CA1313871C - Derives de l'acide (dihydro-2,3 oxo-2 benzofurannyl-3)-2 acetique, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent - Google Patents
Derives de l'acide (dihydro-2,3 oxo-2 benzofurannyl-3)-2 acetique, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennentInfo
- Publication number
- CA1313871C CA1313871C CA000557812A CA557812A CA1313871C CA 1313871 C CA1313871 C CA 1313871C CA 000557812 A CA000557812 A CA 000557812A CA 557812 A CA557812 A CA 557812A CA 1313871 C CA1313871 C CA 1313871C
- Authority
- CA
- Canada
- Prior art keywords
- radical
- carbon atoms
- general formula
- oxo
- substituted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
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- 229910052763 palladium Inorganic materials 0.000 description 1
- 230000001991 pathophysiological effect Effects 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
- 239000011591 potassium Substances 0.000 description 1
- 230000003389 potentiating effect Effects 0.000 description 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 1
- 230000000750 progressive effect Effects 0.000 description 1
- 239000012429 reaction media Substances 0.000 description 1
- 238000010992 reflux Methods 0.000 description 1
- 230000000241 respiratory effect Effects 0.000 description 1
- 239000012047 saturated solution Substances 0.000 description 1
- 230000009758 senescence Effects 0.000 description 1
- 239000000377 silicon dioxide Substances 0.000 description 1
- 230000003595 spectral effect Effects 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 229910021653 sulphate ion Inorganic materials 0.000 description 1
- 239000000829 suppository Substances 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 208000011580 syndromic disease Diseases 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 230000001052 transient effect Effects 0.000 description 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/82—Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
- C07D307/83—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Furan Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Indole Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR87.02630 | 1987-02-27 | ||
| FR8702630A FR2611713B1 (fr) | 1987-02-27 | 1987-02-27 | Nouveaux derives de l'acide (dihydro-2,3 oxo-2 benzofurannyl-3)-2 acetique, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA1313871C true CA1313871C (fr) | 1993-02-23 |
Family
ID=9348401
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA000557812A Expired - Fee Related CA1313871C (fr) | 1987-02-27 | 1988-02-01 | Derives de l'acide (dihydro-2,3 oxo-2 benzofurannyl-3)-2 acetique, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent |
Country Status (16)
| Country | Link |
|---|---|
| US (2) | US4859700A (en, 2012) |
| EP (1) | EP0282390B1 (en, 2012) |
| JP (1) | JPS63227582A (en, 2012) |
| AT (1) | ATE63309T1 (en, 2012) |
| AU (1) | AU598345B2 (en, 2012) |
| CA (1) | CA1313871C (en, 2012) |
| DE (1) | DE3862660D1 (en, 2012) |
| DK (1) | DK167063B1 (en, 2012) |
| ES (1) | ES2009553A6 (en, 2012) |
| FR (1) | FR2611713B1 (en, 2012) |
| GR (1) | GR1000125B (en, 2012) |
| IE (1) | IE60500B1 (en, 2012) |
| NZ (1) | NZ223663A (en, 2012) |
| OA (1) | OA08813A (en, 2012) |
| PT (1) | PT86851B (en, 2012) |
| ZA (1) | ZA881383B (en, 2012) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0370560B1 (en) * | 1988-11-24 | 1994-01-12 | Akzo Nobel N.V. | Pharmaceutical composition containing 1-[mono- or bis (trifluoromethyl)-2-pyridinyl] piperazines |
