CA1294873C - Method of regulating animal reproduction - Google Patents
Method of regulating animal reproductionInfo
- Publication number
- CA1294873C CA1294873C CA000536206A CA536206A CA1294873C CA 1294873 C CA1294873 C CA 1294873C CA 000536206 A CA000536206 A CA 000536206A CA 536206 A CA536206 A CA 536206A CA 1294873 C CA1294873 C CA 1294873C
- Authority
- CA
- Canada
- Prior art keywords
- approximately
- effective amount
- ovine
- stimulating hormone
- follicle
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 241001465754 Metazoa Species 0.000 title claims abstract description 45
- 238000000034 method Methods 0.000 title abstract description 17
- 230000001105 regulatory effect Effects 0.000 title description 2
- 229940028334 follicle stimulating hormone Drugs 0.000 claims abstract description 49
- 102000012673 Follicle Stimulating Hormone Human genes 0.000 claims abstract description 48
- 108010079345 Follicle Stimulating Hormone Proteins 0.000 claims abstract description 48
- 230000016087 ovulation Effects 0.000 claims abstract description 44
- 230000001965 increasing effect Effects 0.000 claims abstract description 20
- 241000282849 Ruminantia Species 0.000 claims abstract description 17
- 230000001939 inductive effect Effects 0.000 claims abstract description 17
- 238000011282 treatment Methods 0.000 claims description 52
- 239000000203 mixture Substances 0.000 claims description 34
- 241000283690 Bos taurus Species 0.000 claims description 33
- 239000003795 chemical substances by application Substances 0.000 claims description 33
- 206010062767 Hypophysitis Diseases 0.000 claims description 19
- 210000003635 pituitary gland Anatomy 0.000 claims description 18
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 9
- 150000003180 prostaglandins Chemical class 0.000 claims description 9
- 230000000977 initiatory effect Effects 0.000 claims description 8
- 229960004509 serum gonadotrophin Drugs 0.000 claims description 4
- 108090000623 proteins and genes Proteins 0.000 claims description 3
- 239000003125 aqueous solvent Substances 0.000 claims description 2
- 238000010367 cloning Methods 0.000 claims description 2
- 125000003259 prostaglandin group Chemical class 0.000 claims description 2
- 230000001592 luteinising effect Effects 0.000 claims 7
- 239000012634 fragment Substances 0.000 claims 1
- 239000003688 hormone derivative Substances 0.000 claims 1
- 238000002347 injection Methods 0.000 description 19
- 239000007924 injection Substances 0.000 description 19
- 241001494479 Pecora Species 0.000 description 17
- 241000243142 Porifera Species 0.000 description 10
- 210000002257 embryonic structure Anatomy 0.000 description 10
- 235000012461 sponges Nutrition 0.000 description 10
- 241000283707 Capra Species 0.000 description 8
- 229940032383 estrumate Drugs 0.000 description 8
- IFEJLMHZNQJGQU-KXXGZHCCSA-M sodium;(z)-7-[(1r,2r,3r,5s)-2-[(e,3r)-4-(3-chlorophenoxy)-3-hydroxybut-1-enyl]-3,5-dihydroxycyclopentyl]hept-5-enoate Chemical compound [Na+].C([C@H](O)\C=C\[C@@H]1[C@H]([C@@H](O)C[C@H]1O)C\C=C/CCCC([O-])=O)OC1=CC=CC(Cl)=C1 IFEJLMHZNQJGQU-KXXGZHCCSA-M 0.000 description 8
- 230000006698 induction Effects 0.000 description 7
- 230000003247 decreasing effect Effects 0.000 description 5
- 229940088597 hormone Drugs 0.000 description 5
- 239000005556 hormone Substances 0.000 description 5
- 210000001672 ovary Anatomy 0.000 description 5
- 238000011010 flushing procedure Methods 0.000 description 4
- 238000004519 manufacturing process Methods 0.000 description 4
