CA1242593A - Optical features of flow cytometry apparatus - Google Patents
Optical features of flow cytometry apparatusInfo
- Publication number
- CA1242593A CA1242593A CA000476974A CA476974A CA1242593A CA 1242593 A CA1242593 A CA 1242593A CA 000476974 A CA000476974 A CA 000476974A CA 476974 A CA476974 A CA 476974A CA 1242593 A CA1242593 A CA 1242593A
- Authority
- CA
- Canada
- Prior art keywords
- particles
- flow chamber
- light
- lens
- stream
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 238000000684 flow cytometry Methods 0.000 title claims abstract description 25
- 230000003287 optical effect Effects 0.000 title abstract description 15
- 239000002245 particle Substances 0.000 claims abstract description 111
- 239000007788 liquid Substances 0.000 claims abstract description 27
- 230000033001 locomotion Effects 0.000 claims description 13
- 230000006872 improvement Effects 0.000 claims description 8
- 230000005540 biological transmission Effects 0.000 claims description 6
- 230000005284 excitation Effects 0.000 claims description 6
- 239000002131 composite material Substances 0.000 claims description 5
- 239000000463 material Substances 0.000 claims description 3
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 2
- 239000005350 fused silica glass Substances 0.000 claims description 2
- 108091008695 photoreceptors Proteins 0.000 abstract 1
- 210000004027 cell Anatomy 0.000 description 19
- 239000012530 fluid Substances 0.000 description 12
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 8
- 230000007246 mechanism Effects 0.000 description 8
- 239000000523 sample Substances 0.000 description 8
- 238000004458 analytical method Methods 0.000 description 6
- 230000004075 alteration Effects 0.000 description 5
- 238000001943 fluorescence-activated cell sorting Methods 0.000 description 5
- 230000008901 benefit Effects 0.000 description 3
- 210000001772 blood platelet Anatomy 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- 239000000725 suspension Substances 0.000 description 3
- 238000004163 cytometry Methods 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 230000006641 stabilisation Effects 0.000 description 2
- 238000011105 stabilization Methods 0.000 description 2
- PIGCSKVALLVWKU-UHFFFAOYSA-N 2-Aminoacridone Chemical compound C1=CC=C2C(=O)C3=CC(N)=CC=C3NC2=C1 PIGCSKVALLVWKU-UHFFFAOYSA-N 0.000 description 1
- 101000637792 Homo sapiens Solute carrier family 35 member G5 Proteins 0.000 description 1
- 241001274197 Scatophagus argus Species 0.000 description 1
- 102100032019 Solute carrier family 35 member G5 Human genes 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000001427 coherent effect Effects 0.000 description 1
- 238000012937 correction Methods 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 239000012470 diluted sample Substances 0.000 description 1
- 238000005206 flow analysis Methods 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 150000002314 glycerols Chemical class 0.000 description 1
- 238000005286 illumination Methods 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- QSHDDOUJBYECFT-UHFFFAOYSA-N mercury Chemical compound [Hg] QSHDDOUJBYECFT-UHFFFAOYSA-N 0.000 description 1
- 229910052753 mercury Inorganic materials 0.000 description 1
- 238000005065 mining Methods 0.000 description 1
- 229920000136 polysorbate Polymers 0.000 description 1
