CA1294546C - Wound healing composition containing collagen - Google Patents
Wound healing composition containing collagenInfo
- Publication number
- CA1294546C CA1294546C CA000535169A CA535169A CA1294546C CA 1294546 C CA1294546 C CA 1294546C CA 000535169 A CA000535169 A CA 000535169A CA 535169 A CA535169 A CA 535169A CA 1294546 C CA1294546 C CA 1294546C
- Authority
- CA
- Canada
- Prior art keywords
- collagen
- platelets
- heparin
- wound
- composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
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- SEEPANYCNGTZFQ-UHFFFAOYSA-N sulfadiazine Chemical compound C1=CC(N)=CC=C1S(=O)(=O)NC1=NC=CC=N1 SEEPANYCNGTZFQ-UHFFFAOYSA-N 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/39—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG]
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Materials For Medical Uses (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US85550886A | 1986-04-23 | 1986-04-23 | |
| US855,508 | 1986-04-23 | ||
| US877,266 | 1986-06-23 | ||
| US06/877,266 US4760131A (en) | 1986-04-23 | 1986-06-23 | Wound-healing composition |
| US89575786A | 1986-08-12 | 1986-08-12 | |
| US895,757 | 1986-08-12 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA1294546C true CA1294546C (en) | 1992-01-21 |
Family
ID=27420380
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA000535169A Expired - Lifetime CA1294546C (en) | 1986-04-23 | 1987-04-21 | Wound healing composition containing collagen |
Country Status (7)
| Country | Link |
|---|---|
| EP (1) | EP0243179B1 (en:Method) |
| JP (1) | JPH068253B2 (en:Method) |
| AU (1) | AU599647B2 (en:Method) |
| CA (1) | CA1294546C (en:Method) |
| DE (1) | DE3782358T2 (en:Method) |
| ES (1) | ES2032373T3 (en:Method) |
| GR (1) | GR3006416T3 (en:Method) |
Families Citing this family (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4889919A (en) * | 1986-08-13 | 1989-12-26 | Zymogenetics, Inc. | Biologically active PDGF derived A-chain homodimers |
| US4886747A (en) * | 1985-03-22 | 1989-12-12 | Genentech, Inc. | Nucleic acid encoding TGF-β and its uses |
| US5284763A (en) * | 1985-03-22 | 1994-02-08 | Genentech, Inc. | Nucleic acid encoding TGF-β and its uses |
| US5474982A (en) * | 1986-08-13 | 1995-12-12 | Zymogenetics, Inc. | PDGF analogs and methods of use |
| JPS6379588A (ja) * | 1986-09-25 | 1988-04-09 | Yasuo Moriya | 細胞培養用基材およびその製造方法 |
| US5273900A (en) * | 1987-04-28 | 1993-12-28 | The Regents Of The University Of California | Method and apparatus for preparing composite skin replacement |
| US4863732A (en) * | 1987-12-16 | 1989-09-05 | Collagen Corporation | Injectable composition for inductive bone repair |
| IL84911A (en) * | 1987-12-22 | 1993-04-04 | Yissum Res Dev Co | Processes for the preparation of collagen products, and pharmaceutical compositions containing the same |
| US4950483A (en) * | 1988-06-30 | 1990-08-21 | Collagen Corporation | Collagen wound healing matrices and process for their production |
| US5219576A (en) * | 1988-06-30 | 1993-06-15 | Collagen Corporation | Collagen wound healing matrices and process for their production |
| US5175147A (en) * | 1988-08-19 | 1992-12-29 | Takeda Chemical Industries, Ltd | Acid-resistant fgf composition and method of treating ulcerating diseases of the gastrointestinal tract |
| FR2637501A1 (fr) * | 1988-10-07 | 1990-04-13 | Inst Develop Valorisa Biotec | Composition stabilisee a base de facteurs de croissance de la famille fgf et de dextrane sulfate, et ses applications |
| US4891359A (en) * | 1988-12-08 | 1990-01-02 | Johnson & Johnson Patient Care, Inc. | Hemostatic collagen paste composition |
| DE3900198A1 (de) * | 1989-01-05 | 1990-07-12 | Merck Patent Gmbh | Topisch anwendbare pharmazeutische zubereitung |
| US5422340A (en) * | 1989-09-01 | 1995-06-06 | Ammann; Arthur J. | TGF-βformulation for inducing bone growth |
| JPH0776175B2 (ja) * | 1990-04-26 | 1995-08-16 | サイトアーレクス・コーポレーシヨン | 損傷されたかまたは病気になった組織の局所的処置用の組成物および方法 |
| US5292362A (en) * | 1990-07-27 | 1994-03-08 | The Trustees Of Columbia University In The City Of New York | Tissue bonding and sealing composition and method of using the same |
| US5192743A (en) * | 1992-01-16 | 1993-03-09 | Genentech, Inc. | Reconstitutable lyophilized protein formulation |
| AU659723B2 (en) * | 1992-02-14 | 1995-05-25 | Kaken Pharmaceutical Co., Ltd. | Remedy for airway diseases |
| GB2272645B8 (en) * | 1992-11-23 | 2010-02-10 | Johnson & Johnson Medical | Wound dressing |
| WO1994022427A1 (en) * | 1993-04-01 | 1994-10-13 | Amgen Inc. | Method for preparing drugs to treat dermal disorders |