- 230000004044 response Effects 0.000 description 4
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 3
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
- 210000003484 anatomy Anatomy 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 150000002500 ions Chemical class 0.000 description 3
- 230000001850 reproductive effect Effects 0.000 description 3
- 239000011780 sodium chloride Substances 0.000 description 3
- 238000011269 treatment regimen Methods 0.000 description 3
- 241000282326 Felis catus Species 0.000 description 2
- 241000283903 Ovis aries Species 0.000 description 2
- BFNBIHQBYMNNAN-UHFFFAOYSA-N ammonium sulfate Chemical compound N.N.OS(O)(=O)=O BFNBIHQBYMNNAN-UHFFFAOYSA-N 0.000 description 2
- 229910052921 ammonium sulfate Inorganic materials 0.000 description 2
- 239000001166 ammonium sulphate Substances 0.000 description 2
- 235000011130 ammonium sulphate Nutrition 0.000 description 2
- 230000037396 body weight Effects 0.000 description 2
- 244000309466 calf Species 0.000 description 2
- 230000001419 dependent effect Effects 0.000 description 2
- 239000012153 distilled water Substances 0.000 description 2
- 230000012173 estrus Effects 0.000 description 2
- 239000007943 implant Substances 0.000 description 2
- 230000001976 improved effect Effects 0.000 description 2
- PSGAAPLEWMOORI-PEINSRQWSA-N medroxyprogesterone acetate Chemical compound C([C@@]12C)CC(=O)C=C1[C@@H](C)C[C@@H]1[C@@H]2CC[C@]2(C)[C@@](OC(C)=O)(C(C)=O)CC[C@H]21 PSGAAPLEWMOORI-PEINSRQWSA-N 0.000 description 2
- 230000002611 ovarian Effects 0.000 description 2
- -1 prostaglandins Natural products 0.000 description 2
- 210000000582 semen Anatomy 0.000 description 2
- 239000002904 solvent Substances 0.000 description 2
- 241000894007 species Species 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- 206010000234 Abortion spontaneous Diseases 0.000 description 1
- 206010002091 Anaesthesia Diseases 0.000 description 1
- 241000282472 Canis lupus familiaris Species 0.000 description 1
- 241000282994 Cervidae Species 0.000 description 1
- 102100032392 Circadian-associated transcriptional repressor Human genes 0.000 description 1
- 101710130150 Circadian-associated transcriptional repressor Proteins 0.000 description 1
- 241000283073 Equus caballus Species 0.000 description 1
- GVGLGOZIDCSQPN-PVHGPHFFSA-N Heroin Chemical compound O([C@H]1[C@H](C=C[C@H]23)OC(C)=O)C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4OC(C)=O GVGLGOZIDCSQPN-PVHGPHFFSA-N 0.000 description 1
- 235000019687 Lamb Nutrition 0.000 description 1
- YJPIGAIKUZMOQA-UHFFFAOYSA-N Melatonin Natural products COC1=CC=C2N(C(C)=O)C=C(CCN)C2=C1 YJPIGAIKUZMOQA-UHFFFAOYSA-N 0.000 description 1
- KWYHDKDOAIKMQN-UHFFFAOYSA-N N,N,N',N'-tetramethylethylenediamine Chemical compound CN(C)CCN(C)C KWYHDKDOAIKMQN-UHFFFAOYSA-N 0.000 description 1
- 206010030113 Oedema Diseases 0.000 description 1
- 241001610364 Ovula Species 0.000 description 1
- 241000282887 Suidae Species 0.000 description 1
- 206010042573 Superovulation Diseases 0.000 description 1
- WAHQVRCNDCHDIB-QZYSPNBYSA-N [(3s,8r,9s,10r,13s,14s,17r)-17-acetyl-17-acetyloxy-6,10,13-trimethyl-1,2,3,8,9,11,12,14,15,16-decahydrocyclopenta[a]phenanthren-3-yl] 3-cyclopentylpropanoate Chemical class O([C@@H]1C=C2C(C)=C[C@H]3[C@@H]4CC[C@]([C@]4(CC[C@@H]3[C@@]2(C)CC1)C)(OC(=O)C)C(C)=O)C(=O)CCC1CCCC1 WAHQVRCNDCHDIB-QZYSPNBYSA-N 0.000 description 1
- 230000004075 alteration Effects 0.000 description 1
- 238000001949 anaesthesia Methods 0.000 description 1
