CA1286389C - Automatic pipetting apparatus - Google Patents
Automatic pipetting apparatusInfo
- Publication number
- CA1286389C CA1286389C CA000533645A CA533645A CA1286389C CA 1286389 C CA1286389 C CA 1286389C CA 000533645 A CA000533645 A CA 000533645A CA 533645 A CA533645 A CA 533645A CA 1286389 C CA1286389 C CA 1286389C
- Authority
- CA
- Canada
- Prior art keywords
- mounting plate
- sample
- plate
- carriage
- barrels
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 239000007788 liquid Substances 0.000 claims abstract description 115
- 238000001962 electrophoresis Methods 0.000 claims abstract description 10
- 238000013519 translation Methods 0.000 claims description 106
- 238000010790 dilution Methods 0.000 claims description 36
- 239000012895 dilution Substances 0.000 claims description 36
- 239000012530 fluid Substances 0.000 claims description 34
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- 229920002301 cellulose acetate Polymers 0.000 abstract description 8
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- 206010010071 Coma Diseases 0.000 description 4
- 230000008569 process Effects 0.000 description 4
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- 238000004809 thin layer chromatography Methods 0.000 description 4
- 238000004140 cleaning Methods 0.000 description 3
- 230000005684 electric field Effects 0.000 description 3
- 238000007693 zone electrophoresis Methods 0.000 description 3
- FUVKFLJWBHVMHX-UHFFFAOYSA-N 1,1,2,2,3,3,4,4,4-nonafluorobutane-1-sulfonamide Chemical compound NS(=O)(=O)C(F)(F)C(F)(F)C(F)(F)C(F)(F)F FUVKFLJWBHVMHX-UHFFFAOYSA-N 0.000 description 2
- 230000009471 action Effects 0.000 description 2
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- 230000000694 effects Effects 0.000 description 2
- 101150034348 gpo gene Proteins 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- PZWWYAHWHHNCHO-FGHAYEPSSA-N (4r,7s,10s,13r,16s,19r)-n-[(2s,3r)-1-amino-3-hydroxy-1-oxobutan-2-yl]-19-[[(2r)-2-amino-3-phenylpropanoyl]amino]-10-(3-aminopropyl)-7-[(1r)-1-hydroxyethyl]-16-[(4-hydroxyphenyl)methyl]-13-(1h-indol-3-ylmethyl)-3,3-dimethyl-6,9,12,15,18-pentaoxo-1,2-dithia Chemical compound C([C@H]1C(=O)N[C@H](CC=2C3=CC=CC=C3NC=2)C(=O)N[C@@H](CCCN)C(=O)N[C@H](C(=O)N[C@@H](C(SSC[C@@H](C(=O)N1)NC(=O)[C@H](N)CC=1C=CC=CC=1)(C)C)C(=O)N[C@@H]([C@H](O)C)C(N)=O)[C@@H](C)O)C1=CC=C(O)C=C1 PZWWYAHWHHNCHO-FGHAYEPSSA-N 0.000 description 1
- FOCGWLUKTRKABV-XBXARRHUSA-N 1-[2-oxo-2-[4-[(e)-3-phenylprop-2-enyl]piperazin-1-yl]ethyl]pyrrolidin-2-one Chemical compound C1CN(C\C=C\C=2C=CC=CC=2)CCN1C(=O)CN1CCCC1=O FOCGWLUKTRKABV-XBXARRHUSA-N 0.000 description 1
- WNTGYJSOUMFZEP-UHFFFAOYSA-N 2-(4-chloro-2-methylphenoxy)propanoic acid Chemical compound OC(=O)C(C)OC1=CC=C(Cl)C=C1C WNTGYJSOUMFZEP-UHFFFAOYSA-N 0.000 description 1
- HRPVXLWXLXDGHG-UHFFFAOYSA-N Acrylamide Chemical compound NC(=O)C=C HRPVXLWXLXDGHG-UHFFFAOYSA-N 0.000 description 1
- 102100038740 Activator of RNA decay Human genes 0.000 description 1
- 229920001817 Agar Polymers 0.000 description 1
- YIQAOPNCIJVKDN-XKNYDFJKSA-N Ala-Asn-Asp-Pro Chemical compound C[C@H](N)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N1CCC[C@H]1C(O)=O YIQAOPNCIJVKDN-XKNYDFJKSA-N 0.000 description 1
- 101100136107 Alteromonas sp pepQ gene Proteins 0.000 description 1
- 101100012527 Arabidopsis thaliana FAF4 gene Proteins 0.000 description 1
- 101100281114 Arabidopsis thaliana FLA5 gene Proteins 0.000 description 1
- 101100503314 Arabidopsis thaliana FPP7 gene Proteins 0.000 description 1
- 102000004506 Blood Proteins Human genes 0.000 description 1
- 108010017384 Blood Proteins Proteins 0.000 description 1
- 102100025399 Breast cancer type 2 susceptibility protein Human genes 0.000 description 1
- 101100012572 Caenorhabditis elegans fat-2 gene Proteins 0.000 description 1