- 238000011002 quantification Methods 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 230000007704 transition Effects 0.000 description 1
- 238000013519 translation Methods 0.000 description 1
- 239000012780 transparent material Substances 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N15/14—Optical investigation techniques, e.g. flow cytometry
- G01N15/1456—Optical investigation techniques, e.g. flow cytometry without spatial resolution of the texture or inner structure of the particle, e.g. processing of pulse signals
- G01N15/1459—Optical investigation techniques, e.g. flow cytometry without spatial resolution of the texture or inner structure of the particle, e.g. processing of pulse signals the analysis being performed on a sample stream
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N15/14—Optical investigation techniques, e.g. flow cytometry
- G01N15/1434—Optical arrangements
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N15/14—Optical investigation techniques, e.g. flow cytometry
- G01N15/1404—Handling flow, e.g. hydrodynamic focusing
- G01N2015/1415—Control of particle position
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N15/14—Optical investigation techniques, e.g. flow cytometry
- G01N2015/1497—Particle shape
Landscapes
- Chemical & Material Sciences (AREA)
- Dispersion Chemistry (AREA)
- Physics & Mathematics (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
- Optical Measuring Cells (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
- Indicating Or Recording The Presence, Absence, Or Direction Of Movement (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US06/606,802 US4660971A (en) | 1984-05-03 | 1984-05-03 | Optical features of flow cytometry apparatus |
US606,802 | 1990-10-30 |
Publications (1)
Publication Number | Publication Date |
---|---|
CA1242593A true CA1242593A (en) | 1988-10-04 |
Family
ID=24429525
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA000476974A Expired CA1242593A (en) | 1984-05-03 | 1985-03-20 | Optical features of flow cytometry apparatus |
Country Status (9)
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5733507A (en) * | 1995-06-07 | 1998-03-31 | Inphocyte, Inc. | Biological cell sample holder for use in infrared and/or Raman spectroscopy analysis holder |
US5848977A (en) * | 1996-02-16 | 1998-12-15 | Inphocyte, Inc. | Sample holder for cells |
Families Citing this family (92)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4989977A (en) * | 1985-07-29 | 1991-02-05 | Becton, Dickinson And Company | Flow cytometry apparatus with improved light beam adjustment |
US4790653A (en) * | 1986-05-22 | 1988-12-13 | Becton Dickinson And Company | Housing for a flow cytometry apparatus with particle unclogging feature |
JPS62274238A (ja) * | 1986-05-22 | 1987-11-28 | ベクトン・デイツキンソン・アンド・カンパニ− | フロ−サイトメトリ−装置に用いる光学的結合用ゲル |
JPS63151855A (ja) * | 1986-12-16 | 1988-06-24 | Japan Spectroscopic Co | フロ−セル兼用ノズル |
US4910402A (en) * | 1987-04-10 | 1990-03-20 | Mcmillan Norman | Apparatus and method for measuring a property of a liquid |
US4988619A (en) * | 1987-11-30 | 1991-01-29 | United States Department Of Energy | Flow cytometry apparatus |
US5213981A (en) * | 1988-09-27 | 1993-05-25 | Kabushiki Kaisha Komatsu Seisakusho | Bedding apparatus |