- 230000037005 anaesthesia Effects 0.000 description 1
- 229940125717 barbiturate Drugs 0.000 description 1
- HNYOPLTXPVRDBG-UHFFFAOYSA-N barbituric acid Chemical compound O=C1CC(=O)NC(=O)N1 HNYOPLTXPVRDBG-UHFFFAOYSA-N 0.000 description 1
- 229960004407 chorionic gonadotrophin Drugs 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 229960002069 diamorphine Drugs 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 230000035558 fertility Effects 0.000 description 1
- 244000309465 heifer Species 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 239000012535 impurity Substances 0.000 description 1
- 230000009027 insemination Effects 0.000 description 1
- 238000003780 insertion Methods 0.000 description 1
- 230000037431 insertion Effects 0.000 description 1
- 238000007918 intramuscular administration Methods 0.000 description 1
- 238000002955 isolation Methods 0.000 description 1
- 230000013011 mating Effects 0.000 description 1
- 229960003987 melatonin Drugs 0.000 description 1
- DRLFMBDRBRZALE-UHFFFAOYSA-N melatonin Chemical compound COC1=CC=C2NC=C(CCNC(C)=O)C2=C1 DRLFMBDRBRZALE-UHFFFAOYSA-N 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 229930014626 natural product Natural products 0.000 description 1
- 230000000624 ovulatory effect Effects 0.000 description 1
- 229940094443 oxytocics prostaglandins Drugs 0.000 description 1
- 230000001817 pituitary effect Effects 0.000 description 1
- 229920001184 polypeptide Polymers 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
- 108090000765 processed proteins & peptides Proteins 0.000 description 1
- 239000000583 progesterone congener Substances 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- JFINOWIINSTUNY-UHFFFAOYSA-N pyrrolidin-3-ylmethanesulfonamide Chemical compound NS(=O)(=O)CC1CCNC1 JFINOWIINSTUNY-UHFFFAOYSA-N 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 208000000995 spontaneous abortion Diseases 0.000 description 1
- 230000004936 stimulating effect Effects 0.000 description 1
- 239000007929 subcutaneous injection Substances 0.000 description 1
- 238000010254 subcutaneous injection Methods 0.000 description 1
- 230000001360 synchronised effect Effects 0.000 description 1
- 230000035899 viability Effects 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/59—Follicle-stimulating hormone [FSH]; Chorionic gonadotropins, e.g.hCG [human chorionic gonadotropin]; Luteinising hormone [LH]; Thyroid-stimulating hormone [TSH]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Endocrinology (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Toxicology (AREA)
- Molecular Biology (AREA)
- Gastroenterology & Hepatology (AREA)
- Reproductive Health (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Guiding Agricultural Machines (AREA)
- Eye Examination Apparatus (AREA)
- Image Processing (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Feeding And Watering For Cattle Raising And Animal Husbandry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AUPH5717 | 1986-05-02 | ||
| AUPH571786 | 1986-05-02 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA1294873C true CA1294873C (en) | 1992-01-28 |
Family
ID=3771594
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA000536206A Expired - Lifetime CA1294873C (en) | 1986-05-02 | 1987-05-01 | Method of regulating animal reproduction |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US4980166A (en:Method) |
| EP (1) | EP0245044B1 (en:Method) |
| JP (1) | JPS63503141A (en:Method) |
| AT (1) | ATE59779T1 (en:Method) |
| AU (2) | AU601421B2 (en:Method) |