- 102220531149 Calcium/calmodulin-dependent protein kinase type II subunit delta_F97E_mutation Human genes 0.000 description 1
- 206010007134 Candida infections Diseases 0.000 description 1
- 235000017165 Caryocar brasiliense Nutrition 0.000 description 1
- 241000176785 Caryocar brasiliense Species 0.000 description 1
- 102100029057 Coagulation factor XIII A chain Human genes 0.000 description 1
- 101100041772 Cricetulus griseus Sec22b gene Proteins 0.000 description 1
- 102220522566 EZH inhibitory protein_F42D_mutation Human genes 0.000 description 1
- 102220575187 Egl nine homolog 1_F82A_mutation Human genes 0.000 description 1
- 239000004249 Erythorbin acid Substances 0.000 description 1
- 239000004262 Ethyl gallate Substances 0.000 description 1
- 101150008304 FAD7 gene Proteins 0.000 description 1
- 241001481828 Glyptocephalus cynoglossus Species 0.000 description 1
- 102100023696 Histone-lysine N-methyltransferase SETDB1 Human genes 0.000 description 1
- 101710168120 Histone-lysine N-methyltransferase SETDB1 Proteins 0.000 description 1
- 101000760663 Hololena curta Mu-agatoxin-Hc1a Proteins 0.000 description 1
- 102220506244 Homeobox protein SIX4_F88E_mutation Human genes 0.000 description 1
- 101000741919 Homo sapiens Activator of RNA decay Proteins 0.000 description 1
- 101000934858 Homo sapiens Breast cancer type 2 susceptibility protein Proteins 0.000 description 1
- 101000918352 Homo sapiens Coagulation factor XIII A chain Proteins 0.000 description 1
- 101000891683 Homo sapiens Fanconi anemia group D2 protein Proteins 0.000 description 1
- 101000930348 Homo sapiens Protein dispatched homolog 2 Proteins 0.000 description 1
- 101000637411 Homo sapiens Rho guanine nucleotide exchange factor TIAM2 Proteins 0.000 description 1
- 101000663183 Homo sapiens Scavenger receptor class F member 1 Proteins 0.000 description 1
- 101150007931 IRO2 gene Proteins 0.000 description 1
- 101100328463 Mus musculus Cmya5 gene Proteins 0.000 description 1
- 101100182136 Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) loc-1 gene Proteins 0.000 description 1
- 102000010410 Nogo Proteins Human genes 0.000 description 1
- 108010077641 Nogo Proteins Proteins 0.000 description 1
- 102100035637 Protein dispatched homolog 2 Human genes 0.000 description 1
- 101001127488 Pseudoalteromonas haloplanktis Xaa-Pro dipeptidase Proteins 0.000 description 1
- 102100032206 Rho guanine nucleotide exchange factor TIAM2 Human genes 0.000 description 1
- 101100272590 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) BIT2 gene Proteins 0.000 description 1
- 102100037081 Scavenger receptor class F member 1 Human genes 0.000 description 1
- 102000012152 Securin Human genes 0.000 description 1
- 108010061477 Securin Proteins 0.000 description 1
- 102220520997 Single-stranded DNA-binding protein, mitochondrial_F91A_mutation Human genes 0.000 description 1
- 101001003185 Triticum aestivum Endogenous alpha-amylase/subtilisin inhibitor Proteins 0.000 description 1
- 239000008272 agar Substances 0.000 description 1
- 230000004075 alteration Effects 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 239000013256 coordination polymer Substances 0.000 description 1
- 239000012470 diluted sample Substances 0.000 description 1
- 239000012153 distilled water Substances 0.000 description 1
- OYFJQPXVCSSHAI-QFPUQLAESA-N enalapril maleate Chemical compound OC(=O)\C=C/C(O)=O.C([C@@H](C(=O)OCC)N[C@@H](C)C(=O)N1[C@@H](CCC1)C(O)=O)CC1=CC=CC=C1 OYFJQPXVCSSHAI-QFPUQLAESA-N 0.000 description 1
- 208000018634 fetal akinesia deformation sequence Diseases 0.000 description 1
- 208000012165 fetal akinesia deformation sequence syndrome Diseases 0.000 description 1
- 238000002421 fluorescence-activated droplet sorting Methods 0.000 description 1