US5239360A (en) * | 1988-10-21 | 1993-08-24 | Applied Biosystems, Inc. | Lens for capillary electrophoresis and chromatography |
US5275787A (en) * | 1989-10-04 | 1994-01-04 | Canon Kabushiki Kaisha | Apparatus for separating or measuring particles to be examined in a sample fluid |
JP2939647B2 (ja) * | 1990-07-24 | 1999-08-25 | シスメックス株式会社 | フローイメージングサイトメータにおける自動焦点調整方法 |
JP3075367B2 (ja) * | 1991-04-05 | 2000-08-14 | シスメックス株式会社 | 粒子分析方法及び装置 |
US5396333A (en) * | 1992-05-21 | 1995-03-07 | General Electric Company | Device and method for observing and analyzing a stream of material |
US5311290A (en) * | 1992-09-30 | 1994-05-10 | Pulp And Paper Research Institute Of Canada | Imaging apparatus and method of fiber analysis |
GB9314926D0 (en) * | 1993-07-19 | 1993-09-01 | Optiglass Ltd | Spectrophotometer cell |
US5582184A (en) * | 1993-10-13 | 1996-12-10 | Integ Incorporated | Interstitial fluid collection and constituent measurement |
US5602349A (en) * | 1994-10-14 | 1997-02-11 | The University Of Washington | Sample introduction system for a flow cytometer |
US6861265B1 (en) * | 1994-10-14 | 2005-03-01 | University Of Washington | Flow cytometer droplet formation system |
WO1996012171A2 (en) * | 1994-10-14 | 1996-04-25 | University Of Washington | High speed flow cytometer droplet formation system |
US6614522B1 (en) | 1995-09-08 | 2003-09-02 | Integ, Inc. | Body fluid sampler |
AU7015096A (en) * | 1995-09-08 | 1997-04-09 | Integ, Inc. | Body fluid sampler |
US6624882B2 (en) * | 1995-09-08 | 2003-09-23 | Integ, Inc. | Methods of sampling body fluid |
US5879367A (en) * | 1995-09-08 | 1999-03-09 | Integ, Inc. | Enhanced interstitial fluid collection |
US5808737A (en) * | 1996-02-29 | 1998-09-15 | Sienna Biotech, Inc. | Pre-analysis chamber for a flow particle analyzer |
EP2264427B1 (en) * | 1997-01-31 | 2017-05-03 | Xy, Llc | Optical apparatus with focussing reflector for converging radiation onto a flow of particles, and related method of analysis |
US6149867A (en) * | 1997-12-31 | 2000-11-21 | Xy, Inc. | Sheath fluids and collection systems for sex-specific cytometer sorting of sperm |
US6071689A (en) | 1997-12-31 | 2000-06-06 | Xy, Inc. | System for improving yield of sexed embryos in mammals |
US6248590B1 (en) | 1998-02-27 | 2001-06-19 | Cytomation, Inc. | Method and apparatus for flow cytometry |
US6818437B1 (en) | 1998-05-16 | 2004-11-16 | Applera Corporation | Instrument for monitoring polymerase chain reaction of DNA |
US7498164B2 (en) | 1998-05-16 | 2009-03-03 | Applied Biosystems, Llc | Instrument for monitoring nucleic acid sequence amplification reaction |
WO1999060381A1 (en) | 1998-05-16 | 1999-11-25 | The Perkin-Elmer Corporation | Instrument for monitoring polymerase chain reaction of dna |
EP2283848A1 (en) | 1998-07-30 | 2011-02-16 | Xy, Llc | Equine system for non-surgical articificial insemination |
US6473171B1 (en) | 1999-01-15 | 2002-10-29 | Coors Brewing Company | Biocompatible apparatus for ultrasensitive and rapid detection of contaminants in liquids |
US6368563B1 (en) * | 1999-03-12 | 2002-04-09 | Integ, Inc. | Collection well for body fluid tester |
US7024316B1 (en) | 1999-10-21 | 2006-04-04 | Dakocytomation Colorado, Inc. | Transiently dynamic flow cytometer analysis system |
US7208265B1 (en) * | 1999-11-24 | 2007-04-24 | Xy, Inc. | Method of cryopreserving selected sperm cells |