| CA (1) | CA1294873C (en:Method) |
| ES (1) | ES2020562B3 (en:Method) |
| GR (1) | GR3001746T3 (en:Method) |
| NZ (1) | NZ220169A (en:Method) |
| WO (1) | WO1987006466A1 (en:Method) |
| ZA (1) | ZA873127B (en:Method) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0310288A3 (en) * | 1987-10-01 | 1990-05-09 | Bunge (Australia) Proprietary Limited | Improved ovulation treatment |
| DK8089A (da) * | 1988-01-12 | 1989-07-13 | Bunge Australia | Monoclonale antistoffer, deres fremstilling og anvendelse. |
| US5087615A (en) * | 1989-03-17 | 1992-02-11 | Applied Research Systems Ars Holding N.V. | Novel method of ovulation induction in humans |
| AU620255B2 (en) * | 1989-06-19 | 1992-02-13 | Bunge (Australia) Pty Ltd | Ovine follicle stimulating hormone |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB547910A (en) * | 1940-01-18 | 1942-09-17 | Chem Ind Basel | Process for concentrating gonadotropic hormones of the pituitary gland |
| US3119740A (en) * | 1959-04-13 | 1964-01-28 | Armour Pharma | Process for preparing purified follicle stimulating hormone |
| US3036103A (en) * | 1959-05-21 | 1962-05-22 | Monsanto Chemicals | Preparation of trialkyltin halides and tetraalkyltin compounds |
| FR3819M (fr) * | 1963-03-11 | 1966-01-10 | Serono Ist Farm | Nouvelle hormone hypophysaire a activité différenciée. |
| CA918067A (en) * | 1966-04-08 | 1973-01-02 | Eli Lilly And Company | Method of improving conception rate in domestic female mammals |
| AU497512B2 (en) * | 1975-04-15 | 1978-12-14 | Ici Australia Limited | Nona and deca-peptides |
| SU1029960A1 (ru) * | 1981-04-23 | 1983-07-23 | Всесоюзный Ордена Трудового Красного Знамени Научно-Исследовательский Институт Животноводства | Способ получени зародышей у самок- доноров крупного рогатого скота |
| US4599227A (en) * | 1983-11-07 | 1986-07-08 | Wisconsin Alumni Research Foundation | Injectable pharmaceutical preparation for the induction of multiple follicular growth |
| AU586252B2 (en) * | 1985-05-10 | 1989-07-06 | University Of Melbourne, The | Induction of ovulation in mares |
-
1987
- 1987-04-29 AU AU72219/87A patent/AU601421B2/en not_active Expired
- 1987-04-30 EP EP87303926A patent/EP0245044B1/en not_active Expired - Lifetime
- 1987-04-30 ZA ZA873127A patent/ZA873127B/xx unknown
- 1987-04-30 ES ES87303926T patent/ES2020562B3/es not_active Expired - Lifetime
- 1987-04-30 US US07/044,305 patent/US4980166A/en not_active Expired - Lifetime
- 1987-04-30 AT AT87303926T patent/ATE59779T1/de active
- 1987-05-01 NZ NZ220169A patent/NZ220169A/en unknown
- 1987-05-01 CA CA000536206A patent/CA1294873C/en not_active Expired - Lifetime
- 1987-05-01 WO PCT/AU1987/000123 patent/WO1987006466A1/en unknown
- 1987-05-01 JP JP62502826A patent/JPS63503141A/ja active Pending
-
1990
- 1990-10-16 AU AU6461590A patent/AU613858B2/en not_active Expired - Lifetime
-
1991
- 1991-04-09 GR GR91400462T patent/GR3001746T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP0245044B1 (en) | 1991-01-09 |
| ATE59779T1 (de) | 1991-01-15 |
| US4980166A (en) | 1990-12-25 |
| ZA873127B (en) | 1988-03-30 |
| AU6461590A (en:Method) | 1991-04-26 |
| EP0245044A2 (en) | 1987-11-11 |
| GR3001746T3 (en) | 1992-11-23 |
| JPS63503141A (ja) | 1988-11-17 |
| NZ220169A (en) | 1990-04-26 |
| AU601421B2 (en) | 1990-09-13 |
| AU7221987A (en) | 1987-11-05 |
| WO1987006466A1 (en) | 1987-11-05 |
| ES2020562B3 (es) | 1991-08-16 |
| AU613858B2 (en) | 1991-08-08 |
| EP0245044A3 (en) | 1988-01-27 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MKEX | Expiry |