- 230000006870 function Effects 0.000 description 1
- 239000000499 gel Substances 0.000 description 1
- 150000002500 ions Chemical class 0.000 description 1
- 101150022285 irx2 gene Proteins 0.000 description 1
- XVCUGNWRDDNCRD-UHFFFAOYSA-M lithium;1,1,2,2,3,3,4,4,5,5,6,6,7,7,8,8,8-heptadecafluorooctane-1-sulfonate Chemical compound [Li+].[O-]S(=O)(=O)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)F XVCUGNWRDDNCRD-UHFFFAOYSA-M 0.000 description 1
- 239000000711 locust bean gum Substances 0.000 description 1
- GDOPTJXRTPNYNR-UHFFFAOYSA-N methyl-cyclopentane Natural products CC1CCCC1 GDOPTJXRTPNYNR-UHFFFAOYSA-N 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 101150041229 opaA gene Proteins 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 108700040302 phenylalanyl-cyclo(cysteinyltyrosyl-tryptophyl-ornithyl-threonyl-penicillamine)threoninamide Proteins 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 238000005070 sampling Methods 0.000 description 1
- 238000002791 soaking Methods 0.000 description 1
- 238000000176 thermal ionisation mass spectrometry Methods 0.000 description 1
- 238000013055 trapped ion mobility spectrometry Methods 0.000 description 1
- 230000000007 visual effect Effects 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L9/00—Supporting devices; Holding devices
- B01L9/54—Supports specially adapted for pipettes and burettes
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
- G01N27/416—Systems
- G01N27/447—Systems using electrophoresis
- G01N27/44704—Details; Accessories
- G01N27/44743—Introducing samples
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N2035/00178—Special arrangements of analysers
- G01N2035/00237—Handling microquantities of analyte, e.g. microvalves, capillary networks
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
- G01N35/1065—Multiple transfer devices
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Analytical Chemistry (AREA)
- Electrochemistry (AREA)
- Physics & Mathematics (AREA)
- Clinical Laboratory Science (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Automatic Analysis And Handling Materials Therefor (AREA)
- Feeding, Discharge, Calcimining, Fusing, And Gas-Generation Devices (AREA)
- Sampling And Sample Adjustment (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US85320186A | 1986-04-17 | 1986-04-17 | |
| US853,201 | 1986-04-17 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA1286389C true CA1286389C (en) | 1991-07-16 |
Family
ID=25315351
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA000533645A Expired - Fee Related CA1286389C (en) | 1986-04-17 | 1987-04-01 | Automatic pipetting apparatus |
Country Status (4)
| Country | Link |
|---|---|
| JP (1) | JP2669821B2 (en, 2012) |
| AU (1) | AU595022B2 (en, 2012) |
| CA (1) | CA1286389C (en, 2012) |
| DE (1) | DE3712776A1 (en, 2012) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7219567B2 (en) * | 2005-01-05 | 2007-05-22 | Bio-Magnetics Ltd. | Combinatorial pipettor device |
| CN108755020A (zh) * | 2018-06-20 | 2018-11-06 | 中山市乐喜电子科技有限公司 | 一种移动式多品类抽液装置 |
| CN109443855A (zh) * | 2018-12-27 | 2019-03-08 | 天津博硕科技有限公司 | 一种防触底采样装置 |
| CN114247494A (zh) * | 2021-12-13 | 2022-03-29 | 江苏领坤生物科技有限公司 | 用于全自动移液工作站的移液管架 |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3023793B2 (ja) * | 1988-02-16 | 2000-03-21 | アプライド バイオシステムズ インコーポレイテッド | 毛管電気泳動方法及びその装置 |
| FR2628215A1 (fr) * | 1988-03-02 | 1989-09-08 | Helena Lab Corp | Procede et appareil automatique d'electrophorese |
| DE4209064C2 (de) * | 1992-03-20 | 1995-07-27 | Gerhard Dr Noss | Verfahren zum Zuführen von Waschflüssigkeit zu kleinen, transparenten, mit Zellkulturen beschichteten Testfeldern und zum Absaugen der Waschflüssigkeit von den Testfeldern |
| DE19605814A1 (de) * | 1996-02-16 | 1997-08-21 | Innova Gmbh | Vorrichtung und Verfahren zur Aufarbeitung einer Mehrzahl von Proben |
