CA1295216C - Rainbow test device - Google Patents
Rainbow test deviceInfo
- Publication number
- CA1295216C CA1295216C CA000529533A CA529533A CA1295216C CA 1295216 C CA1295216 C CA 1295216C CA 000529533 A CA000529533 A CA 000529533A CA 529533 A CA529533 A CA 529533A CA 1295216 C CA1295216 C CA 1295216C
- Authority
- CA
- Canada
- Prior art keywords
- indicator
- reduced
- disulfide
- hue
- nicotinamide adenine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 238000012360 testing method Methods 0.000 title claims abstract description 103
- 239000000203 mixture Substances 0.000 claims abstract description 73
- 229930027945 nicotinamide-adenine dinucleotide Natural products 0.000 claims abstract description 67
- BOPGDPNILDQYTO-NNYOXOHSSA-N nicotinamide-adenine dinucleotide Chemical compound C1=CCC(C(=O)N)=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OC[C@@H]2[C@H]([C@@H](O)[C@@H](O2)N2C3=NC=NC(N)=C3N=C2)O)O1 BOPGDPNILDQYTO-NNYOXOHSSA-N 0.000 claims abstract description 63
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims abstract description 46
- 239000008103 glucose Substances 0.000 claims abstract description 46
- 230000003197 catalytic effect Effects 0.000 claims abstract description 43
- 239000012491 analyte Substances 0.000 claims abstract description 39
- 230000000007 visual effect Effects 0.000 claims abstract description 15
- 210000001124 body fluid Anatomy 0.000 claims abstract description 5
- 239000010839 body fluid Substances 0.000 claims abstract description 5
- 238000006243 chemical reaction Methods 0.000 claims description 48
- KIUMMUBSPKGMOY-UHFFFAOYSA-N 3,3'-Dithiobis(6-nitrobenzoic acid) Chemical compound C1=C([N+]([O-])=O)C(C(=O)O)=CC(SSC=2C=C(C(=CC=2)[N+]([O-])=O)C(O)=O)=C1 KIUMMUBSPKGMOY-UHFFFAOYSA-N 0.000 claims description 43
- 230000002829 reductive effect Effects 0.000 claims description 43
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 34
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- 230000008859 change Effects 0.000 claims description 28
- BAWFJGJZGIEFAR-NNYOXOHSSA-N NAD zwitterion Chemical compound NC(=O)C1=CC=C[N+]([C@H]2[C@@H]([C@H](O)[C@@H](COP([O-])(=O)OP(O)(=O)OC[C@@H]3[C@H]([C@@H](O)[C@@H](O3)N3C4=NC=NC(N)=C4N=C3)O)O2)O)=C1 BAWFJGJZGIEFAR-NNYOXOHSSA-N 0.000 claims description 26
- 229950006238 nadide Drugs 0.000 claims description 26
- 101710167005 Thiol:disulfide interchange protein DsbD Proteins 0.000 claims description 22
- 239000011159 matrix material Substances 0.000 claims description 17
- 230000009467 reduction Effects 0.000 claims description 16
- 108010050375 Glucose 1-Dehydrogenase Proteins 0.000 claims description 14
- -1 potassium ferricyanide Chemical compound 0.000 claims description 13
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- 125000003396 thiol group Chemical class [H]S* 0.000 claims 14
- VQDKCFLPUPEBJC-UHFFFAOYSA-M 1-ethyl-4-methylquinolin-1-ium;iodide Chemical compound [I-].C1=CC=C2[N+](CC)=CC=C(C)C2=C1 VQDKCFLPUPEBJC-UHFFFAOYSA-M 0.000 claims 1
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- 108700023483 L-lactate dehydrogenases Proteins 0.000 description 13
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- 150000001875 compounds Chemical class 0.000 description 13
- FYSNRJHAOHDILO-UHFFFAOYSA-N thionyl chloride Chemical compound ClS(Cl)=O FYSNRJHAOHDILO-UHFFFAOYSA-N 0.000 description 12
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- GPAAEXYTRXIWHR-UHFFFAOYSA-N (1-methylpiperidin-1-ium-1-yl)methanesulfonate Chemical compound [O-]S(=O)(=O)C[N+]1(C)CCCCC1 GPAAEXYTRXIWHR-UHFFFAOYSA-N 0.000 description 10
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 10
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- HEDRZPFGACZZDS-MICDWDOJSA-N Trichloro(2H)methane Chemical compound [2H]C(Cl)(Cl)Cl HEDRZPFGACZZDS-MICDWDOJSA-N 0.000 description 10
- JKMHFZQWWAIEOD-UHFFFAOYSA-N 2-[4-(2-hydroxyethyl)piperazin-1-yl]ethanesulfonic acid Chemical compound OCC[NH+]1CCN(CCS([O-])(=O)=O)CC1 JKMHFZQWWAIEOD-UHFFFAOYSA-N 0.000 description 9