US6263745B1 (en) | 1999-12-03 | 2001-07-24 | Xy, Inc. | Flow cytometer nozzle and flow cytometer sample handling methods |
EP2258174A3 (en) | 2000-05-09 | 2012-06-13 | Xy, Llc | High purity x-chromosome bearing and y-chromosome bearing populations of spermatozoa |
US6809804B1 (en) | 2000-05-11 | 2004-10-26 | Becton, Dickinson And Company | System and method for providing improved event reading and data processing capabilities in a flow cytometer |
US7713687B2 (en) | 2000-11-29 | 2010-05-11 | Xy, Inc. | System to separate frozen-thawed spermatozoa into x-chromosome bearing and y-chromosome bearing populations |
WO2002043486A1 (en) | 2000-11-29 | 2002-06-06 | Xy, Inc. | System for in-vitro fertilization with spermatozoa separated into x-chromosome and y-chromosome bearing populations |
US7280207B2 (en) * | 2001-07-25 | 2007-10-09 | Applera Corporation | Time-delay integration in a flow cytometry system |
US6788409B2 (en) * | 2001-09-07 | 2004-09-07 | Becton, Dickinson And Company | Flow cell system for solubility testing |
NZ538265A (en) * | 2002-07-22 | 2008-12-24 | Xy Inc | Sperm cell process system |
US11243494B2 (en) | 2002-07-31 | 2022-02-08 | Abs Global, Inc. | Multiple laminar flow-based particle and cellular separation with laser steering |
ES2659052T3 (es) * | 2002-07-31 | 2018-03-13 | Premium Genetics (Uk) Limited | Método de clasificación de materiales usando dirección de láser holográfica |
US7699767B2 (en) | 2002-07-31 | 2010-04-20 | Arryx, Inc. | Multiple laminar flow-based particle and cellular separation with laser steering |
US7118676B2 (en) * | 2003-09-04 | 2006-10-10 | Arryx, Inc. | Multiple laminar flow-based particle and cellular separation with laser steering |
US8486618B2 (en) | 2002-08-01 | 2013-07-16 | Xy, Llc | Heterogeneous inseminate system |
CN1674780A (zh) | 2002-08-01 | 2005-09-28 | Xy公司 | 低压精子分离系统 |
MXPA05001654A (es) | 2002-08-15 | 2005-10-18 | Xy Inc | Citometro de flujo de alta resolucion. |
US7169548B2 (en) | 2002-09-13 | 2007-01-30 | Xy, Inc. | Sperm cell processing and preservation systems |
US20040061853A1 (en) * | 2002-09-27 | 2004-04-01 | Blasenheim Barry J. | Prism-based flow cytometry excitation optics |
US7201875B2 (en) * | 2002-09-27 | 2007-04-10 | Becton Dickinson And Company | Fixed mounted sorting cuvette with user replaceable nozzle |
EP2305172B1 (en) * | 2003-03-28 | 2016-05-11 | Inguran, LLC | Apparatus and methods for providing sex-sorted animal sperm |
CA2524786A1 (en) * | 2003-05-07 | 2004-11-25 | Novasite Pharmaceuticals, Inc. | Gain of function sorting for drug discovery and development |
JP2007504837A (ja) * | 2003-05-07 | 2007-03-08 | ノバサイト ファーマシューティカルズ, インコーポレイテッド | 多重多標的スクリーニング方法 |
AU2004242121B2 (en) | 2003-05-15 | 2010-06-24 | Xy, Llc. | Efficient haploid cell sorting for flow cytometer systems |
KR100519672B1 (ko) * | 2003-12-22 | 2005-10-11 | 주식회사 디지탈바이오테크놀러지 | 유체 플로우를 포커싱하기 위한 채널 장치 |
US7468789B2 (en) * | 2004-02-05 | 2008-12-23 | Advanced Analytical Technologies, Inc. | Flow cytometer for rapid bacteria detection |
EP1756547B1 (de) * | 2004-03-01 | 2014-05-14 | Partec GmbH | Vorrichtung zum messen von licht, welches von mikroskopisch kleinen partikeln oder biologischen zellen ausgeht |
EP1730266A2 (en) | 2004-03-29 | 2006-12-13 | Monsanto Technology, LLC | Sperm suspensions for sorting into x or y chromosome-bearing enriched populations |