| DE19635004C1 (de) * | 1996-08-30 | 1997-11-20 | Opaljena Ges Fuer Optische Ana | Spülwannensystem für einen Multipipettor |
| DE19854919A1 (de) * | 1998-11-27 | 2000-06-15 | Luigs & Neumann Feinmechanik U | Arbeitsplatz für mikrobiologische Untersuchungen |
| US6672344B1 (en) * | 2001-10-26 | 2004-01-06 | Perseptive Biosystems, Inc. | Robotic system having positionally adjustable multiple probes |
| US7118659B2 (en) | 2003-02-27 | 2006-10-10 | Combisep, Inc. | Robotic friendly external loading system for electrophoresis instrument and method |
| JP4956533B2 (ja) * | 2006-10-10 | 2012-06-20 | アークレイ株式会社 | カートリッジ、残液除去方法および自動分析装置 |
| FR2920675B1 (fr) * | 2007-09-10 | 2010-12-03 | Gilson Sas | Systeme de pipetage multicanaux comprenant un porte-pistons a guidage ameliore |
| ITTO20120295A1 (it) * | 2012-04-04 | 2013-10-05 | Antonio Gibin | Dispositivi per la preparazione dei supporti per la determinazione della purezza radiochimica di radiofarmaci iniettabili; sistema composto da prelievo, deposizione e migrazione con tecnica cromatografica su strato sottile (tlc) thin layer chromatogr |
| JP5924113B2 (ja) * | 2012-05-15 | 2016-05-25 | 株式会社島津製作所 | ニードル洗浄機構 |
| DE102012106675B3 (de) * | 2012-07-23 | 2013-10-17 | Cybio Ag | Absaugvorrichtung für eine matrixförmige Anordnung von Pipettenspitzen |
| JP6680511B2 (ja) * | 2015-11-06 | 2020-04-15 | メディカテック株式会社 | 洗浄槽、および、それを備えた分注装置 |
| CN108444763B (zh) * | 2018-03-19 | 2023-12-08 | 深圳碳云智能数字生命健康管理有限公司 | 一种采样设备 |
| CN114272853B (zh) * | 2021-12-24 | 2023-06-20 | 河北复朗施纳米科技有限公司 | 一种纳米抑菌涂层制造装置 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3536449A (en) * | 1967-04-13 | 1970-10-27 | Thomas W Astle | Serial dilution machine |
| US3568735A (en) * | 1968-06-26 | 1971-03-09 | Cooke Eng Co | Laboratory microtitration dispensing apparatus |
| US3807959A (en) * | 1972-10-16 | 1974-04-30 | Biochemical Procedures Inc | Thin layer chromatography spotting device |
| JPS5137691A (en, 2012) * | 1974-09-27 | 1976-03-30 | Olympus Optical Co | |
| US3951605A (en) * | 1974-08-08 | 1976-04-20 | Rohe Scientific Corporation | Instrument for automated immunochemical analysis |
| JPS5135393A (en) * | 1974-09-19 | 1976-03-25 | Olympus Optical Co | Denkieidoniokeru ketsuseitofusochi |
| GB1542835A (en, 2012) * | 1976-11-24 | 1979-03-28 | ||
| US4478094A (en) * | 1983-01-21 | 1984-10-23 | Cetus Corporation | Liquid sample handling system |
| US4555957A (en) * | 1983-10-14 | 1985-12-03 | Cetus Corporation | Bi-directional liquid sample handling system |
| US4554839A (en) * | 1983-10-14 | 1985-11-26 | Cetus Corporation | Multiple trough vessel for automated liquid handling apparatus |
-
1987
- 1987-04-01 CA CA000533645A patent/CA1286389C/en not_active Expired - Fee Related
- 1987-04-15 DE DE19873712776 patent/DE3712776A1/de active Granted
- 1987-04-16 JP JP62092137A patent/JP2669821B2/ja not_active Expired - Fee Related
- 1987-04-16 AU AU71757/87A patent/AU595022B2/en not_active Ceased
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7219567B2 (en) * | 2005-01-05 | 2007-05-22 | Bio-Magnetics Ltd. | Combinatorial pipettor device |
| CN108755020A (zh) * | 2018-06-20 | 2018-11-06 | 中山市乐喜电子科技有限公司 | 一种移动式多品类抽液装置 |
| CN109443855A (zh) * | 2018-12-27 | 2019-03-08 | 天津博硕科技有限公司 | 一种防触底采样装置 |
| CN109443855B (zh) * | 2018-12-27 | 2023-12-01 | 天津博硕科技有限公司 | 一种防触底采样装置 |
| CN114247494A (zh) * | 2021-12-13 | 2022-03-29 | 江苏领坤生物科技有限公司 | 用于全自动移液工作站的移液管架 |
Also Published As
| Publication number | Publication date |
|---|---|
| AU595022B2 (en) | 1990-03-22 |
| JPS62251650A (ja) | 1987-11-02 |
| AU7175787A (en) | 1987-10-22 |
| JP2669821B2 (ja) | 1997-10-29 |
| DE3712776C2 (en, 2012) | 1992-12-17 |
| DE3712776A1 (de) | 1987-10-22 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MKLA | Lapsed |