| GB9024960D0 (en) * | 1990-11-16 | 1991-01-02 | Ici Plc | Chemical process |
| GB9205049D0 (en) * | 1992-03-09 | 1992-04-22 | Ici Plc | Polycyclic dyes |
| US6207665B1 (en) | 1997-06-12 | 2001-03-27 | Schering Aktiengesellschaft | Piperazine derivatives and their use as anti-inflammatory agents |
| AU2001278875B2 (en) * | 2000-07-06 | 2007-06-07 | The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Tetrahydrobenzothiazole analogues as neuroprotective agents |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2513698A (en) * | 1945-03-09 | 1950-07-04 | Abbott Lab | 2 (3) benxofuranone derivatives and methods of making them |
| GB1173312A (en) * | 1966-03-17 | 1969-12-10 | Kefalas As | Heterocyclic Compounds |
| GB2044272B (en) * | 1979-02-05 | 1983-03-16 | Sandoz Ltd | Stabilising polymers |
| US4514415A (en) * | 1981-10-28 | 1985-04-30 | Ciba Geigy Corporation | Benzofuran-2(3H)-ones used as anti-inflammatory agents |
| US4663347A (en) * | 1983-10-31 | 1987-05-05 | Merck Frosst Canada, Inc. | Benzofuran 2-carboxylic acid esters useful as inhibitors of leukotriene biosynthesis |
| GB8426424D0 (en) * | 1984-10-19 | 1984-11-28 | Biorex Laboratories Ltd | Chalcone derivatives |
| FR2593504B1 (fr) * | 1986-01-30 | 1988-12-09 | Ile De France | Nouveaux derives de dihydrobenzofuranne - et de chromane - carboxamides, leurs procedes de preparation et leur utilisation comme neuroleptiques |
-
1987
- 1987-02-27 FR FR8702630A patent/FR2611713B1/fr not_active Expired - Lifetime
-
1988
- 1988-02-01 CA CA000557812A patent/CA1313871C/fr not_active Expired - Fee Related
- 1988-02-12 US US07/155,352 patent/US4859700A/en not_active Expired - Fee Related
- 1988-02-26 AT AT88400441T patent/ATE63309T1/de not_active IP Right Cessation
- 1988-02-26 OA OA59290A patent/OA08813A/xx unknown
- 1988-02-26 DK DK104388A patent/DK167063B1/da not_active IP Right Cessation
- 1988-02-26 IE IE52888A patent/IE60500B1/en not_active IP Right Cessation
- 1988-02-26 ZA ZA881383A patent/ZA881383B/xx unknown
- 1988-02-26 AU AU12344/88A patent/AU598345B2/en not_active Ceased
- 1988-02-26 DE DE8888400441T patent/DE3862660D1/de not_active Expired - Lifetime
- 1988-02-26 GR GR880100111A patent/GR1000125B/el unknown
- 1988-02-26 PT PT86851A patent/PT86851B/pt not_active IP Right Cessation
- 1988-02-26 JP JP63044081A patent/JPS63227582A/ja active Granted
- 1988-02-26 EP EP19880400441 patent/EP0282390B1/fr not_active Expired - Lifetime
- 1988-02-26 NZ NZ223663A patent/NZ223663A/en unknown
- 1988-02-27 ES ES8800577A patent/ES2009553A6/es not_active Expired
-
1989
- 1989-01-17 US US07/298,107 patent/US4885299A/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| US4885299A (en) | 1989-12-05 |
| JPH0558633B2 (en, 2012) | 1993-08-27 |
| ZA881383B (en) | 1988-12-28 |
| EP0282390A1 (fr) | 1988-09-14 |
| PT86851A (pt) | 1988-03-01 |
| ATE63309T1 (de) | 1991-05-15 |
| IE60500B1 (en) | 1994-07-27 |
| JPS63227582A (ja) | 1988-09-21 |
| FR2611713B1 (fr) | 1990-11-30 |
| OA08813A (fr) | 1989-03-31 |
| IE880528L (en) | 1988-08-27 |
| EP0282390B1 (fr) | 1991-05-08 |
| DK167063B1 (da) | 1993-08-23 |
| NZ223663A (en) | 1990-01-29 |
| FR2611713A1 (fr) | 1988-09-09 |
| US4859700A (en) | 1989-08-22 |
| PT86851B (pt) | 1992-05-29 |
| DK104388D0 (da) | 1988-02-26 |
| GR880100111A (en) | 1988-12-16 |
| DK104388A (da) | 1988-08-28 |
| ES2009553A6 (es) | 1989-10-01 |
| DE3862660D1 (de) | 1991-06-13 |
| AU1234488A (en) | 1988-09-01 |
| AU598345B2 (en) | 1990-06-21 |
| GR1000125B (el) | 1991-07-31 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MKLA | Lapsed |