US20060000710A1 (en) * | 2004-06-30 | 2006-01-05 | Klaus Peter Weidenhaupt | Fluid handling methods |
BRPI0513685A (pt) | 2004-07-22 | 2008-05-13 | Monsanto Technology Llc | processo para enriquecimento de uma população de células de esperma |
DK2884258T3 (da) | 2004-07-27 | 2017-01-02 | Beckman Coulter Inc | Forbedring af flowcytometrisk diskrimination med computerimplementeret geometrisk transformation |
US7110192B2 (en) * | 2005-01-12 | 2006-09-19 | Dako Denmark A/S | System and method for a composite lens for a flow cytometer |
US7355696B2 (en) * | 2005-02-01 | 2008-04-08 | Arryx, Inc | Method and apparatus for sorting cells |
US7618770B2 (en) * | 2005-07-29 | 2009-11-17 | Xy, Inc. | Methods and apparatus for reducing protein content in sperm cell extenders |
WO2009032827A2 (en) * | 2007-09-04 | 2009-03-12 | Purdue Research Foundation | Electroporative flow cytometry |
CN101842688B (zh) * | 2007-10-29 | 2017-02-08 | 希森美康株式会社 | 细胞分析仪及细胞分析方法 |
WO2009149733A1 (en) * | 2008-06-13 | 2009-12-17 | Embl Heidelberg | Next generation flow cytometer sorter |
US7957002B2 (en) * | 2009-03-13 | 2011-06-07 | The Furukawa Electric Co., Ltd. | Method for optical measurement and optical measurement apparatus |
US8589851B2 (en) * | 2009-12-15 | 2013-11-19 | Memoir Systems, Inc. | Intelligent memory system compiler |
EP3239717B1 (en) * | 2010-04-15 | 2020-05-27 | Accellix Ltd | System and method for determination of a medical condition |
US10908066B2 (en) | 2010-11-16 | 2021-02-02 | 1087 Systems, Inc. | Use of vibrational spectroscopy for microfluidic liquid measurement |
US11668640B2 (en) | 2015-03-06 | 2023-06-06 | Inguran, Llc | Nozzle assembly for a flow cytometry system and methods of manufacture |
EP4230996A3 (en) | 2012-09-19 | 2023-10-11 | Inguran, LLC | A method of sorting cells and a flow cytometer system |
WO2014047358A1 (en) | 2012-09-19 | 2014-03-27 | Inguran, Llc | Flow cytometer nozzle tip |
WO2014097286A1 (en) | 2012-12-17 | 2014-06-26 | Leukodx, Ltd. | Systems and methods for determining a chemical state |
US20140170678A1 (en) | 2012-12-17 | 2014-06-19 | Leukodx Ltd. | Kits, compositions and methods for detecting a biological condition |
US10610861B2 (en) | 2012-12-17 | 2020-04-07 | Accellix Ltd. | Systems, compositions and methods for detecting a biological condition |
US8961904B2 (en) | 2013-07-16 | 2015-02-24 | Premium Genetics (Uk) Ltd. | Microfluidic chip |
US11796449B2 (en) | 2013-10-30 | 2023-10-24 | Abs Global, Inc. | Microfluidic system and method with focused energy apparatus |
EP3201599A1 (en) * | 2014-09-30 | 2017-08-09 | FOSS Analytical A/S | Method, device and system for hydrodynamic flow focusing |
WO2016132222A2 (en) | 2015-02-19 | 2016-08-25 | Premium Genetics (Uk) Ltd. | Scanning infrared measurement system |
JP7073805B2 (ja) * | 2018-03-14 | 2022-05-24 | 株式会社リコー | 液滴形成ヘッド、液滴形成装置、及び液滴形成方法 |
WO2019226790A1 (en) | 2018-05-23 | 2019-11-28 | Abs Global, Inc. | Systems and methods for particle focusing in microchannels |
EP3955735B1 (en) | 2019-04-18 | 2024-05-22 | ABS Global, Inc. | System and process for continuous addition of cryoprotectant |
CN110361316A (zh) * | 2019-08-01 | 2019-10-22 | 桂林优利特医疗电子有限公司 | 用于流式细胞仪的偏心流动池和侧向光收集装置 |
US11628439B2 (en) | 2020-01-13 | 2023-04-18 | Abs Global, Inc. | Single-sheath microfluidic chip |
JP7633402B2 (ja) | 2020-11-23 | 2025-02-19 | エイビーエス グローバル、インコーポレイテッド | モジュール式フロー・サイトメトリ・システム及びサンプル処理方法 |
