CA1262863A - Fusogenic liposomes and method of making same - Google Patents

Fusogenic liposomes and method of making same

Info

Publication number
CA1262863A
CA1262863A CA000505702A CA505702A CA1262863A CA 1262863 A CA1262863 A CA 1262863A CA 000505702 A CA000505702 A CA 000505702A CA 505702 A CA505702 A CA 505702A CA 1262863 A CA1262863 A CA 1262863A
Authority
CA
Canada
Prior art keywords
ammonium hydroxide
salt
liposomes
phospholipid
quaternary ammonium
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA000505702A
Other languages
English (en)
French (fr)
Inventor
Abraham Loyter
Adolfo G. Gitman
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
International Genetic Sciences Partnership
Original Assignee
International Genetic Sciences Partnership
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by International Genetic Sciences Partnership filed Critical International Genetic Sciences Partnership
Application granted granted Critical
Publication of CA1262863A publication Critical patent/CA1262863A/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers
    • A61K9/1272—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers with substantial amounts of non-phosphatidyl, i.e. non-acylglycerophosphate, surfactants as bilayer-forming substances, e.g. cationic lipids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/88—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation using microencapsulation, e.g. using amphiphile liposome vesicle
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/585—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with a particulate label, e.g. coloured latex
    • G01N33/586—Liposomes, microcapsules or cells

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Hematology (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Zoology (AREA)
  • Urology & Nephrology (AREA)
  • Cell Biology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Immunology (AREA)
  • General Engineering & Computer Science (AREA)
  • Dispersion Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Plant Pathology (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Preparation (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CA000505702A 1985-04-04 1986-04-02 Fusogenic liposomes and method of making same Expired CA1262863A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US71986285A 1985-04-04 1985-04-04
US719,862 1985-04-04

Publications (1)

Publication Number Publication Date
CA1262863A true CA1262863A (en) 1989-11-14

Family

ID=24891665

Family Applications (1)

Application Number Title Priority Date Filing Date
CA000505702A Expired CA1262863A (en) 1985-04-04 1986-04-02 Fusogenic liposomes and method of making same

Country Status (16)

Country Link
JP (1) JPS61274739A (zh)
AU (1) AU585330B2 (zh)
BE (1) BE904536A (zh)
BR (1) BR8601554A (zh)
CA (1) CA1262863A (zh)
CH (1) CH668005A5 (zh)
DE (1) DE3610873A1 (zh)
ES (1) ES8802401A1 (zh)
FR (1) FR2579891B1 (zh)
GB (1) GB2188900B (zh)
IL (1) IL78348A (zh)
IT (1) IT1189877B (zh)
NL (1) NL8600794A (zh)
NZ (1) NZ215696A (zh)
SE (1) SE464448B (zh)
ZA (1) ZA862466B (zh)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5545412A (en) * 1985-01-07 1996-08-13 Syntex (U.S.A.) Inc. N-[1, (1-1)-dialkyloxy]-and N-[1, (1-1)-dialkenyloxy]-alk-1-yl-n,n,n-tetrasubstituted ammonium lipids and uses therefor
US4897355A (en) * 1985-01-07 1990-01-30 Syntex (U.S.A.) Inc. N[ω,(ω-1)-dialkyloxy]- and N-[ω,(ω-1)-dialkenyloxy]-alk-1-yl-N,N,N-tetrasubstituted ammonium lipids and uses therefor
US4818537A (en) * 1986-10-21 1989-04-04 Liposome Technology, Inc. Liposome composition for treating dry eye
JPS63275522A (ja) * 1987-05-01 1988-11-14 Terumo Corp 人工赤血球及びその製造方法
JPH04283207A (ja) * 1991-03-13 1992-10-08 Kao Corp ベシクル及び重合体ベシクル
AR013065A1 (es) * 1996-10-25 2000-12-13 Monsanto Technology Llc COMPOSICIoN Y METODO DE TRATAMIENTO PARA PLANTAS.
EP0941029B1 (en) 1996-10-25 2002-09-18 Monsanto Technology LLC Composition and method for treating plants with exogenous chemicals
US20150174068A1 (en) * 2011-09-12 2015-06-25 Cure Ip Holdings, Llc Apparatus, Composition, and Related Methods for Transdermal Delivery of Active Ingredients

