CA1251139A - Mixture of different dihydropyridines, processes for the preparation thereof and the use thereof in medicaments - Google Patents

Mixture of different dihydropyridines, processes for the preparation thereof and the use thereof in medicaments

Info

Publication number
CA1251139A
CA1251139A CA000498231A CA498231A CA1251139A CA 1251139 A CA1251139 A CA 1251139A CA 000498231 A CA000498231 A CA 000498231A CA 498231 A CA498231 A CA 498231A CA 1251139 A CA1251139 A CA 1251139A
Authority
CA
Canada
Prior art keywords
cyano
nitro
component
alkylamino
hydroxyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA000498231A
Other languages
English (en)
French (fr)
Inventor
Siegfried Goldmann
Horst Boshagen
Friedrich Bossert
Gerhard Franckowiak
Horst Meyer
Jurgen Stoltefuss
Rainer Gross
Matthias Schramm
Gunter Thomas
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer AG
Original Assignee
Bayer AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer AG filed Critical Bayer AG
Application granted granted Critical
Publication of CA1251139A publication Critical patent/CA1251139A/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
CA000498231A 1984-12-22 1985-12-20 Mixture of different dihydropyridines, processes for the preparation thereof and the use thereof in medicaments Expired CA1251139A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DEP3447170.7 1984-12-22
DE19843447170 DE3447170A1 (de) 1984-12-22 1984-12-22 Mischung unterschiedlicher dihydropyridine, verfahren zu ihrer herstellung sowie ihre verwendung in arzneimitteln

Publications (1)

Publication Number Publication Date
CA1251139A true CA1251139A (en) 1989-03-14

Family

ID=6253729

Family Applications (1)

Application Number Title Priority Date Filing Date
CA000498231A Expired CA1251139A (en) 1984-12-22 1985-12-20 Mixture of different dihydropyridines, processes for the preparation thereof and the use thereof in medicaments

Country Status (16)

Country Link
US (1) US4895855A (de)
EP (1) EP0186027A3 (de)
JP (1) JPS61155326A (de)
CN (1) CN1008061B (de)
AU (1) AU585916B2 (de)
CA (1) CA1251139A (de)
DE (1) DE3447170A1 (de)
DK (1) DK597285A (de)
FI (1) FI855085A (de)
GR (1) GR853099B (de)
IL (1) IL77391A (de)
NO (1) NO855174L (de)
NZ (1) NZ214627A (de)
PH (1) PH23019A (de)
PT (1) PT81739B (de)
ZA (1) ZA859745B (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5001139A (en) * 1987-06-12 1991-03-19 American Cyanamid Company Enchancers for the transdermal flux of nivadipine
US5455253A (en) * 1992-10-20 1995-10-03 Zeneca Limited Heterocyclic derivatives
US6082358A (en) * 1998-05-05 2000-07-04 1263152 Ontario Inc. Indicating device for aerosol container
US6518279B2 (en) 1999-03-04 2003-02-11 Abbott Laboratories Cyclopentanone dihydropyridine compounds useful as potassium channel openers
KR102484846B1 (ko) * 2015-11-27 2023-01-05 한림제약(주) 벤조피란 유도체의 정제방법, 이의 결정형 및 상기 결정형의 제조방법

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3932646A (en) * 1971-04-10 1976-01-13 Farbenfabriken Bayer Ag Pharmaceutical compositions containing unsymmetrical esters of 1,4-dihydropyridine 3,5-dicarboxylate
US3911123A (en) * 1972-03-06 1975-10-07 Bayer Ag Pharmaceutical compositions utilizing 2-amino-1,4-dihydropyridine derivatives and method of effecting coronary vessel dilation and treating hypertension in humans and animals utilizing said compounds
US4284634A (en) * 1975-07-02 1981-08-18 Fujisawa Pharmaceutical Co., Ltd. 1,4-Dihydropyridine derivatives, and pharmaceutical method of the same
DE2752820A1 (de) * 1977-11-26 1979-05-31 Bayer Ag Neue nitrosubstituierte 1,4-dihydropyridine, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel
SE429652B (sv) * 1978-06-30 1983-09-19 Haessle Ab 2.6-dimetyl-4-(2.3-diklorfenyl)-1.4-dihydropyridin-3.5-dikarboxylsyra-3-metylester-5-etylester
DE3212736A1 (de) * 1982-04-06 1983-10-13 Bayer Ag, 5090 Leverkusen Verwendung von dihydropyridinen in arzneimitteln mit salidiuretischer wirkung
DE3307422A1 (de) * 1983-03-03 1984-09-06 Bayer Ag, 5090 Leverkusen Fluessigzubereitungen von dihydropyridinen, ein verfahren zu ihrer herstellung, sowie ihre verwendung bei der bekaempfung von erkrankungen
DE3317872A1 (de) * 1983-05-17 1984-11-22 Basf Ag, 6700 Ludwigshafen Oral verabreichbares arzneimittel
DE3419131A1 (de) * 1984-05-23 1985-11-28 Bayer Ag, 5090 Leverkusen Dihydropyridinkombinationspraeparate und verfahren zu ihrer herstellung
DE3427402A1 (de) * 1984-07-25 1986-01-30 Bayer Ag, 5090 Leverkusen Neues kombinationspraeparat, verfahren zu seiner herstellung und seine verwendung als arzneimittel
DE3424342A1 (de) * 1984-07-03 1986-01-09 Bayer Ag, 5090 Leverkusen 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-pyridin-3,5-dicarbonsaeure-isopropyl-(2-(3-trifluormethylphenoxy)-ethyl)-ester, mehrere verfahren zu seiner herstellung sowie seine verwendung in arzneimitteln
DE3447169A1 (de) * 1984-12-22 1986-07-03 Bayer Ag, 5090 Leverkusen Optisch aktive nitrodihydropyridine, verfahren zur herstellung und ihre verwendung in arzneimitteln
JPS6289662A (ja) * 1985-06-14 1987-04-24 Sankyo Co Ltd １，４−ジヒドロピリジン誘導体

Also Published As

Publication number Publication date
IL77391A (en) 1989-01-31
EP0186027A3 (de) 1988-11-02
GR853099B (de) 1986-04-18
PT81739A (en) 1986-01-01
CN1008061B (zh) 1990-05-23
US4895855A (en) 1990-01-23
AU585916B2 (en) 1989-06-29
NZ214627A (en) 1989-06-28
FI855085A (fi) 1986-06-23
PH23019A (en) 1989-03-03
DK597285A (da) 1986-06-23
EP0186027A2 (de) 1986-07-02
PT81739B (en) 1987-10-06
AU5128685A (en) 1986-06-26
FI855085A0 (fi) 1985-12-19
NO855174L (no) 1986-06-23
DE3447170A1 (de) 1986-07-03
ZA859745B (en) 1986-08-27
DK597285D0 (da) 1985-12-20
CN85109017A (zh) 1986-08-27
JPS61155326A (ja) 1986-07-15

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Legal Events

Date Code Title Description
MKEX Expiry