WO2022204564A2 (en) | 2021-03-25 | 2022-09-29 | Iovance Biotherapeutics, Inc. | Methods and compositions for t-cell coculture potency assays and use with cell therapy products |
US20230053122A1 (en) * | 2021-08-10 | 2023-02-16 | Becton, Dickinson And Company | Clamps for operably coupling an optical component to a mounting block, and methods and systems for using the same |
Family Cites Families (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3351408A (en) * | 1963-11-08 | 1967-11-07 | John J Krewalk | Sunlight-filtering ocular adapter for telescopes |
US3675768A (en) * | 1969-03-17 | 1972-07-11 | Gildardo Legorreta Sanchez | Method and apparatus for classifying and segregating particles with electrical and optical means |
DE2050672C3 (de) * | 1970-10-15 | 1975-02-06 | Phywe Ag, 3400 Goettingen | Durchflußküvette zur mikroskopfotometrischen Messung von in einer Flüssigkeit suspendierten Teilchen |
US3893766A (en) * | 1973-06-14 | 1975-07-08 | Coulter Electronics | Apparatus for orienting generally flat particles for slit-scan photometry |
US3924947A (en) * | 1973-10-19 | 1975-12-09 | Coulter Electronics | Apparatus for preservation and identification of particles analyzed by flow-through apparatus |
DE2543310C2 (de) * | 1975-09-27 | 1982-04-29 | Gesellschaft für Strahlen- und Umweltforschung mbH, 8000 München | Einrichtung zum Zählen und Klassifizieren von in einer Flüssigkeit suspendierten Teilchen |
US4095898A (en) * | 1976-06-10 | 1978-06-20 | Coulter Electronics, Inc. | Particle analysis system with photochromic filter |
US4110604A (en) * | 1976-11-04 | 1978-08-29 | Becton, Dickinson And Company | Particle density measuring system |
US4165484A (en) * | 1977-03-23 | 1979-08-21 | Becton, Dickinson And Company | Particle counting apparatus utilizing various fluid resistors to maintain proper pressure differentials |
US4408877A (en) * | 1979-04-10 | 1983-10-11 | Ernst Leitz Wetzlar Gmbh | Device for hydrodynamic focussing of a particle-suspension in a liquid flow cytophotometer |
US4240029A (en) * | 1979-04-20 | 1980-12-16 | Becton Dickinson & Company | Apparatus for counting particles in a liquid suspension |
DE2922643A1 (de) * | 1979-06-02 | 1980-12-11 | Strahlen Umweltforsch Gmbh | Vorrichtung zur zaehlung und klassifizierung von teilchen |
NO145176C (no) * | 1979-11-23 | 1982-01-27 | Norsk Hydros Inst For Kreftfor | Anordning ved vaeskestroemsfotometer. |
US4348107A (en) * | 1980-07-18 | 1982-09-07 | Coulter Electronics, Inc. | Orifice inside optical element |
DE3266669D1 (en) * | 1981-06-24 | 1985-11-07 | Becton Dickinson Co | Analyzer for simultaneously determining volume and light emission characteristics of particles |
US4498766A (en) * | 1982-03-25 | 1985-02-12 | Becton, Dickinson And Company | Light beam focal spot elongation in flow cytometry devices |
JPS5914054U (ja) * | 1982-07-19 | 1984-01-27 | 東ソー株式会社 | 液体クロマトグラフ用フロ−セル |
US4541689A (en) * | 1983-09-19 | 1985-09-17 | Optical Storage International | Friction wedge alignment system for laser diode collimator pens |
US4600302A (en) * | 1984-03-26 | 1986-07-15 | Becton, Dickinson And Company | Flow cytometry apparatus with uniform incoherent light excitation |
-
1984
- 1984-05-03 US US06/606,802 patent/US4660971A/en not_active Expired - Lifetime
-
1985
- 1985-03-20 CA CA000476974A patent/CA1242593A/en not_active Expired