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4515736A (en) * 1983-05-12 1985-05-07 The Regents Of The University Of California Method for encapsulating materials into liposomes
US4789633A (en) * 1984-04-19 1988-12-06 University Of Tennessee Research Corporation Fused liposome and acid induced method for liposome fusion
JPH0662517B2 (ja) * 1985-01-07 1994-08-17 シンテツクス（ユー・エス・エイ）インコーポレイテツド 置換アルキルートリ置換アンモニウム界面活性剤

Also Published As

Publication number Publication date
IT1189877B (it) 1988-02-10
GB2188900B (en) 1990-04-04
AU5562286A (en) 1986-10-09
BE904536A (fr) 1986-07-31
IT8683340A0 (it) 1986-04-03
GB2188900A (en) 1987-10-14
AU585330B2 (en) 1989-06-15
NL8600794A (nl) 1986-11-03
NZ215696A (en) 1989-07-27
ES553703A0 (es) 1988-05-16
SE8601408D0 (sv) 1986-03-26
SE464448B (sv) 1991-04-29
JPS61274739A (ja) 1986-12-04
GB8608468D0 (en) 1986-05-14
DE3610873A1 (de) 1986-10-09
FR2579891B1 (zh) 1990-02-02
ZA862466B (en) 1986-11-26
ES8802401A1 (es) 1988-05-16
IL78348A0 (en) 1986-07-31
CH668005A5 (de) 1988-11-30
IL78348A (en) 1989-08-15
FR2579891A1 (zh) 1986-10-10
BR8601554A (pt) 1986-12-09
SE8601408L (sv) 1986-10-05

Similar Documents

Publication Publication Date Title
JP5480764B2 (ja) 両性リポソーム及びその使用
Papahadjopoulos et al. Incorporation of lipid vesicles by mammalian cells provides a potential method for modifying cell behaviour
CA1261751A (en) Fused liposome and acid induced method for liposome fusion
Lasic Liposomes
US4235871A (en) Method of encapsulating biologically active materials in lipid vesicles
US5776908A (en) Amphiphilic derivatives of piperazine
WO1991017424A1 (en) Intracellular delivery of biologically active substances by means of self-assembling lipid complexes
EP0036277B1 (en) Covalently bonded liposome-protein-compositions and method of producing them
JPH10506395A (ja) 二層安定化成分及びプログラムできる融合性リポソームの形成のためへのそれらの使用
EP0152449A1 (en) VESICULAR LIPIDS PREPARED IN A SINGLE PHASE.
CA1262863A (en) Fusogenic liposomes and method of making same
EP0011549A1 (en) Viral liposome particles, methods for their preparation and compositions containing them
MXPA05010499A (es) Particulas lipidicas que tienen un revestimiento lipidico asimetrico y metodo de preparacion de las mismas.
Taraschi et al. Phospholipid spin probes measure the effects of ethanol on the molecular order of liver microsomes
GB2140822A (en) Transformation of plant cells
CN100566810C (zh) 用脂质膜被覆粒子的方法
Freund et al. Encapsulation of DNA in new multilamellar vesicles prepared by shearing a lyotropic lamellar phase
JP2003513901A (ja) タンパク質又はペプチドをリポソームに封入するための方法及びこの方法で調製されたリポソーム及びその使用
US5419914A (en) Phospholipid analogue vesicle
Lawaczeck et al. Interaction of negatively charged liposomes with nuclear membranes: adsorption, lipid mixing and lysis of the vesicles
Papahadjopoulos et al. Liposomes as macromolecular carriers for the introduction of RNA and DNA into cells
US5665879A (en) Amphiphilic derivatives of piperazine
Kim et al. Effect of bovine serum albumin on the stability of methotrexate-encapsulated liposomes
Balakireva et al. Metaphase chromosomes from mammalian cells stimulate fusion of artificial phospholipid vesicles
Hume A comparative study of niosomes (non-ionic surfactant vesicles) and liposomes: their stability in biological environments

Legal Events

Date Code Title Description
MKLA Lapsed