Vegeflore | Composition pour le traitement ou la prevention du ronflement |
| CN111148749A (zh) | 2016-08-31 | 2020-05-12 | 王子控股株式会社 | 酸性低聚木糖的生产方法和酸性低聚木糖 |
| JP6225321B1 (ja) | 2016-08-31 | 2017-11-08 | 王子ホールディングス株式会社 | ポリ硫酸ペントサンの製造方法 |
| JP6281659B1 (ja) | 2017-02-28 | 2018-02-21 | 王子ホールディングス株式会社 | ポリ硫酸ペントサン、医薬組成物及び抗凝固剤 |
| CN110678189A (zh) | 2017-05-31 | 2020-01-10 | 王子控股株式会社 | 保湿外用剂 |
| MX2020002726A (es) | 2017-09-12 | 2020-07-20 | Oji Holdings Corp | Polisulfato de pentosan y metodo para producir polisulfato de pentosan. |
| KR102533822B1 (ko) | 2017-12-20 | 2023-05-17 | 오지 홀딩스 가부시키가이샤 | 폴리황산펜토산 및 폴리황산펜토산을 포함하는 의약 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3323389A1 (de) * | 1983-06-29 | 1985-01-10 | B. Braun Melsungen Ag, 3508 Melsungen | Auf schleimhaeute des mundes, der nase und/oder des rachens wirkende arzneimittel auf der basis von heparin und tensiden |
| GB8614189D0 (en) * | 1986-06-11 | 1986-07-16 | Leo Pharm Prod Ltd | Pharmaceutical composition |
| US4965253A (en) * | 1987-10-14 | 1990-10-23 | University Of Florida | Viscoelastic material for ophthalmic surgery |
-
1989
- 1989-04-12 FR FR8905029A patent/FR2645745B1/fr not_active Expired - Fee Related
-
1990
- 1990-03-06 DE DE9090400614T patent/DE69000295T2/de not_active Expired - Lifetime
- 1990-03-06 ES ES90400614T patent/ES2053131T3/es not_active Expired - Lifetime
- 1990-03-06 DK DK90400614.5T patent/DK0392888T3/da active
- 1990-03-06 AT AT90400614T patent/ATE80304T1/de not_active IP Right Cessation
- 1990-03-06 EP EP90400614A patent/EP0392888B1/de not_active Expired - Lifetime
- 1990-04-11 CA CA002014390A patent/CA2014390C/fr not_active Expired - Lifetime
-
1992
- 1992-12-02 GR GR920402809T patent/GR3006445T3/el unknown
-
1994
- 1994-12-19 US US08/359,342 patent/US5516765A/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| DE69000295T2 (de) | 1993-02-11 |
| DE69000295D1 (de) | 1992-10-15 |
| EP0392888B1 (de) | 1992-09-09 |
| FR2645745B1 (fr) | 1991-09-27 |
| ES2053131T3 (es) | 1994-07-16 |
| US5516765A (en) | 1996-05-14 |
| EP0392888A1 (de) | 1990-10-17 |
| FR2645745A1 (fr) | 1990-10-19 |
| ATE80304T1 (de) | 1992-09-15 |
| CA2014390A1 (fr) | 1990-10-12 |
| GR3006445T3 (de) | 1993-06-21 |
| DK0392888T3 (da) | 1993-01-11 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US10195239B2 (en) | Extract of Trigonella foenum-graecum | |
| EP1076553B1 (de) | Pharmazeutische und/oder kosmetische zusammensetzungen enthaltend meerwasser | |
| CA2014390C (fr) | Compositions therapeutiques pour le traitement ou la prevention du ronflement | |
| US6828308B2 (en) | Compositions and methods for the treatment or prevention of inflammation | |
| WO2019155389A1 (en) | An aqueous mucoadhesive and bioadhesive composition for the treatment | |
| US20020173485A1 (en) | Compositions and methods for the treatment or prevention of inflammation | |
| JP5646446B2 (ja) | 医療用化合物あるいは医療用製品を作成するための生体適合性ポリマーの使用方法 | |
| ES2405314T3 (es) | Composiciones y uso oral de glicosaminoglicanos | |
| WO1994005272A1 (en) | Skin treatment compositions containing dimethylsulphone and dimethylsulphoxide | |
| EP2162491A1 (de) | Flüssige oder pastöse zusammensetzung zur bereitstellung von für die synthese und formierung von proteoglycanen benötigten elementen, insbesondere zur behandlung von knorpelabbau | |
| WO2019038100A1 (fr) | Produit de combinaison pour soulager les symptômes liés aux infections des voies respiratoires supérieures | |
| WO2010075611A1 (en) | Composition comprising proanthocyanidin, proteolytic enzyme and aloe vera/agave species substance | |
| WO1994005279A1 (en) | Dermatological treatment compositions containing dimethylsulphone and a sulfur containing amino acid | |
| EP0468122A1 (de) | Therapeutische Zusammensetzung mit Polihexanid für die Behandlung von ophthalmologischem, dermatologischem und ginekologischem Herpes zoster | |
| EP0805679A1 (de) | Permukösale therapeutische verwendung von beta-mimetika zur behandlung von menstrualen schmerzen | |
| JP2836903B2 (ja) | いびきの治療または予防用組成物 | |
| RU2221584C2 (ru) | Препарат для лечения офтальмологических заболеваний | |
| CN1110306C (zh) | 高效霉素粉针剂药品 | |
| IL94263A (en) | Therapeutical compositions for treatment or prevention of snoring | |
| WO2000024402A1 (fr) | Utilisation d'antifongiques dans le traitement des scleroses | |
| FR2868316A1 (fr) | Utilisation de polymeres biocompatibles pour la preparation d'une composition ou d'un dispositif medical destines a la prevention, au soulagement ou au traitement des genes et douleurs |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| MKEX | Expiry |