- 1985-03-21 DE DE8585103289T patent/DE3577747D1/de not_active Expired - Fee Related
- 1985-03-21 EP EP85103289A patent/EP0160201B1/en not_active Expired
- 1985-04-02 FI FI851323A patent/FI82772C/fi not_active IP Right Cessation
- 1985-04-10 AU AU40989/85A patent/AU573144B2/en not_active Ceased
- 1985-04-26 DK DK187985A patent/DK166233C/da not_active IP Right Cessation
- 1985-05-04 JP JP60095868A patent/JPS60238762A/ja active Granted
-
1987
- 1987-09-29 MY MYPI87002156A patent/MY100374A/en unknown
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5733507A (en) * | 1995-06-07 | 1998-03-31 | Inphocyte, Inc. | Biological cell sample holder for use in infrared and/or Raman spectroscopy analysis holder |
US5848977A (en) * | 1996-02-16 | 1998-12-15 | Inphocyte, Inc. | Sample holder for cells |
Also Published As
Publication number | Publication date |
---|---|
DK187985D0 (da) | 1985-04-26 |
FI82772B (fi) | 1990-12-31 |
DK166233B (da) | 1993-03-22 |
US4660971A (en) | 1987-04-28 |
EP0160201B1 (en) | 1990-05-16 |
AU4098985A (en) | 1985-11-07 |
FI851323L (fi) | 1985-11-04 |
EP0160201A3 (en) | 1987-03-25 |
DE3577747D1 (de) | 1990-06-21 |
FI851323A0 (fi) | 1985-04-02 |
DK187985A (da) | 1985-11-04 |
DK166233C (da) | 1993-08-16 |
AU573144B2 (en) | 1988-05-26 |
FI82772C (fi) | 1991-04-10 |
JPS60238762A (ja) | 1985-11-27 |
JPH0431353B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1992-05-26 |
EP0160201A2 (en) | 1985-11-06 |
MY100374A (en) | 1990-08-28 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CA1242593A (en) | Optical features of flow cytometry apparatus | |
EP0210343B1 (en) | Flow cytometry apparatus with improved light beam adjustment | |
US4498766A (en) | Light beam focal spot elongation in flow cytometry devices | |
US4545677A (en) | Prismatic beam expander for light beam shaping in a flow cytometry apparatus | |
US4927268A (en) | Optical analysis | |
US7075647B2 (en) | Back-scatter detection in flow cytometers | |
US5030002A (en) | Method and apparatus for sorting particles with a moving catcher tube | |
EP2207025B1 (en) | Cuvette for flow-type particle analyzer | |
EP0068404B1 (en) | Analyzer for simultaneously determining volume and light emission characteristics of particles | |
EP2264427B1 (en) | Optical apparatus with focussing reflector for converging radiation onto a flow of particles, and related method of analysis | |
CA1117310A (en) | Parabolic cell analyzer | |
US4737025A (en) | Flow chamber device for flow cytometers | |
US5552885A (en) | Measuring chamber for flow cytometer | |
US4915501A (en) | Device for measuring the light scattering of biological cells in flow cytophotometers | |
US3873204A (en) | Optical extinction photoanalysis apparatus for small particles | |
EP1924837A1 (en) | Flow cytometer for differentiating small particles in suspension | |
GB2125181A (en) | Flow cells for particle study | |
Steen et al. | Differential light-scattering detection in an arc lamp-based flow cytometer | |
KR20230142515A (ko) | 큐벳 어셈블리, 큐벳 어셈블리를 포함하는 플로우 셀,및 큐벳 어셈블리 또는 플로우 셀을 포함하는 샘플 프로세서 | |
EP4047347A1 (en) | Optical particle analyser with illumination at an oblique angle onto a non-transparent microfluidic chip | |
US4822167A (en) | Laser fluorometric detector for microcolumn chromatography | |
JPH0552895B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
MKEX | Expiry |