CA1252086A - Pyrazole derivatives with an ergoline skeleton, their acid addition salts, and a process for the preparation thereof - Google Patents

Pyrazole derivatives with an ergoline skeleton, their acid addition salts, and a process for the preparation thereof

Info

Publication number
CA1252086A
CA1252086A CA000455626A CA455626A CA1252086A CA 1252086 A CA1252086 A CA 1252086A CA 000455626 A CA000455626 A CA 000455626A CA 455626 A CA455626 A CA 455626A CA 1252086 A CA1252086 A CA 1252086A
Authority
CA
Canada
Prior art keywords
group
methyl
stands
methylene
alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA000455626A
Other languages
English (en)
French (fr)
Inventor
Tivadar Rettegi
Lajos Toldy
Erzsebet Nee Karacsony Mago
Jozsef Borsy
Ilona Berzetei
Andras Ronai
Aliz Druga
Gyorgy Cseh
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Richter Gedeon Vegyeszeti Gyar Nyrt
Original Assignee
Richter Gedeon Vegyeszeti Gyar RT
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Richter Gedeon Vegyeszeti Gyar RT filed Critical Richter Gedeon Vegyeszeti Gyar RT
Application granted granted Critical
Publication of CA1252086A publication Critical patent/CA1252086A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
    • C07D457/02—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with hydrocarbon or substituted hydrocarbon radicals, attached in position 8
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CA000455626A 1983-06-03 1984-06-01 Pyrazole derivatives with an ergoline skeleton, their acid addition salts, and a process for the preparation thereof Expired CA1252086A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
HU832001A HU190105B (en) 1983-06-03 1983-06-03 Process for production of pirazolyl-methyl-ergolin- derivatives and their acid additional salts
HU2001/83 1983-06-03

Publications (1)

Publication Number Publication Date
CA1252086A true CA1252086A (en) 1989-04-04

Family

ID=10957235

Family Applications (1)

Application Number Title Priority Date Filing Date
CA000455626A Expired CA1252086A (en) 1983-06-03 1984-06-01 Pyrazole derivatives with an ergoline skeleton, their acid addition salts, and a process for the preparation thereof

Country Status (15)

Country Link
US (1) US4632928A (enEXAMPLES)
EP (1) EP0128479B1 (enEXAMPLES)
JP (1) JPS6084286A (enEXAMPLES)
AR (1) AR240323A1 (enEXAMPLES)
AT (1) ATE55129T1 (enEXAMPLES)
AU (1) AU569518B2 (enEXAMPLES)
CA (1) CA1252086A (enEXAMPLES)
DE (1) DE3482854D1 (enEXAMPLES)
DK (1) DK162050C (enEXAMPLES)
ES (1) ES8800940A1 (enEXAMPLES)
FI (1) FI80272C (enEXAMPLES)
GR (1) GR82419B (enEXAMPLES)
HU (1) HU190105B (enEXAMPLES)
IL (1) IL71988A (enEXAMPLES)
ZA (1) ZA844162B (enEXAMPLES)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2173189B (en) * 1985-02-21 1988-04-27 Maruko Pharmaceutical Co Ergoline derivatives and salts thereof and pharmaceutical compositions thereof
GB8702364D0 (en) * 1987-02-03 1987-03-11 Erba Farmitalia Ergolinyl heterocycles
GB9603226D0 (en) * 1996-02-15 1996-04-17 Pharmacia Spa Heterocyclyl-ergoline derivatives
US6407250B1 (en) 2000-09-14 2002-06-18 Allergan Sales, Inc. Interphenylene 7-oxabicyclic [2.2.1] heptane oxazoles as prostaglandin F2a antagonists
US6511999B2 (en) 2000-09-14 2003-01-28 Allergan, Inc. Interheteroaryl 7-oxabicyclic [2.2.1]heptane oxazoles as prostaglandin F2α antagonists
US6369089B1 (en) 2000-09-14 2002-04-09 Allergan Sales, Inc. Interheteroaryl 7-oxabicyclic [2.2.1]heptane oxazoles as prostaglandin F2α antagonists
US7045634B2 (en) * 2003-09-05 2006-05-16 Allergan, Inc. Prostamide receptor antagonists
AU2010232556A1 (en) 2009-04-02 2011-11-03 Allergan, Inc. Prostaglandin E receptor antagonists

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1695752C3 (de) * 1966-07-29 1974-06-06 Societa Farmaceutici Italia, Mailand (Italien) 1 ,ö-Dimethyl-ebeta-N-carbobenzoxyaminomethyl-2,3-dihydro-1 Oalpha-ergolin und ein Verfahren zu seiner Herstellung
US4134987A (en) * 1976-01-14 1979-01-16 Huppatz John L Compounds and compositions
HU178396B (en) * 1978-03-20 1982-04-28 Vianova Kunstharz Ag Process for producing new 8-beta-hydrazion-methyl-ergoline-and -ergolene derivatives
GB2056437A (en) * 1979-08-07 1981-03-18 Erba Farmitalia Secoergoline derivatives
GB2120242A (en) * 1982-04-30 1983-11-30 Erba Farmitalia Ergoline derivatives

Also Published As

Publication number Publication date
ES533086A0 (es) 1987-12-01
DK162050B (da) 1991-09-09
FI80272C (fi) 1990-05-10
ZA844162B (en) 1984-12-24
JPH0342274B2 (enEXAMPLES) 1991-06-26
DK162050C (da) 1992-02-10
AU2903284A (en) 1984-12-06
HU190105B (en) 1986-08-28
IL71988A0 (en) 1984-10-31
FI842233A7 (fi) 1984-12-04
FI80272B (fi) 1990-01-31
EP0128479A2 (en) 1984-12-19
HUT34748A (en) 1985-04-28
ES8800940A1 (es) 1987-12-01
ATE55129T1 (de) 1990-08-15
JPS6084286A (ja) 1985-05-13
IL71988A (en) 1987-01-30
US4632928A (en) 1986-12-30
AU569518B2 (en) 1988-02-04
EP0128479A3 (en) 1985-10-30
EP0128479B1 (en) 1990-08-01
GR82419B (enEXAMPLES) 1984-12-13
DE3482854D1 (de) 1990-09-06
DK273884A (da) 1984-12-04
AR240323A1 (es) 1990-03-30
DK273884D0 (da) 1984-06-01
FI842233A0 (fi) 1984-06-04

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Legal Events

Date Code Title Description
MKEX Expiry