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 9
- 239000000872 buffer Substances 0.000 description 9
- 238000009472 formulation Methods 0.000 description 9
- RWSXRVCMGQZWBV-WDSKDSINSA-N glutathione Chemical compound OC(=O)[C@@H](N)CCC(=O)N[C@@H](CS)C(=O)NCC(O)=O RWSXRVCMGQZWBV-WDSKDSINSA-N 0.000 description 9
- 239000002904 solvent Substances 0.000 description 9
- 102100031126 6-phosphogluconolactonase Human genes 0.000 description 8
- 210000004369 blood Anatomy 0.000 description 8
- 239000008280 blood Substances 0.000 description 8
- 150000001718 carbodiimides Chemical class 0.000 description 8
- 239000007995 HEPES buffer Substances 0.000 description 7
- 239000007983 Tris buffer Substances 0.000 description 7
- 239000003086 colorant Substances 0.000 description 7
- 231100000673 dose–response relationship Toxicity 0.000 description 7
- 238000003756 stirring Methods 0.000 description 7
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 6
- CSNNHWWHGAXBCP-UHFFFAOYSA-L Magnesium sulfate Chemical compound [Mg+2].[O-][S+2]([O-])([O-])[O-] CSNNHWWHGAXBCP-UHFFFAOYSA-L 0.000 description 6
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 description 6
- 230000003993 interaction Effects 0.000 description 6
- 238000002360 preparation method Methods 0.000 description 6
- 238000001228 spectrum Methods 0.000 description 6
- LWIHDJKSTIGBAC-UHFFFAOYSA-K tripotassium phosphate Chemical compound [K+].[K+].[K+].[O-]P([O-])([O-])=O LWIHDJKSTIGBAC-UHFFFAOYSA-K 0.000 description 6
- OCKGFTQIICXDQW-ZEQRLZLVSA-N 5-[(1r)-1-hydroxy-2-[4-[(2r)-2-hydroxy-2-(4-methyl-1-oxo-3h-2-benzofuran-5-yl)ethyl]piperazin-1-yl]ethyl]-4-methyl-3h-2-benzofuran-1-one Chemical compound C1=C2C(=O)OCC2=C(C)C([C@@H](O)CN2CCN(CC2)C[C@H](O)C2=CC=C3C(=O)OCC3=C2C)=C1 OCKGFTQIICXDQW-ZEQRLZLVSA-N 0.000 description 5
- 108010028127 Dihydrolipoamide Dehydrogenase Proteins 0.000 description 5
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- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 5
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 description 5
- 239000004094 surface-active agent Substances 0.000 description 5
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- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 5
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- RZQXOGQSPBYUKH-UHFFFAOYSA-N 3-[[1,3-dihydroxy-2-(hydroxymethyl)propan-2-yl]azaniumyl]-2-hydroxypropane-1-sulfonate Chemical compound OCC(CO)(CO)NCC(O)CS(O)(=O)=O RZQXOGQSPBYUKH-UHFFFAOYSA-N 0.000 description 3
- RXGJTUSBYWCRBK-UHFFFAOYSA-M 5-methylphenazinium methyl sulfate Chemical compound COS([O-])(=O)=O.C1=CC=C2[N+](C)=C(C=CC=C3)C3=NC2=C1 RXGJTUSBYWCRBK-UHFFFAOYSA-M 0.000 description 3
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Classifications
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- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/52—Use of compounds or compositions for colorimetric, spectrophotometric or fluorometric investigation, e.g. use of reagent paper and including single- and multilayer analytical elements
- G01N33/525—Multi-layer analytical elements
- G01N33/526—Multi-layer analytical elements the element being adapted for a specific analyte
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/26—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/54—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving glucose or galactose
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- Pathology (AREA)
- Emergency Medicine (AREA)
- Food Science & Technology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Meat, Egg Or Seafood Products (AREA)
- Sampling And Sample Adjustment (AREA)
- Apparatuses For Bulk Treatment Of Fruits And Vegetables And Apparatuses For Preparing Feeds (AREA)
- Investigating Or Analyzing Non-Biological Materials By The Use Of Chemical Means (AREA)
- Measuring Pulse, Heart Rate, Blood Pressure Or Blood Flow (AREA)
- Spinning Or Twisting Of Yarns (AREA)
- Indicating And Signalling Devices For Elevators (AREA)
- Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
- Superconductors And Manufacturing Methods Therefor (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US84870686A | 1986-04-04 | 1986-04-04 | |
| US848,706 | 1986-04-04 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA1295216C true CA1295216C (en) | 1992-02-04 |
Family
ID=25304059
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA000529533A Expired - Lifetime CA1295216C (en) | 1986-04-04 | 1987-02-12 | Rainbow test device |
Country Status (12)
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4855228A (en) * | 1987-09-11 | 1989-08-08 | Miles Inc. | Multiple oxidative indicator system for visual determination of hydrogen peroxide |
| AU602277B2 (en) * | 1988-02-10 | 1990-10-04 | Miles Inc. | Self-indicating and improved resolution analyses employing stoichiometric chemical substraction |
| AU666821B2 (en) * | 1993-08-05 | 1996-02-22 | Bayer Corporation | Analyte detection device and process |
| NZ529366A (en) | 2001-11-21 | 2007-02-23 | Unitika Ltd | Visually determinable ATP measurement method and reagent therefor |
| US6958039B2 (en) | 2003-05-02 | 2005-10-25 | Oculir, Inc. | Method and instruments for non-invasive analyte measurement |
| US6968222B2 (en) | 2003-05-02 | 2005-11-22 | Oculir, Inc. | Methods and device for non-invasive analyte measurement |
| US6975892B2 (en) | 2003-10-21 | 2005-12-13 | Oculir, Inc. | Methods for non-invasive analyte measurement from the conjunctiva |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3211167A1 (de) * | 1982-03-26 | 1983-09-29 | Merck Patent Gmbh, 6100 Darmstadt | Testsystem und verfahren zur bestimmung von substanzen in fluessigkeiten |
| DE3247894A1 (de) * | 1982-12-24 | 1984-06-28 | Merck Patent Gmbh, 6100 Darmstadt | Testsystem und verfahren zur bestimmung von nad(p)h |
| EP0160847A1 (de) * | 1984-04-09 | 1985-11-13 | Akademie der Wissenschaften der DDR | Analystisches Element zur Bestimmung von Glucose, glucosehaltigen Oligosacchariden und Harnsäure |
| US4898813A (en) * | 1986-04-04 | 1990-02-06 | Albarella James P | Catalytic test composition intended to produce a range of colors |
-
1987
- 1987-02-12 CA CA000529533A patent/CA1295216C/en not_active Expired - Lifetime
- 1987-02-25 ZA ZA871361A patent/ZA871361B/xx unknown
- 1987-03-24 NO NO871222A patent/NO175218C/no unknown
- 1987-03-25 DE DE87104429T patent/DE3786286T2/de not_active Expired - Fee Related
- 1987-03-25 AT AT87104429T patent/ATE90970T1/de not_active IP Right Cessation
- 1987-03-25 EP EP87104429A patent/EP0239926B1/en not_active Expired - Lifetime
- 1987-03-25 ES ES198787104429T patent/ES2041251T3/es not_active Expired - Lifetime
- 1987-04-01 JP JP62077645A patent/JPH0698037B2/ja not_active Expired - Lifetime
- 1987-04-02 FI FI871450A patent/FI871450L/fi not_active Application Discontinuation
- 1987-04-03 DK DK171087A patent/DK169040B1/da not_active IP Right Cessation
- 1987-04-03 IE IE86687A patent/IE60583B1/en not_active IP Right Cessation
- 1987-04-03 AU AU71035/87A patent/AU579507B2/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| EP0239926A3 (en) | 1990-11-07 |
| NO175218C (no) | 1994-09-14 |
| DK171087D0 (da) | 1987-04-03 |
| DK171087A (da) | 1987-10-05 |
| EP0239926A2 (en) | 1987-10-07 |
| DE3786286T2 (de) | 1993-09-30 |
| ATE90970T1 (de) | 1993-07-15 |
| EP0239926B1 (en) | 1993-06-23 |
| NO871222L (no) | 1987-10-05 |
| NO175218B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1994-06-06 |
| DK169040B1 (da) | 1994-08-01 |
| AU7103587A (en) | 1987-10-08 |
| JPS62239054A (ja) | 1987-10-19 |
| IE60583B1 (en) | 1994-07-27 |
| FI871450A0 (fi) | 1987-04-02 |
| IE870866L (en) | 1987-10-04 |
| ZA871361B (en) | 1987-08-20 |
| NO871222D0 (no) | 1987-03-24 |
| DE3786286D1 (de) | 1993-07-29 |
| FI871450A7 (fi) | 1987-10-05 |
| FI871450L (fi) | 1987-10-05 |
| ES2041251T3 (es) | 1993-11-16 |
| JPH0698037B2 (ja) | 1994-12-07 |
| AU579507B2 (en) | 1988-11-24 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MKLA | Lapsed | ||
| MKLA | Lapsed |
Effective date: 19950805 |