| WO1995005840A1 (fr) * | 1993-08-25 | 1995-03-02 | Kaken Pharmaceutical Co., Ltd. | Remede contre les affections periodontiques |
| US5693341A (en) * | 1995-03-16 | 1997-12-02 | Collagen Corporation | Affinity bound collagen matrices for the delivery of biologically active agents |
| US7883693B2 (en) | 1995-12-18 | 2011-02-08 | Angiodevice International Gmbh | Compositions and systems for forming crosslinked biomaterials and methods of preparation of use |
| US6833408B2 (en) | 1995-12-18 | 2004-12-21 | Cohesion Technologies, Inc. | Methods for tissue repair using adhesive materials |
| WO1997022371A1 (en) | 1995-12-18 | 1997-06-26 | Collagen Corporation | Crosslinked polymer compositions and methods for their use |
| US6458889B1 (en) | 1995-12-18 | 2002-10-01 | Cohesion Technologies, Inc. | Compositions and systems for forming crosslinked biomaterials and associated methods of preparation and use |
| AT407484B (de) * | 1997-11-12 | 2001-03-26 | Bio Prod & Bio Eng Ag | Arzneimittel zur förderung der wundheilung |
| DE19841698A1 (de) * | 1998-09-11 | 2000-03-16 | Curative Technologies Gmbh | Wachstumsfaktor-enthaltende Zusammensetzung zur Heilung von Gewebeschäden |
| ATE314863T1 (de) * | 1999-04-22 | 2006-02-15 | Eidgenoess Tech Hochschule | Kontrollierte abgabe der wachstumsfaktoren von heparin enthaltenden matrizen |
| US6046160A (en) * | 1999-07-22 | 2000-04-04 | Deroyal Industries, Inc. | Composition and method for enhancing wound healing |
| US7622562B2 (en) | 2002-06-26 | 2009-11-24 | Zimmer Orthobiologics, Inc. | Rapid isolation of osteoinductive protein mixtures from mammalian bone tissue |
| US7241874B2 (en) | 2002-06-26 | 2007-07-10 | Zimmer Ortho Biologics, Inc. | Rapid isolation of osteoinductive protein mixtures from mammalian bone tissue |
| US8303973B2 (en) | 2004-09-17 | 2012-11-06 | Angiotech Pharmaceuticals (Us), Inc. | Multifunctional compounds for forming crosslinked biomaterials and methods of preparation and use |
| JP2010501072A (ja) * | 2006-08-17 | 2010-01-14 | エフ．ホフマン−ラ ロシュ アーゲー | 血小板機能を測定し、血小板関連疾患および心血管疾患を診断するための方法および手段 |
| EP1890155A1 (en) * | 2006-08-17 | 2008-02-20 | F. Hoffmann-Roche AG | Methods and means for determining platelet function and diagnosing platelet-related and cardiovascular disorders |
| CN107530371B (zh) * | 2015-01-09 | 2021-10-26 | 新加坡科技研究局 | 硫酸乙酰肝素的pdgf-b/pdgf-bb结合变体 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3037513C2 (de) * | 1980-10-03 | 1983-05-05 | Steffan, Wolfgang, 8425 Neustadt | Kollagene Wundauflage |
| DE3105624A1 (de) * | 1981-02-16 | 1982-09-02 | Hormon-Chemie München GmbH, 8000 München | Material zum abdichten und heilen von wunden |
| US4350629A (en) * | 1981-07-29 | 1982-09-21 | Massachusetts Institute Of Technology | Procedures for preparing composite materials from collagen and glycosaminoglycan |
| FR2517315B1 (fr) * | 1981-11-30 | 1985-12-20 | Tech Cuir Centre | Procede de preparation de formes nouvelles de collagene, natif ou dereticule, a structure helicoidale preservee, associees a des mucopolysaccharides et leurs applications notamment dans les domaines cosmetologiques, pharmaceutiques, analytiques et autres |
| DE3382562D1 (de) * | 1982-09-24 | 1992-06-25 | Us Health | Wiederherstellung von gewebe bei tieren. |
| US4444760A (en) * | 1983-06-17 | 1984-04-24 | Merck & Co., Inc. | Purification and characterization of a protein fibroblast growth factor |
| US4745098A (en) * | 1984-02-24 | 1988-05-17 | The Regents Of The University Of California | Compositions and method for improving wound healing |
-
1987
- 1987-04-21 CA CA000535169A patent/CA1294546C/en not_active Expired - Lifetime
- 1987-04-22 DE DE8787303549T patent/DE3782358T2/de not_active Expired - Fee Related
- 1987-04-22 EP EP87303549A patent/EP0243179B1/en not_active Expired - Lifetime
- 1987-04-22 ES ES87303549T patent/ES2032373T3/es not_active Expired - Lifetime
- 1987-04-23 JP JP62101112A patent/JPH068253B2/ja not_active Expired - Lifetime
- 1987-04-23 AU AU71914/87A patent/AU599647B2/en not_active Ceased
-
1992
- 1992-12-02 GR GR920402780T patent/GR3006416T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ES2032373T1 (es) | 1993-02-16 |
| AU599647B2 (en) | 1990-07-26 |
| DE3782358D1 (de) | 1992-12-03 |
| JPS6354328A (ja) | 1988-03-08 |
| GR3006416T3 (en:Method) | 1993-06-21 |
| EP0243179B1 (en) | 1992-10-28 |
| EP0243179A1 (en) | 1987-10-28 |
| DE3782358T2 (de) | 1993-03-11 |
| JPH068253B2 (ja) | 1994-02-02 |
| AU7191487A (en) | 1987-10-29 |
| ES2032373T3 (es) | 1993-12-16 |
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